Recombinant Monovalent Llama-Derived Antibody Fragments (VHH) to Rotavirus VP6 Protect Neonatal Gnotobiotic Piglets against Human Rotavirus-Induced Diarrhea

PLoS Pathogens

Volumn 9, Issue 5, 2013, Pages

  Vega, Celina G ^a   Bok, Marina ^a   Vlasova, Anastasia N ^b   Chattha, Kuldeep S ^b   Gómez Sebastián, Silvia ^c   Nuñez, Carmen ^c   Alvarado, Carmen ^c   Lasa, Rodrigo ^c   Escribano, José M ^d   Garaicoechea, Lorena L ^a   Fernandez, Fernando ^a   Bok, Karin ^e   Wigdorovitz, Andrés ^a   Saif, Linda J ^b   Parreño, Viviana ^a  

^a INSTITUTO NACIONAL DE TECNOLOGÍA AGROPECUARIA INTA   (Argentina)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^d INIA   (Spain)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN Y; NANOBODY; PROTEIN VP6; UNCLASSIFIED DRUG; VP6 SPECIFIC LLAMA DERIVED SINGLE DOMAIN NANOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIARRHEA; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; GNOTOBIOTICS; HEN; HUMAN ROTAVIRUS; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; MONONUCLEAR CELL; NEWBORN; NONHUMAN; PIGLET; ROTAVIRUS INFECTION; VIRUS DETECTION; VIRUS NEUTRALIZATION; VIRUS SHEDDING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAMELIDS, NEW WORLD; CAPSID PROTEINS; DIARRHEA; HUMANS; RECOMBINANT PROTEINS; ROTAVIRUS; ROTAVIRUS INFECTIONS; SWINE;

ANIMALIA; HUMAN ROTAVIRUS A; LAMA (MAMMAL); ROTAVIRUS; ROTAVIRUS A; SUIDAE; SUS;

EID: 84878499313     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003334     Document Type: Article

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