Mitochondrial DNA content in peripheral blood monocytes: Relationship with age of diabetes onsetand diabetic complications

Diabetologia

Volumn 52, Issue 9, 2009, Pages 1953-1961

  Wong, J ^a,b   McLennan, S V ^a,b   Molyneaux, L ^a,b   Min, D ^a   Twigg, S M ^a,b   Yue, D K ^a,b  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Age of onset; Diabetic complications; DNA; Macrophage; Mitochondria; Monocyte; Type 2 diabetes

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DISEASE DURATION; DNA CONTENT; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL GENE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PRIORITY JOURNAL;

ADULT; AGE FACTORS; AGE OF ONSET; AGED; CYTOCHROMES B; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; DNA, MITOCHONDRIAL; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MONOCYTES; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 68449084284     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1424-6     Document Type: Article

References (44)

1. T Yoshiharu I Toshiharu M Kana E Toru K Azuma 2008 Predictors of glycemic control in Japanese subjects with type 2 diabetes mellitus Metab Clin Exp 57 453 457
2. TA Hillier KL Pedula 2003 Complications in young adults with early-onset type 2 diabetes: losing the relative protection of youth Diabetes Care 26 2999 3005
3. J Wong L Molyneaux M Constantino SM Twigg DK Yue 2008 Timing is everything: age of onset influences long-term retinopathy risk in type 2 diabetes, independent of traditional risk factors Diabetes Care 31 1985 1990
4. L Ji X Hou X Han 2001 Prevalence and clinical characteristics of mitochondrial tRNA leu(UUR) mt 3243 A→G and ND-1 gene mt 3316 G→A mutations in Chinese patients with type 2 diabetes Chin Med J (Engl) 114 1205 1207 (Pubitemid 33100156)
5. A Wiederkehr CB Wollheim 2006 Minireview: implication of mitochondria in insulin secretion and action Endocrinology 147 2643 2649
6. KF Petersen S Dufour D Befroy R Garcia GI Shulman 2004 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 664 671
7. P Serradas MH Giroix C Saulnier 1995 Mitochondrial deoxyribonucleic acid content is specifically decreased in adult, but not fetal, pancreatic islets of the Goto-Kakizaki rat, a genetic model of noninsulin-dependent diabetes Endocrinology 136 5623 5631
8. DA Antonetti C Reynet CR Kahn 1995 Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus J Clin Invest 95 1383 1388
9. H Wang WR Hiatt TJ Barstow EP Brass 1999 Relationships between muscle mitochondrial DNA content, mitochondrial enzyme activity and oxidative capacity in man: alterations with disease Eur J Appl Physiol Occup Physiol 80 22 27
10. VS Sukhorukov RP Nartsissov SV Petrichuk 2000 Comparative diagnostic value of the analysis of the skeletal muscle and lymphocytes in mitochondrial diseases Arkh Patol 62 19 21
11. HK Lee JH Song CS Shin 1998 Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus Diabetes Res Clin Pract 42 161 167
12. MC Arkan AL Hevener FR Greten 2005 IKK-β links inflammation to obesity-induced insulin resistance Nat Med 11 191 198
13. J Song JY Oh YA Sung YK Pak KS Park HK Lee 2001 Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients Diabetes Care 24 865 869
14. McGill M ML DK Yue JR Turtle 1993 A single visit diabetes complication assessment service: a complement to diabetes management at the primary care level Diabet Med 10 366 370
15. Group ETDRSR 1991 Grading diabetic retinopathy from stereoscopic color fundus photographs-an extension of the modified Airlie House classification. ETDRS report number 10 Ophthalmology 98 5 Suppl 786 806
16. KG Alberti PZ Zimmet 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 539 553
17. K Gourlain B Amellal Z Ait Arkoub N Dupin C Katlama V Calvez 2003 Quantitative analysis of human mitochondrial DNA using a real-time PCR assay HIV Med 4 287 292
18. MW Pfaffl 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 e45
19. M Ochi H Osawa Y Hirota 2007 Frequency of the G/G genotype of resistin single nucleotide polymorphism at 420 appears to be increased in younger-onset type 2 diabetes Diabetes 56 2834 2838
20. DM Lehman KJ Hunt RJ Leach 2007 Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans Diabetes 56 389 393
21. Y Guo M Traurig L Ma 2006 CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians Diabetes 55 3625 3629
22. U Jaakkola U Pesonen E Vainio-Jylha M Koulu M Pollonen J Kallio 2006 The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy Exp Clin Endocrinol Diabetes 114 147 152
23. DM Flavell H Ireland JW Stephens 2005 Peroxisome proliferator-activated receptor α gene variation influences age of onset and progression of type 2 diabetes Diabetes 54 582 586
24. E Zeggini J Parkinson S Halford 2004 Association studies of insulin receptor substrate 1 gene (irs1) variants in type 2 diabetes samples enriched for family history and early age of onset Diabetes 53 3319 3322
25. R Oliva A Novials M Sánchez 2004 The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2 Endocr 24 111 114
26. S Wiltshire TM Frayling CJ Groves 2004 Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q24 Diabetes 53 855 860
27. RL Hanson C Bogardus D Duggan 2007 A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array Diabetes 56 3045 3052
28. JE Curran MP Johnson TD Dyer 2007 Genetic determinants of mitochondrial content Hum Mol Genet 16 1504 1514
29. JP Silva M Kohler C Graff 2000 Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes Nat Genet 26 336 340
30. GS Hotamisligil 2006 Inflammation and metabolic disorders Nature 444 860 867
31. AL Hevener JM Olefsky D Reichart 2007 Macrophage PPAR γ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones J Clin Invest 117 1658 1669
32. JA Ehses A Perren E Eppler 2007 Increased number of islet-associated macrophages in type 2 diabetes Diabetes 56 2356 2370
33. DC Wallace 2005 A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu Rev Genet 39 359 407
34. S Gordon PR Taylor 2005 Monocyte and macrophage heterogeneity Nat Rev Immunol 5 953 964
35. GH Heine C Ulrich E Seibert 2007 CD14++CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients Kidney Int 73 622 629
36. M Brownlee 2005 The pathobiology of diabetic complications: a unifying mechanism Diabetes 54 1615 1625
37. T Yu JL Robotham Y Yoon 2006 Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology Proc Natl Acad Sci U S A 103 2653 2658
38. JM Baughman VK Mootha 2006 Buffering mitochondrial DNA variation Nat Genet 38 1232 1233
39. R Moreno-Loshuertos R Acin-Perez P Fernandez-Silva 2006 Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants Nat Genet 38 1261 1268
40. E Nisoli MO Carruba 2006 Nitric oxide and mitochondrial biogenesis J Cell Sci 119 2855 2862
41. L Tedesco A Valerio C Cervino 2008 Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes Diabetes 57 2028 2036
42. BA Schick R Laaksonen JJ Frohlich 2007 Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin Clin Pharmacol Ther 81 650 653
43. I Bogacka H Xie GA Bray SR Smith 2005 Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo Diabetes 54 1392 1399
44. R Singh AT Hattersley LW Harries 2007 Reduced peripheral blood mitochondrial DNA content is not a risk factor for type 2 diabetes Diabet Med 24 784 787