-
1
-
-
74549165352
-
An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
-
doi: 10.1111/j.1476-5381.2009.00207.x
-
Pollard CE, Abi Gerges N, Bridgland-Taylor MH, Easter A, Hammond TG, et al. (2010) An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk. Br J Pharmacol 159: 12-21 doi:10.1111/j.1476-5381.2009.00207.x.
-
(2010)
Br J Pharmacol
, vol.159
, pp. 12-21
-
-
Pollard, C.E.1
Abi Gerges, N.2
Bridgland-Taylor, M.H.3
Easter, A.4
Hammond, T.G.5
-
2
-
-
80052338033
-
Novel roles for hERG K(+) channels in cell proliferation and apoptosis
-
doi: 10.1038/cddis.2011.77
-
Jehle J, Schweizer PA, Katus HA, Thomas D, (2011) Novel roles for hERG K(+) channels in cell proliferation and apoptosis. Cell Death Dis 2: e193 doi:10.1038/cddis.2011.77.
-
(2011)
Cell Death Dis
, vol.2
-
-
Jehle, J.1
Schweizer, P.A.2
Katus, H.A.3
Thomas, D.4
-
3
-
-
33645322386
-
KATP channels as molecular sensors of cellular metabolism
-
doi: 10.1038/nature04711
-
Nichols CG, (2006) KATP channels as molecular sensors of cellular metabolism. Nature 440: 470-476 doi:10.1038/nature04711.
-
(2006)
Nature
, vol.440
, pp. 470-476
-
-
Nichols, C.G.1
-
4
-
-
35649001607
-
A quantitative description of membrane current and its application to conduction and excitation in nerve
-
Hodgkin AL, Huxley AF, (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500-544.
-
(1952)
J Physiol
, vol.117
, pp. 500-544
-
-
Hodgkin, A.L.1
Huxley, A.F.2
-
6
-
-
0032478818
-
The structure of the potassium channel: molecular basis of K+ conduction and selectivity
-
doi: 10.1126/science.280.5360.69
-
Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, et al. (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280: 69-77 doi:10.1126/science.280.5360.69.
-
(1998)
Science
, vol.280
, pp. 69-77
-
-
Doyle, D.A.1
Morais Cabral, J.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
-
7
-
-
0033516494
-
Structural rearrangements underlying K+-channel activation gating
-
doi: 10.1126/science.285.5424.73
-
Perozo E, Cortes DM, Cuello LG, (1999) Structural rearrangements underlying K+-channel activation gating. Science 285: 73-78 doi:10.1126/science.285.5424.73.
-
(1999)
Science
, vol.285
, pp. 73-78
-
-
Perozo, E.1
Cortes, D.M.2
Cuello, L.G.3
-
8
-
-
0037387189
-
Potassium channel gating observed with site-directed mass tagging
-
doi: 10.1038/nsb908
-
Kelly BL, Gross A, (2003) Potassium channel gating observed with site-directed mass tagging. Nat Struct Biol 10: 280-284 doi:10.1038/nsb908.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 280-284
-
-
Kelly, B.L.1
Gross, A.2
-
9
-
-
33646145322
-
Structural characterization and pH-induced conformational transition of full-length KcsA
-
doi: 10.1529/biophysj.105.071175
-
Zimmer J, Doyle D a, Grossmann JG, (2006) Structural characterization and pH-induced conformational transition of full-length KcsA. Biophys J 90: 1752-1766 doi:10.1529/biophysj.105.071175.
-
(2006)
Biophys J
, vol.90
, pp. 1752-1766
-
-
Zimmer, J.1
Doyle, D.2
Grossmann, J.G.3
-
10
-
-
37649021608
-
Global twisting motion of single molecular KcsA potassium channel upon gating
-
doi: 10.1016/j.cell.2007.11.040
-
Shimizu H, Iwamoto M, Konno T, Nihei A, Sasaki YC, et al. (2008) Global twisting motion of single molecular KcsA potassium channel upon gating. Cell 132: 67-78 doi:10.1016/j.cell.2007.11.040.
-
(2008)
Cell
, vol.132
, pp. 67-78
-
-
Shimizu, H.1
Iwamoto, M.2
Konno, T.3
Nihei, A.4
Sasaki, Y.C.5
-
11
-
-
66149127336
-
Crystal structure of full-length KcsA in its closed conformation
-
doi: 10.1073/pnas.0810663106
-
Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, et al. (2009) Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A 106: 6644-6649 doi:10.1073/pnas.0810663106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6644-6649
-
-
Uysal, S.1
Vásquez, V.2
Tereshko, V.3
Esaki, K.4
Fellouse, F.A.5
-
12
-
-
77954485089
-
Structural mechanism of C-type inactivation in K(+) channels
-
doi: 10.1038/nature09153
-
Cuello LG, Jogini V, Cortes DM, Perozo E, (2010) Structural mechanism of C-type inactivation in K(+) channels. Nature 466: 203-208 doi:10.1038/nature09153.
-
(2010)
Nature
, vol.466
, pp. 203-208
-
-
Cuello, L.G.1
Jogini, V.2
Cortes, D.M.3
Perozo, E.4
-
13
-
-
37249032102
-
Dynamic personalities of proteins
-
doi: 10.1038/nature06522
-
Henzler-Wildman K, Kern D, (2007) Dynamic personalities of proteins. Nature 450: 964-972 doi:10.1038/nature06522.
-
(2007)
Nature
, vol.450
, pp. 964-972
-
-
Henzler-Wildman, K.1
Kern, D.2
-
14
-
-
0036787715
-
Open-state models of a potassium channel
-
doi: 10.1016/S0006-3495(02)73951-9
-
Biggin PC, Sansom MSP, (2002) Open-state models of a potassium channel. Biophys J 83: 1867-1876 doi:10.1016/S0006-3495(02)73951-9.
-
(2002)
Biophys J
, vol.83
, pp. 1867-1876
-
-
Biggin, P.C.1
Sansom, M.S.P.2
-
15
-
-
4444261061
-
In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices
-
doi: 10.1529/biophysj.103.037770
-
Tikhonov DB, Zhorov BS, (2004) In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices. Biophys J 87: 1526-1536 doi:10.1529/biophysj.103.037770.
-
(2004)
Biophys J
, vol.87
, pp. 1526-1536
-
-
Tikhonov, D.B.1
Zhorov, B.S.2
-
16
-
-
23044517429
-
Targeted molecular dynamics of an open-state KcsA channel
-
doi: 10.1063/1.1869413
-
Compoint M, Picaud F, Ramseyer C, Girardet C, (2005) Targeted molecular dynamics of an open-state KcsA channel. J Chem Phys 122: 134707 doi:10.1063/1.1869413.
-
(2005)
J Chem Phys
, vol.122
, pp. 134707
-
-
Compoint, M.1
Picaud, F.2
Ramseyer, C.3
Girardet, C.4
-
17
-
-
33744926664
-
Common mechanism of pore opening shared by five different potassium channels
-
doi: 10.1529/biophysj.105.080093
-
Shrivastava IH, Bahar I, (2006) Common mechanism of pore opening shared by five different potassium channels. Biophys J 90: 3929-3940 doi:10.1529/biophysj.105.080093.
-
(2006)
Biophys J
, vol.90
, pp. 3929-3940
-
-
Shrivastava, I.H.1
Bahar, I.2
-
18
-
-
56049102616
-
Generation, comparison, and merging of pathways between protein conformations: gating in K-channels
-
doi: 10.1529/biophysj.108.135285
-
Enosh A, Raveh B, Furman-Schueler O, Halperin D, Ben-Tal N, (2008) Generation, comparison, and merging of pathways between protein conformations: gating in K-channels. Biophys J 95: 3850-3860 doi:10.1529/biophysj.108.135285.
-
(2008)
Biophys J
, vol.95
, pp. 3850-3860
-
-
Enosh, A.1
Raveh, B.2
Furman-Schueler, O.3
Halperin, D.4
Ben-Tal, N.5
-
19
-
-
50949126927
-
Cooperative transition between open and closed conformations in potassium channels
-
doi: 10.1371/journal.pcbi.1000164
-
Haliloglu T, Ben-Tal N, (2008) Cooperative transition between open and closed conformations in potassium channels. PLoS Comput Biol 4: e1000164 doi:10.1371/journal.pcbi.1000164.
-
(2008)
PLoS Comput Biol
, vol.4
-
-
Haliloglu, T.1
Ben-Tal, N.2
-
20
-
-
44849124493
-
End-point targeted molecular dynamics: large-scale conformational changes in potassium channels
-
doi: 10.1529/biophysj.107.118778
-
Mashl RJ, Jakobsson E, (2008) End-point targeted molecular dynamics: large-scale conformational changes in potassium channels. Biophys J 94: 4307-4319 doi:10.1529/biophysj.107.118778.
-
(2008)
Biophys J
, vol.94
, pp. 4307-4319
-
-
Mashl, R.J.1
Jakobsson, E.2
-
21
-
-
77951236840
-
Cooperative nature of gating transitions in K(+) channels as seen from dynamic importance sampling calculations
-
doi: 10.1002/prot.22632
-
Denning EJ, Woolf TB, (2010) Cooperative nature of gating transitions in K(+) channels as seen from dynamic importance sampling calculations. Proteins 78: 1105-1119 doi:10.1002/prot.22632.
-
(2010)
Proteins
, vol.78
, pp. 1105-1119
-
-
Denning, E.J.1
Woolf, T.B.2
-
22
-
-
36849022651
-
Open-state conformation of the KcsA K+ channel: Monte Carlo normal mode following simulations
-
doi: 10.1016/j.str.2007.09.022
-
Miloshevsky G V, Jordan PC, (2007) Open-state conformation of the KcsA K+ channel: Monte Carlo normal mode following simulations. Structure 15: 1654-1662 doi:10.1016/j.str.2007.09.022.
-
(2007)
Structure
, vol.15
, pp. 1654-1662
-
-
Miloshevsky, G.V.1
Jordan, P.C.2
-
23
-
-
0029985860
-
An efficient method for sampling the essential subspace of proteins
-
doi: 10.1080/07391102.1996.10508874
-
Amadei A, Linssen AB, De Groot BL, Van Aalten DM, Berendsen HJ, (1996) An efficient method for sampling the essential subspace of proteins. J Biomol Struct Dyn 13: 615-625 doi:10.1080/07391102.1996.10508874.
-
(1996)
J Biomol Struct Dyn
, vol.13
, pp. 615-625
-
-
Amadei, A.1
Linssen, A.B.2
de Groot, B.L.3
van Aalten, D.M.4
Berendsen, H.J.5
-
24
-
-
0029967692
-
Toward an exhaustive sampling of the configurational spaces of the two forms of the peptide hormone guanylin
-
doi: 10.1080/07391102.1996.10508888
-
De Groot BL, Amadei A, Van Aalten DM, Berendsen HJ, (1996) Toward an exhaustive sampling of the configurational spaces of the two forms of the peptide hormone guanylin. J Biomol Struct Dyn 13: 741-751 doi:10.1080/07391102.1996.10508888.
-
(1996)
J Biomol Struct Dyn
, vol.13
, pp. 741-751
-
-
de Groot, B.L.1
Amadei, A.2
van Aalten, D.M.3
Berendsen, H.J.4
-
25
-
-
84891726258
-
AID-PROT7>3.0.CO;2-D
-
De Groot BL, Amadei A, Scheek RM, Van Nuland NA, Berendsen HJ, (1996) AID-PROT7>3.0.CO;2-D.
-
(1996)
-
-
de Groot, B.L.1
Amadei, A.2
Scheek, R.M.3
van Nuland, N.A.4
Berendsen, H.J.5
-
26
-
-
0030833135
-
Protein dynamics derived from clusters of crystal structures
-
doi: 10.1016/S0006-3495(97)78317-6
-
Van Aalten DM, Conn DA, De Groot BL, Berendsen HJ, Findlay JB, et al. (1997) Protein dynamics derived from clusters of crystal structures. Biophys J 73: 2891-2896 doi:10.1016/S0006-3495(97)78317-6.
-
(1997)
Biophys J
, vol.73
, pp. 2891-2896
-
-
van Aalten, D.M.1
Conn, D.A.2
de Groot, B.L.3
Berendsen, H.J.4
Findlay, J.B.5
-
27
-
-
58149218369
-
Protein Folding Pathways Revealed by Essential Dynamics Sampling
-
doi: 10.1021/ct800157v
-
Narzi D, Daidone I, Amadei A, Di Nola A, (2008) Protein Folding Pathways Revealed by Essential Dynamics Sampling. J Chem Theory Comput 4: 1940-1948 doi:10.1021/ct800157v.
-
(2008)
J Chem Theory Comput
, vol.4
, pp. 1940-1948
-
-
Narzi, D.1
Daidone, I.2
Amadei, A.3
Di Nola, A.4
-
28
-
-
77949325249
-
Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels
-
doi: 10.1002/prot.22618
-
Anishkin A, Milac AL, Guy HR, (2010) Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels. Proteins 78: 932-949 doi:10.1002/prot.22618.
-
(2010)
Proteins
, vol.78
, pp. 932-949
-
-
Anishkin, A.1
Milac, A.L.2
Guy, H.R.3
-
29
-
-
0042213113
-
Molecular dynamics of the KcsA K(+) channel in a bilayer membrane
-
doi: 10.1016/S0006-3495(00)76831-7
-
Bernèche S, Roux B, (2000) Molecular dynamics of the KcsA K(+) channel in a bilayer membrane. Biophys J 78: 2900-2917 doi:10.1016/S0006-3495(00)76831-7.
-
(2000)
Biophys J
, vol.78
, pp. 2900-2917
-
-
Bernèche, S.1
Roux, B.2
-
30
-
-
33748802222
-
Surface structure and its dynamic rearrangements of the KcsA potassium channel upon gating and tetrabutylammonium blocking
-
doi: 10.1074/jbc.M602018200
-
Iwamoto M, Shimizu H, Inoue F, Konno T, Sasaki YC, et al. (2006) Surface structure and its dynamic rearrangements of the KcsA potassium channel upon gating and tetrabutylammonium blocking. J Biol Chem 281: 28379-28386 doi:10.1074/jbc.M602018200.
-
(2006)
J Biol Chem
, vol.281
, pp. 28379-28386
-
-
Iwamoto, M.1
Shimizu, H.2
Inoue, F.3
Konno, T.4
Sasaki, Y.C.5
-
31
-
-
84872189670
-
Amphipathic antenna of an inward rectifier K+ channel responds to changes in the inner membrane leaflet
-
doi: 10.1073/pnas.1217323110
-
Iwamoto M, Oiki S, (2013) Amphipathic antenna of an inward rectifier K+ channel responds to changes in the inner membrane leaflet. Proc Natl Acad Sci U S A 110: 749-754 doi:10.1073/pnas.1217323110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 749-754
-
-
Iwamoto, M.1
Oiki, S.2
-
32
-
-
0030404988
-
HOLE: A program for the analysis of the pore dimensions of ion channel structural models
-
doi: 10.1016/S0263-7855(97)00009-X
-
Smart OS, Neduvelil JG, Wang X, Wallace BA, Sansom MSP, (1996) HOLE: A program for the analysis of the pore dimensions of ion channel structural models. J Mol Graph 14: 354-360 doi:10.1016/S0263-7855(97)00009-X.
-
(1996)
J Mol Graph
, vol.14
, pp. 354-360
-
-
Smart, O.S.1
Neduvelil, J.G.2
Wang, X.3
Wallace, B.A.4
Sansom, M.S.P.5
-
33
-
-
77954515664
-
Structural basis for the coupling between activation and inactivation gates in K(+) channels
-
doi: 10.1038/nature09136
-
Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, et al. (2010) Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature 466: 272-275 doi:10.1038/nature09136.
-
(2010)
Nature
, vol.466
, pp. 272-275
-
-
Cuello, L.G.1
Jogini, V.2
Cortes, D.M.3
Pan, A.C.4
Gagnon, D.G.5
-
34
-
-
84855505933
-
Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations
-
doi: 10.1085/jgp.201110670
-
Pan AC, Cuello LG, Perozo E, Roux B, (2011) Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations. J Gen Physiol 138: 571-580 doi:10.1085/jgp.201110670.
-
(2011)
J Gen Physiol
, vol.138
, pp. 571-580
-
-
Pan, A.C.1
Cuello, L.G.2
Perozo, E.3
Roux, B.4
-
35
-
-
33745041507
-
Molecular determinants of gating at the potassium-channel selectivity filter
-
doi: 10.1038/nsmb1069
-
Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, et al. (2006) Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol 13: 311-318 doi:10.1038/nsmb1069.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 311-318
-
-
Cordero-Morales, J.F.1
Cuello, L.G.2
Zhao, Y.3
Jogini, V.4
Cortes, D.M.5
-
36
-
-
35848958366
-
Molecular driving forces determining potassium channel slow inactivation
-
doi: 10.1038/nsmb1309
-
Cordero-Morales JF, Jogini V, Lewis A, Vásquez V, Cortes DM, et al. (2007) Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol 14: 1062-1069 doi:10.1038/nsmb1309.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1062-1069
-
-
Cordero-Morales, J.F.1
Jogini, V.2
Lewis, A.3
Vásquez, V.4
Cortes, D.M.5
-
37
-
-
84866560561
-
Protonation state of E71 in KcsA and its role for channel collapse and inactivation
-
doi: 10.1073/pnas.1211900109
-
Bhate MP, McDermott AE, (2012) Protonation state of E71 in KcsA and its role for channel collapse and inactivation. Proc Natl Acad Sci U S A 2012: 1-6 doi:10.1073/pnas.1211900109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.2012
, pp. 1-6
-
-
Bhate, M.P.1
McDermott, A.E.2
-
38
-
-
0034690250
-
Ion permeation mechanism of the potassium channel
-
doi: 10.1038/35009114
-
Aqvist J, Luzhkov V, (2000) Ion permeation mechanism of the potassium channel. Nature 404: 881-884 doi:10.1038/35009114.
-
(2000)
Nature
, vol.404
, pp. 881-884
-
-
Aqvist, J.1
Luzhkov, V.2
-
39
-
-
0037137218
-
Opening the KcsA K + Channel: Tryptophan Scanning and Complementation Analysis Lead to Mutants with Altered Gating
-
doi: 10.1021/bi026393r
-
Irizarry SN, Kutluay E, Drews G, Hart SJ, Heginbotham L, (2002) Opening the KcsA K + Channel: Tryptophan Scanning and Complementation Analysis Lead to Mutants with Altered Gating. Biochemistry 41: 13653-13662 doi:10.1021/bi026393r.
-
(2002)
Biochemistry
, vol.41
, pp. 13653-13662
-
-
Irizarry, S.N.1
Kutluay, E.2
Drews, G.3
Hart, S.J.4
Heginbotham, L.5
-
40
-
-
0037131520
-
Energetics of Pore Opening in a Voltage-Gated K+ Channel
-
doi: 10.1016/S0092-8674(02)01013-9
-
Yifrach O, MacKinnon R, (2002) Energetics of Pore Opening in a Voltage-Gated K+ Channel. Cell 111: 231-239 doi:10.1016/S0092-8674(02)01013-9.
-
(2002)
Cell
, vol.111
, pp. 231-239
-
-
Yifrach, O.1
MacKinnon, R.2
-
41
-
-
38049148291
-
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel
-
doi: 10.1073/pnas.0708120104
-
Sadovsky E, Yifrach O, (2007) Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel. Proc Natl Acad Sci U S A 104: 19813-19818 doi:10.1073/pnas.0708120104.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19813-19818
-
-
Sadovsky, E.1
Yifrach, O.2
-
42
-
-
64149115115
-
Genetic selection of activatory mutations in KcsA
-
doi: 10.4161/chan.2.6.6874
-
Paynter J, Sarkies P, Andres-Enguix I, Tucker SJ, (2008) Genetic selection of activatory mutations in KcsA. Channels 2: 413-418 doi:10.4161/chan.2.6.6874.
-
(2008)
Channels
, vol.2
, pp. 413-418
-
-
Paynter, J.1
Sarkies, P.2
Andres-Enguix, I.3
Tucker, S.J.4
-
43
-
-
66149157329
-
Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels
-
doi: 10.1371/journal.pbio.1000047
-
Lee S-Y, Banerjee A, MacKinnon R, (2009) Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol 7: e47 doi:10.1371/journal.pbio.1000047.
-
(2009)
PLoS Biol
, vol.7
-
-
Lee, S.-Y.1
Banerjee, A.2
MacKinnon, R.3
-
44
-
-
0038076054
-
X-ray structure of a voltage-dependent K+ channel
-
doi: 10.1038/nature01580
-
Jiang Y, Lee A, Chen J, Ruta V, Cadene M, et al. (2003) X-ray structure of a voltage-dependent K+ channel. Nature 423: 33-41 doi:10.1038/nature01580.
-
(2003)
Nature
, vol.423
, pp. 33-41
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Ruta, V.4
Cadene, M.5
-
45
-
-
23244456428
-
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
-
doi: 10.1126/science.1116269
-
Long SB, Campbell EB, Mackinnon R, (2005) Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science 309: 897-903 doi:10.1126/science.1116269.
-
(2005)
Science
, vol.309
, pp. 897-903
-
-
Long, S.B.1
Campbell, E.B.2
Mackinnon, R.3
-
46
-
-
0036016539
-
Scanning the Intracellular S6 Activation Gate in the Shaker K+ Channel
-
doi: 10.1085/jgp.20028569
-
Hackos DH, (2002) Scanning the Intracellular S6 Activation Gate in the Shaker K+ Channel. J Gen Physiol 119: 521-532 doi:10.1085/jgp.20028569.
-
(2002)
J Gen Physiol
, vol.119
, pp. 521-532
-
-
Hackos, D.H.1
-
47
-
-
0033761957
-
A Localized Interaction Surface for Voltage-Sensing Domains on the Pore Domain of a K+ Channel
-
doi: 10.1016/S0896-6273(00)80904-6
-
Li-Smerin Y, Hackos DH, Swartz KJ, (2000) A Localized Interaction Surface for Voltage-Sensing Domains on the Pore Domain of a K+ Channel. Neuron 25: 411-423 doi:10.1016/S0896-6273(00)80904-6.
-
(2000)
Neuron
, vol.25
, pp. 411-423
-
-
Li-Smerin, Y.1
Hackos, D.H.2
Swartz, K.J.3
-
48
-
-
0026663246
-
Evidence for cooperative interactions in potassium channel gating
-
doi: 10.1038/359420a0
-
Tytgat J, Hess P, (1992) Evidence for cooperative interactions in potassium channel gating. Nature 359: 420-423 doi:10.1038/359420a0.
-
(1992)
Nature
, vol.359
, pp. 420-423
-
-
Tytgat, J.1
Hess, P.2
-
49
-
-
0031905513
-
Role of the S4 in cooperativity of voltage-dependent potassium channel activation
-
doi: 10.1085/jgp.111.3.399
-
Smith-Maxwell CJ, Ledwell JL, Aldrich RW, (1998) Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J Gen Physiol 111: 399-420 doi:10.1085/jgp.111.3.399.
-
(1998)
J Gen Physiol
, vol.111
, pp. 399-420
-
-
Smith-Maxwell, C.J.1
Ledwell, J.L.2
Aldrich, R.W.3
-
50
-
-
0032894433
-
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation
-
doi: 10.1085/jgp.113.3.389
-
Ledwell JL, Aldrich RW, (1999) Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol 113: 389-414 doi:10.1085/jgp.113.3.389.
-
(1999)
J Gen Physiol
, vol.113
, pp. 389-414
-
-
Ledwell, J.L.1
Aldrich, R.W.2
-
51
-
-
12344259926
-
The cooperative voltage sensor motion that gates a potassium channel
-
doi: 10.1085/jgp.200409197
-
Pathak M, Kurtz L, Tombola F, Isacoff E, (2005) The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol 125: 57-69 doi:10.1085/jgp.200409197.
-
(2005)
J Gen Physiol
, vol.125
, pp. 57-69
-
-
Pathak, M.1
Kurtz, L.2
Tombola, F.3
Isacoff, E.4
-
52
-
-
58149527755
-
Fluorescence detection of the movement of single KcsA subunits reveals cooperativity
-
doi: 10.1073/pnas.0807056106
-
Blunck R, McGuire H, Hyde HC, Bezanilla F, (2008) Fluorescence detection of the movement of single KcsA subunits reveals cooperativity. Proc Natl Acad Sci U S A 105: 20263-20268 doi:10.1073/pnas.0807056106.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20263-20268
-
-
Blunck, R.1
McGuire, H.2
Hyde, H.C.3
Bezanilla, F.4
-
53
-
-
50149112602
-
Direct analysis of cooperativity in multisubunit allosteric proteins
-
doi: 10.1073/pnas.0804104105
-
Zandany N, Ovadia M, Orr I, Yifrach O, (2008) Direct analysis of cooperativity in multisubunit allosteric proteins. Proc Natl Acad Sci U S A 105: 11697-11702 doi:10.1073/pnas.0804104105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 11697-11702
-
-
Zandany, N.1
Ovadia, M.2
Orr, I.3
Yifrach, O.4
-
54
-
-
0035499892
-
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
-
doi: 10.1038/35102009
-
Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R, (2001) Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature 414: 43-48 doi:10.1038/35102009.
-
(2001)
Nature
, vol.414
, pp. 43-48
-
-
Zhou, Y.1
Morais-Cabral, J.H.2
Kaufman, A.3
MacKinnon, R.4
-
55
-
-
0031473847
-
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling
-
doi: 10.1002/elps.1150181505
-
Guex N, Peitsch MC, (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18: 2714-2723 doi:10.1002/elps.1150181505.
-
(1997)
Electrophoresis
, vol.18
, pp. 2714-2723
-
-
Guex, N.1
Peitsch, M.C.2
-
56
-
-
77954256616
-
g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation
-
doi: 10.1002/jcc.21507
-
Wolf MG, Hoefling M, Aponte-Santamaría C, Grubmüller H, Groenhof G, (2010) g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation. J Comput Chem 31: 2169-2174 doi:10.1002/jcc.21507.
-
(2010)
J Comput Chem
, vol.31
, pp. 2169-2174
-
-
Wolf, M.G.1
Hoefling, M.2
Aponte-Santamaría, C.3
Grubmüller, H.4
Groenhof, G.5
-
57
-
-
83455205897
-
In silico Analysis of Conformational Changes Induced by Mutation of Aromatic Binding Residues: Consequences for Drug Binding in the hERG K+ Channel
-
doi: 10.1371/journal.pone.0028778
-
Knape K, Linder T, Wolschann P, Beyer A, Stary-Weinzinger A, (2011) In silico Analysis of Conformational Changes Induced by Mutation of Aromatic Binding Residues: Consequences for Drug Binding in the hERG K+ Channel. PloS one 6: e28778 doi:10.1371/journal.pone.0028778.
-
(2011)
PloS One
, vol.6
-
-
Knape, K.1
Linder, T.2
Wolschann, P.3
Beyer, A.4
Stary-Weinzinger, A.5
-
58
-
-
46249092554
-
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
-
doi: 10.1021/ct700301q
-
Hess B, Kutzner C, Van der Spoel D, Lindahl E, (2008) GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. J Chem Theory Comput 4: 435-447 doi:10.1021/ct700301q.
-
(2008)
J Chem Theory Comput
, vol.4
, pp. 435-447
-
-
Hess, B.1
Kutzner, C.2
van der Spoel, D.3
Lindahl, E.4
-
59
-
-
33748518255
-
Comparison of multiple Amber force fields and development of improved protein backbone parameters
-
doi: 10.1002/prot.21123
-
Hornak V, Abel R, Okur A, Strockbine B, Roitberg A, et al. (2006) Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins 65: 712-725 doi:10.1002/prot.21123.
-
(2006)
Proteins
, vol.65
, pp. 712-725
-
-
Hornak, V.1
Abel, R.2
Okur, A.3
Strockbine, B.4
Roitberg, A.5
-
60
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
doi: 10.1063/1.445869
-
Jorgensen WL, Chandrasekhar J, Madura JD, Impey RW, Klein ML, (1983) Comparison of simple potential functions for simulating liquid water. J Chem Phys 79: 926 doi:10.1063/1.445869.
-
(1983)
J Chem Phys
, vol.79
, pp. 926
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Impey, R.W.4
Klein, M.L.5
-
61
-
-
41549149586
-
Biomolecular simulations of membranes: physical properties from different force fields
-
doi: 10.1063/1.2897760
-
Siu SWI, Vácha R, Jungwirth P, Böckmann R a, (2008) Biomolecular simulations of membranes: physical properties from different force fields. J Chem Phys 128: 125103 doi:10.1063/1.2897760.
-
(2008)
J Chem Phys
, vol.128
, pp. 125103
-
-
Siu, S.W.I.1
Vácha, R.2
Jungwirth, P.3
Böckmann, R.4
-
62
-
-
37649031391
-
Diffuse scattering provides material parameters and electron density profiles of biomembranes
-
doi: 10.1103/PhysRevE.69.040901
-
Liu Y, Nagle JF, (2004) Diffuse scattering provides material parameters and electron density profiles of biomembranes. Phys Rev E: Stat, Nonlinear, Soft Matter Phys 69: 040901 doi:10.1103/PhysRevE.69.040901.
-
(2004)
Phys Rev E: Stat, Nonlinear, Soft Matter Phys
, vol.69
, pp. 040901
-
-
Liu, Y.1
Nagle, J.F.2
-
63
-
-
33846823909
-
Particle mesh Ewald: An N log(N) method for Ewald sums in large systems
-
doi: 10.1063/1.464397
-
Darden T, York D, Pedersen L, (1993) Particle mesh Ewald: An N log(N) method for Ewald sums in large systems. J Chem Phys 98: 10089 doi:10.1063/1.464397.
-
(1993)
J Chem Phys
, vol.98
, pp. 10089
-
-
Darden, T.1
York, D.2
Pedersen, L.3
-
65
-
-
0027441950
-
Essential dynamics of proteins
-
doi: 10.1002/prot.340170408
-
Amadei A, Linssen AB, Berendsen HJ, (1993) Essential dynamics of proteins. Proteins 17: 412-425 doi:10.1002/prot.340170408.
-
(1993)
Proteins
, vol.17
, pp. 412-425
-
-
Amadei, A.1
Linssen, A.B.2
Berendsen, H.J.3
-
66
-
-
78651282170
-
g_wham-A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates
-
doi: 10.1021/ct100494z
-
Hub JS, De Groot BL, Van der Spoel D, (2010) g_wham-A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates. J Chem Theory Comput 6: 3713-3720 doi:10.1021/ct100494z.
-
(2010)
J Chem Theory Comput
, vol.6
, pp. 3713-3720
-
-
Hub, J.S.1
de Groot, B.L.2
van der Spoel, D.3
|