Elo1p-dependent carboxy-terminal elongation of C14:1δ9 to C16:1δ11 fatty acids in Saccharomyces cerevisiae

Journal of Bacteriology

Volumn 182, Issue 13, 2000, Pages 3655-3660

  Schneiter, Roger ^a   Tatzer, Verena ^a   Gogg, Gabriela ^a   Leitner, Erich ^a   Kohlwein, Sepp Dieter ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

MEDIUM CHAIN FATTY ACID; MYRISTIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE;

ARTICLE; BACTERIAL GROWTH; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL MUTANT; CELL SURVIVAL; DELETION MUTANT; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; LIPID COMPOSITION; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ACETYLTRANSFERASES; CULTURE MEDIA; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, UNSATURATED; PHOSPHOLIPIDS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0034043251     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.13.3655-3660.2000     Document Type: Article

References (37)

1. Becker, G. W., and R. L. Lester. 1980. Biosynthesis of phosphoinositol-containing sphingolipids from phosphatidylinositol by a membrane preparation from Saccharomyces cerevisiae. J. Bacteriol. 142:747-754.
2. Bloom, M., E. Evans, and O. G. Mouritsen. 1991. Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective. Q. Rev. Biophys. 24:293-397.
3. Bossie, M. A., and C. E. Martin. 1989. Nutritional regulation of yeast delta-9 fatty acid desaturase activity. J. Bacteriol. 171:6409-6413.
4. Broekhuyse, R. M. 1968. Phospholipids in tissues of the eye. Isolation, characterization and quantitative analysis by two-dimensional thin-layer chromatography of diacyl-ether phospholipids. Biochim. Biophys. Acta 260: 449-459.
5. Browse, J., and C. Somerville. 1991. Glycerolipid synthesis: biochemistry and regulation. Annu. Rev. Plant Physiol. Plant Mol. Biol. 42:467-506.
6. Carman, G. M., and S. A. Henry. 1999. Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes. Prog. Lipid Res. 38:361-399.
7. Cleves, A. E., T. P. McGee, E. A. Whitters, K. M. Champion, J. R. Aitken, W. Dowhan, M. Goebl, and V. A. Bankaitis. 1991. Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 64:789-800.
8. Cook, H. W. 1996. Fatty acid desaturation and chain elongation in eukaryotes. New Compr. Biochem. 31:129-152.
9. Cottrell, M., B. C. Viljoen, J. L. F. Kock, and P. M. Lategan. 1986. The long-chain fatty acid compositions of species representing the genera Saccharomyces, Schanniomyces and Lipomyces. J. Gen. Microbiol. 132:2401-2403.
10. Cullis, P. R., and B. de Kruijff. 1979. Lipid polymorphism and the functional roles of lipids in biological membranes. Biochim. Biophys. Acta 559:399-420.
11. Cullis, P. R., D. B. Fenske, and M. J. Hope. 1996. Physical properties and functional roles of lipids in membranes. New Compr. Biochem. 31:1-33.
12. Daum, G., N. D. Lees, M. Bard, and R. Dickson. 1998. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14: 1471-1510.
13. Daum, G., G. Tuller, T. Nemec, C. Hrastnik, G. Balliano, L. Cattel, P. Milla, F. Rocco, A. Conzelmann, C. Vionnet, D. E. Kelly, S. Kelly, E. Schweizer, H. J. Schuller, U. Hojad, E. Greiner, and K. Finger. 1999. Systematic analysis of yeast strains with possible defects in lipid metabolism. Yeast 15:601-614.
14. David, D., S. Sundarababu, and J. E. Gerst. 1998. Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J. Cell Biol. 143:1167-1182.
15. de Kruijff, B. 1997. Lipid polymorphism and biomembrane function. Curr. Opin. Chem. Biol. 1:564-569.
16. DeLong, C. J., Y. J. Shen, M. J. Thomas, and Z. Cui. 1999. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J. Biol. Chem. 274: 29683-29688.
17. Dittrich, F., D. Zajonc, K. Hühne, U. Hoja, A. Ekici, E. Greiner, H. Klein, J. Hofmann, J. J. Bessoule, P. Sperling, and E. Schweizer. 1998. Fatty acid elongation in yeast - biochemical characteristics of the enzyme system and isolation of elongation-defective mutants. Eur. J. Biochem. 252:477-485.
18. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
19. Houweling, M., Z. Cui, and D. E. Vance. 1995. Expression of phosphatidylethanolamine N-methyltransferase-2 cannot compensate for an impaired CDP-choline pathway in mutant Chinese hamster ovary cells. J. Biol. Chem. 270:16277-16282.
20. Kearns, B. G., J. G. Alb, and V. A. Bankaitis. 1998. Phosphatidylinositol transfer proteins: the long and winding road to physiological function. Trends Cell Biol. 8:276-282.
21. Kent, C. 1995. Eukaryotic phospholipid biosynthesis. Annu. Rev. Biochem. 64:315-343.
22. Kent, C., and G. M. Carman. 1999. Interactions among pathways for phosphatidylcholine metabolism, CTP synthesis and secretion through the Golgi apparatus. Trends Biochem. Sci. 24:146-150.
23. Morrison, W. R., and L. M. Smith. 1964. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J. Lipid Res. 5:600-608.
24. Oh, C. S., D. A. Toke, S. Mandala, and C. E. Martin. 1997. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J. Biol. Chem. 272:17376-17384.
25. Schneiter, R., B. Brugger, R. Sandhoff, G. Zellnig, A. Leber, M. Lampl, K. Athenstaedt, C. Hrastnik, S. Eder, G. Daum, F. Paltauf, F. T. Wieland, and S. D. Kohlwein. 1999. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membrane. J. Cell Biol. 146: 741-754.
26. Schweizer, E. 1984. Genetics of fatty acid biosynthesis in yeast. New Compr. Biochem. 7:59-83.
27. Sherman, F., G. R. Fink, and J. B. N. Hicks. 1986. Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
28. Somerharju, P., J. A. Virtanen, and K. H. Cheng. 1999. Lateral organisation of membrane lipids. The superlattice view. Biochim. Biophys. Acta 1440: 32-48.
29. Stukey, J. E., V. M. McDonough, and C. E. Martin. 1989. Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae. J. Biol. Chem. 264:16537-16544.
30. Stukey, J. E., V. M. McDonough, and C. E. Martin. 1990. The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene. J. Biol. Chem. 265:20144-20149.
31. Tate, M. W., E. F. Eikenberry, D. C. Turner, E. Shyamsunder, and S. M. Gruner. 1991. Nonbilayer phase of membrane lipids. Chem. Phys. Lipids 57: 147-164.
32. Toke, D. A., and C. E. Martin. 1996. Isolation and characterization of a gene affecting fatty add elongation in Saccharomyces cerevisiae. J. Biol. Chem. 271:18413-18422.
33. Tuller, G., T. Nemec, C. Hrastnik, and G. Daum. 1999. Lipid composition of subcellular membranes of an FY1679-derived haploid yeast wild-type strain grown on different carbon sources. Yeast 15:1555-1564.
34. Wagner, S., and F. Paltauf. 1994. Generation of glycerophospholipid molecular species in the yeast Saccharomyces cerevisiae. Fatty acid pattern of phospholipid classes and selective acyl turnover at sn-1 and sn-2 positions. Yeast 10:1429-1437.
35. Wakil, S. J. 1989. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28:4523-4530.
36. Welch, J. W., and A. L. Burlingame. 1973. Very long-chain fatty acids in yeast. J. Bacteriol. 115:464-466.
37. Yamamoto, K., A. Shibahara, T. Nakayama, and G. Kajimoto. 1991. Determination of double-bond positions in methylene-interrupted dienoic fatty acids by GC-MS as their dimethyl disulfide adducts. Chem. Phys. Lipids 60: 39-50.