Total synthesis and biological evaluation of grassypeptolide A

Chemistry - A European Journal

Volumn 19, Issue 21, 2013, Pages 6774-6784

  Liu, Hui ^a   Liu, Yuqing ^b   Wang, Zhuo ^b   Xing, Xiangyou ^a   Maguire, Anita R ^c   Luesch, Hendrik ^d   Zhang, Hui ^a   Xu, Zhengshuang ^a,b   Ye, Tao ^a,b  

^a PEKING UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

cyclodepsipeptides; cytotoxicity; grassypeptolide; thiazolines; total synthesis

Indexed keywords

BIOLOGICAL EVALUATION; CANCER CELL APOPTOSIS; CYCLODEPSIPEPTIDES; DOSE-DEPENDENT MANNER; GRASSYPEPTOLIDE; POLY(ADP-RIBOSE) POLYMERASE; THIAZOLINES; TOTAL SYNTHESIS;

CELL DEATH; CELL PROLIFERATION; CYTOTOXICITY;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DEPSIPEPTIDE; GRASSYPEPTOLIDE A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; THIAZOLE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL PROLIFERATION; CELL STRAIN HT29; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENETICS; HELA CELL; HUMAN; MARINE BIOLOGY; METABOLISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE; G2 PHASE; HELA CELLS; HT29 CELLS; HUMANS; MARINE BIOLOGY; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; THIAZOLES;

EID: 84877733979     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201203667     Document Type: Article

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