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Bioorganic and Medicinal Chemistry

Volumn 21, Issue 12, 2013, Pages 3614-3623

Investigation of the role of linker moieties in bifunctional tacrine hybrids

(5) Eckroat, Todd J a Green, Keith D a Reed, Rebecca A a Bornstein, Joshua J a Garneau Tsodikova, Sylvie a

a UNIVERSITY OF MICHIGAN (United States)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Bifunctional molecules; Mefenamic acid; Tacrine

Indexed keywords

6 CHLOROTACRINE; ACETYLCHOLINESTERASE; AMINE; CARBENE; HYDROXYL GROUP; MEFENAMIC ACID; METHYL GROUP; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; COVALENT BOND; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYBRID; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; RESIDUE ANALYSIS; STRUCTURE ANALYSIS;

CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84878230024 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.02.047 Document Type: Article

Times cited : (16)

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