Male hypogonadism induced by high fat diet and low dose streptozotocin is mediated by activated endoplasmic reticulum stress and IκBβ and attenuated by argirein and valsartan

European Journal of Pharmacology

Volumn 713, Issue 1-3, 2013, Pages 78-88

  Liu, Gui Lai ^a   Zhang, Yu Mao ^a   Dai, De Zai ^a   Ding, Ming Jian ^a,b   Cong, Xiao Dong ^b   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Argirein; ER stress; I B ; p Akt Akt; Testopathy; Type 2 diabetes

Indexed keywords

ARGIREIN; CONNEXIN 40; CONNEXIN 43; ENDOPLASMIC RETICULUM STRESS SENSOR PKR LIKE ENDOPLASMIC RETICULUM KINASE; GELATINASE A; GELATINASE B; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; I KAPPA B BETA; INSULIN RECEPTOR SUBSTRATE 1; LACTATE DEHYDROGENASE; LUTEINIZING HORMONE; MALONALDEHYDE; MESSENGER RNA; PHOSPHATASE; PROTEIN KINASE B; RHEIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STREPTOZOCIN; SUCCINATE DEHYDROGENASE; TESTOSTERONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VALSARTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; CELL CULTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HYPOGONADISM; IN VITRO STUDY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LEYDIG CELL; LIPID DIET; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; TESTOSTERONE BLOOD LEVEL; UPREGULATION;

ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS; ARGININE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DRUG COMBINATIONS; ENDOPLASMIC RETICULUM STRESS; HYPOGONADISM; I-KAPPA B PROTEINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL BEHAVIOR, ANIMAL; STREPTOZOCIN; TETRAZOLES; VALINE;

EID: 84878314738     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.04.030     Document Type: Article

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