PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Du, Jun ^a   Xu, Rui ^a   Hu, Zhenzhen ^a   Tian, Yinhui ^a   Zhu, Yichao ^a   Gu, Luo ^a   Zhou, Lei ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; VASCULOTROPIN; 1,3 BUTADIENE DERIVATIVE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; NITRILE;

ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; INHIBITION KINETICS; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL HYPOXIA; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; BUTADIENES; CELL HYPOXIA; CELL LINE, TUMOR; CHROMONES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MORPHOLINES; NITRILES; PHOSPHATIDYLINOSITOL 3-KINASES; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES;

EID: 80053208251     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025213     Document Type: Article

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