Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes

Reproductive Toxicology

Volumn 36, Issue , 2013, Pages 60-70

  Zhang, Guo Lin ^a   Dai, De Zai ^a   Zhang, Can ^a   Dai, Yin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apocynin; Endoplasmic reticulum stress; Intermittent hypoxia; NADPH oxidase; Oxidative stress; P66Shc; Raisanberine; Testis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; APOCYNIN; BIOLOGICAL MARKER; CALCIUM CHANNEL BLOCKING AGENT; FOLLITROPIN; GELATINASE B; LUTEINIZING HORMONE; PROTEIN CX43; PROTEIN P22; PROTEIN P47; PROTEIN P47 PHOX; PROTEIN P66SHC; PROTEIN PERK; PROTEIN SHC; PROTEIN STAR; RAISANBERINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FOLLITROPIN BLOOD LEVEL; HYPOGONADISM; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; RAT; SPERMATOZOON DENSITY; TESTIS; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL; UPREGULATION; WESTERN BLOTTING;

3-HYDROXYSTEROID DEHYDROGENASES; ACETOPHENONES; ANIMALS; BERBERINE; BIOLOGICAL MARKERS; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; EUNUCHISM; GENE EXPRESSION REGULATION; LEYDIG CELLS; MALE; NADPH OXIDASE; PHOSPHOPROTEINS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SHC SIGNALING ADAPTOR PROTEINS; TESTIS; TESTOSTERONE;

RATTUS;

EID: 84872152466     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.12.002     Document Type: Article

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