Rotavirus vaccines: An overview

Clinical Microbiology Reviews

Volumn 21, Issue 1, 2008, Pages 198-208

  Dennehy, Penelope H ^a,b  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; NONSTRUCTURAL PROTEIN 1; PLACEBO; PROTEIN VP4; PROTEIN VP7; ROTAVIRUS VACCINE; ROTAVIRUS VACCINE RV3; UNCLASSIFIED DRUG;

ANTIBODY TITER; CLINICAL TRIAL; CONTROLLED STUDY; DECISION MAKING; DEVELOPING COUNTRY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; GASTROENTERITIS; GENOTYPE; GEOGRAPHIC DISTRIBUTION; HEALTH PROGRAM; HUMAN; HUMORAL IMMUNITY; IMMUNOGENICITY; INTUSSUSCEPTION; PROTEIN GLYCOSYLATION; REVIEW; ROTAVIRUS; SEROTYPING; STRAIN IDENTIFICATION; VACCINATION; VACCINE PRODUCTION; VIRUS INFECTION;

ADMINISTRATION, ORAL; ANIMALS; CATTLE; CHILD, PRESCHOOL; CLINICAL TRIALS AS TOPIC; EUROPE; HUMANS; INFANT; INTUSSUSCEPTION; LATIN AMERICA; ROTAVIRUS; ROTAVIRUS INFECTIONS; ROTAVIRUS VACCINES; TREATMENT OUTCOME; UNITED STATES; VACCINATION; VACCINES, ATTENUATED;

BOVINAE; HUMAN ROTAVIRUS A; ROTAVIRUS;

EID: 38549103583     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/CMR.00029-07     Document Type: Review

References (92)

1. Angel, J., M. A. Franco, and H. B. Greenberg. 2007. Rotavirus vaccines: recent developments and future considerations. Nat. Rev. Microbiol. 5:529-539.
2. Ball, J. M., P. Tian, C. Q. Zeng, A. P. Morris, and M. K. Estes. 1996. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 272:101-104.
3. Banerjee, I., B. P. Gladstone, A. M. Le Fevre, S. Ramani, M. Iturriza-Gomara, J. J. Gray, D. W. Brown, M. K. Estes, J. P. Muliyil, S. Jaffar, and G. Kang. 2007. Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India. J. Infect. Dis. 195:625-632.
4. Barnes, G. L., J. S. Lund, S. V. Mitchell, L. De Bruyn, L. Piggford, A. L. Smith, J. Furmedge, P. J. Masendycz, H. C. Bugg, N. Bogdanovic-Sakran, J. B. Carlin, and R. F. Bishop. 2002. Early phase II trial of human rotavirus vaccine candidate RV3. Vaccine 20:2950-2956.
5. Bernstein, D. I., D. A. Sack, E. Rothstein, K. Reisinger, V. E. Smith, D. O'Sullivan, D. R. Spriggs, and R. L. Ward. 1999. Efficacy of live, attenuated, human rotavirus vaccine 89-12 in infants: a randomised placebo-controlled trial. Lancet 354:287-290.
6. Bhan, M. K., J. F. Lew, S. Sazawal, B. K. Das, J. R. Gentsch, and R. I. Glass. 1993. Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea. J. Infect. Dis. 168:282-287.
7. Bhandari, N., P. Sharma, R. I. Glass, P. Ray, H. Greenberg, S. Taneja, M. Saksena, C. D. Rao, J. R. Gentsch, U. Parashar, Y. Maldonado, R. L. Ward, and M. K. Bhan. 2006. Safety and immunogenicity of two live attenuated human rotavirus vaccine candidates, 116E and I321, in infants: results of a randomised controlled trial. Vaccine 24:5817-5823.
8. Bishop, R. F., G. L. Barnes, E. Cipriani, and J. S. Lund. 1983. Clinical immunity after neonatal rotavirus infection. A prospective longitudinal study in young children. N. Engl. J. Med. 309:72-76.
9. Bishop, R. F., G. P. Davidson, I. H. Holmes, and B. J. Ruck. 1973. Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet ii:1281-1283.
10. Block, S. L., T. Vesikari, M. G. Goveia, S. B. Rivers, B. A. Adeyi, M. J. Dallas, J. Bauder, J. W. Boslego, and P. M. Heaton. 2007. Efficacy, immunogenicity, and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine at the end of shelf life. Pediatrics 119:11-18.
11. Blutt, S. E., C. D. Kirkwood, V. Parreno, K. L. Warfield, M. Clarlet, M. K. Estes, K. Bok, R. F. Bishop, and M. E. Conner. 2003. Rotavirus antigenaemia and viraemia: a common event? Lancet 362:1445-1449.
12. Blutt, S. E., D. O. Matson, S. E. Crawford, M. A. Staat, P. Azimi, B. L. Bennett, P. A. Piedra, and M. E. Conner. 2007. Rotavirus antigenemia in children is associated with viremia. PLoS Med. 4:e121.
13. Brandt, C. D., H. W. Kim, W. J. Rodriguez, J. O. Arrobio, B. C. Jeffries, E. P. Stallings, C. Lewis, A. J. Miles, R. M. Chanock, A. Z. Kapikian, and R. H. Parrott. 1983. Pediatric viral gastroenteritis during eight years of study. J. Clin. Microbiol. 18:71-78.
14. Centers for Disease Control and Prevention. 1999. Intussusception among recipients of rotavirus vaccine - United States, 1998-1999. MMWR Morb. Mortal. Wkly. Rep. 48:577-581.
15. Centers for Disease Control and Prevention. 2007. Postmarketing monitoring of intussusception after RotaTeq vaccination - United States, February 1, 2006-February 15, 2007. MMWR Morb. Mortal. Wkly. Rep. 56:218-222.
16. Centers for Disease Control and Prevention. 1999. Rotavirus vaccine for the prevention of rotavirus gastroenteritis among children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb. Mortal. Wkly. Rep. 48:1-20.
17. Chiappini, E., C. Azzari, M. Moriondo, L. Galli, and M. de Martino. 2005. Viraemia is a common finding in immunocompetent children with rotavirus infection. J. Med. Virol. 76:265-267.
18. Chiappini, E., L. Galli, and M. de Martino. 2006. Viremia and clinical manifestations in children with rotavirus infection. J. Infect. Dis. 193:1333.
19. Chiba, S., T. Yokoyama, S. Nakata, Y. Morita, T. Urasawa, K. Taniguchi, S. Urasawa, and T. Nakao. 1986. Protective effect of naturally acquired homotypic and heterotypic rotavirus antibodies. Lancet ii:417-421.
20. Christy, C., H. P. Madore, M. E. Pichichero, C. Gala, P. Pincus, D. Vosefski, Y. Hoshino, A. Kapikian, and R. Dolin. 1988. Field trial of rhesus rotavirus vaccine in infants. Pediatr. Infect. Dis. J. 7:645-650.
21. Chrystie, I. L., B. M. Totterdell, and J. E. Banatvala. 1978. Asymptomatic endemic rotavirus infections in the newborn. Lancet i:1176-1178.
22. Clark, H. F., F. E. Borian, L. M. Bell, K. Modesto, V. Gouvea, and S. A. Plotkin. 1988. Protective effect of WC3 vaccine against rotavirus diarrhea in infants during a predominantly serotype 1 rotavirus season. J. Infect. Dis. 158:570-587.
23. Clark, H. F., K. T. Dolan, P. Horton-Slight, J. Palmer, and S. A. Plotkin. 1985. Diverse serologic response to rotavirus infection of infants in a single epidemic. Pediatr. Infect. Dis. 4:626-631.
24. Clements-Mann, M. L., R. Dudas, Y. Hoshino, P. Nehring, E. Sperber, M. Wagner, I. Stephens, R. Karron, A. Deforest, and A. Z. Kapikian. 2001. Safety and immunogenicity of live attenuated quadrivalent human-bovine (UK) reassortant rotavirus vaccine administered with childhood vaccines to infants. Vaccine 19:4676-4684.
25. Cunliffe, N. A., B. K. Das, M. Ramachandran, M. K. Bhan, R. I. Glass, and J. R. Gentsch. 1997. Sequence analysis demonstrates that VP6, NSP1 and NSP4 genes of Indian neonatal rotavirus strain 116E are of human origin. Virus Genes 15:39-44.
26. Danovaro-Holliday, M. C., A. L. Wood, and C. W. LeBaron. 2002. Rotavirus vaccine and the news media, 1987-2001. JAMA 287:1455-1462.
27. Dunn, S. J., H. B. Greenberg, R. L. Ward, O. Nakagomi, J. W. Burns, P. T. Vo, K. A. Pax, M. Das, K. Gowda, and C. D. Rao. 1993. Serotypic and genotypic characterization of human serotype 10 rotaviruses from asymptomatic neonates. J. Clin. Microbiol. 31:165-169.
28. Feudtner, C., and E. K. Marcuse. 2001. Ethics and immunization policy: promoting dialogue to sustain consensus. Pediatrics 107:1158- 1164.
29. Fischer, T. K., P. Valentiner-Branth, H. Steinsland, M. Perch, G. Santos, P. Aaby, K. Molbak, and H. Sommerfelt. 2002. Protective immunity after natural rotavirus infection: a community cohort study of newborn children in Guinea-Bissau, west Africa. J. Infect. Dis. 186:593-597.
30. Fischer, T. K., C. Viboud, U. Parashar, M. Malek, C. Steiner, R. Glass, and L. Simonsen. 2007. Hospitalizations and deaths from diarrhea and rotavirus among children <5 years of age in the United States, 1993-2003. J. Infect. Dis. 195:1117-1125.
31. Franco, M. A., J. Angel, and H. B. Greenberg. 2006. Immunity and correlates of protection for rotavirus vaccines. Vaccine 24:2718-2731.
32. Franco, M. A., N. Feng, and H. B. Greenberg. 1996. Molecular determinants of immunity and pathogenicity of rotavirus infection in the mouse model. J. Infect. Dis. 174(Suppl. 1):S47-S50.
33. Gentsch, J. R., A. R. Laird, B. Bielfelt, D. D. Griffin, K. Banyai, M. Ramachandran, V. Jain, N. A. Cunliffe, O. Nakagomi, C. D. Kirkwood, T. K. Fischer, U. D. Parashar, J. S. Bresee, B. Jiang, and R. I. Glass. 2005. Serotype diversity and reassortment between human and animal rotavirus strains: implications for rotavirus vaccine programs. J. Infect. Dis. 192(Suppl. 1):S146-S159.
34. Glass, R. I., M. K. Bhan, P. Ray, R. Bahl, U. D. Parashar, H. Greenberg, C. D. Rao, N. Bhandari, Y. Maldonado, R. L. Ward, D. I. Bernstein, and J. R. Gentsch. 2005. Development of candidate rotavirus vaccines derived from neonatal strains in India. J. Infect. Dis. 192(Suppl. 1):S30-S35.
35. Glass, R. I., J. Bresee, B. Jiang, U. Parashar, E. Yee, and J. Gentsch. 2006. Rotavirus and rotavirus vaccines. Adv. Exp. Med. Biol. 582:45-54.
36. Glass, R. I., P. E. Kilgore, R. C. Holman, S. Jin, J. C. Smith, P. A. Woods, M. J. Clarke, M. S. Ho, and J. R. Gentsch. 1996. The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden. J. Infect. Dis. 174(Suppl. 1):S5-S11.
37. Hanlon, P., L. Hanlon, V. Marsh, P. Byass, F. Shenton, M. Hassan-King, O. Jobe, H. Sillah, R. Hayes, B. H. M'Boge, et al. 1987. Trial of an attenuated bovine rotavirus vaccine (RIT 4237) in Gambian infants. Lancet i:1342-1345.
38. Hoshino, Y., and A. Z. Kapikian. 2000. Rotavirus serotypes: classification and importance in epidemiology, immunity, and vaccine development. J. Health Popul. Nutr. 18:5-14.
39. Hoshino, Y., and A. Z. Kapikian. 1994. Rotavirus vaccine development for the prevention of severe diarrhea in infants and young children. Trends Microbiol. 2:242-249.
40. Jiang, B., J. R. Gentsch, and R. I. Glass. 2002. The role of serum antibodies in the protection against rotavirus disease: an overview. Clin. Infect. Dis. 34:1351-1361.
41. Jin, S., P. E. Kilgore, R. C. Holman, M. J. Clarke, E. J. Gangarosa, and R. I. Glass. 1996. Trends in hospitalizations for diarrhea in United States children from 1979 through 1992: estimates of the morbidity associated with rotavirus. Pediatr. Infect. Dis. J. 15:397-404.
42. Joensuu, J., E. Koskenniemi, X. L. Pang, and T. Vesikari. 1997. Randomised placebo-controlled trial of rhesus-human reassortant rotavirus vaccine for prevention of severe rotavirus gastroenteritis. Lancet 350:1205-1209.
43. Kalica, A. R., H. B. Greenberg, R. G. Wyatt, J. Flores, M. M. Sereno, A. Z. Kapikian, and R. M. Chanock. 1981. Genes of human (strain Wa) and bovine (strain UK) rotaviruses that code for neutralization and subgroup antigens. Virology 112:385-390.
44. Kapikian, A. Z., Y. Hoshino, R. M. Chanock, and I. Perez-Schael. 1996. Efficacy of a quadrivalent rhesus rotavirus-based human rotavirus vaccine aimed at preventing severe rotavirus diarrhea in infants and young children. J. Infect. Dis. 174(Suppl. 1):S65-S72.
45. Kapikian, A. Z., Y. Hoshino, R. M. Chanock, and I. Perez-Schael. 1996. Jennerian and modified Jennerian approach to vaccination against rotavirus diarrhea using a quadrivalent rhesus rotavirus (RRV) and human-RRV reassortant vaccine. Arch. Virol. Suppl. 12:163-175.
46. Kapikian, A. Z., L. Simonsen, T. Vesikari, Y. Hoshino, D. M. Morens, R. M. Chanock, J. R. La Montagne, and B. R. Murphy. 2005. A hexavalent human rotavirus-bovine rotavirus (UK) reassortant vaccine designed for use in developing countries and delivered in a schedule with the potential to eliminate the risk of intussusception. J. Infect. Dis. 192(Suppl. 1):S22-S29.
47. Kilgore, P. E., R. C. Holman, M. J. Clarke, and R. I. Glass. 1995. Trends of diarrheal disease-associated mortality in US children, 1968 through 1991. JAMA 274:1143-1148.
48. Koopman, J. S., V. J. Turkish, A. S. Monto, V. Gouvea, S. Srivastava, and R. E. Isaacson. 1984. Patterns and etiology of diarrhea in three clinical settings. Am. J. Epidemiol. 119:114-123.
49. Kramarz, P., E. K. France, F. Destefano, S. B. Black, H. Shinefield, J. I. Ward, E. J. Chang, R. T. Chen, D. Shatin, J. Hill, T. Lieu, and J. M. Ogren. 2001. Population-based study of rotavirus vaccination and intussusception. Pediatr. Infect. Dis. J. 20:410-416.
50. Lanata, C. F., R. E. Black, R. del Aguila, A. Gil, H. Verastegui, G. Gerna, J. Flores, A. Z. Kapikian, and F. E. Andre. 1989. Protection of Peruvian children against rotavirus diarrhea of specific serotypes by one, two, or three doses of the RIT 4237 attenuated bovine rotavirus vaccine. J. Infect. Dis. 159:452-459.
51. LeBaron, C. W., J. Lew, R. I. Glass, J. M. Weber, G. M. Ruiz-Palacios, et al. 1990. Annual rotavirus epidemic patterns in North America. Results of a 5-year retrospective survey of 88 centers in Canada, Mexico, and the United States. JAMA 264:983-988.
52. Ling-Qiao, Z. 2001. A rotavirus vaccine licensed in China. Health News 31:1.
53. Linhares, A. C., T. Verstraeten, J. Wolleswinkel-van den Bosch, R. Clemens, and T. Breuer. 2006. Rotavirus serotype G9 is associated with more-severe disease in Latin America. Clin. Infect. Dis. 43:312-314.
54. Lynch, M., B. Lee, P. Azimi, J. Gentsch, C. Glaser, S. Gilliam, H. G. Chang, R. Ward, and R. I. Glass. 2001. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin. Infect. Dis. 33:932-938.
55. Lynch, M., W. J. Shieh, K. Tatti, J. R. Gentsch, T. Ferebee-Harris, B. Jiang, J. Guarner, J. S. Bresee, M. Greenwald, S. Cullen, H. D. Davies, C. Trevenen, S. R. Zaki, and R. I. Glass. 2003. The pathology of rotavirus-associated deaths, using new molecular diagnostics. Clin. Infect. Dis. 37:1327-1333.
56. Malek, M. A., A. T. Curns, R. C. Holman, T. K. Fischer, J. S. Bresee, R. I. Glass, C. A. Steiner, and U. D. Parashar. 2006. Diarrhea- and rotavirus-associated hospitalizations among children less than 5 years of age: United States, 1997 and 2000. Pediatrics 117:1887-1892.
57. Matson, D. O., and M. K. Estes. 1990. Impact of rotavirus infection at a large pediatric hospital. J. Infect. Dis. 162:598-604.
58. Matson, D. O., M. L. O'Ryan, L. K. Pickering, S. Chiba, S. Nakata, P. Raj, and M. K. Estes. 1992. Characterization of serum antibody responses to natural rotavirus infections in children by VP7-specific epitope-blocking assays. J. Clin. Microbiol. 30:1056-1061.
59. Midthun, K., and A. Z. Kapikian. 1996. Rotavirus vaccines: an overview. Clin. Microbiol. Rev. 9:423-434.
60. Murphy, T. V., P. M. Gargiullo, M. S. Massoudi, D. B. Nelson, A. O. Jumaan, C. A. Okoro, L. R. Zanardi, S. Setia, E. Fair, C. W. LeBaron, M. Wharton, and J. R. Livengood. 2001. Intussusception among infants given an oral rotavirus vaccine. N. Engl. J. Med. 344:564-572.
61. Murphy, T. V., P. M. Gargiullo, and M. Wharton. 2002. More on rotavirus vaccination and intussusception. N. Engl. J. Med. 346:211-212.
62. Newman, R. D., J. Grupp-Phelan, D. K. Shay, and R. L. Davis. 1999. Perinatal risk factors for infant hospitalization with viral gastroenteritis. Pediatrics 103:E3.
63. Offit, P. A., and H. F. Clark. 2006. RotaTeq: a pentavalent bovine-human reassortment rotavirus vaccine. Pediatr. Ann. 35:29-34.
64. O'Ryan, M. L., D. O. Matson, M. K. Estes, and L. K. Pickering. 1994. Anti-rotavirus G type-specific and isotype-specific antibodies in children with natural rotavirus infections. J. Infect. Dis. 169:504-511.
65. Pang, X. L., J. Joensuu, and T. Vesikari. 1996. Detection of rotavirus RNA in cerebrospinal fluid in a case of rotavirus gastroenteritis with febrile seizures. Pediatr. Infect. Dis. J. 15:543-545.
66. Parashar, U. D., J. P. Alexander, and R. I. Glass. 2006. Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommend. Rep. 55:1-13.
67. Parashar, U. D., C. J. Gibson, J. S. Bresse, and R. I. Glass. 2006. Rotavirus and severe childhood diarrhea. Emerg. Infect. Dis. 12:304-306.
68. Perez-Schael, I., G. Daoud, L. White, G. Urbina, N. Daoud, M. Perez, and J. Flores. 1984. Rotavirus shedding by newborn children. J. Med. Virol. 14:127-136.
69. Perez-Schael, I., M. J. Guntinas, M. Perez, V. Pagone, A. M. Rojas, R. Gonzalez, W. Cunto, Y. Hoshino, and A. Z. Kapikian. 1997. Efficacy of the rhesus rotavirus-based quadrivalent vaccine in infants and young children in Venezuela. N. Engl. J. Med. 337:1181-1187.
70. Peter, G., and M. G. Myers. 2002. Intussusception, rotavirus, and oral vaccines: summary of a workshop. Pediatrics 110:e67.
71. Ramig, R. F. 2007. Systemic rotavirus infection. Expert Rev. Anti Infect. Ther. 5:591-612.
72. Rennels, M. B., R. I. Glass, P. H. Dennehy, D. I. Bernstein, M. E. Pichkhero, E. T. Zito, M. E. Mack, B. L. Davidson, A. Z. Kapikian, et al. 1996. Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines - report of the National Multicenter Trial. Pediatrics 97:7-13.
73. Rodriguez, W. J., H. W. Kim, C. D. Brandt, B. Bise, A. Z. Kapikian, R. M. Chanock, G. Curlin, and R. H. Parrott. 1980. Rotavirus gastroenteritis in the Washington, DC, area: incidence of cases resulting in admission to the hospital. Am. J. Dis. Child. 134:777-779.
74. Ruiz-Palacios, G. M., I. Perez-Schael, F. R. Velazquez, H. Abate, T. Breuer, S. C. Clemens, B. Cheuvart, F. Espinoza, P. Gillard, B. L. Innis, Y. Cervantes, A. C. Linhares, P. Lopez, M. Macias-Parra, E. Ortega-Barria, V. Richardson, D. M. Rivera-Medina, L. Rivera, B. Salinas, N. Pavia-Ruz, J. Salmeron, R. Ruttimann, J. C. Tinoco, P. Rubio, E. Nunez, M. L. Guerrero, J. P. Yarzabal, S. Damaso, N. Tornieporth, X. Saez-Llorens, R. F. Vergara, T. Vesikari, A. Bouckenooghe, R. Clemens, B. De Vos, and M. O'Ryan. 2006. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N. Engl. J. Med. 354:11-22.
75. Santos, N., and Y. Hoshino. 2005. Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Rev. Med. Virol. 15:29-56.
76. Santosham, M., L. H. Moulton, R. Reid, J. Croll, R. Weatherholt, R. Ward, J. Forro, E. Zito, M. Mack, G. Brenneman, and B. L. Davidson. 1997. Efficacy and safety of high-dose rhesus-human reassortant rotavirus vaccine in Native American populations. J. Pediatr. 131:632-638.
77. Steele, A. D., and B. Ivanoff. 2003. Rotavirus strains circulating in Africa during 1996-1999: emergence of G9 strains and P[6] strains. Vaccine 21:361-367.
78. Svensson, L., H. Sheshberadaran, T. Vesikari, E. Norrby, and G. Wadell. 1987. Immune response to rotavirus polypeptides after vaccination with heterologous rotavirus vaccines (RIT 4237, RRV-1). J. Gen. Virol. 68:1993-1999.
79. Torok, T. J., P. E. Kilgore, M. J. Clarke, R. C. Holman, J. S. Bresee, R. I. Glass, et al. 1997. Visualizing geographic and temporal trends in rotavirus activity in the United States, 1991 to 1996. Pediatr. Infect. Dis. J. 16:941-946.
80. Turcios, R. M., A. T. Curns, R. C. Holman, I. Pandya-Smith, A. LaMonte, J. S. Bresee, and R. I. Glass. 2006. Temporal and geographic trends of rotavirus activity in the United States, 1997-2004. Pediatr. Infect. Dis. J. 25:451-454.
81. Velazquez, F. R., D. O. Matson, J. J. Calva, L. Guerrero, A. L. Morrow, S. Carter-Campbell, R. I. Glass, M. K. Estes, L. K. Pickering, and G. M. Ruiz-Palacios. 1996. Rotavirus infections in infants as protection against subsequent infections. N. Engl. J. Med. 335:1022-1028.
82. Velazquez, F. R., D. O. Matson, M. L. Guerrero, J. Shults, J. J. Calva, A. L. Morrow, R. I. Glass, L. K. Pickering, and G. M. Ruiz-Palacios. 2000. Serum antibody as a marker of protection against natural rotavirus infection and disease. J. Infect. Dis. 182:1602-1609.
83. Vesikari, T., E. Isolauri, and E. D'Hondt. 1984. Protection of infants against rotavirus diarrhea by RIT 4237 attenuated bovine rotavirus strain vaccine. Lancet i:977-981.
84. Vesikari, T., A. Karvonen, R. Prymula, V. Schuster, J. C. Tejedor, R. Cohen, F. Meurice, H. H. Han, S. Damaso, and A. Bouckenooghe. 2007. Efficacy of human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in European infants: randomised, double-blind controlled study. Lancet 370:1757-1763.
85. Vesikari, T., A. V. Karvonen, J. Majuri, S. Q. Zeng, X. L. Pang, R. Kohberger, B. D. Forrest, Y. Hoshino, R. M. Chanock, and A. Z. Kapikian. 2006. Safety, efficacy, and immunogenicity of 2 doses of bovine-human (UK) and rhesus-rhesus-human rotavirus reassortant tetravalent vaccines in Finnish children. J. Infect. Dis. 194:370-376.
86. Vesikari, T., D. O. Matson, P. Dennehy, P. Van Damme, M. Santosham, Z. Rodriguez, M. J. Dallas, J. F. Heyse, M. G. Goveia, S. B. Black, H. R. Shinefield, C. D. Christie, S. Ylitalo, R. F. Itzler, M. L. Coia, M. T. Onorato, B. A. Adeyi, G. S. Marshall, L. Gothefors, D. Campens, A. Karvonen, J. P. Watt, K. L. O'Brien, M. J. DiNubile, H. F. Clark, J. W. Boslego, P. A. Offit, and P. M. Heaton. 2006. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N. Engl. J. Med. 354:23-33.
87. Vesikari, T., T. Ruuska, H. P. Koivu, K. Y. Green, J. Flores, and A. Z. Kapikian. 1991. Evaluation of the M37 human rotavirus vaccine in 2- to 6-month-old infants. Pediatr. Infect. Dis. J. 10:912-917.
88. Ward, R. L. 2003. Possible mechanisms of protection elicited by candidate rotavirus vaccines as determined with the adult mouse model. Viral Immunol. 16:17-24.
89. Wenman, W. M., D. Hinde, S. Feltham, and M. Gurwith. 1979. Rotavirus infection in adults. Results of a prospective family study. N. Engl. J. Med. 301:303-306.
90. Westerman, L. E., H. M. McClure, B. Jiang, J. W. Almond, and R. I. Glass. 2005. Serum IgG mediates mucosal immunity against rotavirus infection. Proc. Natl. Acad. Sci. USA 102:7268-7273.
91. Widdowson, M. A., J. S. Bresee, J. R. Gentsch, and R. I. Glass. 2005. Rotavirus disease and its prevention. Curr. Opin. Gastroenterol. 21:26-31.
92. Zissis, G., J. P. Lambert, P. Marbehant, D. Marissens, M. Lobmann, P. Charlier, A. Delem, and N. Zygraich. 1983. Protection studies in colostrum-deprived piglets of a bovine rotavirus vaccine candidate using human rotavirus strains for challenge. J. Infect. Dis. 148:1061-1068.