메뉴 건너뛰기




Volumn 16, Issue 22, 2010, Pages 5374-5380

Target of rapamycin signaling in leukemia and lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; AZD 8055; BGT 226; BORTEZOMIB; DASATINIB; DEFEROLIMUS; DEXAMETHASONE; DOXORUBICIN; EVEROLIMUS; IMATINIB; INK 128; KU 0063794; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OSI 027; PHOSPHATIDYLINOSITOL 3 KINASE; PP 242; PROTEIN; PROTEIN KINASE B; PROTEIN TORC1; PROTEIN TORC2; RAPAMYCIN; RAPAMYCIN DERIVATIVE; TEMSIROLIMUS; TORIN 1; UNCLASSIFIED DRUG; WYE 132; WYE 354; XL 675;

EID: 78349277366     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0480     Document Type: Review
Times cited : (42)

References (69)
  • 1
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-19.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 2
    • 77953724897 scopus 로고    scopus 로고
    • Inhibition of the PI3K pathway: Hope we can believe in?
    • van der Heijden MS, Bernards R. Inhibition of the PI3K pathway: hope we can believe in? Clin Cancer Res 2010;16:3094-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3094-3099
    • Van Der Heijden, M.S.1    Bernards, R.2
  • 3
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261-74.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 4
    • 39649101082 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a therapeutic target in oncology
    • Abraham RT, Eng CH. Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opin Ther Targets 2008;12:209-22.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 209-222
    • Abraham, R.T.1    Eng, C.H.2
  • 5
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 6
    • 78349261103 scopus 로고    scopus 로고
    • Targeting TOR dependence in cancer
    • Janes MR, Fruman DA. Targeting TOR dependence in cancer. Oncotarget 2010;1:69-76.
    • (2010) Oncotarget , vol.1 , pp. 69-76
    • Janes, M.R.1    Fruman, D.A.2
  • 7
    • 74849131091 scopus 로고    scopus 로고
    • Targeting mTOR globally in cancer: Thinking beyond rapamycin
    • Shor B, Gibbons JJ, Abraham RT, Yu K. Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 2009;8:3831-7.
    • (2009) Cell Cycle , vol.8 , pp. 3831-3837
    • Shor, B.1    Gibbons, J.J.2    Abraham, R.T.3    Yu, K.4
  • 8
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009;19:R1046-52.
    • (2009) Curr Biol , vol.19
    • Laplante, M.1    Sabatini, D.M.2
  • 9
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 10
    • 77952967459 scopus 로고    scopus 로고
    • mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs
    • Dowling RJ, Topisirovic I, Alain T, et al. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010;328:1172-6.
    • (2010) Science , vol.328 , pp. 1172-1176
    • Dowling, R.J.1    Topisirovic, I.2    Alain, T.3
  • 11
    • 77649286736 scopus 로고    scopus 로고
    • Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
    • Hsieh AC, Costa M, Zollo O, et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 2010;17:249-61.
    • (2010) Cancer Cell , vol.17 , pp. 249-261
    • Hsieh, A.C.1    Costa, M.2    Zollo, O.3
  • 12
    • 70449900928 scopus 로고    scopus 로고
    • TOR complex 2: A signaling pathway of its own
    • Cybulski N, Hall MN. TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 2009;34:620-7.
    • (2009) Trends Biochem Sci , vol.34 , pp. 620-627
    • Cybulski, N.1    Hall, M.N.2
  • 13
    • 77954235821 scopus 로고    scopus 로고
    • Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy
    • Sparks CA, Guertin DA. Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene 2010;29:3733-44.
    • (2010) Oncogene , vol.29 , pp. 3733-3744
    • Sparks, C.A.1    Guertin, D.A.2
  • 14
    • 77951911593 scopus 로고    scopus 로고
    • FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
    • Chen CC, Jeon SM, Bhaskar PT, et al. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell 2010;18:592-604.
    • (2010) Dev Cell , vol.18 , pp. 592-604
    • Chen, C.C.1    Jeon, S.M.2    Bhaskar, P.T.3
  • 15
    • 77952373274 scopus 로고    scopus 로고
    • FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
    • Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J Biol Chem 2010;285:15960-5.
    • (2010) J Biol Chem , vol.285 , pp. 15960-15965
    • Khatri, S.1    Yepiskoposyan, H.2    Gallo, C.A.3    Tandon, P.4    Plas, D.R.5
  • 16
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the PI3K/Akt pathway in cancer
    • Garcia-Echeverria C, Sellers WR. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 2008;27:5511-26.
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 18
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010;115:453-74.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.H.2    Amadori, S.3
  • 19
    • 33750459743 scopus 로고    scopus 로고
    • A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
    • Billottet C, Grandage VL, Gale RE, et al. A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16. Oncogene 2006;25:6648-59.
    • (2006) Oncogene , vol.25 , pp. 6648-6659
    • Billottet, C.1    Grandage, V.L.2    Gale, R.E.3
  • 20
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-κB, Mapkinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-κB, Mapkinase and p53 pathways. Leukemia 2005;19:586-94.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 21
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Kornblau SM, Womble M, Qiu YH, et al. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood 2006;108:2358-65.
    • (2006) Blood , vol.108 , pp. 2358-2365
    • Kornblau, S.M.1    Womble, M.2    Qiu, Y.H.3
  • 22
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: Its significance as a prognostic variable
    • Min YH, Eom JI, Cheong JW, et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 2003;17:995-7.
    • (2003) Leukemia , vol.17 , pp. 995-997
    • Min, Y.H.1    Eom, J.I.2    Cheong, J.W.3
  • 23
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003;102:972-80.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 24
    • 1242285048 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
    • Zhao S, Konopleva M, Cabreira-Hansen M, et al. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia 2004;18:267-75.
    • (2004) Leukemia , vol.18 , pp. 267-275
    • Zhao, S.1    Konopleva, M.2    Cabreira-Hansen, M.3
  • 25
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002;100:1532-42.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 26
    • 27544450742 scopus 로고    scopus 로고
    • Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation
    • Brandts CH, Sargin B, Rode M, et al. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res 2005;65:9643-50.
    • (2005) Cancer Res , vol.65 , pp. 9643-9650
    • Brandts, C.H.1    Sargin, B.2    Rode, M.3
  • 28
    • 77949900650 scopus 로고    scopus 로고
    • Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
    • Kharas MG, Okabe R, Ganis JJ, et al. Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. Blood 2010;115:1406-15.
    • (2010) Blood , vol.115 , pp. 1406-1415
    • Kharas, M.G.1    Okabe, R.2    Ganis, J.J.3
  • 29
    • 76349104427 scopus 로고    scopus 로고
    • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
    • Janes MR, Limon JJ, So L, et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 2010;16:205-13.
    • (2010) Nat Med , vol.16 , pp. 205-213
    • Janes, M.R.1    Limon, J.J.2    So, L.3
  • 30
    • 16844366670 scopus 로고    scopus 로고
    • ABL oncogenes and phosphoinositide 3-kinase: Mechanism of activation and downstream effectors
    • Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res 2005;65:2047-53.
    • (2005) Cancer Res , vol.65 , pp. 2047-2053
    • Kharas, M.G.1    Fruman, D.A.2
  • 31
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006;354:2531-41.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 32
    • 51349108718 scopus 로고    scopus 로고
    • Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
    • Kharas MG, Janes MR, Scarfone VM, et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 2008;118:3038-50.
    • (2008) J Clin Invest , vol.118 , pp. 3038-3050
    • Kharas, M.G.1    Janes, M.R.2    Scarfone, V.M.3
  • 33
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000;403:503-11.
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3
  • 34
    • 77951010885 scopus 로고    scopus 로고
    • Aggressive lymphomas
    • Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med 2010;362:1417-29.
    • (2010) N Engl J Med , vol.362 , pp. 1417-1429
    • Lenz, G.1    Staudt, L.M.2
  • 35
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010;463:88-92.
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 36
    • 0037179847 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
    • Pene F, Claessens YE, Muller O, et al. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 2002;21:6587-97.
    • (2002) Oncogene , vol.21 , pp. 6587-6597
    • Pene, F.1    Claessens, Y.E.2    Muller, O.3
  • 37
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson TR, Laplante M, Thoreen CC, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009;137:873-86.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3
  • 38
    • 70149087158 scopus 로고    scopus 로고
    • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    • Gutierrez A, Sanda T, Grebliunaite R, et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 2009;114:647-50.
    • (2009) Blood , vol.114 , pp. 647-650
    • Gutierrez, A.1    Sanda, T.2    Grebliunaite, R.3
  • 39
    • 70349235938 scopus 로고    scopus 로고
    • High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response
    • Remke M, Pfister S, Kox C, et al. High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-β and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood 2009;114:1053-62.
    • (2009) Blood , vol.114 , pp. 1053-1062
    • Remke, M.1    Pfister, S.2    Kox, C.3
  • 40
    • 34948908663 scopus 로고    scopus 로고
    • Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    • Palomero T, Sulis ML, Cortina M, et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007;13:1203-10.
    • (2007) Nat Med , vol.13 , pp. 1203-1210
    • Palomero, T.1    Sulis, M.L.2    Cortina, M.3
  • 41
  • 42
    • 77953091045 scopus 로고    scopus 로고
    • Structure of the human mTOR complex I and its implications for rapamycin inhibition
    • Yip CK, Murata K, Walz T, Sabatini DM, Kang SA. Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol Cell 2010;38:768-74.
    • (2010) Mol Cell , vol.38 , pp. 768-774
    • Yip, C.K.1    Murata, K.2    Walz, T.3    Sabatini, D.M.4    Kang, S.A.5
  • 43
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 2008;5:e8.
    • (2008) PLoS Med , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3
  • 44
    • 33646023695 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
    • Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006;22:159-68.
    • (2006) Mol Cell , vol.22 , pp. 159-168
    • Sarbassov, D.D.1    Ali, S.M.2    Sengupta, S.3
  • 45
    • 34147146014 scopus 로고    scopus 로고
    • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    • Zeng Z, Sarbassov dos D, Samudio IJ, et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 2007;109:3509-12.
    • (2007) Blood , vol.109 , pp. 3509-3512
    • Zeng, Z.1    Sarbassov Dos, D.2    Samudio, I.J.3
  • 46
    • 67650228579 scopus 로고    scopus 로고
    • Rapamycin inhibits mTORC1, but not completely
    • Thoreen CC, Sabatini DM. Rapamycin inhibits mTORC1, but not completely. Autophagy 2009;5:725-6.
    • (2009) Autophagy , vol.5 , pp. 725-726
    • Thoreen, C.C.1    Sabatini, D.M.2
  • 48
    • 75149112670 scopus 로고    scopus 로고
    • AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
    • Chresta CM, Davies BR, Hickson I, et al. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res 2009;70:288-98.
    • (2009) Cancer Res , vol.70 , pp. 288-298
    • Chresta, C.M.1    Davies, B.R.2    Hickson, I.3
  • 49
    • 61349141302 scopus 로고    scopus 로고
    • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • Feldman ME, Apsel B, Uotila A, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 2009;7:e38.
    • (2009) PLoS Biol , vol.7
    • Feldman, M.E.1    Apsel, B.2    Uotila, A.3
  • 50
    • 67650312583 scopus 로고    scopus 로고
    • Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
    • Garcia-Martinez JM, Moran J, Clarke RG, et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J 2009;421:29-42.
    • (2009) Biochem J , vol.421 , pp. 29-42
    • Garcia-Martinez, J.M.1    Moran, J.2    Clarke, R.G.3
  • 51
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009;284:8023-32.
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3
  • 52
    • 76549107351 scopus 로고    scopus 로고
    • Beyond rapalog therapy: Preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2
    • Yu K, Shi C, Toral-Barza L, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res 2010;70:621-31.
    • (2010) Cancer Res , vol.70 , pp. 621-631
    • Yu, K.1    Shi, C.2    Toral-Barza, L.3
  • 53
    • 68049137608 scopus 로고    scopus 로고
    • Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin
    • Yu K, Toral-Barza L, Shi C, et al. Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 2009;69:6232-40.
    • (2009) Cancer Res , vol.69 , pp. 6232-6240
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3
  • 54
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 55
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 56
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 2009;27:3822-9.
    • (2009) J Clin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 57
    • 77951450222 scopus 로고    scopus 로고
    • The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation
    • Zent CS, LaPlant BR, Johnston PB, et al. The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation. Cancer 2010;116:2201-7.
    • (2010) Cancer , vol.116 , pp. 2201-2207
    • Zent, C.S.1    LaPlant, B.R.2    Johnston, P.B.3
  • 58
    • 20144363954 scopus 로고    scopus 로고
    • Antileukemic activity of rapamycin in acute myeloid leukemia
    • Recher C, Beyne-Rauzy O, Demur C, et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 2005;105:2527-34.
    • (2005) Blood , vol.105 , pp. 2527-2534
    • Recher, C.1    Beyne-Rauzy, O.2    Demur, C.3
  • 59
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee KW, Zeng Z, Konopleva M, et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2006;12:5165-73.
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.W.1    Zeng, Z.2    Konopleva, M.3
  • 60
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri DA, Feldman E, Dipersio JF, et al. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2008;14:2756-62.
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 61
    • 0141508021 scopus 로고    scopus 로고
    • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin
    • Ly C, Arechiga AF, Melo JV, Walsh CM, Ong ST. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res 2003;63:5716-22.
    • (2003) Cancer Res , vol.63 , pp. 5716-5722
    • Ly, C.1    Arechiga, A.F.2    Melo, J.V.3    Walsh, C.M.4    Ong, S.T.5
  • 62
    • 17444440115 scopus 로고    scopus 로고
    • Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
    • Stromberg T, Dimberg A, Hammarberg A, et al. Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood 2004;103:3138-47.
    • (2004) Blood , vol.103 , pp. 3138-3147
    • Stromberg, T.1    Dimberg, A.2    Hammarberg, A.3
  • 63
    • 51649088622 scopus 로고    scopus 로고
    • PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML
    • Park S, Chapuis N, Bardet V, et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 2008;22:1698-706.
    • (2008) Leukemia , vol.22 , pp. 1698-1706
    • Park, S.1    Chapuis, N.2    Bardet, V.3
  • 64
    • 58149481284 scopus 로고    scopus 로고
    • The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
    • Baumann P, Mandl-Weber S, Oduncu F, Schmidmaier R. The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma. Exp Cell Res 2009;315:485-97.
    • (2009) Exp Cell Res , vol.315 , pp. 485-497
    • Baumann, P.1    Mandl-Weber, S.2    Oduncu, F.3    Schmidmaier, R.4
  • 65
    • 77249091826 scopus 로고    scopus 로고
    • Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study
    • Lilly MB, Ottmann OG, Shah NP, et al. Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study. Am J Hematol 2010;85:164-70.
    • (2010) Am J Hematol , vol.85 , pp. 164-170
    • Lilly, M.B.1    Ottmann, O.G.2    Shah, N.P.3
  • 66
    • 0037105560 scopus 로고    scopus 로고
    • A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
    • Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood 2002;100:1965-71.
    • (2002) Blood , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 67
    • 65949088837 scopus 로고    scopus 로고
    • Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
    • Chiarini F, Fala F, Tazzari PL, et al. Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. Cancer Res 2009;69:3520-8.
    • (2009) Cancer Res , vol.69 , pp. 3520-3528
    • Chiarini, F.1    Fala, F.2    Tazzari, P.L.3
  • 68
    • 77449114201 scopus 로고    scopus 로고
    • Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Husu EN, et al. Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. Blood 2010;115:559-69.
    • (2010) Blood , vol.115 , pp. 559-569
    • Roccaro, A.M.1    Sacco, A.2    Husu, E.N.3
  • 69
    • 33746118057 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    • Vega F, Medeiros LJ, Leventaki V, et al. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Cancer Res 2006;66:6589-97.
    • (2006) Cancer Res , vol.66 , pp. 6589-6597
    • Vega, F.1    Medeiros, L.J.2    Leventaki, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.