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Volumn 1, Issue 1, 2008, Pages

Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways

Author keywords

[No Author keywords available]

Indexed keywords

6 PHENYLHEXYL ISOTHIOCYANATE; 6-PHENYLHEXYL ISOTHIOCYANATE; HISTONE; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 6 RECEPTOR; ISOTHIOCYANIC ACID DERIVATIVE; RAS PROTEIN; VASCULOTROPIN A;

EID: 65349138314     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-1-6     Document Type: Article
Times cited : (44)

References (38)
  • 3
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • DOI 10.1182/blood-2002-06-1735
    • Galm O, Yoshikawa H, Esteller M, Osieka R, Herman JG: SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood 2003, 101:2784-2788. (Pubitemid 36857644)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2784-2788
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.G.5
  • 5
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002, 3:415-428. (Pubitemid 34587077)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 7
    • 0037697734 scopus 로고    scopus 로고
    • INK4a gene methylation in multiple myeloma
    • Guillerm G, Depil S, Wolowiec D, Quesnel B: Different prognostic values of p15(INK4b) and p16(INK4a) gene methylations in multiple myeloma. Haematologica 2003, 88:476-478. (Pubitemid 36547138)
    • (2003) Haematologica , vol.88 , Issue.4 , pp. 476-478
    • Guillerm, G.1    Depil, S.2    Wolowiec, D.3    Quesnel, B.4
  • 8
    • 0030940091 scopus 로고    scopus 로고
    • Frequent hypermethylation of p16 and p15 genes in multiple myeloma
    • Ng MHL, Chung YF, Lo KW, Wickham NWR, Lee JCK, Huang DP: Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma. Blood 1997, 89:2500-2506. (Pubitemid 27143298)
    • (1997) Blood , vol.89 , Issue.7 , pp. 2500-2506
    • Ng, M.H.L.1    Chung, Y.F.2    Lo, K.W.3    Wickham, N.W.R.4    Lee, J.C.K.5    Huang, D.P.6
  • 11
    • 0026005560 scopus 로고
    • Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-My 1 to 7 established from patients with advanced stage of the disease
    • Hitzler JK, Martinez-Valdez H, Bergsagel DB, Minden MD, Messner HA: Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-My 1 to 7 established from patients with advanced stage of the disease. Blood 1991, 78:1996-2004.
    • (1991) Blood , vol.78 , pp. 1996-2004
    • Hitzler, J.K.1    Martinez-Valdez, H.2    Bergsagel, D.B.3    Minden, M.D.4    Messner, H.A.5
  • 12
    • 0028928641 scopus 로고
    • Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis
    • Kawano MM, Mihara K, Huang N, Tsujimoto T, Kuramoto A: Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis. Blood 1995, 85:487-494.
    • (1995) Blood , vol.85 , pp. 487-494
    • Kawano, M.M.1    Mihara, K.2    Huang, N.3    Tsujimoto, T.4    Kuramoto, A.5
  • 13
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
    • Vacca A, Ribatti D, Presta M, Minischetti M, Lurlaro M, Ria R, Albini A, Bussolino F, Dammacco F: Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma. Blood 1999, 93:3064-3073. (Pubitemid 29200799)
    • (1999) Blood , vol.93 , Issue.9 , pp. 3064-3073
    • Vacca, A.1    Ribatti, D.2    Presta, M.3    Minischetti, M.4    Iurlaro, M.5    Ria, R.6    Albini, A.7    Bussolino, F.8    Dammacco, F.9
  • 14
    • 0038284068 scopus 로고    scopus 로고
    • A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma
    • Vacca A, Ria R, Ribatti D, Semeraro F, Djonov V, Di Raimondo F, Dammacco F: A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma. Haematologica 2003, 88:176-185. (Pubitemid 37101495)
    • (2003) Haematologica , vol.88 , Issue.2 , pp. 176-185
    • Vacca, A.1    Ria, R.2    Ribatti, D.3    Semeraro, F.4    Djonov, V.5    Di Raimondo, F.6    Dammacco, F.7
  • 15
    • 0033787241 scopus 로고    scopus 로고
    • Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma
    • Sezer O, Niemoller K, Eucker J, Jakob C, Kaufmann O, Zavrski I, et al.: Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma. Ann Hematol 2000, 79:574-577.
    • (2000) Ann Hematol , vol.79 , pp. 574-577
    • Sezer, O.1    Niemoller, K.2    Eucker, J.3    Jakob, C.4    Kaufmann, O.5    Zavrski, I.6
  • 16
    • 0034765511 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors as new cancer drugs
    • DOI 10.1097/00001622-200111000-00010
    • Marks PA, Richon VM, Breslow R, Rifkind RA: Histone deacetylase inhibitors as new cancer drugs. Current Opinion in Oncology 2001, 13:477-483. (Pubitemid 33027900)
    • (2001) Current Opinion in Oncology , vol.13 , Issue.6 , pp. 477-483
    • Marks, P.A.1    Richon, V.M.2    Breslow, R.3    Rifkind, R.A.4
  • 17
    • 0033523203 scopus 로고    scopus 로고
    • Chromatin remodeling and transcriptional regulation
    • Luo RX, Dean DC: Chromatin remodeling and transcriptional regulation. Journal of the National Cancer Institute 1999, 91:1288-1294. (Pubitemid 29387570)
    • (1999) Journal of the National Cancer Institute , vol.91 , Issue.15 , pp. 1288-1294
    • Luo, R.X.1    Dean, D.C.2
  • 18
    • 0034252183 scopus 로고    scopus 로고
    • Histone acetylation modifiers in the pathogenesis of malignant disease
    • Mahlknecht U, Hoelzer D: Histone acetylation modifiers in the pathogenesis of malignant disease. Molecular Medicine 2000, 6:623-644.
    • (2000) Molecular Medicine , vol.6 , pp. 623-644
    • Mahlknecht, U.1    Hoelzer, D.2
  • 20
    • 0028986992 scopus 로고
    • Trichostatin A inhbits both ras-induced neurite outgrowth of P12 cells and morphological transformation of NIH3T3 cells
    • Futamura M, Monden Y, Okabe T, Fujita-Yoshigaki J, Yokoyama S, Nishimura S: Trichostatin A inhbits both ras-induced neurite outgrowth of P12 cells and morphological transformation of NIH3T3 cells. Oncogene 1995, 10:1119-1123.
    • (1995) Oncogene , vol.10 , pp. 1119-1123
    • Futamura, M.1    Monden, Y.2    Okabe, T.3    Fujita-Yoshigaki, J.4    Yokoyama, S.5    Nishimura, S.6
  • 23
    • 0036014986 scopus 로고    scopus 로고
    • Histone deacetylases as therapeutic targets in hematologic malignancies
    • DOI 10.1097/00062752-200207000-00010
    • Melnick A, Licht JD: Histone Deacetylases as therapeutic targets in hematologic malignancies. Current Opinion in Hematology 2002, 9:322-332. (Pubitemid 34596877)
    • (2002) Current Opinion in Hematology , vol.9 , Issue.4 , pp. 322-332
    • Melnick, A.1    Licht, J.D.2
  • 25
    • 2042505684 scopus 로고    scopus 로고
    • Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma
    • DOI 10.1111/j.1365-2141.2004.04882.x
    • Khan SB, Maududi T, Barton K, Ayers J, Alkan S: Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma. Brit J Haematol 2004, 125(2):156-161. (Pubitemid 38534966)
    • (2004) British Journal of Haematology , vol.125 , Issue.2 , pp. 156-161
    • Khan, S.B.1    Maududi, T.2    Barton, K.3    Ayers, J.4    Alkan, S.5
  • 26
    • 33644554220 scopus 로고    scopus 로고
    • The effects of the histone deacetylase inhibitor valproic acid on cell cycle growth suppression and apoptosis in multiple myeloma
    • Kaiser M, Zavrski I, Sterz J, Jakob C, Fleissner C, Kloetzel PM, Sezer O, Heider U: The effects of the histone deacetylase inhibitor valproic acid on cell cycle growth suppression and apoptosis in multiple myeloma. Haematologica 2006, 91:248-251.
    • (2006) Haematologica , vol.91 , pp. 248-251
    • Kaiser, M.1    Zavrski, I.2    Sterz, J.3    Jakob, C.4    Fleissner, C.5    Kloetzel, P.M.6    Sezer, O.7    Heider, U.8
  • 28
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • DOI 10.1182/blood-2006-06-025999
    • Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR: Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007, 109:31-39. (Pubitemid 46053039)
    • (2007) Blood , vol.109 , Issue.1 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3    Zhang, C.4    Hazarika, P.5    Kelly, C.6    Chiao, J.H.7    Reilly, J.F.8    Ricker, J.L.9    Richon, V.M.10    Frankel, S.R.11
  • 29
    • 33646823481 scopus 로고    scopus 로고
    • Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells
    • Ma X, Fang Y, Beklemisheva A, Dai W, Feng J, Ahmed T, Liu D, Chiao JW: Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells. Intl J Oncol 2006, 28(5):1287-93.
    • (2006) Intl J Oncol , vol.28 , Issue.5 , pp. 1287-1293
    • Ma, X.1    Fang, Y.2    Beklemisheva, A.3    Dai, W.4    Feng, J.5    Ahmed, T.6    Liu, D.7    Chiao, J.W.8
  • 30
    • 39049192119 scopus 로고    scopus 로고
    • The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo
    • Lu L, Liu D, Ma X, Beklomisheva A, Seiter K, Ahmed T, Chiao JW: The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. Oncol Reports 2006, 16(6):1363-1367.
    • (2006) Oncol Reports , vol.16 , Issue.6 , pp. 1363-1367
    • Lu, L.1    Liu, D.2    Ma, X.3    Beklomisheva, A.4    Seiter, K.5    Ahmed, T.6    Chiao, J.W.7
  • 31
    • 33645822781 scopus 로고    scopus 로고
    • Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells
    • Beklomisheva A, Fang Y, Feng J, Ma X, Dai W, Chiao JW: Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells. Anticancer Res 2006, 26:1225-1230.
    • (2006) Anticancer Res , vol.26 , pp. 1225-1230
    • Beklomisheva, A.1    Fang, Y.2    Feng, J.3    Ma, X.4    Dai, W.5    Chiao, J.W.6
  • 34
    • 0027374638 scopus 로고
    • A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro- 1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
    • DOI 10.1006/bbrc.1993.2438
    • Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi A: A new method for the cytofluorimetric analysis of mitochondrial membrane potentials using the J aggregate forming lipophilic cation 5,5.,6,6.-tetrachloro-1,1.,3,3. tetraethyl benzimidazolyl carbocyanine iodide (JC-1). Biochem Biophys Res Commun 1993, 197:40-45. (Pubitemid 23358874)
    • (1993) Biochemical and Biophysical Research Communications , vol.197 , Issue.1 , pp. 40-45
    • Cossarizza, A.1    Baccarani-Contri, M.2    Kalashnikova, G.3    Franceschi, C.4
  • 35
    • 23244459828 scopus 로고    scopus 로고
    • Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma
    • DOI 10.1593/neo.04655
    • Fandy TE, Shankar S, Ross RD, Sausville E, Srivastava RK: Interactive effects of HDAC inhibitors and trail on apoptosis are associated with changes in mitochondrial functions and expression of cell cycle regulatory genes in multiple myeloma. Neoplasia 2005, 7:646-657. (Pubitemid 41099418)
    • (2005) Neoplasia , vol.7 , Issue.7 , pp. 646-657
    • Fandy, T.E.1    Shankar, S.2    Ross, D.D.3    Sausville, E.4    Srivastava, R.K.5
  • 38
    • 34249810897 scopus 로고    scopus 로고
    • Acute myeloid leukemia and myelodysplastic syndromes in older patients
    • DOI 10.1200/JCO.2006.10.2731
    • Estey E: Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol 2007, 25:1908-1915. (Pubitemid 46854425)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.14 , pp. 1908-1915
    • Estey, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.