In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia

Life Sciences

Volumn 78, Issue 21, 2006, Pages 2449-2453

  Marrazzo, Agostino ^a   Parenti, Carmela ^b   Scavo, Valentina ^b   Ronsisvalle, Simone ^a   Maria Scoto, Giovanna ^b   Ronsisvalle, Giuseppe ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b Pharmacology Section   (Italy)

Author keywords

(+) MR200; Analgesia; Opioids; Sigma

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR AGONIST; METHYL 2 [[4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL]METHYL] 1 PHENYLCYCLOPROPANE CARBOXYLIC ACID; MR 200; MU OPIATE RECEPTOR AGONIST; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANALGESIA; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LATENT PERIOD; MALE; NONHUMAN; PAIN; RAT; TAIL FLICK TEST;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS, OPIOID; ANIMALS; CYCLOPROPANES; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; INJECTIONS, INTRAVENTRICULAR; MALE; PAIN MEASUREMENT; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; RECEPTORS, SIGMA;

EID: 33645958854     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.10.005     Document Type: Article

References (30)

1. Barro M., Ruiz F., and Hurlè M.H. κ-Opioid receptor mediated antinociception in rats is dependent on the functional state of dihydropyridine-sensitive calcium channels. Brain Research 672 (1995) 148-152
2. Bowen W.D. Sigma receptors: recent advances and new clinical potentials. Pharmaceutica Acta Helvetiae 74 (2000) 215-218
3. Chien C.C., and Pasternak G.W. Functional antagonism of morphine analgesia by (+)-pentazocine: evidence for an anti-opioid sigma 1 system. European Journal Pharmacolology 250 (1993) R7-R8
4. Chien C.C., and Pasternak G.W. Selective antagonism of opioid analgesia by a sigma system. Journal of Pharmacology and Experimental Therapeutics 271 (1994) 1583-1590
5. Chien C.C., and Pasternak G.W. Sigma antagonists potentiate opioid analgesia in rats. Neuroscience Letters 190 (1995) 137-139
6. Ganapathy M.E., Prasad P.D., Huang W., Seth P., Leibach F.H., and Ganapathy V. Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line. Journal of Pharmacology and Experimental Therapeutics 289 (1999) 251-260
7. Gardner B., Zhu L.X., Roth M.D., Tashkin D.P., Dubinett S.M., and Sharma S. Cocaine modulates cytokine and enhances tumor growth through sigma receptors. Journal of Neuroimmunology 147 (2004) 95-98
8. Gibbs T.T., and Farb D.H. Dueling enigmas: neurosteroids and sigma receptors in the limelight. Science's STKE 28 (2000) PE1
9. Guitart X., Codony X., and Monroy X. Sigma receptors: biology and therapeutic potential. Psychopharmacology 174 (2004) 301-319
10. Haley T.J., and Mc Cormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. British Journal of Pharmacology 12 (1957) 12-15
11. Hanner M., Moebius F.F., Flandorfer A., Knaus H.G., Striessnig J., Kempner E., and Glossmann H. Purification, molecular cloning, and expression of the mammalian sigma1-binding site. Proceedings of the National Academy of Sciences of the United States of America 93 15 (1996) 8072-8077
12. Hayashi T., and Su T.P. Regulating ankyrin dynamics: Roles of sigma-1 receptors. Proceedings of the National Academy of Sciences of the United States of America 98 2 (2001) 491-496
13. Horan B., Gifford A.N., Matsuno K., Mita S., and Ashby Jr. C.R. Effect of SA4503 on the electrically evoked release of (3)H-acetylcholine from striatal and hippocampal rat brain slices. Synapse 46 (2002) 1-3
14. Itzhak, Y., 1994. Sigma Receptors, Ed. Academic Press: San Diego, CA.
15. King M., Pan Y.X., Mei J., Chang A., Xu J., and Pasternak G.W. Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor. European Journal of Pharmacology 331 (1997) R5-R6
16. Martin W.R., Eades C.G., Thomson J.A., Huppler R.E., and Gilbert P.E. The effects of morphine and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. Journal of Pharmacology and Experimental Therapeutics 197 (1976) 517-532
17. Matsumoto R.R., Liu Y., Lerner M., Howard E.W., and Brackett D.J. Sigma receptors: potential medications development target for anti-cocaine agents. European Journal of Pharmacology 469 (2003) 1-12
18. Maurice T., Urani A., Phan V.L., and Romieu P. The interaction between neuroactive steroids and the ó1 receptor function: behavioral consequences and therapeutic opportunities. Brain Research Reviews 37 (2001) 116-132
19. Maurice T., Martin-Fardon R., Romieu P., and Matsumoto R.R. Sigma(1) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neuroscience and Biobehavioral Reviews 26 (2002) 499-527
20. Mei J., and Pasternak G.W. Sigma1 receptor modulation of opioid analgesia in the mouse. Journal of Pharmacology and Experimental Therapeutics 300 (2002) 1070-1074
21. Moison D., De Deurwaerdere P., Cagnotto A., Marrazzo A., Prezzavento O., Ronsisvalle G., Mennini T., and Spampinato U. Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo. Neuropharmacology 45 (2003) 945-953
22. Nuwayhid S.J., and Werling L.L. Steroids modulate N-methyl-d-aspartate-stimulated [3H] dopamine release from rat striatum via sigma receptors. Journal of Pharmacology and Experimental Therapeutics 306 (2003) 934-940
23. Omote K., and Sonoda K. Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord. Anaesthesiology 79 (1993) 746-752
24. Phan V.L., Urani A., Romieu P., and Maurice T. Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels. European Journal of Neuroscience 15 (2002) 1523-1534
25. Quirion R., Bowen W.D., Itzhak T., Junien J.L., Musacchio J.M., Rothman R.B., Su T.P., Tam S.W., and Taylor D.P. A proposal for the classification of sigma binding sites. Trends in Pharmacological Sciences 13 (1992) 85-86
26. Ronsisvalle G., Marrazzo A., Prezzavento O., Cagnotto A., Mennini T., Parenti C., and Scoto G.M. Opioid and sigma receptor studies. New developments in the design of selective sigma ligands. Pure and Applied Chemistry 73 (2001) 1499-1509
27. Santiccioli P., and Bianco E.D. Release of calcium gene related peptide like-immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels. Neuroscience 136 (1992) 161-164
28. Su T.P. Delineating biochemical and functional properties of sigma receptors: emerging concepts. Critical Reviews in Neurobiology 7 (1993) 187-203
29. Su T.P., and Hayashi T. Cocaina affects the dynamics of cytoskeletal proteins via sigma (1) receptors. Trends in Pharmacological Sciences 22 9 (2001) 456-458
30. Walker J.M., Bowen W.D., Walker F.O., Matsumoto R.R., DeCosta B., and Rice K.C. Sigma receptors: biology and function. Pharmacological Reviews 42 (1990) 355-402