An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells

Diabetologia

Volumn 54, Issue 11, 2011, Pages 2845-2855

  Beck, A ^a   Isaac, R ^a   Lavelin, I ^a   Hart, Y ^a   Volberg, T ^a   Shatz Azoulay, H ^a   Geiger, B ^a   Zick, Y ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Pancreatic beta cells; Pro inflammatory cytokines; siRNA screens; TM7SF3

Indexed keywords

CASPASE 3; CASPASE 7; DEUBIQUITINATING ENZYME; GAMMA INTERFERON; INSULIN; INTERLEUKIN 1BETA; MEMBRANE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CAMKK2 GENE; CELL DEATH; CONTROLLED STUDY; EPN3 GENE; FOXP3 GENE; GENE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TM7SF3 GENE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES, EFFECTOR; CELL LINE; CYTOKINES; FEMALE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; UBIQUITIN-PROTEIN LIGASES;

EID: 80054715737     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2277-3     Document Type: Article

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