Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African trypanosomiasis

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14256-14263

  Cestari, Igor ^a   Stuart, Kenneth ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; DRUG DEVELOPMENT; EXPERIMENTAL ANALYSIS; SLEEPING SICKNESS; SMALL MOLECULES; STRUCTURE PREDICTION; TRYPANOSOMA BRUCEI;

MAMMALS;

MOLECULES;

DOXYCYCLINE; ISOLEUCINE TRANSFER RNA LIGASE; NSC 70422; PROTEIN INHIBITOR; TETRACYCLINE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MAMMAL CELL; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TREATMENT RESPONSE; TRYPANOSOMA BRUCEI;

AMINOACYL-TRNA SYNTHETASE; CHEMICAL BIOLOGY; DRUG DEVELOPMENT; ENZYME INHIBITORS; MOLECULAR BIOLOGY; PARASITOLOGY; TRYPANOSOMA BRUCEI;

ANIMALS; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME INHIBITORS; ISOLEUCINE-TRNA LIGASE; MALE; MICE; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; RECOMBINANT PROTEINS; RNA INTERFERENCE; TRANSFECTION; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 84877894777     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.447441     Document Type: Article

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