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Volumn 23, Issue 10, 2012, Pages 2526-2535

mTOR inhibitors in the management of hormone receptor-positive breast cancer: The latest evidence and future directions

Author keywords

Breast cancer; Endocrine resistance; Everolimus; MTOR inhibitors; Temsirolimus

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; CORTICOSTEROID; EVEROLIMUS; EXEMESTANE; FULVESTRANT; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PLACEBO; RAPAMYCIN; TAMOXIFEN; TEMSIROLIMUS;

EID: 84867138398     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds075     Document Type: Article
Times cited : (43)

References (64)
  • 1
    • 15544385759 scopus 로고    scopus 로고
    • Optimizing endocrine therapy for breast cancer
    • Winer EP. Optimizing endocrine therapy for breast cancer. J Clin Oncol 2005; 23: 1609-1610.
    • (2005) J Clin Oncol , vol.23 , pp. 1609-1610
    • Winer, E.P.1
  • 2
    • 0029759541 scopus 로고    scopus 로고
    • Annual hazard rates of recurrence for breast cancer after primary therapy
    • Saphner T, Tormey DC, Gray R. Annual hazard rates of recurrence for breast cancer after primary therapy. J Clin Oncol 1996; 14: 2738-2746.
    • (1996) J Clin Oncol , vol.14 , pp. 2738-2746
    • Saphner, T.1    Tormey, D.C.2    Gray, R.3
  • 3
    • 39149137567 scopus 로고    scopus 로고
    • Advances in adjuvant endocrine therapy for postmenopausal women
    • Lin NU, Winer EP. Advances in adjuvant endocrine therapy for postmenopausal women. J Clin Oncol 2008; 26: 798-805.
    • (2008) J Clin Oncol , vol.26 , pp. 798-805
    • Lin, N.U.1    Winer, E.P.2
  • 4
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised, trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 5
    • 69449090120 scopus 로고    scopus 로고
    • Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009
    • Goldhirsch A, Ingle JN, Gelber RD et al. Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann Oncol 2009; 20: 1319-1329.
    • (2009) Ann Oncol , vol.20 , pp. 1319-1329
    • Goldhirsch, A.1    Ingle, J.N.2    Gelber, R.D.3
  • 6
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • Goldhirsch A, Wood WC, Coates AS et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 2011; 22: 1736-1747.
    • (2011) Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3
  • 7
    • 80052764314 scopus 로고    scopus 로고
    • Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Aebi S, Davidson T, Gruber G, Cardoso F. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011; 22Suppl 6vi12-vi24.
    • (2011) Ann Oncol , vol.22 , Issue.SUPPL.
    • Aebi, S.1    Davidson, T.2    Gruber, G.3    Cardoso, F.4
  • 8
    • 77955551055 scopus 로고    scopus 로고
    • American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer
    • Burstein HJ, Prestrud AA, Seidenfeld J et al. American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. J Clin Oncol 2010; 28: 3784-3796.
    • (2010) J Clin Oncol , vol.28 , pp. 3784-3796
    • Burstein, H.J.1    Prestrud, A.A.2    Seidenfeld, J.3
  • 9
    • 34247516968 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network. (9 December date last accessed)
    • National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology - Breast Cancer. http://www.nccn.org/professionals/physician_gls/pdf/ breast.pdf (9 December 2011, date last accessed).
    • (2011) NCCN Clinical Practice Guidelines in Oncology - Breast, Cancer.
  • 11
    • 3342946114 scopus 로고    scopus 로고
    • Anastrozole ('Arimidex') versus tamoxifen as first-line therapy in postmenopausal women with advanced breast cancer: results of the double-blind cross-over SAKK trial 21/95-a sub-study of the TARGET (Tamoxifen or 'Arimidex' Randomized Group Efficacy and Tolerability) trial
    • Thurlimann B, Hess D, Koberle D et al. Anastrozole ('Arimidex') versus tamoxifen as first-line therapy in postmenopausal women with advanced breast cancer: results of the double-blind cross-over SAKK trial 21/95-a sub-study of the TARGET (Tamoxifen or 'Arimidex' Randomized Group Efficacy and Tolerability) trial. Breast Cancer Res Treat 2004; 85: 247-254.
    • (2004) Breast Cancer Res Treat , vol.85 , pp. 247-254
    • Thurlimann, B.1    Hess, D.2    Koberle, D.3
  • 12
    • 0034669435 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study
    • Bonneterre J, Thurlimann B, Robertson JF et al. Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study. J Clin Oncol 2000; 18: 3748-3757.
    • (2000) J Clin Oncol , vol.18 , pp. 3748-3757
    • Bonneterre, J.1    Thurlimann, B.2    Robertson, J.F.3
  • 13
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial, Arimidex Study Group
    • Nabholtz JM, Buzdar A, Pollak M et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. J Clin Oncol 2000; 18: 3758-3767.
    • (2000) J Clin Oncol , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3
  • 14
    • 0037841365 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy in postmenopausal patients with hormone-dependent advanced breast cancer: a prospective, randomized, phase III study
    • Milla-Santos A, Milla L, Portella J et al. Anastrozole versus tamoxifen as first-line therapy in postmenopausal patients with hormone-dependent advanced breast cancer: a prospective, randomized, phase III study. Am J Clin Oncol 2003; 26: 317-322.
    • (2003) Am J Clin Oncol , vol.26 , pp. 317-322
    • Milla-Santos, A.1    Milla, L.2    Portella, J.3
  • 15
    • 34948836781 scopus 로고    scopus 로고
    • Letrozole in advanced breast cancer: the PO25 trial
    • Mouridsen HT. Letrozole in advanced breast cancer: the PO25 trial. Breast Cancer Res Treat 2007; 105 (Suppl 1): 19-29.
    • (2007) Breast Cancer Res Treat , vol.105 , Issue.SUPPL 1 , pp. 19-29
    • Mouridsen, H.T.1
  • 16
    • 54449099359 scopus 로고    scopus 로고
    • Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    • Paridaens RJ, Dirix LY, Beex LV et al. Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group. J Clin Oncol 2008; 26: 4883-4890.
    • (2008) J Clin Oncol , vol.26 , pp. 4883-4890
    • Paridaens, R.J.1    Dirix, L.Y.2    Beex, L.V.3
  • 17
    • 33749003747 scopus 로고    scopus 로고
    • Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis
    • Mauri D, Pavlidis N, Polyzos NP, Ioannidis JP. Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. J Natl Cancer Inst 2006; 98: 1285-1291.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1285-1291
    • Mauri, D.1    Pavlidis, N.2    Polyzos, N.P.3    Ioannidis, J.P.4
  • 18
    • 77649189240 scopus 로고    scopus 로고
    • Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women
    • Gibson L, Lawrence D, Dawson C, Bliss J. Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women. Cochrane Database Syst Rev. 2009; (4): CD003370.
    • (2009) Cochrane Database Syst Rev , Issue.4
    • Gibson, L.1    Lawrence, D.2    Dawson, C.3    Bliss, J.4
  • 19
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, doubleblind, randomized trial
    • Howell A, Robertson JF, Abram P et al. Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, doubleblind, randomized trial. J Clin Oncol 2004; 22: 1605-1613.
    • (2004) J Clin Oncol , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3
  • 20
    • 78049523306 scopus 로고    scopus 로고
    • Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer
    • Di Leo A, Jerusalem G, Petruzelka L et al. Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol 2010; 28: 4594-4600.
    • (2010) J Clin Oncol , vol.28 , pp. 4594-4600
    • Di Leo, A.1    Jerusalem, G.2    Petruzelka, L.3
  • 21
    • 79953799672 scopus 로고    scopus 로고
    • A comparison of fulvestrant 500 mg with anastrozole as first-line treatment for advanced breast cancer: follow-up analysis from the 'FIRST' study
    • (Abstr S1-3)
    • Robertson JFR, Lindemann JPO, Llombart-Cussac A et al. A comparison of fulvestrant 500 mg with anastrozole as first-line treatment for advanced breast cancer: follow-up analysis from the 'FIRST' study. Cancer Res 2011; 70: S1-S3; (Abstr S1-3).
    • (2011) Cancer Res , vol.70
    • Robertson, J.F.R.1    Lindemann, J.P.O.2    Llombart-Cussac, A.3
  • 22
    • 60349130840 scopus 로고    scopus 로고
    • Lack of complete cross-resistance between different aromatase inhibitors; a real finding in search for an explanation?
    • Lonning PE. Lack of complete cross-resistance between different aromatase inhibitors; a real finding in search for an explanation?. Eur J Cancer 2009; 45: 527-535.
    • (2009) Eur J Cancer , vol.45 , pp. 527-535
    • Lonning, P.E.1
  • 23
    • 32044460822 scopus 로고    scopus 로고
    • Sequential treatment with exemestane and non-steroidal aromatase inhibitors in advanced breast cancer
    • Bertelli G, Garrone O, Merlano M et al. Sequential treatment with exemestane and non-steroidal aromatase inhibitors in advanced breast cancer. Oncology 2005; 69: 471-477.
    • (2005) Oncology , vol.69 , pp. 471-477
    • Bertelli, G.1    Garrone, O.2    Merlano, M.3
  • 24
    • 22244449598 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials
    • Howell A, Pippen J, Elledge RM et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trials. Cancer 2005; 104: 236-239.
    • (2005) Cancer , vol.104 , pp. 236-239
    • Howell, A.1    Pippen, J.2    Elledge, R.M.3
  • 25
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial
    • Osborne CK, Pippen J, Jones SE et al. Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002; 20: 3386-3395.
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3
  • 26
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JF, Quaresma Albano J et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002; 20: 3396-3403.
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Quaresma Albano, J.3
  • 27
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptorpositive, advanced breast cancer: results from EFECT
    • Chia S, Gradishar W, Mauriac L et al. Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptorpositive, advanced breast cancer: results from EFECT. J Clin Oncol 2008; 26: 1664-1670.
    • (2008) J Clin Oncol , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3
  • 28
    • 9144256614 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
    • Schiff R, Massarweh SA, Shou J et al. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin Cancer Res 2004; 10: 331S-336S.
    • (2004) Clin Cancer Res , vol.10
    • Schiff, R.1    Massarweh, S.A.2    Shou, J.3
  • 29
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Annu Rev Med 2011; 62: 233-247.
    • (2011) Annu Rev Med , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 30
    • 42049121934 scopus 로고    scopus 로고
    • Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance
    • Arpino G, Wiechmann L, Osborne CK, Schiff R. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance. Endocr Rev 2008; 29: 217-233.
    • (2008) Endocr Rev , vol.29 , pp. 217-233
    • Arpino, G.1    Wiechmann, L.2    Osborne, C.K.3    Schiff, R.4
  • 31
    • 79960835593 scopus 로고    scopus 로고
    • "Overcoming breast cancer drug resistance with mTOR inhibitors". Could it be a myth or a real possibility in the short-term future?
    • Margariti N, Fox SB, Bottini A, Generali D. "Overcoming breast cancer drug resistance with mTOR inhibitors". Could it be a myth or a real possibility in the short-term future?. Breast Cancer Res Treat 2011; 128: 599-606.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 599-606
    • Margariti, N.1    Fox, S.B.2    Bottini, A.3    Generali, D.4
  • 32
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006; 441: 424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 33
    • 27544515272 scopus 로고    scopus 로고
    • Somatic mutation and gain of copy number of PIK3CA in human breast cancer
    • Wu G, Xing M, Mambo E et al. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Res 2005; 7: R609-616.
    • (2005) Breast Cancer Res , vol.7
    • Wu, G.1    Xing, M.2    Mambo, E.3
  • 34
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005; 65: 2554-2559.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3
  • 35
    • 6944235337 scopus 로고    scopus 로고
    • Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity
    • deGraffenried LA, Friedrichs WE, Russell DH et al. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. Clin Cancer Res 2004; 10: 8059-8067.
    • (2004) Clin Cancer Res , vol.10 , pp. 8059-8067
    • deGraffenried, L.A.1    Friedrichs, W.E.2    Russell, D.H.3
  • 36
    • 34548187212 scopus 로고    scopus 로고
    • Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling
    • Beeram M, Tan QT, Tekmal RR et al. Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling. Ann Oncol 2007; 18: 1323-1328.
    • (2007) Ann Oncol , vol.18 , pp. 1323-1328
    • Beeram, M.1    Tan, Q.T.2    Tekmal, R.R.3
  • 37
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • Boulay A, Rudloff J, Ye J et al. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 2005; 11: 5319-5328.
    • (2005) Clin Cancer Res , vol.11 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3
  • 38
    • 79960843088 scopus 로고    scopus 로고
    • The mammalian target of rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study
    • Macaskill EJ, Bartlett JM, Sabine VS et al. The mammalian target of rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study. Breast Cancer Res Treat 2011; 128: 725-734.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 725-734
    • Macaskill, E.J.1    Bartlett, J.M.2    Sabine, V.S.3
  • 39
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009; 27: 2630-2637.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    van Dam, P.3
  • 40
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial
    • Ellis MJ, Coop A, Singh B et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 2001; 19: 3808-3816.
    • (2001) J Clin Oncol , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 41
    • 27244443082 scopus 로고    scopus 로고
    • Proliferation marker Ki-67 in early breast cancer
    • Urruticoechea A, Smith IE, Dowsett M. Proliferation marker Ki-67 in early breast cancer. J Clin Oncol 2005; 23: 7212-7220.
    • (2005) J Clin Oncol , vol.23 , pp. 7212-7220
    • Urruticoechea, A.1    Smith, I.E.2    Dowsett, M.3
  • 42
    • 34848885214 scopus 로고    scopus 로고
    • Treatment of postmenopausal women with locally advanced or metastatic breast cancer with letrozole alone or in combination with temsirolimus: a randomized, 3-arm, phase 2 study
    • Baselga J, Roche H, Fumoleau P. Treatment of postmenopausal women with locally advanced or metastatic breast cancer with letrozole alone or in combination with temsirolimus: a randomized, 3-arm, phase 2 study. Breast Cancer Res Treat 2005; 94 (Suppl 1): S62.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.SUPPL 1
    • Baselga, J.1    Roche, H.2    Fumoleau, P.3
  • 43
    • 34447106387 scopus 로고    scopus 로고
    • Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer
    • Chow L, Sun Y, Jassem J et al. Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer. Breast Cancer Res Treat 2006; 100: 6091.
    • (2006) Breast Cancer Res Treat , vol.100 , pp. 6091
    • Chow, L.1    Sun, Y.2    Jassem, J.3
  • 45
    • 84876089161 scopus 로고    scopus 로고
    • Exploratory subgroup analysis of the TAMRAD Phase 2 GINECO Trial comparing tamoxifen (TAM) plus everolimus (RAD) with TAM alone in patients with hormone-receptor-positive, HER2-negative metastatic breast cancer (mBC) with prior exposure to aromatase inhibitors (AIs): implication for research strategies
    • Edition Stockholm, Sweden
    • Bourgier C, Coquard R, Provencal J et al. Exploratory subgroup analysis of the TAMRAD Phase 2 GINECO Trial comparing tamoxifen (TAM) plus everolimus (RAD) with TAM alone in patients with hormone-receptor-positive, HER2-negative metastatic breast cancer (mBC) with prior exposure to aromatase inhibitors (AIs): implication for research strategies. In 2011 European Multidiscliplinary Cancer Congress, Edition Stockholm, Sweden: 2011.
    • (2011) 2011 European Multidiscliplinary Cancer Congress
    • Bourgier, C.1    Coquard, R.2    Provencal, J.3
  • 46
    • 84867115413 scopus 로고    scopus 로고
    • Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer
    • Edition Stockholm, Sweden
    • Bhattacharyya GS, Biswas J, Singh JK et al. Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer. In 2011 European Multidiscliplinary Cancer Congress, Edition Stockholm, Sweden: 2011.
    • (2011) 2011 European Multidiscliplinary Cancer Congress
    • Bhattacharyya, G.S.1    Biswas, J.2    Singh, J.K.3
  • 47
    • 84857100003 scopus 로고    scopus 로고
    • Everolimus in combination with exemestane for postmenopausal women with advanced breast cancer who are refractory to letrozole or anastrozole: results of the BOLERO-2 Phase III Trial
    • Edition Stockholm, Sweden
    • Baselga J, Campone M, Sahmoud T et al. Everolimus in combination with exemestane for postmenopausal women with advanced breast cancer who are refractory to letrozole or anastrozole: results of the BOLERO-2 Phase III Trial. In 2011 European Multidiscliplinary Cancer Congress, Edition Stockholm, Sweden: 2011.
    • (2011) 2011 European Multidiscliplinary Cancer Congress
    • Baselga, J.1    Campone, M.2    Sahmoud, T.3
  • 48
    • 84860470442 scopus 로고    scopus 로고
    • Everolimus for postmenopausal women with advanced breast cancer: updated results of the BOLERO-2 Phase III Trial
    • Edition San Antonio, US
    • Hortobagyi GN, Piccart M, Rugo H et al. Everolimus for postmenopausal women with advanced breast cancer: updated results of the BOLERO-2 Phase III Trial. In 2011 San Antonio Breast Cancer Symposium, Edition San Antonio, US: 2011.
    • (2011) 2011 San Antonio Breast Cancer Symposium
    • Hortobagyi, G.N.1    Piccart, M.2    Rugo, H.3
  • 49
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366(6) 520-529.
    • (2012) N Engl J Med , vol.366 , Issue.6 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 50
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006; 6: 729-734.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 51
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006; 66: 1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 52
    • 56949094800 scopus 로고    scopus 로고
    • Targeted therapies in breast cancer: where are we now?
    • Di Cosimo S, Baselga J. Targeted therapies in breast cancer: where are we now? Eur J Cancer 2008; 44: 2781-2790.
    • (2008) Eur J Cancer , vol.44 , pp. 2781-2790
    • Di Cosimo, S.1    Baselga, J.2
  • 54
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E, Loewith R, Schmidt A et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6: 1122-1128.
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3
  • 55
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 56
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356: 2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 57
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372: 449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 58
    • 77956227464 scopus 로고    scopus 로고
    • Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors
    • Motzer RJ, Escudier B, Oudard S et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010; 116: 4256-4265.
    • (2010) Cancer , vol.116 , pp. 4256-4265
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 59
    • 79957566962 scopus 로고    scopus 로고
    • Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma
    • Porta C, Osanto S, Ravaud A et al. Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma. Eur J Cancer 2011; 47: 1287-1298.
    • (2011) Eur J Cancer , vol.47 , pp. 1287-1298
    • Porta, C.1    Osanto, S.2    Ravaud, A.3
  • 60
    • 33748053644 scopus 로고    scopus 로고
    • Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of metaanalyses
    • Stokman MA, Spijkervet FK, Boezen HM et al. Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of metaanalyses. J Dent Res 2006; 85: 690-700.
    • (2006) J Dent Res , vol.85 , pp. 690-700
    • Stokman, M.A.1    Spijkervet, F.K.2    Boezen, H.M.3
  • 61
    • 33845385653 scopus 로고    scopus 로고
    • The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review
    • Potting CM, Uitterhoeve R, Op Reimer WS, Van Achterberg T. The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review. Eur J Cancer Care (Engl) 2006; 15: 431-439.
    • (2006) Eur J Cancer Care (Engl) , vol.15 , pp. 431-439
    • Potting, C.M.1    Uitterhoeve, R.2    Op Reimer, W.S.3    Van Achterberg, T.4
  • 62
    • 73649109111 scopus 로고    scopus 로고
    • Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND, 163
    • Ellard SL, Clemons M, Gelmon KA et al. Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND.163. J Clin Oncol 2009; 27: 4536-4541.
    • (2009) J Clin Oncol , vol.27 , pp. 4536-4541
    • Ellard, S.L.1    Clemons, M.2    Gelmon, K.A.3
  • 63
    • 41149160871 scopus 로고    scopus 로고
    • Risk of early recurrence among postmenopausal women with estrogen receptor-positive early breast cancer treated with adjuvant tamoxifen
    • Kennecke H, McArthur H, Olivotto IA et al. Risk of early recurrence among postmenopausal women with estrogen receptor-positive early breast cancer treated with adjuvant tamoxifen. Cancer 2008; 112: 1437-1444.
    • (2008) Cancer , vol.112 , pp. 1437-1444
    • Kennecke, H.1    McArthur, H.2    Olivotto, I.A.3
  • 64
    • 75749092296 scopus 로고    scopus 로고
    • Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    • Dowsett M, Cuzick J, Ingle J et al. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 2010; 28: 509-518.
    • (2010) J Clin Oncol , vol.28 , pp. 509-518
    • Dowsett, M.1    Cuzick, J.2    Ingle, J.3


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