Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective

Progress in Lipid Research

Volumn 52, Issue 4, 2013, Pages 374-394

  De Kroon, Anton I P M ^a   Rijken, Pieter J ^a   De Smet, Cedric H ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Membrane fluidity; Membrane intrinsic curvature; Membrane sensors; Phospholipid biosynthesis; Phospholipid properties; Phospholipid turnover

Indexed keywords

ACYL COENZYME A; CARDIOLIPIN; CYCLIN DEPENDENT KINASE 1; CYTIDINE DIPHOSPHATE DIGLYCERIDE; CYTIDINE TRIPHOSPHATE; FUNGAL PROTEIN; GLYCEROPHOSPHOLIPID; INOSITOL; MEMBRANE PHOSPHOLIPID; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; S ADENOSYLHOMOCYSTEINE; UNCLASSIFIED DRUG; ZAP1P PROTEIN; ZINC;

CHEMICAL INTERACTION; CHEMICAL STRUCTURE; ENZYME PHOSPHORYLATION; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; FUNGAL GENE; FUNGAL MEMBRANE; GENE EXPRESSION; GENETIC REGULATION; HOMEOSTASIS; INO1 GENE; LIPID COMPOSITION; LIPID METABOLISM; LIPOGENESIS; MEMBRANE STRUCTURE; NONHUMAN; OPI1 GENE; PIS1 GENE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

MEMBRANE FLUIDITY; MEMBRANE INTRINSIC CURVATURE; MEMBRANE SENSORS; PHOSPHOLIPID BIOSYNTHESIS; PHOSPHOLIPID PROPERTIES; PHOSPHOLIPID TURNOVER;

ACYL COENZYME A; FATTY ACIDS; MEMBRANE LIPIDS; PHOSPHATIDIC ACIDS; PHOSPHOLIPIDS; SACCHAROMYCES CEREVISIAE;

EID: 84878131033     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2013.04.006     Document Type: Review

References (262)

1. C.S. Ejsing, J.L. Sampaio, V. Surendranath, E. Duchoslav, K. Ekroos, and R.W. Klemm Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry Proc Natl Acad Sci USA 106 2009 2136 2141
2. G. Daum, N.D. Lees, M. Bard, and R. Dickson Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae Yeast 14 1998 1471 1510
3. O.G. Mouritsen The liquid-ordered state comes of age Biochim Biophys Acta 1798 2010 1286 1288
4. R. Schneiter, B. Brugger, R. Sandhoff, G. Zellnig, A. Leber, and M. Lampl Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane J Cell Biol 146 1999 741 754
5. R.W. Klemm, C.S. Ejsing, M.A. Surma, H.J. Kaiser, M.J. Gerl, and J.L. Sampaio Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network J Cell Biol 185 2009 601 612
6. D.A. Los, and N. Murata Membrane fluidity and its roles in the perception of environmental signals Biochim Biophys Acta 1666 2004 142 157
7. S. Wagner, and F. Paltauf Generation of glycerophospholipid molecular species in the yeast Saccharomyces cerevisiae. Fatty acid pattern of phospholipid classes and selective acyl turnover at sn-1 and sn-2 positions Yeast 10 1994 1429 1437
8. M. Suutari, K. Liukkonen, and S. Laakso Temperature adaptation in yeasts: the role of fatty acids J Gen Microbiol 136 1990 1469 1474
9. C.E. Martin, C.S. Oh, and Y. Jiang Regulation of long chain unsaturated fatty acid synthesis in yeast Biochim Biophys Acta 1771 2007 271 285
10. S.M. Gruner Intrinsic curvature hypothesis for biomembrane lipid composition: a role for nonbilayer lipids Proc Natl Acad Sci USA 82 1985 3665 3669
11. P.R. Cullis, and B. de Kruijff Lipid polymorphism and the functional roles of lipids in biological membranes Biochim Biophys Acta 559 1979 399 420
12. K. Emoto, T. Kobayashi, A. Yamaji, H. Aizawa, I. Yahara, and K. Inoue Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis Proc Natl Acad Sci USA 93 1996 12867 12872
13. E. van den Brink-van der Laan, J.A. Killian, and B. de Kruijff Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile Biochim Biophys Acta 1666 2004 275 288
14. M.J. Janssen, M.C. Koorengevel, B. de Kruijff, and A.I. de Kroon The phosphatidylcholine to phosphatidylethanolamine ratio of Saccharomyces cerevisiae varies with the growth phase Yeast 16 2000 641 650
15. G. Tuller, T. Nemec, C. Hrastnik, and G. Daum Lipid composition of subcellular membranes of an FY1679-derived haploid yeast wild-type strain grown on different carbon sources Yeast 15 1999 1555 1564
16. C. Klose, M.A. Surma, M.J. Gerl, F. Meyenhofer, A. Shevchenko, and K. Simons Flexibility of a eukaryotic lipidome-insights from yeast lipidomics PLoS One 7 2012 e35063
17. G. Lindblom, and L. Rilfors Nonlamellar phases formed by membrane lipids Adv Colloid Interface Sci 41 1992 101 125
18. M.K. Storey, K.L. Clay, T. Kutateladze, R.C. Murphy, M. Overduin, and D.R. Voelker Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures J Biol Chem 276 2001 48539 48548
19. R. Birner, M. Burgermeister, R. Schneiter, and G. Daum Roles of phosphatidylethanolamine and of its several biosynthetic pathways in Saccharomyces cerevisiae Mol Biol Cell 12 2001 997 1007
20. R. Birner, R. Nebauer, R. Schneiter, and G. Daum Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine biosynthetic machinery with the prohibitin complex of Saccharomyces cerevisiae Mol Biol Cell 14 2003 370 383
21. Y. Ichimura, T. Kirisako, T. Takao, Y. Satomi, Y. Shimonishi, and N. Ishihara A ubiquitin-like system mediates protein lipidation Nature 408 2000 488 492
22. M. Opekarova, I. Robl, and W. Tanner Phosphatidyl ethanolamine is essential for targeting the arginine transporter Can1p to the plasma membrane of yeast Biochim Biophys Acta 1564 2002 9 13
23. L. Pineau, L. Bonifait, J.M. Berjeaud, P. Alimardani-Theuil, T. Berges, and T. Ferreira A lipid-mediated quality control process in the Golgi apparatus in yeast Mol Biol Cell 19 2008 807 821
24. T. Kodaki, and S. Yamashita Characterization of the methyltransferases in the yeast phosphatidylethanolamine methylation pathway by selective gene disruption Eur J Biochem 185 1989 243 251
25. A.G. Howe, V. Zaremberg, and C.R. McMaster Cessation of growth to prevent cell death due to inhibition of phosphatidylcholine synthesis is impaired at 37 C in Saccharomyces cerevisiae J Biol Chem 277 2002 44100 44107
26. H.A. Boumann, J. Gubbens, M.C. Koorengevel, C.S. Oh, C.E. Martin, and A.J. Heck Depletion of phosphatidylcholine in yeast induces shortening and increased saturation of the lipid acyl chains: evidence for regulation of intrinsic membrane curvature in a eukaryote Mol Biol Cell 17 2006 1006 1017
27. A.I. de Kroon Metabolism of phosphatidylcholine and its implications for lipid acyl chain composition in Saccharomyces cerevisiae Biochim Biophys Acta 1771 2007 343 352
28. J.R. Silvius, P.M. Brown, and T.J. O'Leary Role of head group structure in the phase behavior of amino phospholipids. 1. Hydrated and dehydrated lamellar phases of saturated phosphatidylethanolamine analogues Biochemistry 25 1986 4249 4258
29. A.S. Ulrich, and A. Watts Molecular response of the lipid headgroup to bilayer hydration monitored by 2H-NMR Biophys J 66 1994 1441 1449
30. 2+ influx, a yeast "deletome" analysis Faseb J 21 2007 1813 1820
31. J.H. Exton Phosphatidylcholine breakdown and signal transduction Biochim Biophys Acta 1212 1994 26 42
32. R. Mendonsa, and J. Engebrecht Phospholipase D function in Saccharomyces cerevisiae Biochim Biophys Acta 1791 2009 970 974
33. P. Griac, M.J. Swede, and S.A. Henry The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast J Biol Chem 271 1996 25692 25698
34. J. Gubbens, and A.I. de Kroon Proteome-wide detection of phospholipid-protein interactions in mitochondria by photocrosslinking and click chemistry Mol Biosyst 6 2010 1751 1759
35. T. Strahl, and J. Thorner Synthesis and function of membrane phosphoinositides in budding yeast. Saccharomyces cerevisiae Biochim Biophys Acta 1771 2007 353 404
36. M. Fujita, and T. Kinoshita Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins FEBS Lett 584 2010 1670 1677
37. R.C. Dickson Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast J Lipid Res 49 2008 909 921
38. M.B. Abramson, G. Colacicco, R. Curci, and M.M. Rapport Ionic properties of acidic lipids. Phosphatidylinositol Biochemistry 7 1968 1692 1698
39. M.J. Kelley, A.M. Bailis, S.A. Henry, and G.M. Carman Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by inositol. Inositol is an inhibitor of phosphatidylserine synthase activity J Biol Chem 263 1988 18078 18085
40. M.L. Gaspar, M.A. Aregullin, S.A. Jesch, and S.A. Henry Inositol induces a profound alteration in the pattern and rate of synthesis and turnover of membrane lipids in Saccharomyces cerevisiae J Biol Chem 281 2006 22773 22785
41. J.M. Boggs Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function Biochim Biophys Acta 906 1987 353 404
42. A.I. de Kroon, J.W. Timmermans, J.A. Killian, and B. de Kruijff The pH dependence of headgroup and acyl chain structure and dynamics of phosphatidylserine, studied by 2H-NMR Chem Phys Lipids 54 1990 33 42
43. J.E. Vance, and R. Steenbergen Metabolism and functions of phosphatidylserine Prog Lipid Res 44 2005 207 234
44. K. Atkinson, S. Fogel, and S.A. Henry Yeast mutant defective in phosphatidylserine synthesis J Biol Chem 255 1980 6653 6661
45. G.D. Fairn, M. Hermansson, P. Somerharju, and S. Grinstein Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity Nat Cell Biol 13 2011 1424 1430
46. G. Daum Lipids of mitochondria Biochim Biophys Acta 822 1985 1 42
47. A.I. de Kroon, M.C. Koorengevel, S.S. Goerdayal, P.C. Mulders, M.J. Janssen, and B. de Kruijff Isolation and characterization of highly purified mitochondrial outer membranes of the yeast Saccharomyces cerevisiae (method) Mol Membr Biol 16 1999 205 211
48. N. Gebert, A.S. Joshi, S. Kutik, T. Becker, M. McKenzie, and X.L. Guan Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome Curr Biol 19 2009 2133 2139
49. M. Kates, J.Y. Syz, D. Gosser, and T.H. Haines PH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue Lipids 28 1993 877 882
50. R. Hielscher, T. Wenz, C. Hunte, and P. Hellwig Monitoring the redox and protonation dependent contributions of cardiolipin in electrochemically induced FTIR difference spectra of the cytochrome bc(1) complex from yeast Biochim Biophys Acta 1787 2009 617 625
51. T.H. Haines, and N.A. Dencher Cardiolipin: a proton trap for oxidative phosphorylation FEBS Lett 528 2002 35 39
52. P.R. Cullis, A.J. Verkleij, and P.H. Ververgaert Polymorphic phase behaviour of cardiolipin as detected by 31P NMR and freeze-fracture techniques. Effects of calcium, dibucaine and chlorpromazine Biochim Biophys Acta 513 1978 11 20
53. 2+ and temperature Biochim Biophys Acta 684 1982 282 286
54. M.B. Sankaram, G.L. Powell, and D. Marsh Effect of acyl chain composition on salt-induced lamellar to inverted hexagonal phase transitions in cardiolipin Biochim Biophys Acta 980 1989 389 392
55. M. Schlame, M. Ren, Y. Xu, M.L. Greenberg, and I. Haller Molecular symmetry in mitochondrial cardiolipins Chem Phys Lipids 138 2005 38 49
56. R.M. DeVay, L. Dominguez-Ramirez, L.L. Lackner, S. Hoppins, H. Stahlberg, and J. Nunnari Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion J Cell Biol 186 2009 793 803
57. A.S. Joshi, M.N. Thompson, N. Fei, M. Huttemann, and M.L. Greenberg Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae J Biol Chem 287 2012 17589 17597
58. N. Khalifat, N. Puff, S. Bonneau, J.B. Fournier, and M.I. Angelova Membrane deformation under local pH gradient: mimicking mitochondrial cristae dynamics Biophys J 95 2008 4924 4933
59. F. Jiang Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources Mol Microbiol 26 1997 481 491
60. A.S. Joshi, J. Zhou, V.M. Gohil, S. Chen, and M.L. Greenberg Cellular functions of cardiolipin in yeast Biochim Biophys Acta 1793 2009 212 218
61. E. Mileykovskaya, and W. Dowhan Cardiolipin membrane domains in prokaryotes and eukaryotes Biochim Biophys Acta 1788 2009 2084 2091
62. V.M. Gohil, M.N. Thompson, and M.L. Greenberg Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae J Biol Chem 280 2005 35410 35416
63. C. Osman, D.R. Voelker, and T. Langer Making heads or tails of phospholipids in mitochondria J Cell Biol 192 2011 7 16
64. E.E. Kooijman, K.M. Carter, E.G. van Laar, V. Chupin, K.N. Burger, and B. de Kruijff What makes the bioactive lipids phosphatidic acid and lysophosphatidic acid so special? Biochemistry 44 2005 17007 17015
65. E.E. Kooijman, D.P. Tieleman, C. Testerink, T. Munnik, D.T. Rijkers, and K.N. Burger An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins J Biol Chem 282 2007 11356 11364
66. B.P. Young, J.J. Shin, R. Orij, J.T. Chao, S.C. Li, and X.L. Guan Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism Science 329 2010 1085 1088
67. E.E. Kooijman, V. Chupin, B. de Kruijff, and K.N. Burger Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid Traffic 4 2003 162 174
68. E.E. Kooijman, and K.N. Burger Biophysics and function of phosphatidic acid: a molecular perspective Biochim Biophys Acta 1791 2009 881 888
69. J.J. Shin, and C.J. Loewen Putting the pH into phosphatidic acid signaling BMC Biol 9 2011 85
70. G.M. Carman, and G.S. Han Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae Annu Rev Biochem 80 2011 859 883
71. S.A. Henry, S.D. Kohlwein, and G.M. Carman Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae Genetics 190 2012 317 349
72. Z. Zheng, and J. Zou The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae J Biol Chem 276 2001 41710 41716
73. K. Athenstaedt, and G. Daum 1-acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles J Biol Chem 275 Jan 2000 235 240
74. M. Benghezal, C. Roubaty, V. Veepuri, J. Knudsen, and A. Conzelmann SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast J Biol Chem 282 2007 30845 30855
75. P.N. Black, and C.C. DiRusso Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation Biochim Biophys Acta 1771 2007 286 298
76. 2+-dependent phosphatidate phosphatase enzyme J Biol Chem 281 2006 9210 9218
77. H. Shen, P.N. Heacock, C.J. Clancey, and W. Dowhan The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth J Biol Chem 271 1996 789 795
78. P. Oelkers, D. Cromley, M. Padamsee, J.T. Billheimer, and S.L. Sturley The DGA1 gene determines a second triglyceride synthetic pathway in yeast J Biol Chem 277 2002 8877 8881
79. D. Sorger, and G. Daum Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae J Bacteriol 184 2002 519 524
80. P. Oelkers, A. Tinkelenberg, N. Erdeniz, D. Cromley, J.T. Billheimer, and S.L. Sturley A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast J Biol Chem 275 2000 15609 15612
81. 2+-independent phosphatidate phosphatase J Biol Chem 273 1998 14331 14338
82. D.A. Toke, W.L. Bennett, D.A. Dillon, W.I. Wu, X. Chen, and D.B. Ostrander Isolation and characterization of the Saccharomyces cerevisiae DPP1 gene encoding diacylglycerol pyrophosphate phosphatase J Biol Chem 273 1998 3278 3284
83. M. Chae, G.S. Han, and G.M. Carman The Saccharomyces cerevisiae actin patch protein App 1p is a phosphatidate phosphatase enzyme J Biol Chem 287 2012 40186 40196
84. F. Pascual, and G.M. Carman Phosphatidate phosphatase, a key regulator of lipid homeostasis Biochim Biophys Acta 1831 2013 514 522
85. G.S. Han, L. O'Hara, G.M. Carman, and S. Siniossoglou An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth J Biol Chem 283 2008 20433 20442
86. S. Fakas, C. Konstantinou, and G.M. Carman DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae J Biol Chem 286 2011 1464 1474
87. K. Kuchler, G. Daum, and F. Paltauf Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae J Bacteriol 165 1986 901 910
88. J. Nikawa, and S. Yamashita Molecular cloning of the gene encoding CDP diacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae Eur J Biochem 143 1984 251 256
89. V.A. Letts, L.S. Klig, M. Bae-Lee, G.M. Carman, and S.A. Henry Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase Proc Natl Acad Sci USA 80 1983 7279 7283
90. S.C. Chang, P.N. Heacock, C.J. Clancey, and W. Dowhan The PEL1 gene (renamed PGS1) encodes the phosphatidylglycero-phosphate synthase of Saccharomyces cerevisiae J Biol Chem 273 1998 9829 9836
91. C.J. Clancey, S.C. Chang, and W. Dowhan Cloning of a gene (PSD1) encoding phosphatidylserine decarboxylase from Saccharomyces cerevisiae by complementation of an Escherichia coli mutant J Biol Chem 268 1993 24580 24590
92. P.J. Trotter, J. Pedretti, and D.R. Voelker Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele J Biol Chem 268 1993 21416 21424
93. P.J. Trotter, and D.R. Voelker Identification of a non-mitochondrial phosphatidylserine decarboxylase activity (PSD2) in the yeast Saccharomyces cerevisiae J Biol Chem 270 1995 6062 6070
94. M. Burgermeister, R. Birner-Grunberger, R. Nebauer, and G. Daum Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae Biochim Biophys Acta 1686 2004 161 168
95. T. Kodaki, and S. Yamashita Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes J Biol Chem 262 1987 15428 15435
96. E.F. Summers, V.A. Letts, P. McGraw, and S.A. Henry Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis Genetics 120 1988 909 922
97. P. McGraw, and S.A. Henry Mutations in the Saccharomyces cerevisiae opi3 gene: effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis Genetics 122 1989 317 330
98. C. Osman, M. Haag, F.T. Wieland, B. Brugger, and T. Langer A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4 EMBO J 29 2010 1976 1987
99. S.C. Chang, P.N. Heacock, E. Mileykovskaya, D.R. Voelker, and W. Dowhan Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae J Biol Chem 273 1998 14933 14941
100. G. Tuller, C. Hrastnik, G. Achleitner, U. Schiefthaler, F. Klein, and G. Daum YDL142c encodes cardiolipin synthase (Clslp) and is non-essential for aerobic growth of Saccharomyces cerevisiae FEBS Lett 421 1998 15 18
101. K. Hosaka, T. Kodaki, and S. Yamashita Cloning and characterization of the yeast CKI gene encoding choline kinase and its expression in Escherichia coli J Biol Chem 264 1989 2053 2059
102. K. Natter, P. Leitner, A. Faschinger, H. Wolinski, S. McCraith, and S. Fields The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy Mol Cell Proteomics 4 2005 662 672
103. Y. Tsukagoshi, J. Nikawa, and S. Yamashita Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae Eur J Biochem 169 1987 477 486
104. C.R. McMaster, and R.M. Bell Phosphatidylcholine biosynthesis via the CDP-choline pathway in Saccharomyces cerevisiae. Multiple mechanisms of regulation J Biol Chem 269 1994 14776 14783
105. R.H. Hjelmstad, and R.M. Bell Mutants of Saccharomyces cerevisiae defective in sn-1,2-diacylglycerol cholinephosphotransferase. Isolation, characterization, and cloning of the CPT1 gene J Biol Chem 262 1987 3909 3917
106. K. Kim, K.H. Kim, M.K. Storey, D.R. Voelker, and G.M. Carman Isolation and characterization of the Saccharomyces cerevisiae EKI1 gene encoding ethanolamine kinase J Biol Chem 274 1999 14857 14866
107. R. Min-Seok, Y. Kawamata, H. Nakamura, A. Ohta, and M. Takagi Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae J Biochem 120 1996 1040 1047
108. R.H. Hjelmstad, and R.M. Bell The sn-1,2-diacylglycerol ethanolaminephosphotransferase activity of Saccharomyces cerevisiae. Isolation of mutants and cloning of the EPT1 gene J Biol Chem 263 1988 19748 19757
109. R.H. Hjelmstad, and R.M. Bell Sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products J Biol Chem 266 1991 5094 5103
110. C.R. McMaster, and R.M. Bell Phosphatidylcholine biosynthesis in Saccharomyces cerevisiae JBC 269 1994 28010 28016
111. G.M. Carman, and S.A. Henry Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae J Biol Chem 282 2007 37293 37297
112. C.J. Loewen, M.L. Gaspar, S.A. Jesch, C. Delon, N.T. Ktistakis, and S.A. Henry Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid Science 304 2004 1644 1647
113. M.L. Greenberg, B. Reiner, and S.A. Henry Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants Genetics 100 1982 19 33
114. M.L. Greenberg, and J.M. Lopes Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae Microbiol Rev 60 1996 1 20
115. J.P. Fernandez-Murray, G.J. Gaspard, S.A. Jesch, and C.R. McMaster NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genes J Biol Chem 284 2009 36034 36046
116. S.H. Han, G.S. Han, W.M. Iwanyshyn, and G.M. Carman Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc J Biol Chem 280 2005 29017 29024
117. W.M. Iwanyshyn, G.S. Han, and G.M. Carman Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc J Biol Chem 279 2004 21976 21983
118. M.C. Kersting, and G.M. Carman Regulation of the Saccharomyces cerevisiae EKI1-encoded ethanolamine kinase by zinc depletion J Biol Chem 281 2006 13110 13116
119. A. Soto, and G.M. Carman Regulation of the Saccharomyces cerevisiae CKI1-encoded choline kinase by zinc depletion J Biol Chem 283 2008 10079 10088
120. A. Soto-Cardalda, S. Fakas, F. Pascual, H.S. Choi, and G.M. Carman Phosphatidate phosphatase plays role in zinc-mediated regulation of phospholipid synthesis in yeast J Biol Chem 287 2012 968 977
121. Y.F. Chang, and G.M. Carman CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae Prog Lipid Res 47 2008 333 339
122. G.S. Han, L. O'Hara, S. Siniossoglou, and G.M. Carman Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase J Biol Chem 283 2008 20443 20453
123. P.M. Gaynor, and G.M. Carman Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties Biochim Biophys Acta 1045 1990 156 163
124. N. Malanovic, I. Streith, H. Wolinski, G. Rechberger, S.D. Kohlwein, and O. Tehlivets S-adenosyl-l-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis J Biol Chem 283 2008 23989 23999
125. E. Karanasios, G.S. Han, Z. Xu, G.M. Carman, and S. Siniossoglou A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase Proc Natl Acad Sci USA 107 2010 17539 17544
126. C.F. Kurat, H. Wolinski, J. Petschnigg, S. Kaluarachchi, B. Andrews, and K. Natter Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression Mol Cell 33 2009 53 63
127. M.W. Bratschi, D.P. Burrowes, A. Kulaga, J.F. Cheung, A.L. Alvarez, and J. Kearley Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth Eukaryot Cell 8 2009 1184 1196
128. D. Pultz, M.V. Bennetzen, S.V. Rodkaer, C. Zimmermann, J.M. Enserink, and J.S. Andersen Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae Mol Biosyst 8 2012 796 803
129. G. Daum, G. Tuller, T. Nemec, C. Hrastnik, G. Balliano, and L. Cattel Systematic analysis of yeast strains with possible defects in lipid metabolism Yeast 15 1999 601 614
130. O. Tehlivets, K. Scheuringer, and S.D. Kohlwein Fatty acid synthesis and elongation in yeast Biochim Biophys Acta 1771 2007 255 270
131. H. Okuyama, M. Saito, V.C. Joshi, S. Gunsberg, and S.J. Wakil Regulation by temperature of the chain length of fatty acids in yeast J Biol Chem 254 1979 12281 12284
132. H. Rossler, C. Rieck, T. Delong, U. Hoja, and E. Schweizer Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis Mol Genet Genomics 269 2003 290 298
133. C.S. Oh, D.A. Toke, S. Mandala, and C.E. Martin ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation J Biol Chem 272 1997 17376 17384
134. J.E. Stukey, V.M. McDonough, and C.E. Martin Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae J Biol Chem 264 1989 16537 16544
135. J.Y. Choi, J. Stukey, S.Y. Hwang, and C.E. Martin Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene J Biol Chem 271 1996 3581 3589
136. M.A. Bossie, and C.E. Martin Nutritional regulation of yeast delta-9 fatty acid desaturase activity J Bacteriol 171 1989 6409 6413
137. S. Zhang, T.J. Burkett, I. Yamashita, and D.J. Garfinkel Genetic redundancy between SPT23 and MGA2: regulators of Ty-induced mutations and Ty1 transcription in Saccharomyces cerevisiae Mol Cell Biol 17 1997 4718 4729
138. T. Hoppe, K. Matuschewski, M. Rape, S. Schlenker, H.D. Ulrich, and S. Jentsch Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing Cell 102 2000 577 586
139. M. Rape, T. Hoppe, I. Gorr, M. Kalocay, H. Richly, and S. Jentsch Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone Cell 107 2001 667 677
140. R. Chellappa, P. Kandasamy, C.S. Oh, Y. Jiang, M. Vemula, and C.E. Martin The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription activator J Biol Chem 276 2001 43548 43556
141. P. Kandasamy, M. Vemula, C.S. Oh, R. Chellappa, and C.E. Martin Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms J Biol Chem 279 2004 36586 36592
142. V. Tatzer, G. Zellnig, S.D. Kohlwein, and R. Schneiter Lipid-dependent subcellular relocalization of the acyl chain desaturase in yeast Mol Biol Cell 13 2002 4429 4442
143. S. Braun, K. Matuschewski, M. Rape, S. Thoms, and S. Jentsch Role of the ubiquitin-selective CDC48(UFD1/NPL4)chaperone (segregase) in ERAD of OLE1 and other substrates EMBO J 21 2002 615 621
144. N.J. Faergeman, P.N. Black, X.D. Zhao, J. Knudsen, and C.C. DiRusso The Acyl-CoA synthetases encoded within FAA1 and FAA4 in Saccharomyces cerevisiae function as components of the fatty acid transport system linking import, activation, and intracellular utilization J Biol Chem 276 2001 37051 37059
145. C.K. Schjerling, R. Hummel, J.K. Hansen, C. Borsting, J.M. Mikkelsen, and K. Kristiansen Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae J Biol Chem 271 1996 22514 22521
146. C.H. De Smet, E. Vittone, M. Scherer, M. Houweling, G. Liebisch, and J.F. Brouwers The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p Mol Biol Cell 23 2012 1146 1156
147. L. Sandager, M.H. Gustavsson, U. Stahl, A. Dahlqvist, E. Wiberg, and A. Banas Storage lipid synthesis is non-essential in yeast J Biol Chem 277 2002 6478 6482
148. D. Lockshon, L.E. Surface, E.O. Kerr, M. Kaeberlein, and B.K. Kennedy The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function Genetics 175 2007 77 91
149. N. Marr, J. Foglia, M. Terebiznik, K. Athenstaedt, and V. Zaremberg Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation J Biol Chem 287 2012 10251 10264
150. J. Petschnigg, H. Wolinski, D. Kolb, G. Zellnig, C.F. Kurat, and K. Natter Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast J Biol Chem 284 2009 30981 30993
151. J. Garbarino, M. Padamsee, L. Wilcox, P.M. Oelkers, D. D'Ambrosio, and K.V. Ruggles Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death J Biol Chem 284 2009 30994 31005
152. M. Le Guedard, J.J. Bessoule, V. Boyer, S. Ayciriex, G. Velours, and W. Kulik PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast FEBS J 276 2009 6412 6424
153. G. Shui, X.L. Guan, P. Gopalakrishnan, Y. Xue, J.S. Goh, and H. Yang Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay PLoS One 2010 5
154. S. Fakas, Y. Qiu, J.L. Dixon, G.S. Han, K.V. Ruggles, and J. Garbarino Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast J Biol Chem 286 2011 29074 29085
155. R. Schneiter, V. Tatzer, G. Gogg, E. Leitner, and S.D. Kohlwein Elo1p-dependent carboxy-terminal elongation of C14:1Delta(9) to C16:1Delta(11) fatty acids in Saccharomyces cerevisiae J Bacteriol 182 2000 3655 3660
156. S. Kajiwara, T. Aritomi, K. Suga, K. Ohtaguchi, and O. Kobayashi Overexpression of the OLE1 gene enhances ethanol fermentation by Saccharomyces cerevisiae Appl Microbiol Biotechnol 53 2000 568 574
157. B. Gaigg, T.B. Neergaard, R. Schneiter, J.K. Hansen, N.J. Faergeman, and N.A. Jensen Depletion of acyl-coenzyme A-binding protein affects sphingolipid synthesis and causes vesicle accumulation and membrane defects in Saccharomyces cerevisiae Mol Biol Cell 12 2001 1147 1160
158. S. Feddersen, T.B. Neergaard, J. Knudsen, and N.J. Faergeman Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae Biochem J 407 2007 219 230
159. P.J. Rijken, R.H. Houtkooper, H. Akbari, J.F. Brouwers, M.C. Koorengevel, and B. de Kruijff Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin J Biol Chem 284 2009 27609 27619
160. L.E. Cybulski, M. Martin, M.C. Mansilla, A. Fernandez, and D. de Mendoza Membrane thickness cue for cold sensing in a bacterium Curr Biol 20 2010 1539 1544
161. P.S. Aguilar, and D. de Mendoza Control of fatty acid desaturation: a mechanism conserved from bacteria to humans Mol Microbiol 62 2006 1507 1514
162. Y. Shimura, Y. Shiraiwa, and I. Suzuki Characterization of the subdomains in the N-terminal region of histidine kinase Hik33 in the cyanobacterium Synechocystis sp. PCC 6803 Plant Cell Physiol 53 2012 1255 1266
163. K.S. Mironov, R.A. Sidorov, M.S. Trofimova, V.S. Bedbenov, V.D. Tsydendambaev, and S.I. Allakhverdiev Light-dependent cold-induced fatty acid unsaturation, changes in membrane fluidity, and alterations in gene expression in Synechocystis Biochim Biophys Acta 1817 2012 1352 1359
164. K. Mikami, Y. Kanesaki, I. Suzuki, and N. Murata The histidine kinase Hik33 perceives osmotic stress and cold stress in Synechocystis sp. PCC 6803 Mol Microbiol 46 2002 905 915
165. J. Panadero, C. Pallotti, S. Rodriguez-Vargas, F. Randez-Gil, and J.A. Prieto A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiae J Biol Chem 281 2006 4638 4645
166. G.H. Lyman, D. Papahadjopoulos, and H.D. Preisler Phospholipid membrane stabilization by dimethylsulfoxide and other inducers of Friend leukemic cell differentiation Biochim Biophys Acta 448 1976 460 473
167. M.S. Brown, and J.L. Goldstein Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J Lipid Res 50 Suppl. 2009 S15 S27
168. M. Motamed, Y. Zhang, M.L. Wang, J. Seemann, H.J. Kwon, and J.L. Goldstein Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis J Biol Chem 286 2011 18002 18012
169. V.A. Bankaitis, D.E. Malehorn, S.D. Emr, and R. Greene The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex J Cell Biol 108 1989 1271 1281
170. A.E. Cleves, T.P. McGee, E.A. Whitters, K.M. Champion, J.R. Aitken, and W. Dowhan Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein Cell 64 1991 789 800
171. H.B. Skinner, T.P. McGee, C.R. McMaster, M.R. Fry, R.M. Bell, and V.A. Bankaitis The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity Proc Natl Acad Sci USA 92 1995 112 116
172. T.P. McGee, H.B. Skinner, E.A. Whitters, S.A. Henry, and V.A. Bankaitis A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes J Cell Biol 124 1994 273 287
173. V.A. Bankaitis, C.J. Mousley, and G. Schaaf The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling Trends Biochem Sci 35 2010 150 160
174. P. Griac Sec14 related proteins in yeast Biochim Biophys Acta 1771 2007 737 745
175. W.I. Wu, S. Routt, V.A. Bankaitis, and D.R. Voelker A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/ phosphatidylcholine transfer protein, SEC14 J Biol Chem 275 2000 14446 14456
176. T. Desfougeres, T. Ferreira, T. Berges, and M. Regnacq SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion Biochem J 409 2008 299 309
177. J.S. Cox, R.E. Chapman, and P. Walter The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane Mol Biol Cell 8 1997 1805 1814
178. K.J. Travers, C.K. Patil, L. Wodicka, D.J. Lockhart, J.S. Weissman, and P. Walter Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation Cell 101 2000 249 258
179. S.A. Jesch, P. Liu, X. Zhao, M.T. Wells, and S.A. Henry Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanisms J Biol Chem 281 2006 24070 24083
180. L. Pineau, J. Colas, S. Dupont, L. Beney, P. Fleurat-Lessard, and J.M. Berjeaud Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids Traffic 10 2009 673 690
181. T. Promlek, Y. Ishiwata-Kimata, M. Shido, M. Sakuramoto, K. Kohno, and Y. Kimata Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways Mol Biol Cell 22 2011 3520 3532
182. P. Lajoie, R.D. Moir, I.M. Willis, and E.L. Snapp Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells Mol Biol Cell 23 2012 955 964
183. J.E. Johnson, G.B. Kalmar, P.S. Sohal, C.J. Walkey, S. Yamashita, and R.B. Cornell Comparison of the lipid regulation of yeast and rat CTP: phosphocholine cytidylyltransferase expressed in COS cells Biochem J 285 Pt 3 1992 815 820
184. G.S. Attard, R.H. Templer, W.S. Smith, A.N. Hunt, and S. Jackowski Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress Proc Natl Acad Sci USA 97 2000 9032 9036
185. S.M. Davies, R.M. Epand, R. Kraayenhof, and R.B. Cornell Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy Biochemistry 40 2001 10522 10531
186. M.A. MacKinnon, A.J. Curwin, G.J. Gaspard, A.B. Suraci, J.P. Fernandez-Murray, and C.R. McMaster The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis J Biol Chem 284 2009 7376 7384
187. D. Lockshon, C.P. Olsen, C.L. Brett, A. Chertov, A.J. Merz, and D.A. Lorenz Rho signaling participates in membrane fluidity homeostasis PLoS One 7 2012 e45049
188. L.R. Nunez, S.A. Jesch, M.L. Gaspar, C. Almaguer, M. Villa-Garcia, and M. Ruiz-Noriega Cell wall integrity MAPK pathway is essential for lipid homeostasis J Biol Chem 283 2008 34204 34217
189. H. Tamaki, A. Shimada, Y. Ito, M. Ohya, J. Takase, and M. Miyashita LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae J Biol Chem 282 2007 34288 34298
190. S. Jain, N. Stanford, N. Bhagwat, B. Seiler, M. Costanzo, and C. Boone Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae J Biol Chem 282 2007 30562 30569
191. W.R. Riekhof, J. Wu, M.A. Gijon, S. Zarini, R.C. Murphy, and D.R. Voelker Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation J Biol Chem 282 2007 36853 36861
192. A.K. Ghosh, G. Ramakrishnan, and R. Rajasekharan YLR099C (ICT1) encodes a soluble Acyl-CoA-dependent lysophosphatidic acid acyltransferase responsible for enhanced phospholipid synthesis on organic solvent stress in Saccharomyces cerevisiae J Biol Chem 283 2008 9768 9775
193. S. Ayciriex, M. Le Guedard, N. Camougrand, G. Velours, M. Schoene, and S. Leone YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis Mol Biol Cell 23 2012 233 246
194. S. Rajakumari, and G. Daum Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae J Biol Chem 285 2010 15769 15776
195. S. Rajakumari, and G. Daum Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions Mol Biol Cell 21 2010 501 510
196. M. Burgermeister, R. Birner-Grunberger, M. Heyn, and G. Daum Contribution of different biosynthetic pathways to species selectivity of aminoglycerophospholipids assembled into mitochondrial membranes of the yeast Saccharomyces cerevisiae Biochim Biophys Acta 1686 2004 148 160
197. H.A. Boumann, M.J. Damen, C. Versluis, A.J. Heck, B. de Kruijff, and A.I. de Kroon The two biosynthetic routes leading to phosphatidylcholine in yeast produce different sets of molecular species. Evidence for lipid remodeling Biochemistry 42 2003 3054 3059
198. H.A. Boumann, P.T. Chin, A.J. Heck, B. De Kruijff, and A.I. De Kroon The yeast phospholipid N-methyltransferases catalyzing the synthesis of phosphatidylcholine preferentially convert di-C16:1 substrates both in vivo and in vitro J Biol Chem 279 2004 40314 40319
199. H.A. Boumann, B. de Kruijff, A.J. Heck, and A.I. de Kroon The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast FEBS Lett 569 2004 173 177
200. M. Bilgin, D.F. Markgraf, E. Duchoslav, J. Knudsen, O.N. Jensen, and A.I. de Kroon Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism Biochim Biophys Acta 1811 2011 1081 1089
201. R.H. Hjelmstad, S.C. Morash, C.R. McMaster, and R.M. Bell Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases J Biol Chem 269 1994 20995 21002
202. D.R. Voelker Genetic and biochemical analysis of non-vesicular lipid traffic Annu Rev Biochem 78 2009 827 856
203. B. Gaigg, R. Simbeni, C. Hrastnik, F. Paltauf, and G. Daum Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria Biochim Biophys Acta 1234 1995 214 220
204. G. Achleitner, B. Gaigg, A. Krasser, E. Kainersdorfer, S.D. Kohlwein, and A. Perktold Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact Eur J Biochem 264 1999 545 553
205. M.M. Schumacher, J.Y. Choi, and D.R. Voelker Phosphatidylserine transport to the mitochondria is regulated by ubiquitination J Biol Chem 277 2002 51033 51042
206. B. Kornmann, E. Currie, S.R. Collins, M. Schuldiner, J. Nunnari, and J.S. Weissman An ER-mitochondria tethering complex revealed by a synthetic biology screen Science 325 2009 477 481
207. T.T. Nguyen, A. Lewandowska, J.Y. Choi, D.F. Markgraf, M. Junker, and M. Bilgin Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance Traffic 13 2012 880 890
208. L. Heikinheimo, and P. Somerharju Preferential decarboxylation of hydrophilic phosphatidylserine species in cultured cells. Implications on the mechanism of transport to mitochondria and cellular aminophospholipid species compositions J Biol Chem 273 1998 3327 3335
209. L. Heikinheimo, and P. Somerharju Translocation of phosphatidylthreonine and -serine to mitochondria diminishes exponentially with increasing molecular hydrophobicity Traffic 3 2002 367 377
210. M. Pagac, H.V. de la Mora, C. Duperrex, C. Roubaty, C. Vionnet, and A. Conzelmann Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae J Biol Chem 286 2011 36438 36447
211. M. Pagac, H.M. Vazquez, A. Bochud, C. Roubaty, C. Knopfli, and C. Vionnet Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae Mol Microbiol 86 2012 1156 1166
212. A. Sreenivas, J.L. Patton-Vogt, V. Bruno, P. Griac, and S.A. Henry A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast J Biol Chem 273 1998 16635 16638
213. S.R. Dowd, M.E. Bier, and J.L. Patton-Vogt Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway J Biol Chem 276 2001 3756 3763
214. O. Zaccheo, D. Dinsdale, P.A. Meacock, and P. Glynn Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells J Biol Chem 279 2004 24024 24033
215. J.P. Murray, and C.R. McMaster Nte1p-mediated deacylation of phosphatidylcholine functionally interacts with Sec14p J Biol Chem 280 2005 8544 8552
216. J.P. Fernandez-Murray, and C.R. McMaster Phosphatidylcholine synthesis and its catabolism by yeast neuropathy target esterase 1 Biochim Biophys Acta 1771 2007 331 336
217. J.L. Patton-Vogt, P. Griac, A. Sreenivas, V. Bruno, S. Dowd, and M.J. Swede Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation J Biol Chem 272 1997 20873 20883
218. V. Zaremberg, and C.R. McMaster Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs J Biol Chem 277 2002 39035 39044
219. M.J. Villa-Garcia, M.S. Choi, F.I. Hinz, M.L. Gaspar, S.A. Jesch, and S.A. Henry Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling Mol Genet Genomics 285 2011 125 149
220. K.S. Lee, J.L. Patton, M. Fido, L.K. Hines, S.D. Kohlwein, and F. Paltauf The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity J Biol Chem 269 1994 19725 19730
221. O. Merkel, M. Fido, J.A. Mayr, H. Pruger, F. Raab, and G. Zandonella Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae J Biol Chem 274 1999 28121 28127
222. H. Fyrst, B. Oskouian, F.A. Kuypers, and J.D. Saba The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase Biochemistry 38 1999 5864 5871
223. M. Zhang, Y. Zhang, E.M. Giblin, and D.C. Taylor Ectopic expression of arabidopsis phospholipase A genes elucidates role of phospholipase Bs in S. cerevisiae cells Open Microbiol J 3 2009 136 145
224. J.P. Fernandez-Murray, and C.R. McMaster Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway J Biol Chem 280 2005 38290 38296
225. E. Fisher, C. Almaguer, R. Holic, P. Griac, and J. Patton-Vogt Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae J Biol Chem 280 2005 36110 36117
226. K. Stalberg, A.C. Neal, H. Ronne, and U. Stahl Identification of a novel GPCAT activity and a new pathway for phosphatidylcholine biosynthesis in S. cerevisiae J Lipid Res 49 2008 1794 1806
227. O. Merkel, O.V. Oskolkova, F. Raab, R. El-Toukhy, and F. Paltauf Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae Biochem J 387 2005 489 496
228. A. Dahlqvist, U. Stahl, M. Lenman, A. Banas, M. Lee, and L. Sandager Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants Proc Natl Acad Sci USA 97 2000 6487 6492
229. S.E. Horvath, A. Wagner, E. Steyrer, and G. Daum Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae Biochim Biophys Acta 1811 2011 1030 1037
230. J.A. Mayr, S.D. Kohlwein, and F. Paltauf Identification of a novel, Ca(2+)-dependent phospholipase D with preference for phosphatidylserine and phosphatidylethanolamine in Saccharomyces cerevisiae FEBS Lett 393 1996 236 240
231. 2+-dependent, phosphatidylethanolamine-hydrolyzing phospholipase D in yeast bearing a disruption in PLD1 J Biol Chem 272 1997 36 39
232. M. Simockova, R. Holic, D. Tahotna, J. Patton-Vogt, and P. Griac Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism J Biol Chem 283 2008 17107 17115
233. W.E. Lands Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin J Biol Chem 235 1960 2233 2237
234. A. Yamashita, T. Sugiura, and K. Waku Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells J Biochem 122 1997 1 16
235. K. Yamada, H. Okuyama, Y. Endo, and H. Ikezawa Acyltransferase systems involved in phospholipid metabolism in Saccharomyces cerevisiae Arch Biochem Biophys 183 1977 281 289
236. C.H. De Smet, R. Cox, J.F. Brouwers, and A.I. de Kroon Yeast cells accumulate excess endogenous palmitate in phosphatidylcholine by acyl chain remodeling involving the phospholipase B Plb1p Biochim Biophys Acta 1831 2013 1167 1176
237. K. Tanaka, R. Fukuda, Y. Ono, H. Eguchi, S. Nagasawa, and Y. Nakatani Incorporation and remodeling of extracellular phosphatidylcholine with short acyl residues in Saccharomyces cerevisiae Biochim Biophys Acta 1781 2008 391 399
238. Q. Chen, M. Kazachkov, Z. Zheng, and J. Zou The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover FEBS Lett 581 2007 5511 5516
239. L. Deng, R. Fukuda, T. Kakihara, K. Narita, and A. Ohta Incorporation and remodeling of phosphatidylethanolamine containing short acyl residues in yeast Biochim Biophys Acta 1801 2010 635 645
240. R.W. Yost, S.J. Grauvickel, R. Cantwell, J.S. Bomalaski, and A.P. Hudson Yeast mitochondria (Saccharomyces cerevisiae) contain Ca(2+)-independent phospholipase A1 and A2 activities: effect of respiratory state Biochem Int 24 1991 199 208
241. P.C. Bradshaw, D.W. Jung, and D.R. Pfeiffer Free fatty acids activate a vigorous Ca(2+):2H(+) antiport activity in yeast mitochondria J Biol Chem 276 2001 40502 40509
242. M. Scharnewski, P. Pongdontri, G. Mora, M. Hoppert, and M. Fulda Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling FEBS J 275 2008 2765 2778
243. E. Testet, J. Laroche-Traineau, A. Noubhani, D. Coulon, O. Bunoust, and N. Camougrand Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis Biochem J 387 2005 617 626
244. S. Rajakumari, R. Rajasekharan, and G. Daum Triacylglycerol lipolysis is linked to sphingolipid and phospholipid metabolism of the yeast Saccharomyces cerevisiae Biochim Biophys Acta 1801 2010 1314 1322
245. M. Schlame Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes J Lipid Res 49 2008 1607 1620
246. Z. Gu, F. Valianpour, S. Chen, F.M. Vaz, G.A. Hakkaart, and R.J. Wanders Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome Mol Microbiol 51 2004 149 158
247. A. Beranek, G. Rechberger, H. Knauer, H. Wolinski, S.D. Kohlwein, and R. Leber Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast J Biol Chem 284 2009 11572 11578
248. A. Malhotra, Y. Xu, M. Ren, and M. Schlame Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Biochim Biophys Acta 1791 2009 314 320
249. M. Schlame, D. Acehan, B. Berno, Y. Xu, S. Valvo, and M. Ren The physical state of lipid substrates provides transacylation specificity for tafazzin Nat Chem Biol 8 2012 862 869
250. L. Rilfors, and G. Lindblom Regulation of lipid composition in biological membranes - biophysical studies of lipids and lipid synthesizing enzymes Colloids Surf B: Biointerfaces 26 2002 112 124
251. E.R. Moellering, B. Muthan, and C. Benning Freezing tolerance in plants requires lipid remodeling at the outer chloroplast membrane Science 330 2010 226 228
252. J.R. Hazel, and E.E. Williams The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment Prog Lipid Res 29 1990 167 227
253. T. Ferreira, M. Regnacq, P. Alimardani, C. Moreau-Vauzelle, and T. Berges Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion Biochem J 378 2004 899 908
254. P. Kaliszewski, T. Ferreira, B. Gajewska, A. Szkopinska, T. Berges, and T. Zoladek Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase Biochem J 395 2006 173 181
255. K. Grillitsch, M. Connerth, H. Kofeler, T.N. Arrey, B. Rietschel, and B. Wagner Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome Biochim Biophys Acta 1811 2011 1165 1176
256. I. Schuiki, M. Schnabl, T. Czabany, C. Hrastnik, and G. Daum Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae Biochim Biophys Acta 1801 2010 480 486
257. M. Matsushita, and J. Nikawa Isolation and characterization of a SCT1 gene which can suppress a choline-transport mutant of Saccharomyces cerevisiae J Biochem 117 1995 447 451
258. X.L. Guan, C.M. Souza, H. Pichler, G. Dewhurst, O. Schaad, and K. Kajiwara Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology Mol Biol Cell 20 2009 2083 2095
259. M.L. Gaspar, H.F. Hofbauer, S.D. Kohlwein, and S.A. Henry Coordination of storage lipid synthesis and membrane biogenesis: evidence for cross-talk between triacylglycerol metabolism and phosphatidylinositol synthesis J Biol Chem 286 2011 1696 1708
260. R. Koynova, and M. Caffrey Phases and phase transitions of the phosphatidylcholines Biochim Biophys Acta 1376 1998 91 145
261. J.R. Silvius, and R.N. McElhaney Effects of phospholipid acyl chain structure on physical properties: I. Isobranched phosphatidylcholines Chem Phys Lipids 24 1979 287 296
262. R. Koynova, and M. Caffrey Phases and phase transitions of the hydrated phosphatidylethanolamines Chem Phys Lipids 69 1994 1 34