A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel

Neuron

Volumn 25, Issue 2, 2000, Pages 411-423

  Li Smerin, Yingying ^a   Hackos, David H ^a   Swartz, Kenton J ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; POTASSIUM CHANNEL; PROTEIN KCSA; PROTEIN SUBUNIT; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; ION CONDUCTANCE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; XENOPUS LAEVIS;

EID: 0033761957     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80904-6     Document Type: Article

References (62)

1. + channel
2. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
3. Voltage-gated ion channels and electrical excitability
4. Gating currents
5. + channel with fluorescence
6. Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation
7. Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel
8. + channel
9. + conduction and selectivity
10. + channels from Leiurus quinquestriatus var. hebraeus venom
11. + channels
12. + channel
13. + channels. Functional asymmetries and sidedness of proton activation
14. + channel signature sequence
15. + channels: Evidence for a trap door mechanism of activation gating
16. + channel can be trapped in the open state by an intersubunit metal bridge
17. + channel
18. Biophysical and molecular mechanisms of Shaker potassium channel inactivation
19. Shaker potassium channel gating. I: Transitions near the open state
20. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity
21. Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels
22. + channel S4
23. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation
24. Images of purified Shaker potassium channels
25. + channel
26. + channel determined by construction of multimeric cDNAs
27. + channels
28. + channel
29. + channel
30. Determination of the subunit stoichiometry of a voltage-activated potassium channel
31. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor
32. + channels
33. Structural conservation in prokaryotic and eukaryotic potassium channels
34. Direct physical measure of conformational rearrangement underlying potassium channel gating
35. + channel
36. Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
37. + channel
38. + channels. Implications for activation and inactivation models
39. + channels
40. + channels
41. + channel studied by EPR spectroscopy
42. +-channel activation gating
43. + channel selectively modulates channel gating
44. + channel selectivity filter by mutant cycle-based structure analysis
45. Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions
46. Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel
47. Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels
48. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans
49. + channel
50. Features of MotA proton channel structure revealed by tryptophan-scanning mutagenesis
51. Tryptophan-scanning mutagenesis of MotB, an integral membrane protein essential for flagellar rotation in Escherichia coli
52. Role of the S4 in cooperativity of voltage-dependent potassium channel activation
53. Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation
54. + channel (SKC1): Secondary structure characterization from FTIR spectroscopy
55. + channel subunits
56. Molecular basis of charge movement in voltage-gated sodium channels
57. How does the W434F mutation block current in Shaker potassium channels?
58. + channel
59. + channel by mutation of the H5 region
60. Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel
61. Shaker potassium channel gating. III: Evaluation of kinetic models for activation
62. Shaker potassium channel gating. II: Transitions in the activation pathway