Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets

Diabetologia

Volumn 56, Issue 6, 2013, Pages 1317-1326

  Beck, A ^a   Vinik, Y ^a   Shatz Azoulay, H ^a   Isaac, R ^a   Streim, S ^a   Jona, G ^a   Boura Halfon, S ^a   Zick, Y ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Human islets; OTUB2; Pro inflammatory cytokines; siRNA screens

Indexed keywords

CASPASE 3; CASPASE 7; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; LIGASE; OTUBAIN 2; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE IDENTIFICATION; GENE SILENCING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; INSULIN RELEASE; NUCLEOTIDE SEQUENCE; OTUB2 GENE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; CASPASE 3; CASPASE 7; CELL SURVIVAL; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIOLESTER HYDROLASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84877758698     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2889-x     Document Type: Article

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