Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart

Molecular Genetics and Metabolism

Volumn 91, Issue 3, 2007, Pages 285-293

  Hattori, Kiyoko ^a   Nakamura, Kimitoshi ^a   Hisatomi, Yuichiro ^a   Matsumoto, Shirou ^a   Suzuki, Misao ^a   Harvey, Richard P ^b,c   Kurihara, Hiroki ^d   Hattori, Shinzaburo ^a   Yamamoto, Tetsuro ^a   Michalak, Marek ^e   Endo, Fumio ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Arrhythmia; Calreticulin; Cardiac edema; HCN1; MEF2C; Overexpression; Sudden death

Indexed keywords

CALRETICULIN; CARRIER PROTEIN; CONNEXIN 40; CONNEXIN 43; CRE RECOMBINASE; GAP JUNCTION PROTEIN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EDEMA; ENDOPLASMIC RETICULUM; FEMALE; GENE OVEREXPRESSION; HEART ARRHYTHMIA; HEART DEVELOPMENT; HEART DILATATION; LOXP SITE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUDDEN DEATH; TRANSGENIC MOUSE;

ANIMALS; ARRHYTHMIA; CALRETICULIN; CONNEXIN 43; CONNEXINS; ENDOPLASMIC RETICULUM; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOGENIC REGULATORY FACTORS; POTASSIUM CHANNELS;

MUS; MUS MUSCULUS;

EID: 34249335334     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2007.02.003     Document Type: Article

References (34)

1. Michalak M., Corbett E.F., Mesaeli N., Nakamura K., and Opas M. Calreticulin: one protein, one gene, many functions. Biochem. J. 344 (1999) 281-292
2. 2+ signaling and calcium binding chaperones of the endoplasmic reticulum. Cell Calcium 32 (2002) 269-278
3. Webb S.E., and Miller A.L. Calcium signalling during embryonic development. Nat. Rev. Mol. Cell Biol. 4 (2003) 539-551
4. Mesaeli N., Nakamura K., Zvaritch E., Dickie P., Dziak E., Krause K.H., Opas M., MacLennan D.H., and Michalak M. Calreticulin is essential for cardiac development. J. Cell Biol. 144 (1999) 857-868
5. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., and Olson E.N. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93 (1998) 215-228
6. 2+-dependent signaling cascade. J. Cell Biol. 170 (2005) 37-47
7. Nakamura K., Robertson M., Liu G., Dickie P., Nakamura K., Guo J.Q., Duff H.J., Opas M., Kavanagh K., and Michalak M. Complete heart block and sudden death in mice overexpressing calreticulin. J. Clin. Invest. 107 (2001) 1245-1253
8. Lints T.J., Parsons L.M., Hartley L., Lyons I., and Harvey R.P. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119 (1993) 419-431
9. Moses K.A., DeMayo F., Braun R.M., Reecy J.L., and Schwartz R.J. Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis 31 (2001) 176-180
10. Michalak M., Burns K., Andrin C., Mesaeli N., Jass G.H., Busaan J.L., and Opas M. Endoplasmic reticulum form of calreticulin modulates glucocorticoid-sensitive gene expression. J. Biol. Chem. 271 (1996) 29436-29445
11. Okumura K., Nakamura K., Hisatomi Y., Nagano K., Tanaka Y., Terada K., Sugiyama T., Umeyama K., Matsumoto K., Yamamoto T., and Endo F. Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages. Hepatology 38 (2003) 104-113
12. Hisatomi Y., Okumura K., Nakamura K., Matsumoto S., Satoh A., Nagano K., Yamamoto T., and Endo F. Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages. Hepatology 39 (2004) 667-675
13. Sun M.S., Hattori S., Kubo S., Awata H., Matsuda I., and Endo F. A mouse model of renal tubular injury of Tyrosinemia type 1: Development of de Toni Fanconi Syndrome and Apoptosis of Renal Tubular Cells in Fah/Hpd Double Mutant Mice. J. Am. Soc. Nephrol. 11 (2000) 291-300
14. Perriard J.C., Hirschy A., and Ehler E. Dilated cardiomyopathy: a disease of the intercalated disc?. Trends Cardiovasc. Med. 13 (2003) 30-38
15. Kageyama K., Ihara Y., Goto S., Urata Y., Toda G., Yano K., and Kondo T. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. J. Biol. Chem. 277 (2002) 19255-19264
16. Stanley E.G., Biben C., Elefanty A.., Barnett L., Koentgen F., Robb L., and Harvey R.P. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int. J. Dev. Biol. 46 (2002) 431-439
17. Zeisberg E.M., Ma Q., Juraszek A.L., Moses K., Schwartz R.J., Izumo S., and Pu W.T. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J. Clin. Invest. 105 (2005) 1522-1531
18. McFadden D.G., Barbosa A.C., Richardson J.A., Schneider M.D., Srivastava D., and Olson E.N. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132 (2005) 189-201
19. Pashmforoush M., Lu J.T., Chen H., Amand T.S., Kondo R., Pradervand S., Evans S.M., Clark B., Feramisco J.R., Giles W., Ho S.Y., Benson D.W., Silberbach M., Shou W., and Chien K.R. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 117 (2004) 373-386
20. Simon A.M., Goodenough D.A., and Paul D.L. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr. Biol. 8 (1998) 295-298
21. van Rijen H.V., van Veen T.A., van Kempen M.J., Wilms-Schopman F.J., Potse M., Krueger O., Willecke K., Opthof T., Jongsma H.J., and de Bakker J.M. Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40. Circulation 103 (2001) 1591-1598
22. Gutstein D.E., Morley G.E., Tamaddon H., Vaidya D., Schneider M.D., Chen J., Chien K., Stuhlmann H., and Fishman G.I. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 88 (2001) 333-339
23. Petrich B.G., Gong X., Lerner D.L., Wang X., Brown J.H., Saffitz J.E., and Wang Y. c-jun N-terminal activation mediates downregulation of connexin43 in cardiomyocyte. Circ. Res. 91 (2002) 640-647
24. Saffitz J.E., and Kleber A.G. Effect of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart. Circ. Res. 94 (2004) 585-591
25. Lyons G.E., Schiaffino S., Sassoon D., Barton P., and Buckingham M. Developmental regulation of myosin gene expression in mouse cardiac muscle. J. Cell Biol. 111 (1990) 2427-2436
26. Wencker D., Chandra M., Nguyen K., Miao W., Garantziotis S., Factor S.M., Shirani J., Armstrong R.C., and Kitsis R.N. A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 111 (2003) 1497-1504
27. Biel M., Schneider A., and Wahl C. Cardiac HCN channels: structure, function, and modulation. Trends Cardiovasc. Med. 12 (2002) 206-212
28. Stieber J., Hofmann F., and Ludwig A. Pacemaker channels and sinus node arrhythmia. Trends Cardiovasc. Med. 14 (2004) 23-28
29. Ludwig A., Budde T., Stieber J., Moosmang S., Wahl C., Holthoff K., Langebartels A., Wotjak C., Munsch T., Feil X., Feil R., Lancel M., Chien K.R., Konnerth A., Pape H.C., Biel M., and Hofmann F. Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J. 22 (2003) 216-224
30. Stieber J., Herrmann S., Feil S., Loster J., Feil R., Biel M., Hofmann F., and Ludwig A. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc. Natl. Acad. Sci. USA 100 (2003) 15235-15240
31. Moosmang S., Stieber J., Zong X., Biel M., Hofmann F., and Ludwig A. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur. J. Biochem. 268 (2001) 1646-1652
32. Nolan M.F., Malleret G., Lee K.H., Gibbs E., Dudman J.T., Santoro B., Yin D., Thompson R.F., Siegelbaum S.A., Kandel E.R., and Morozov A. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell 115 (2003) 551-564
33. Xu J., Gong N.L., Bodi I., Aronow B.J., Backx P.H., and Molkentin J.D. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J. Biol. Chem. 281 (2006) 9152-9162
34. Kolodziejczyk S.M., Wang L., Balazsi K., DeRepentigny Y., Kothary R., and Megeney L.A. MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr. Biol. 9 (1999) 1203-1206