Characteristic mTOR activity in Hodgkin-lymphomas offers a potential therapeutic target in high risk disease - a combined tissue microarray, in vitro and in vivo study

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Márk, Ágnes ^a   Hajdu, Melinda ^a   Váradi, Zsófia ^b   Sticz, Tamás Béla ^a   Nagy, Noémi ^a   Csomor, Judit ^a   Berczi, Lajos ^a   Varga, Viktória ^a   Csóka, Monika ^b   Kopper, László ^a   Sebestyén, Anna ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Hodgkin lymphoma; Hodgkin lymphoma xenograft; mTOR activity; Rapalogs; TMA

Indexed keywords

BLEOMYCIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DACARBAZINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PREDNISONE; PROCARBAZINE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN S6; RAPAMYCIN; S6 KINASE; SURVIVIN; VINBLASTINE; VINCRISTINE; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CANCER INHIBITION; CANCER PATIENT; CANCER RECURRENCE; CANCER REGRESSION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HIGH RISK PATIENT; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LARGE CELL LYMPHOMA; LYMPHOID TISSUE; LYMPHOMA CELL; MAJOR CLINICAL STUDY; MALE; MANTLE CELL LYMPHOMA; MOUSE; MULTIPLE CYCLE TREATMENT; NONHODGKIN LYMPHOMA; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL TIME; TISSUE MICROARRAY; TREATMENT RESPONSE; ANIMAL; DRUG EFFECTS; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HODGKIN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, SCID; MIDDLE AGED; SIGNAL TRANSDUCTION; SIROLIMUS; TISSUE ARRAY ANALYSIS; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS; YOUNG ADULT;

EID: 84878008302     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-250     Document Type: Article

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