Intrathecal treatment with σ 1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice

British Journal of Pharmacology

Volumn 148, Issue 4, 2006, Pages 490-498

  Kim, Hyun Woo ^a   Kwon, Young Bae ^b   Roh, Dae Hyun ^a   Yoon, Seo Yeon ^a   Han, Ho Jae ^c   Kim, Kee Won ^b   Beitz, Alvin J ^d   Lee, Jang Hern ^a  

^a Seoul National University   (South Korea)

^b Chonbuk National University Medical School   (South Korea)

^c Chonnam National University   (South Korea)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

1 receptor; BD 1047; BMY 14802; Formalin test; Fos; NMDA phosphorylation

Indexed keywords

ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORMALDEHYDE; N [2 (2,3 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (DIMETHYLAMINO)ETHYLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; OPIATE ANTAGONIST; PROPRANOLOL; PROTEIN FOS; PROTEIN KINASE C; SERINE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SIGMA 1 OPIATE RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINE BUTANOL; ALPHA-(4-FLUOROPHENYL)-4-(5-FLUORO-2-PYRIMIDINYL)-1-PIPERAZINE BUTANOL; ETHYLENEDIAMINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NR1 NMDA RECEPTOR; PROTEIN C FOS; PYRIMIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SIGMA OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; SPINAL CORD DORSAL HORN; STATISTICAL SIGNIFICANCE; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; MOTOR ACTIVITY; PAIN ASSESSMENT; PHOSPHORYLATION; PHYSIOLOGY; POSTERIOR HORN CELL;

ANIMALS; ETHYLENEDIAMINES; FORMALDEHYDE; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; PAIN MEASUREMENT; PHOSPHORYLATION; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIMIDINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA;

EID: 33745101432     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706764     Document Type: Article

References (47)

1. ABBADIE, C. & BESSON, J.M. (1994). Chronic treatments with aspirin or acetaminophen reduce both the development of polyarthritis and Fos-like immunoreactivity in rat lumbar spinal cord. Pain, 57, 45-54.
2. ABBADIE, C., TAYLOR, B.K., PETERSON, M.A. & BASBAUM, A.I. (1997). Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine. Pain, 69, 101-110.
3. 1) receptor in the adult rat central nervous system. Neuroscience, 97, 155-170.
4. BERMACK, J., LAVOIE, N., DRYVER, E. & DEBONNEL, G. (2002). Effects of sigma ligands on NMDA receptor function in the bulbectomy model of depression: a behavioural study in the rat. Int. J. Neuropsychopharmacol., 5, 53-62.
5. BRENNER, G.J., JI, R.R., SHAFFER, S. & WOOLF, C.J. (2004). Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur. J. Neurosci., 20, 375-384.
6. BURITOVA, J., LARRUE, S., ALIAGA, M., BESSON, J.M. & COLPAERT, F. (2005). Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. Eur. J. Pharmacol., 514, 121-130.
7. CAUDLE, R.M., PEREZ, F.M., DEL VALLE-PINERO, A.Y. & IADAROLA, M.J. (2005). Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation. Mol. Pain, 1, 25.
8. CENDAN, C.M., PUJALTE, J.M., PORTILLO-SALIDO, E. & BAEYENS, J.M. (2005a). Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice. Psychopharmacology (Berlin), 182, 485-493.
9. CENDAN, C.M., PUJALTE, J.M., PORTILLO-SALIDO, E., MONTOLIU, L. & BAEYENS, J.M. (2005b). Formalin-induced pain is reduced in sigma (1) receptor knockout mice. Eur. J. Pharmacol., 511, 73-74.
10. CHAPLAN, S.R., MALMBERG, A.B. & YAKSH, T.L. (1997). Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J. Pharmacol. Exp. Ther., 280, 829-838.
11. CODERRE, T.J. & MELZACK, R. (1992). The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury. J. Neurosci., 12, 3671-3675.
12. ERNBERG, M., LUNDEBERG, T. & KOPP, S. (2000). Effect of propranolol and granisetron on experimentally induced pain and allodynia/hyperalgesia by intramuscular injection of serotonin into the human masseter muscle. Pain, 84, 339-346.
13. FUKUDA, T., NISHIMOTO, C., HISANO, S., MIYABE, M. & TOYOOKA, H. (2002). The analgesic effect of xenon on the formalin test in rats: a comparison with nitrous oxide. Anesth. Analg., 95, 1300-1304.
14. FUKUDA, T., WATANABE, K., HISANO, S. & TOYOOKA, H. (2006). Licking and C-fos expression in the dorsal horn of the spinal cord after the formalin test. Anesth. Analg., 102, 811-814.
15. GAO, X., KIM, H.K., CHUNG, J.M. & CHUNG, K. (2005). Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain, 116, 62-72.
16. GEWIRTZ, G.R., GORMAN, J.M., VOLAVKA, J., MACALUSO, J., GRIBKOFF, G., TAYLOR, D.P. & BORISON, R. (1994). BMY 14802, a sigma receptor ligand for the treatment of schizophrenia. Neuropsychopharmacology, 10, 37-40.
17. GUITART, X., CODONY, X. & MONROY, X. (2004). Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berlin), 74, 301-319.
18. HOLLMANN, M. & HEINEMANN, S. (1994). Cloned glutamate receptors. Annu. Rev. Neurosci., 17, 31-108.
19. HYLDEN, J.L. & WILCOX, G.L. (1980). Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol., 67, 313-316.
20. JEONG, C.Y., CHOI, J.I. & YOON, M.H. (2004). Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. Eur. J. Pharmacol., 502, 205-211.
21. KIM, H.W., KWON, Y.B., HAN, H.J., YANG, I.S., BEITZ, A.J. & LEE, J.H. (2005). Antinociceptive mechanisms associated with diluted bee venom acupuncture (apipuncture) in the rat formalin test: involvement of descending adrenergic and serotonergic pathways. Pharmacol. Res., 51, 183-188.
22. KWON, Y.B., LEE, J.D., LEE, H.J., HAN, H.J., MAR, W.C., KANG, S.K., BEITZ, A.J. & LEE, J.H. (2001). Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain, 90, 271-280.
23. LEE, J.H., KIM, H.W., KWON, Y.B., KANG, M.S., CHOI, D.W., NA, J.H., KWON, O.K., YOUN, H.J., HAN, H.J., BYUN, T.H., PARK, S.Y., CHUN, B.H., PYUN, J.H., AN, G.H., LEE, Y.J. & CHO, M.H. (2000). General pharmacology studies on beta-domain deleted recombinant factor VIII. Arzneimittelforschung, 50, 86-92.
24. LEONARD, A.S. & HELL, J.W. (1997). Cyclic AMP-dependent protein kinase and protein kinase C phosphorylate N-methyl-D-aspartate receptors at different sites. J. Biol. Chem., 272, 12107-12115.
25. LIAO, G.Y., WAGNER, D.A., HSU, M.H. & LEONARD, J.P. (2001). Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol. Pharmacol., 59, 960-964.
26. LLANSOLA, M., SANCHEZ-PEREZ, A., CAULI, O. & FELIPO, V. (2005). Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function. Cerebellum, 4, 154-161.
27. MASU, M., NAKAJIMA, Y., MORIYOSHI, K., ISHII, T., AKAZAWA, C. & NAKANASHI, S. (1993). Molecular characterization of NMDA and metabotropic glutamate receptors. Ann. NY Acad. Sci., 707, 153-164.
28. MATOS, F.F., KORPINEN, C. & YOCCA, F.D. (1996). 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. Eur. J. Pharmacol., 317, 49-54.
29. MATSUMOTO, R.R., BOWEN, W.D., TOM, M.A., VO, V.N., TRUONG, D.D. & DE COSTA, B.R. (1995). Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur. J. Pharmacol., 280, 301-310.
30. MCCRACKEN, K.A., BOWEN, W.D., DE COSTA, B.R. & MATSUMOTO, R.R. (1999). Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur. J. Pharmacol., 370, 225-232.
31. MIYATA, M., KASHIWADANI, H., FUKAIYA, M., HAYASHI, T., WU, D., SUZUKI, T., WATANABE, M. & KAWAKAMI, Y. (2003). Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain. J. Neurosci., 23, 8098-8108.
32. MORI, H. & MISHINA, M. (1995). Structure and function of the NMDA receptor channel. Neuropharmacology, 34, 1219-1237.
33. 3H]dopamine release is dependent upon protein kinase C. J. Pharmacol. Exp. Ther., 304, 364-369.
34. OZAWA, S., KAMIYA, H. & TSUZUKI, K. (1998). Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol., 54, 581-618.
35. RYDH-RINDER, M., BERGE, O.G. & HOKFELT, T. (2001). Antinociceptive effects after intrathecal administration of phosphodiester-, 2′-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse. Brain Res. Mol. Brain Res., 86, 23-33.
36. SOUTH, S.M., KOHNO, T., KASPAR, B.K., HEGARTY, D., VISSEL, B., DRAKE, C.T., OHATA, M., JENAB, S., SAILER, A.W., MALKMUS, S., MASUYAMA, T., HORNER, P., BOGULAVSKY, J., GAGE, F.H., YAKSH, T.L., WOOLF, C.J., HEINEMANN, S.F. & INTURRISI, C.E. (2003). A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J. Neurosci., 23, 5031-5040.
37. SU, T.P. (1982). Evidence for sigma opioid receptor: binding of H SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J. Pharmacol. Exp. Ther., 223, 284-290.
38. TAM, S.W. & COOK, L. (1984). Sigma opiates and certain antipsychotic drugs mutually inhibit q - H SKF10, 047 and H haloperidol binding in guinea pig brain membranes, Proc. Proc. Natl. Acad. Sci. U.S.A., 81, 5618-5621.
39. UEDA, H., INOUE, M., YOSHIDA, A., MIZUNO, K., YAMAMOTO, H., MARUO, J., MATSUNO, K. & MITA, S. (2001). Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice. J. Pharmacol. Exp. Ther., 298, 703-710.
40. WALKER, J.M., BOWEN, W.D., WALKER, F.O., MATSUMOTO, R.R., DE COSTA, B. & RICE, K.C. (1990). Sigma receptors: biology and function. Pharmacol. Rev., 42, 355-402.
41. WANG, H. & TAKIGAWA, M. (2002). The selective sigma ligand MS-377 attenuates the blockade by phencyclidine of NMDA-induced intracellular calcium. Int. J. Neuropsychopharmacol., 5, 239-242.
42. WANG, L., PRESCOTT, A.R., SPRUCE, B.A., SANDERSON, J. & DUNCAN, G. (2005). Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. Invest. Ophthalmol. Vis. Sci., 46, 1403-1408.
43. YAJIMA, Y., NARITA, M., SHIMAMURA, M., NARITA, M., KUBOTA, C. & SUZUKI, T. (2003). Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice. Brain Res., 992, 288-293.
44. YAMAKURA, T. & SHIMOJI, K. (1999). Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog. Neurobiol., 59, 279-298.
45. ZHANG, Y.Q., GAO, X., JI, G.C., HUANG, Y.L., WU, G.C. & ZHAO, Z.Q. (2002). Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation. Pain, 98, 287-295.
46. ZIMMERMANN, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110.
47. ZOU, X., LIN, Q. & WILLIS, W.D. (2002). Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. Neuroscience, 115, 775-786.