The NAD ratio redox paradox: Why does too much reductive power cause oxidative stress?

Toxicology Mechanisms and Methods

Volumn 23, Issue 5, 2013, Pages 297-302

  Teodoro, João Soeiro ^a   Rolo, Anabela Pinto ^a,b   Palmeira, Carlos Marques ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

Author keywords

Diabetes; Glucose; Mitochondria; NADH; NADPH; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

LIVER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

HUMANS; NAD; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 84878533789     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2012.759305     Document Type: Review

References (69)

1. Avogaro A, Crepaldi C, Miola M, et al. (1996). High blood ketone body concentration in type 2 non-insulin dependent diabetic patients. J Endocrinol Invest 19:99-105. (Pubitemid 26107179)
2. Befroy DE, Petersen KF, Dufour S, et al. (2007). Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 56:1376-81. (Pubitemid 46715630)
3. Berg JM, Tymoczko JL, Stryer L. (2002). Biochemistry. 5th ed. New York, NY: W H Freeman, Section 30.5, Ethanol Alters Energy Metabolism in the Liver.
4. Berríos-Rivera SJ, Bennett GN, San KY. (2002). Metabolic engineering of Escherichia coli: increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenase. Metab Eng 4:217-29. (Pubitemid 35474128)
5. Beyer TA, Xu W, Teupser D, et al. (2008). Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J 27:212-23.
6. Blinova K, Carroll S, Bose S, et al. (2005). Distribution of mitochondrial NADH fluorescence lifetimes: steady-state kinetics of matrix NADH interactions. Biochemistry 44:2585-94. (Pubitemid 40279562)
7. Boden, G. (2003). Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp Clin Endocrinol Diabetes 111:121-4. (Pubitemid 36682048)
8. Brownlee M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-20. (Pubitemid 34000785)
9. Brownlee M, Cerami, A. (1981). The biochemistry of the complications of diabetes-mellitus. Ann Rev Biochem 50:385-432.
10. Cantó C, Auwerx J. (2009). PGC-1 alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20:98-105.
11. Chabi B, Adhihetty PJ, O'Leary MF, et al. (2009). Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. J Appl Physiol 107:1730-5.
12. Chau MD, Gao J, Yang Q, et al. (2010). Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci USA 107:12553-8.
13. Chaudhary N, Pfluger PT. (2009). Metabolic benefits from Sirt1 and Sirt1 activators. Curr Opin Clin Nutr Metab Care 12:431-7.
14. Choi YS, Kim S, Pak YK. (2001). Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin Pract 54:S3-9. (Pubitemid 33081103)
15. Chung SS, Ho EC, Lam KS, Chung SK. (2003). Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol 14:S233-6. (Pubitemid 36903931)
16. Costa CD, Hammes TO, Rohden F, et al. (2009). SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis. Obes Surg 20:633-9.
17. Feige JN, Lagouge M, Canto C, et al. (2008). Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8:347-58.
18. Frohlich J, Steiner G. (2000). Dyslipidaemia and coagulation defects of insulin resistance. Int J Clin Pract Suppl 113:14-22.
19. Gardner CD, Eguchi S, Reynolds CM, et al. (2003). Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells. Exp Biol Med (Maywood) 228:836-42. (Pubitemid 37169269)
20. + channels in mouse B cells. J Clin Invest 89:1288-95.
21. Goldstein BJ, Mahadev K, Wu X, et al. (2005). Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 7:1021-31. (Pubitemid 40973798)
22. Gumaa KA, McLean P, Greenbaum AL. (1971). Compartmentation in relation to metabolic control in liver. Essays Biochem 7:39-86.
23. Gurd BJ, Yoshida Y, Lally J, et al. (2009). The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis. J Physiol 587:1817-28.
24. Hammes HP, Du X, Edelstein D, et al. (2003). Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 9:294-9. (Pubitemid 36362784)
25. Hardie DG, Carling D. (1997). The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246:259-73. (Pubitemid 27232500)
26. Henquin JC, Meissner P. (1984). Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells. Experientia (Basel) 40:1043-52. (Pubitemid 15147090)
27. Houten SM, Auwerx J. (2004). PGC-1a: Turbocharging mitochondria. Cell 119:5-7.
28. Hwang YC, Bakr S, Ellery CA, et al. (2003). Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. FASEB J 17:2331-3. (Pubitemid 39561483)
29. Ido Y. (2007). Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal 9:931-42. (Pubitemid 46919594)
30. Ii S, Ohta M, Kudo E, et al. (2004). Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with trans-gene-derived human aldose reductase and sorbitol dehydrogenase deficiency. Diabetologia 47:541-8. (Pubitemid 38491252)
31. Jäger S, Handschin C, St-Pierre J, Spiegelman BM. (2007). AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci USA 104:12017-22. (Pubitemid 47185622)
32. Kaneko M, Bucciarelli L, Hwang YC, et al. (2005). Aldose reductase and AGE-RAGE pathways: key players in myocardial ischemic injury. Ann NY Acad Sci 1043:702-9. (Pubitemid 41123963)
33. Kelley DE, Mandarino LJ. (1990). Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus. J Clin Invest 86: 1999-2007.
34. Laye MJ, Rector RS, Warner SO, et al. (2009). Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats. J Physiol, 587:3729-39.
35. Liang W, Ward, WF. (2006). PGC-1a: a key regulator of energy metabolism. Adv Physiol Educ, 30:145-51. (Pubitemid 44749372)
36. López-Lluch G, Hunt N, Jones B, et al. (2006). Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc Natl Acad Sci USA 103:1768-73. (Pubitemid 43228768)
37. MacDonald MJ. (1995). Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270:20051-8.
38. McGarry JD, Dobbins RL. (1999). Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-38. (Pubitemid 29064233)
39. Menshikova EV, Ritov VB, Fairfull L, et al. (2006). Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci 61:534-40.
40. Miettinen TA, Taskinen MR, Pelkonen R, Nikkilä EA. (1969). Glucose tolerance and plasma insulin in man during acute and chronic administration of nicotinic acid. Acta Med Scand 186:247-53.
41. Mintun MA, Vlassenko AG, Rundle MM, Raichle ME. (2004). Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain. Proc Natl Acad Sci USA 101:659-64. (Pubitemid 38084693)
42. Nemoto S, Fergusson MM, Finkel T. (2005). SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1a. J Biol Chem 280:16456-60. (Pubitemid 40616776)
43. Nishikawa T, Edelstein D, Du XL, et al. (2000). Normalizing mitochondrial superox-ide production blocks three pathways of hyperglycaemic damage. Nature 404:787-90. (Pubitemid 30212409)
44. Okazaki IJ, Moss J. (1999). Characterization of glycosylphosphatidyli- nositiol-anchored, secreted, and intracellular vertebrate mono-ADP- ribosyltransferases. Annu Rev Nutr 19:485-509. (Pubitemid 29380614)
45. Oliveira RL, Ueno M, de Souza CT, et al. (2004). Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. Am J Physiol Endocrinol Metab 287:E686-95. (Pubitemid 39237897)
46. Palmeira CM, Rolo AP, Berthiaume J, et al. (2007). Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis. Toxicol Appl Pharmacol 225:214-20. (Pubitemid 350088064)
47. Purushotham A, Schug TT, Xu Q, et al. (2009). Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9:327-38.
48. Rabøl R, Højberg PM, Almdal T, et al. (2009). Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes. J Clin Endocrinol Metab 94:1372-8.
49. Randle PJ, Garland PB, Hales CN, Newsholme EA. (1963). The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-9.
50. Rao P, Kodavanti P, Mehendale H. (1991). Biochemical methods of studying hepatotoxicity. In Meeks RG Harrison SD, Bull RJ, eds. Hepatotoxicity. Boca Raton (FL): CRC Press, 241-326.
51. Rodgers JT, Lerin C, Haas W, et al. (2005). Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434:113-18. (Pubitemid 40349395)
52. Rodrigues F, Ludovico P, Leão C. (2006). Sugar metabolism in yeasts: an overview of aerobic and anaerobic glucose Catabolism. In Péter G, Rosa C, eds. Biodiversity and ecophysiology of yeasts. The yeast handbook. Berlin: Springer-Verlag, 101-21.
53. Rolo AP, Palmeira CM. (2006). Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212:167-78.
54. Ruderman NB, Xu XJ, Nelson L, et al. (2010). AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 298:E751-60.
55. Salway JG. (1999). Metabolism at a glance. 2nd ed. Cambridge: Blackwell Science.
56. Scarpulla RC. (2008). Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88:611-38. (Pubitemid 351520089)
57. Shaw JE, Sicree RA, Zimmet PZ. (2009). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87:4-14.
58. Sinclair DA. (2005). Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 126:987-1002. (Pubitemid 41033180)
59. Steinberg GR, Kemp BE. (2009). AMPK in health and disease. Physiol Rev 89:1025-78.
60. Streffer C, Brauer W, Benes J. (1971). Levels of pyridine nucleotides after repeated applications of nicotinic acid in animal tissues. In Gey KF, Carlson LA, eds. Metabolic effects of nicotinic acid and its derivatives. Bern, Switzerland: Hans Huber Verlag, 97-114.
61. Tilton RG, Chang K, Nyengaard JR, et al. (1995). Inhibition of sorbitol dehydrogenase. Effects on vascular and neural dysfunction in streptozocin-induced diabetic rats. Diabetes 44:234-42.
62. Tilton RG, Kawamura T, Chang KC, et al. (1997). Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest, 99:2192-202. (Pubitemid 27203775)
63. Ukropcova B, Sereda O, de Jonge L, et al. (2007). Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle. Diabetes 56:720-7. (Pubitemid 46348476)
64. Vannini P, Marchesini G, Forlani G, et al. (1982). Branched-chain amino acids and alanine as indices of the metabolic control in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. Diabetologia 22:217-19. (Pubitemid 12183684)
65. Vemuri GN, Eiteman MA, McEwen JE, et al. (2007). Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104:2402-7. (Pubitemid 46391409)
66. Vettor R, Lombardi AM, Fabris R, et al. (1997). Lactate infusion in anesthetized rats produces insulin resistance in heart and skeletal muscles. Metabolism 46:684-90. (Pubitemid 27247305)
67. Wahlberg G, Walldius G, Efendic S. (1992). Effects of nicotinic acid treatment on glucose tolerance and glucose incorporation into adipose tissue in hypertriglyceridemia. Scand J Clin Lab Invest 52:537-45.
68. Winder WW. (2001). Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91:1017-28. (Pubitemid 32803891)
69. Wong J, McLennan SV, Molyneaux L, et al. (2009). Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onset and diabetic complications. Diabetologia 52: 1953-61.