Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

BMC Biology

Volumn 11, Issue , 2013, Pages

  Shi, Lei ^a   Li, Ming ^a,b   Lin, Qiang ^a,b   Qi, Xuebin ^a   Su, Bing ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Brain size; E2F1; Evolution; Functional divergence; MCPH1; Primates

Indexed keywords

HOMINIDAE; MACACA MULATTA; PRIMATES;

MCPH1 PROTEIN, HUMAN; MUTANT PROTEIN; NERVE PROTEIN; TRANSCRIPTION FACTOR E2F1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ARTICLE; BRAIN; CHEMISTRY; EVOLUTION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENETICS; HISTOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; ORGAN SIZE; PHYLOGENY; PROTEIN ANALYSIS; RHESUS MONKEY; SEQUENCE ALIGNMENT; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL EVOLUTION; BRAIN; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; NERVE TISSUE PROTEINS; ORGAN SIZE; PHYLOGENY; PROTEIN INTERACTION MAPPING; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 84878008766     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-11-62     Document Type: Article

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