Small interfering RNA targeting Rac1 sensitizes colon cancer to dihydroartemisinin-induced cell cycle arrest and inhibited cell migration by suppressing NFκB activity

Molecular and Cellular Biochemistry

Volumn 379, Issue 1-2, 2013, Pages 171-180

  Han, Peng ^a   Luan, Ying ^a   Liu, Yanlong ^a   Yu, Zhiwei ^a   Li, Jingwen ^a   Sun, Zicheng ^a   Chen, Gang ^a   Cui, Binbin ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Cell cycle arrest; Colon cancer; Dihydroartemisinin; Rac1

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLINE; DIHYDROARTEMISININ; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P21; RAC1 PROTEIN; SMALL INTERFERING RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL PROLIFERATION; CHEMOSENSITIZATION; COLON CANCER; CONTROLLED STUDY; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTEMISININS; CELL CYCLE CHECKPOINTS; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; MICE; MICE, NUDE; NF-KAPPA B; RAC1 GTP-BINDING PROTEIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878445414     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1639-1     Document Type: Article

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