Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects

European Journal of Pharmacology

Volumn 711, Issue 1-3, 2013, Pages 63-72

  Vidal Torres, Alba ^a   De La Puente, Beatriz ^a   Rocasalbas, Maria ^a   Touriño, Clara ^b   Andreea Bura, Simona ^b   Fernández Pastor, Begoña ^a   Romero, Luz ^a   Codony, Xavier ^a   Zamanillo, Daniel ^a   Buschmann, Helmut ^c   Merlos, Manuel ^a   Manuel Baeyens, José ^d   Maldonado, Rafael ^b   Vela, José Miguel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c Universidad de Granada ^*  (Germany)

^d UNIVERSITY OF GRANADA   (Spain)

Author keywords

Antinociception; Opioid adjuvant; Reward; S1RA (E 52862); Sigma 1 receptor; Tolerance

Indexed keywords

4 [2 [5 METHYL 1 (NAPHTHALEN 2 YL) 1H PYRAZOL 3 YLOXY]ETHYL]MORPHOLINE; BUPRENORPHINE; CODEINE; E 52862; FENTANYL CITRATE; MORPHINE; OPIATE; OPIATE ANTAGONIST; OXYCODONE; SIGMA 1 OPIATE RECEPTOR; TRAMADOL; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; DRUG TOLERANCE; GASTROINTESTINAL TRANSIT; MALE; MOUSE; MYDRIASIS; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR BLOCKING; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CHEMOTHERAPY, ADJUVANT; CONDITIONING (PSYCHOLOGY); DRUG SYNERGISM; DRUG TOLERANCE; GASTROINTESTINAL TRANSIT; GENE KNOCKOUT TECHNIQUES; INTESTINES; MALE; MICE; MORPHINE; MYDRIASIS; NALOXONE; RECEPTORS, SIGMA; REWARD; SPATIAL BEHAVIOR;

EID: 84878163668     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.04.018     Document Type: Article

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