Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 159-165

  Bourne, Yves ^b   Radić, Zoran ^c   Kolb, Hartmuth C ^d   Sharpless, K Barry ^d   Taylor, Palmer ^c   Marchot, Pascale ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CNRS   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acetylcholinesterase; Active center gorge; Click chemistry; Crystal structure; Dipolar cycloaddition; Femtomolar inhibitor; Freeze frame triazole; Molecular flexibility; Peripheral site

Indexed keywords

ACETYLCHOLINESTERASE; ALANINE; CHEMICAL COMPOUND; CHOLINESTERASE INHIBITOR; DECIDIUM; GALLAMINE; PROPIDIUM IODIDE; TACRINE; TACRINE(DIMETHYLENE)AZIDE PROPIDIUM(HEXAMETHYLENE)ACETYLENE; TRIAZOLE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; CATALYSIS; CONFERENCE PAPER; CRYSTAL STRUCTURE; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ISOMERISM; LIGAND BINDING; MOLECULAR MECHANICS; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ANIMALS; APOENZYMES; CATALYSIS; CHOLINESTERASE INHIBITORS; MICE; MUTATION; PLIABILITY; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRIAZOLES; TYROSINE;

EID: 28744444023     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.018     Document Type: Conference Paper

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