Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 38, 2010, Pages 16595-16600

  Pulvers, Jeremy N ^a,e   Bryk, Jarosław ^b,f   Fish, Jennifer L ^a,g   Wilsch Bräuninger, Michaela ^a   Arai, Yoko ^a   Schreier, Dora ^a   Naumann, Ronald ^a   Helppi, Jussi ^a   Habermann, Bianca ^a,h   Vogt, Johannes ^c,i   Nitsch, Robert ^c,i   Tóth, Attila ^d   Enard, Wolfgang ^b   Pääbo, Svante ^b   Huttner, Wieland B ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e RIKEN Center for Biosystems Dynamics Research   (Japan)

^f MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

ⁱ JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cerebral cortex; Evolution; Fertility; Germ cells; Neural stem cells

Indexed keywords

ABNORMAL SPINDLE LIKE MICROCEPHALY ASSOCIATED GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE M PHASE; CELL LOSS; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; GENE; GENE MUTATION; GERM LINE; MALE; MALE INFERTILITY; MICROCEPHALY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SPECIES COMPARISON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TRANSGENE; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; EMBRYONIC STEM CELL; GENE DELETION; GENETICS; GERMLINE MUTATION; HUMAN; INFERTILITY; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; NERVE CELL; NEWBORN; NUCLEOTIDE SEQUENCE; OLIGOSPERMIA; OVARY; PATHOLOGY; PHYSIOLOGY; TESTIS; TRANSGENIC MOUSE;

MUS; PRIMATES;

ASPM PROTEIN, HUMAN; ASPM PROTEIN, MOUSE; CALMODULIN BINDING PROTEIN; NERVE PROTEIN; PEPTIDE FRAGMENT; PRIMER DNA; RECOMBINANT PROTEIN;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; BRAIN; CALMODULIN-BINDING PROTEINS; DISEASE MODELS, ANIMAL; DNA PRIMERS; EMBRYONIC STEM CELLS; FEMALE; GERM-LINE MUTATION; HUMANS; INFERTILITY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MICROCEPHALY; MUTATION; NERVE TISSUE PROTEINS; NEURONS; OLIGOSPERMIA; OVARY; PEPTIDE FRAGMENTS; PHENOTYPE; RECOMBINANT PROTEINS; SEQUENCE DELETION; SPERM MOTILITY; TESTIS;

EID: 78049310300     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010494107     Document Type: Article

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