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Volumn 62, Issue 1, 2013, Pages 36-38

Direct effects of PPARα agonists on retinal inflammation and angiogenesis may explain how fenofibrate lowers risk of severe proliferative diabetic retinopathy

Author keywords

[No Author keywords available]

Indexed keywords

FENOFIBRATE; GW 590758; GW590785; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

EID: 84872024160     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1223     Document Type: Note
Times cited : (18)

References (21)
  • 1
    • 84872016068 scopus 로고    scopus 로고
    • Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models
    • Chen Y, Hu Y, Lin M, et al. Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models. Diabetes 2013;62:261-272
    • (2013) Diabetes , vol.62 , pp. 261-272
    • Chen, Y.1    Hu, Y.2    Lin, M.3
  • 2
    • 42449121829 scopus 로고    scopus 로고
    • Effect of glycemic exposure on the risk of microvascular complications in the Diabetes Control and Complications Trial-revisited
    • Lachin JM, Genuth S, Nathan DM, Zinman B, Rutledge BN. Effect of glycemic exposure on the risk of microvascular complications in the Diabetes Control and Complications Trial-revisited. Diabetes 2008;57:995-1001
    • (2008) Diabetes , vol.57 , pp. 995-1001
    • Lachin, J.M.1    Genuth, S.2    Nathan, D.M.3    Zinman, B.4    Rutledge, B.N.5
  • 3
    • 82755165018 scopus 로고    scopus 로고
    • Intensive glycaemic control for patients with type 2 diabetes: Systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
    • Hemmingsen B, Lund SS, Gluud C, et al. Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ 2011;343:d6898
    • (2011) BMJ , vol.343
    • Hemmingsen, B.1    Lund, S.S.2    Gluud, C.3
  • 4
    • 79959494229 scopus 로고    scopus 로고
    • Recent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus
    • Wanner C, Krane V. Recent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus. Kidney Blood Press Res 2011;34:209-217
    • (2011) Kidney Blood Press Res , vol.34 , pp. 209-217
    • Wanner, C.1    Krane, V.2
  • 6
    • 77954654472 scopus 로고    scopus 로고
    • Effects of medical therapies on retinopathy progression in type 2 diabetes
    • Chew EY, Ambrosius WT, Davis MD, et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 2010;363:233-244
    • (2010) N Engl J Med , vol.363 , pp. 233-244
    • Chew, E.Y.1    Ambrosius, W.T.2    Davis, M.D.3
  • 8
    • 84862734043 scopus 로고    scopus 로고
    • Fenofibrate - A potential systemic treatment for diabetic retinopathy?
    • Wong TY, Simó R, Mitchell P. Fenofibrate - a potential systemic treatment for diabetic retinopathy? Am J Ophthalmol 2012;154:6-12
    • (2012) Am J Ophthalmol , vol.154 , pp. 6-12
    • Wong, T.Y.1    Simó, R.2    Mitchell, P.3
  • 9
    • 79960462692 scopus 로고    scopus 로고
    • Medical management of diabetic retinopathy: Fenofibrate and ACCORD eye studies
    • Lond
    • Wright AD, Dodson PM. Medical management of diabetic retinopathy: fenofibrate and ACCORD eye studies. Eye (Lond) 2011;25:843-849
    • (2011) Eye , vol.25 , pp. 843-849
    • Wright, A.D.1    Dodson, P.M.2
  • 10
    • 77955057772 scopus 로고    scopus 로고
    • PPARalpha: An emerging therapeutic target in diabetic microvascular damage
    • Hiukka A, Maranghi M, Matikainen N, Taskinen MR. PPARalpha: an emerging therapeutic target in diabetic microvascular damage. Nat Rev Endocrinol 2010;6:454-463
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 454-463
    • Hiukka, A.1    Maranghi, M.2    Matikainen, N.3    Taskinen, M.R.4
  • 11
    • 68549107838 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier
    • Mysiorek C, Culot M, Dehouck L, et al. Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier. Curr Neurovasc Res 2009;6:181-193
    • (2009) Curr Neurovasc Res , vol.6 , pp. 181-193
    • Mysiorek, C.1    Culot, M.2    Dehouck, L.3
  • 12
    • 68349142979 scopus 로고    scopus 로고
    • Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: An in vitro study
    • Huang WP, Yin WH, Chen JW, Jen HL, Young MS, Lin SJ. Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro study. Eur J Clin Invest 2009;39:775-783
    • (2009) Eur J Clin Invest , vol.39 , pp. 775-783
    • Huang, W.P.1    Yin, W.H.2    Chen, J.W.3    Jen, H.L.4    Young, M.S.5    Lin, S.J.6
  • 13
    • 41149095864 scopus 로고    scopus 로고
    • PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation
    • Okayasu T, Tomizawa A, Suzuki K, Manaka K, Hattori Y. PPARalpha activators upregulate eNOS activity and inhibit cytokine-induced NF-kappaB activation through AMP-activated protein kinase activation. Life Sci 2008;82:884-891
    • (2008) Life Sci , vol.82 , pp. 884-891
    • Okayasu, T.1    Tomizawa, A.2    Suzuki, K.3    Manaka, K.4    Hattori, Y.5
  • 15
    • 85047684089 scopus 로고    scopus 로고
    • PPARkappa and GR differentially down-regulate the expression of nuclear factor-kappaB-responsive genes in vascular endothelial cells
    • DOI 10.1210/en.142.8.3332
    • Xu X, Otsuki M, Saito H, et al. PPARalpha and GR differentially downregulate the expression of nuclear factor-kappaB-responsive genes in vascular endothelial cells. Endocrinology 2001;142:3332-3339 (Pubitemid 32681737)
    • (2001) Endocrinology , vol.142 , Issue.8 , pp. 3332-3339
    • Xu, X.1    Otsuki, M.2    Saito, H.3    Sumitani, S.4    Yamamoto, H.5    Asanuma, N.6    Kouhara, H.7    Kasayama, S.8
  • 17
    • 1242297567 scopus 로고    scopus 로고
    • PPARalpha Activators Inhibit Vascular Endothelial Growth Factor Receptor-2 Expression by Repressing Sp1-Dependent DNA Binding and Transactivation
    • DOI 10.1161/01.RES.0000113781.08139.81
    • Meissner M, Stein M, Urbich C, et al. PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circ Res 2004;94:324-332 (Pubitemid 38240723)
    • (2004) Circulation Research , vol.94 , Issue.3 , pp. 324-332
    • Meissner, M.1    Stein, M.2    Urbich, C.3    Reisinger, K.4    Suske, G.5    Staels, B.6    Kaufmann, R.7    Gille, J.8
  • 18
    • 79952986434 scopus 로고    scopus 로고
    • Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation
    • Tomizawa A, Hattori Y, Inoue T, Hattori S, Kasai K. Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate-activated protein kinase activation. Metabolism 2011;60:513-522
    • (2011) Metabolism , vol.60 , pp. 513-522
    • Tomizawa, A.1    Hattori, Y.2    Inoue, T.3    Hattori, S.4    Kasai, K.5
  • 20
    • 34247108235 scopus 로고    scopus 로고
    • Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway
    • DOI 10.1016/j.exer.2007.01.009, PII S0014483507000310
    • Kim J, Ahn JH, Kim JH, et al. Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway. Exp Eye Res 2007;84:886-893 (Pubitemid 46590130)
    • (2007) Experimental Eye Research , vol.84 , Issue.5 , pp. 886-893
    • Kim, J.1    Ahn, J.-H.2    Kim, J.-H.3    Yu, Y.-S.4    Kim, H.-S.5    Ha, J.6    Shinn, S.-H.7    Oh, Y.-S.8
  • 21
    • 0141960109 scopus 로고    scopus 로고
    • AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells
    • DOI 10.1074/jbc.M306104200
    • Lee M, Hwang JT, Lee HJ, et al. AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J Biol Chem 2003;278:39653-39661 (Pubitemid 37248526)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.41 , pp. 39653-39661
    • Lee, M.1    Hwang, J.-T.2    Lee, H.-J.3    Jung, S.-N.4    Kang, I.5    Chi, S.-G.6    Kim, S.-S.7    Ha, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.