Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring

Vaccine

Volumn 19, Issue 30, 2001, Pages 4167-4174

  Coste, Alix ^a,b   Cohen, Jean ^c   Reinhardt, Monique ^a   Kraehenbuhl, Jean Pierre ^a   Sirard, Jean Claude ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b Laboratoire De Microbiologie INRA   (France)

^c CEMAGREF   (France)

Author keywords

Rotavirus; Salmonella typhimurium; Vaccine

Indexed keywords

LIVE VACCINE; PROTEIN VP2; PROTEIN VP6; RECOMBINANT VACCINE; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS PROTEIN; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; BREAST MILK; CONTROLLED STUDY; CYTOPLASM; DRUG ACTIVITY; DRUG EFFICACY; EUKARYOTIC CELL; FEMALE; IMMUNOGENICITY; INFANTILE DIARRHEA; MICROBIAL ATTENUATION; MOUSE; NEWBORN; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROVOCATION TEST; ROTAVIRUS; SALMONELLA TYPHIMURIUM; SERUM; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS PARTICLE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAPSID; CAPSID PROTEINS; FEMALE; IMMUNIZATION; MALE; MICE; MICE, INBRED BALB C; MILK; ROTAVIRUS; SALMONELLA TYPHIMURIUM; VACCINES, SYNTHETIC; VIRAL VACCINES;

EID: 0035919564     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00164-5     Document Type: Article

References (45)

1. The epidemiology of rotavirus diarrhea in the United States: Surveillance and estimates of disease burden
2. Expression of rotavirus VP2 produces empty corelike particles
3. Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells
4. Rotavirus virus-like particles administered mucosally induce protective immunity
5. Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity
6. Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunised with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines
7. Biochemical and immunologic comparison of virus-like particles for a rotavirus subunit vaccine
8. Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea
9. Virus-like particles as a rotavirus subunit vaccine
10. Characterization and replicase activity of double-layered and single-layered rotavirus-like particles expressed from baculovirus recombinants
11. A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization
12. Salmonella-based vaccines
13. Stability, immunogenicity and expression of foreign antigens in bacterial vaccine vectors
14. The use of live attenuated Salmonella for oral vaccination
15. Live attenuated Salmonella: A paradigm of mucosal vaccines
16. Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice
17. Expression and stability of herpes simplex virus antigens in Salmonella typhimurium
18. Expression of hepatitis B virus antigens in attenuated Salmonellae for oral immunization
19. The nature of the attenuation of Salmonella typhimurium strains expressing human papillomavirus type 16 virus-like particles determines the systemic and mucosal antibody responses in nasally immunised mice
20. Immune response to rotavirus VP4 expressed in an attenuated strain of Shigella flexneri
21. Synthesis of the surface glycoprotein of rotavirus SA11 in the aroA strain of Salmonella typhimurium SL3261
22. During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen
23. Maturation of the humoral immune response in mice
24. Effect of different routes of immunization with bovine rotavirus on lactogenic antibody response in mice
25. Role of maternally derived circulating antibodies in protection of neonatal swine against porcine group A rotavirus
26. Maternal antibody-mediated protection against gastroenteritis due to rotavirus in newborn mice is dependent on both serotype and titer of antibody
27. Effect of maternal rotavirus immunization on milk and serum antibody titres
28. Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages
29. Expression of the major capsid protein VP6 of group C rotavirus and synthesis of chimeric single-shelled particles by using recombinant baculoviruses
30. Structure of hepatitis B virus core and e-antigen. A single precore amino acid prevents nucleocapsid assembly
31. Localization of group-specific epitopes on the major capsid protein of group A rotavirus
32. Salmonella vaccines with mutations in the phoP virulence regulon
33. Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium
34. Hybrid hepatitis B virus core antigen as a vaccine carrier moiety. II. Expression in avirulent Salmonella spp. for mucosal immunization
35. Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits
36. Synthesis of the major inner capsid protein VP6 of the human rotavirus Wa in Escherichia coli
37. Vaccinia-rotavirus VP7 recombinants protect mice against rotavirus-induced diarrhea
38. Antirotavirus immunoglobulin A neutralizes virus in vitro after transcytosis through epithelial cells and protects infant mice from diarrhea
39. Functional mapping of protective domains and epitopes in the rotavirus VP6 protein
40. Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein
41. Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system
42. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity
43. Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs
44. Rotavirus gene structure and function