Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice

British Journal of Pharmacology

Volumn 154, Issue 5, 2008, Pages 1125-1134

  Kim, H W ^a   Roh, D H ^b   Yoon, S Y ^b   Seo, H S ^b   Kwon, Y B ^c   Han, H J ^d   Kim, K W ^c   Beitz, A J ^e   Lee, J H ^b  

^a Chungnam National University   (South Korea)

^b Seoul National University   (South Korea)

^c Chonbuk National University Medical School   (South Korea)

^d Chonnam National University   (South Korea)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Mice; NMDA receptor; NR1 subunit; Pain; Phosphorylation; Sigma 1 receptor

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; CYCLIC AMP DEPENDENT PROTEIN KINASE; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; PENTOXYVERINE; PROTEIN KINASE C; SIGMA 1 OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SENSITIZATION; SENSORY SYSTEM; SPINAL CORD DORSAL HORN;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOPENTANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENEDIAMINES; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED ICR; MORPHOLINES; N-METHYLASPARTATE; PAIN; PAIN MEASUREMENT; PHOSPHORYLATION; POSTERIOR HORN CELLS; PROTEIN KINASE C; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SERINE; SIGNAL PROCESSING, COMPUTER-ASSISTED; SIGNAL TRANSDUCTION; SPINAL CORD; TIME FACTORS;

EID: 46249094157     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.159     Document Type: Article

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