Calreticulin regulates transforming growth factor-β-stimulated extracellular matrix production

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14584-14598

  Zimmerman, Kurt A ^a   Graham, Lauren V ^a,b   Pallero, Manuel A ^a   Murphy Ullrich, Joanne E ^a  

^a University of Alabama at Birmingham   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR RESPONSE; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PRODUCTION; IDIOPATHIC PULMONARY FIBROSIS; MOUSE EMBRYONIC FIBROBLASTS; NUCLEAR TRANSLOCATIONS; TRANSFORMING GROWTH FACTORS;

CALCIUM; CELL CULTURE; CELL MEMBRANES; ENZYME INHIBITION; FIBROBLASTS; SIGNALING;

TISSUE;

CALRETICULIN; COLLAGEN TYPE 1; FIBRONECTIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; TUNICAMYCIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOKINE RESPONSE; EMBRYO; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSING ALVEOLITIS; GENE SILENCING; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CALCIUM; CALRETICULIN; COLLAGEN; ENDOPLASMIC RETICULUM STRESS; FIBRONECTIN; FIBROSIS; NFAT TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR Β (TGFΒ);

ANIMALS; CALCIUM; CALRETICULIN; CELL LINE; COLLAGEN; ENDOPLASMIC RETICULUM; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; LUNG; MICE; NFATC TRANSCRIPTION FACTORS; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 84877906606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.447243     Document Type: Article

References (86)

1. Lawson, W. E., Cheng, D. S., Degryse, A. L., Tanjore, H., Polosukhin, V. V., Xu, X. C., Newcomb, D. C., Jones, B. R., Roldan, J., Lane, K. B., Morrisey, E. E., Beers, M. F., Yull, F. E., and Blackwell, T. S. (2011) Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc. Natl. Acad. Sci. U. S. A. 108, 10562-10567
2. Kypreou, K. P., Kavvadas, P., Karamessinis, P., Peroulis, M., Alberti, A., Sideras, P., Psarras, S., Capetanaki, Y., Politis, P. K., and Charonis, A. S. (2008) Altered expression of calreticulin during the development of fibrosis. Proteomics 8, 2407-2419
3. Khan, M. I., Pichna, B. A., Shi, Y., Bowes, A. J., and Werstuck, G. H. (2009) Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model. Antioxid. Redox. Signal. 11, 2289-2298
4. Kurokawa, M., Hideshima, M., Ishii, Y., Kyuwa, S., and Yoshikawa, Y. (2009) Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters. Exp. Anim. 58, 113-121
5. Qi, W., Mu, J., Luo, Z. F., Zeng, W., Guo, Y. H., Pang, Q., Ye, Z. L., Liu, L., Yuan, F. H., and Feng, B. (2011) Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. Metabolism 60, 594-603
6. Korfei, M., Ruppert, C., Mahavadi, P., Henneke, I., Markart, P., Koch, M., Lang, G., Fink, L., Bohle, R. M., Seeger, W., Weaver, T. E., and Guenther, A. (2008) Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 178, 838-846
7. Kassan, M., Galán, M., Partyka, M., Saifudeen, Z., Henrion, D., Trebak, M., and Matrougui, K. (2012) Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice. Arterioscler. Thromb. Vasc. Biol. 32, 1652-1661
8. Lenna, S., and Trojanowska, M. (2012) The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis. Curr. Opin. Rheumatol. 24, 663-668
9. Cui, Y., Robertson, J., Maharaj, S., Waldhauser, L., Niu, J., Wang, J., Farkas, L., Kolb, M., and Gauldie, J. (2011) Oxidative stress contributes to the induction and persistence of TGF-β1 induced pulmonary fibrosis. Int. J. Biochem. Cell Biol. 43, 1122-1133
10. -/- mice. Atherosclerosis 219, 134-140
11. Ayala, P., Montenegro, J., Vivar, R., Letelier, A., Urroz, P. A., Copaja, M., Pivet, D., Humeres, C., Troncoso, R., Vicencio, J. M., Lavandero, S., and Díaz-Araya, G. (2012) Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp. Mol. Pathol. 92, 97-104
12. Wang, J. Q., Chen, X., Zhang, C., Tao, L., Zhang, Z. H., Liu, X. Q., Xu, Y. B., Wang, H., Li, J., and Xu, D. X. (2013) Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice. Toxicol. Appl. Pharmacol. 266, 307-316
13. Bowes, A. J., Khan, M. I., Shi, Y., Robertson, L., and Werstuck, G. H. (2009) Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice. Evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis. Am. J. Pathol. 174, 330-342
14. Rishikof, D. C., Ricupero, D. A., Liu, H., and Goldstein, R. H. (2004) Phenylbutyrate decreases type I collagen production in human lung fibroblasts. J. Cell Biochem. 91, 740-748
15. Tanjore, H., Cheng, D. S., Degryse, A. L., Zoz, D. F., Abdolrasulnia, R., Lawson, W. E., and Blackwell, T. S. (2011) Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J. Biol. Chem. 286, 30972-30980
16. Coe, H., and Michalak, M. (2009) Calcium binding chaperones of the endoplasmic reticulum. Gen. Physiol. Biophys. 28, F96-F103
17. Michalak, M., Groenendyk, J., Szabo, E., Gold, L. I., and Opas, M. (2009) Calreticulin, a multiprocess calcium-buffering chaperone of the endoplasmic reticulum. Biochem. J. 417, 651-666
18. 2+, and calcineurin signaling from the endoplasmic reticulum. Mol. Cells 17, 383-389
19. 2+ influx. J. Biol. Chem. 271, 9332-9339
20. Mesaeli, N., Nakamura, K., Zvaritch, E., Dickie, P., Dziak, E., Krause, K. H., Opas, M., MacLennan, D. H., and Michalak, M. (1999) Calreticulin is essential for cardiac development. J. Cell Biol. 144, 857-868 (Pubitemid 29238963)
21. 2+-dependent signaling cascade. J. Cell Biol. 170, 37-47
22. Lynch, J., and Michalak, M. (2003) Calreticulin is an upstream regulator of calcineurin. Biochem. Biophys. Res. Commun. 311, 1173-1179 (Pubitemid 37393440)
23. Guo, L., Nakamura, K., Lynch, J., Opas, M., Olson, E. N., Agellon, L. B., and Michalak, M. (2002) Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse. J. Biol. Chem. 277, 50776-50779 (Pubitemid 36042241)
24. Van Duyn Graham, L., Sweetwyne, M. T., Pallero, M. A., and Murphy-Ullrich, J. E. (2010) Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix. J. Biol. Chem. 285, 7067-7078
25. Papp, S., Fadel, M. P., Kim, H., McCulloch, C. A., and Opas, M. (2007) Calreticulin affects fibronectin-based cell-substratum adhesion via the regulation of c-Src activity. J. Biol. Chem. 282, 16585-16598 (Pubitemid 47100404)
26. Papp, S., Szabo, E., Kim, H., McCulloch, C. A., and Opas, M. (2008) Kinase-dependent adhesion to fibronectin. Regulation by calreticulin. Exp. Cell Res. 314, 1313-1326
27. Hattori, K., Nakamura, K., Hisatomi, Y., Matsumoto, S., Suzuki, M., Harvey, R. P., Kurihara, H., Hattori, S., Yamamoto, T., Michalak, M., and Endo, F. (2007) Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. Mol. Genet. Metab. 91, 285-293 (Pubitemid 46819117)
28. Pan, C., Giraldo, G. S., Prentice, H., and Wu, J. Y. (2010) Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress. J. Biomed. Sci. 17, S17
29. Kelsen, S. G., Duan, X., Ji, R., Perez, O., Liu, C., and Merali, S. (2008) Cigarette smoke induces an unfolded protein response in the human lung. A proteomic approach. Am. J. Respir. Cell Mol. Biol. 38, 541-550 (Pubitemid 351758672)
30. Jia, L., Xu, M., Zhen, W., Shen, X., Zhu, Y., Wang, W., and Wang, X. (2008) Novel anti-oxidative role of calreticulin in protecting A549 human type II alveolar epithelial cells against hypoxic injury. Am. J. Physiol. Cell Physiol. 294, C47-C55
31. Roberts, A. B. (1998) Molecular and cell biology of TGF-β. Miner. Electrolyte Metab. 24, 111-119
32. Jayaraman, L., and Massague, J. (2000) Distinct oligomeric states ofSMAD proteins in the transforming growth factor-β pathway. J. Biol. Chem. 275, 40710-40717 (Pubitemid 32054888)
33. Wrana, J. L. (2000) Regulation of Smad activity. Cell 100, 189-192
34. Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J., Shibuya, H., Matsumoto, K., and Nishida, E. (1999) Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression. J. Biol. Chem. 274, 27161-27167
35. Hayashida, T., Decaestecker, M., and Schnaper, H. W. (2003) Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-β-dependent responses in human mesangial cells. FASEB J. 17, 1576-1578
36. Derynck, R., and Zhang, Y. E. (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577-584 (Pubitemid 37280136)
37. Gooch, J. L., Gorin, Y., Zhang, B. X., and Abboud, H. E. (2004) Involvement of calcineurin in transforming growth factor-β-mediated regulation of extracellular matrix accumulation. J. Biol. Chem. 279, 15561-15570 (Pubitemid 38618957)
38. Cobbs, S. L., and Gooch, J. L. (2007) NFATc is required for TGFβ-mediated transcriptional regulation of fibronectin. Biochem. Biophys. Res. Commun. 362, 288-294 (Pubitemid 47332403)
39. Muldoon, L. L., Rodland, K. D., and Magun, B. E. (1988) Transforming growth factor β and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts. J. Biol. Chem. 263, 18834-18841 (Pubitemid 19016341)
40. 2+ influx involves the type III IP3 receptor and regulates actin cytoskeleton. Am. J. Physiol. Renal Physiol. 282, F910-F920
41. Ishiyama, N., Shibata, H., Kanzaki, M., Shiozaki, S., Miyazaki, J., Kobayashi, I., and Kojima, I. (1996) Calcium as a second messenger of the action of transforming growth factor-β on insulin secretion. Mol. Cell. Endocrinol. 117, 1-6 (Pubitemid 26085684)
42. Junn, E., Lee, K. N., Ju, H. R., Han, S. H., Im, J. Y., Kang, H. S., Lee, T. H., Bae, Y. S., Ha, K. S., Lee, Z. W., Rhee, S. G., and Choi, I. (2000) Requirement of hydrogen peroxide generation in TGF-β 1 signal transduction in human lung fibroblast cells. Involvement of hydrogen peroxide and Ca2+ in TGF-β 1-induced IL-6 expression. J. Immunol. 165, 2190-2197 (Pubitemid 30643169)
43. 2+ signaling. Int. J. Biochem. Cell Biol. 43, 1104-1113
44. Pallero, M. A., Elzie, C. A., Chen, J., Mosher, D. F., and Murphy-Ullrich, J. E. (2008) Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J. 22, 3968-3979
45. Burns, K., Duggan, B., Atkinson, E. A., Famulski, K. S., Nemer, M., Bleackley, R. C., and Michalak, M. (1994) Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 367, 476-480 (Pubitemid 24046052)
46. Barker, T. H., Grenett, H. E., MacEwen, M. W., Tilden, S. G., Fuller, G. M., Settleman, J., Woods, A., Murphy-Ullrich, J., and Hagood, J. S. (2004) Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization, and migration through modulation of p190 RhoGAP and Rho GTPase activity. Exp. Cell Res. 295, 488-496 (Pubitemid 38490501)
47. Sweetwyne, M. T., Pallero, M. A., Lu, A., Van Duyn Graham, L., and Murphy-Ullrich, J. E. (2010) The calreticulin binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling. Am. J. Pathol. 177, 1710-1724
48. Midwood, K. S., Wierzbicka-Patynowski, I., and Schwarzbauer, J. E. (2002) Preparation and analysis of synthetic multicomponent extracellular matrix. Methods Cell Biol. 69, 145-161 (Pubitemid 44245292)
49. Prockop, D. J., and Kivirikko, K. I. (1995) Collagens. Molecular biology, diseases, and potentials for therapy. Annu. Rev. Biochem. 64, 403-434
50. Davidson, J. M., LuValle, P. A., Zoia, O., Quaglino, D., Jr., and Giro, M. (1997) Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. J. Biol. Chem. 272, 345-352
51. Zhou, Y., Hagood, J. S., and Murphy-Ullrich, J. E. (2004) Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-β in response to fibrogenic stimuli. Am. J. Pathol. 165, 659-669 (Pubitemid 38971395)
52. Hagood, J. S., Prabhakaran, P., Kumbla, P., Salazar, L., MacEwen, M. W., Barker, T. H., Ortiz, L. A., Schoeb, T., Siegal, G. P., Alexander, C. B., Pardo, A., and Selman, M. (2005) Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am. J. Pathol. 167, 365-379 (Pubitemid 43026094)
53. Lee, G. H., Oh, H. W., Lim, H. D., Lee, W., Chae, H. J., and Kim, H. R. (2011) 4-Phenylbutyric acid regulates collagen synthesis and secretion induced by high concentrations of glucose in human gingival fibroblasts. Korean J. Physiol. Pharmacol. 15, 345-351
54. Piek, E., Ju, W. J., Heyer, J., Escalante-Alcalde, D., Stewart, C. L., Weinstein, M., Deng, C., Kucherlapati, R., Bottinger, E. P., and Roberts, A. B. (2001) Functional characterization of transforming growth factor β signaling in Smad2- and Smad3-deficient fibroblasts. J. Biol. Chem. 276, 19945-19953
55. Yang, K. L., Chang, W. T., Chuang, C. C., Hung, K. C., and Li, E. I. (2008) Antagonizing TGF-β induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx. Biochem. Biophys. Res. Commun. 365, 484-489
56. 2+ response amplitude and duration. Nature 386, 855-858
57. 2+ signals and immunosuppression. Nature 383, 837-840
58. 2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane. Biochem. J. 300, 665-672
59. 2+-ATPase. Proc. Natl. Acad. Sci. U.S.A. 87, 2466-2470
60. 2+-ATPase of sarcoplasmic reticulum. J. Biol. Chem. 264, 17816-17823
61. Crabtree, G. R., and Olson, E. N. (2002) NFAT signaling. Choreographing the social lives of cells. Cell 109, S67-S79 (Pubitemid 34457853)
62. Aramburu, J., Yaffe, M. B., López-Rodríguez, C., Cantley, L. C., Hogan, P. G., and Rao, A. (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285, 2129-2133 (Pubitemid 29451431)
63. Trevillyan, J. M., Chiou, X. G., Chen, Y. W., Ballaron, S. J., Sheets, M. P., Smith, M. L., Wiedeman, P. E., Warrior, U., Wilkins, J., Gubbins, E. J., Gagne, G. D., Fagerland, J., Carter, G. W., Luly, J. R., Mollison, K. W., and Djuric, S. W. (2001) Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds. J. Biol. Chem. 276, 48118-48126
64. Inagaki, Y., Truter, S., and Ramirez, F. (1994) Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J. Biol. Chem. 269, 14828-14834
65. Raghow, R., Postlethwaite, A. E., Keski-Oja, J., Moses, H. L., and Kang, A. H. (1987) Transforming growth factor-β increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J. Clin. Invest. 79, 1285-1288 (Pubitemid 17065515)
66. Varga, J., Rosenbloom, J., and Jimenez, S. A. (1987) Transforming growth factor β (TGF β) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem. J. 247, 597-604 (Pubitemid 17158405)
67. Ignotz, R. A., and Massagué, J. (1986) Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261, 4337-4345 (Pubitemid 17198877)
68. Putney, J. W., Jr. (1990) Capacitative calcium entry revisited. Cell Calcium 11, 611-624
69. Baksh, S., and Michalak, M. (1991) Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains. J. Biol. Chem. 266, 21458-21465 (Pubitemid 121000207)
70. Nakamura, K., Zuppini, A., Arnaudeau, S., Lynch, J., Ahsan, I., Krause, R., Papp, S., De Smedt, H., Parys, J. B., Muller-Esterl, W., Lew, D. P., Krause, K. H., Demaurex, N., Opas, M., and Michalak, M. (2001) Functional specialization of calreticulin domains. J. Cell Biol. 154, 961-972 (Pubitemid 34286176)
71. + stores and reveals aspects of their lumenal microenvironment and function. J. Cell Biol. 130, 847-855
72. 2+ store depletion. J. Biol. Chem. 275, 36676-36682
73. Herum, K. M., Lunde, I. G., Skrbic, B., Florholmen, G., Behmen, D., Sjaastad, I., Carlson, C. R., Gomez, M. F., and Christensen, G. (2013) Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress. J. Mol. Cell. Cardiol. 54, 73-81
74. Nilsson-Berglund, L. M., Zetterqvist, A. V., Nilsson-Ohman, J., Sigvardsson, M., González Bosc, L. V., Smith, M. L., Salehi, A., Agardh, E., Fredrikson, G. N., Agardh, C. D., Nilsson, J., Wamhoff, B. R., Hultgårdh-Nilsson, A., and Gomez, M. F. (2010) Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetesinduced hyperglycemia. Arterioscler. Thromb. Vasc. Biol. 30, 218-224
75. Nanney, L. B., Woodrell, C. D., Greives, M. R., Cardwell, N. L., Pollins, A. C., Bancroft, T. A., Chesser, A., Michalak, M., Rahman, M., Siebert, J. W., and Gold, L. I. (2008) Calreticulin enhances porcine wound repair by diverse biological effects. Am. J. Pathol. 173, 610-630
76. Gold, L. I., Eggleton, P., Sweetwyne, M. T., Van Duyn, L. B., Greives, M. R., Naylor, S. M., Michalak, M., and Murphy-Ullrich, J. E. (2010) Calreticulin. Non-endoplasmic reticulum functions in physiology and disease. FASEB J. 24, 665-683
77. Dedhar, S., Rennie, P. S., Shago, M., Hagesteijn, C. Y., Yang, H., Filmus, J., Hawley, R. G., Bruchovsky, N., Cheng, H., and Matusik, R. J. (1994) Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367, 480-483 (Pubitemid 24046053)
78. Tili, E., Michaille, J. J., Alder, H., Volinia, S., Delmas, D., Latruffe, N., and Croce, C. M. (2010) Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells. Biochem. Pharmacol. 80, 2057-2065
79. Isono, M., Chen, S., Hong, S. W., Iglesias-de la Cruz, M. C., and Ziyadeh, F. N. (2002) Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells. Biochem. Biophys. Res. Commun. 296, 1356-1365
80. Srinivasan, V., Tatu, U., Mohan, V., and Balasubramanyam, M. (2009) Molecular convergence of hexosamine biosynthetic pathway and ER stress leading to insulin resistance in L6 skeletal muscle cells. Mol. Cell. Biochem. 328, 217-224
81. Sage, A. T., Walter, L. A., Shi, Y., Khan, M. I., Kaneto, H., Capretta, A., and Werstuck, G. H. (2010) Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells. Am. J. Physiol. Endocrinol. Metab. 298, E499-E511
82. Baek, H. A., Kim do, S., Park, H. S., Jang, K. Y., Kang, M. J., Lee, D. G., Moon, W. S., Chae, H. J., and Chung, M. J. (2012) Involvement of endoplasmic reticulum stress in myofibroblastic differentiation of lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 46, 731-739
83. Tanaka, K., Shirai, A., Ito, Y., Namba, T., Tahara, K., Yamakawa, N., and Mizushima, T. (2012) Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice. Biochem. Biophys. Res. Commun. 425, 818-824
84. Vonk, L. A., Doulabi, B. Z., Huang, C. L., Helder, M. N., Everts, V., and Bank, R. A. (2010) Endoplasmic reticulum stress inhibits collagen synthesis independent of collagen-modifying enzymes in different chondrocyte populations and dermal fibroblasts. Biochem. Cell Biol. 88, 539-552
85. Torres-González, E., Bueno, M., Tanaka, A., Krug, L. T., Cheng, D. S., Polosukhin, V. V., Sorescu, D., Lawson, W. E., Blackwell, T. S., Rojas, M., and Mora, A. L. (2012) Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. Am. J. Respir. Cell Mol. Biol. 46, 748 -756
86. Knee, R., Ahsan, I., Mesaeli, N., Kaufman, R. J., and Michalak, M. (2003) Compromised calnexin function in calreticulin-deficient cells. Biochem. Biophys. Res. Commun. 304, 661-666 (Pubitemid 36513538)