Selective cleavage of tert-butyl esters in the presence of tert-butyl ethers. Application to the synthesis of tert-butoxy amino acids

Synthesis

Volumn , Issue 12, 1996, Pages 1433-1434

  Trzeciak, Arnold ^a   Bannwarth, Willi ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

deprotection; tert butyl ether of hydroxyl amino acids; trimethylsilyl triflate

Indexed keywords

AMINO ACID DERIVATIVE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030458374     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1996-4408     Document Type: Article

References (11)

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3. Emde, H.; Simchen, G. Synthesis 1977, 867.
4. Emde, H.; Domsch, D.; Feger, H.; Frick, U.; Götz, A.; Hergott, H. H.; Hofmann, K.; Kober, W.; Krägeloh, K.; Österle, T.; Steppan, W.; West, W.; Simchen, G. Synthesis 1982, 1.
5. Borgulya, J.; Bernauer, K. Synthesis 1980, 545.
6. Roeske, R. J. Org. Chem. 1963, 28, 1251.
7. Wünsch, E.; Jentsch, J. Chem. Ber. 1964, 97, 2490.
8. Wünsch, E. In Houben-Weyl, 4th ed., Vol. 15/1; Wünsch, E., Ed.; Thieme: Stuttgart, 1974; p599.
9. Fields, G. B.; Noble, R. L. Int. J. Peptide Protein Res. 1990, 35, 161-214.
10. D + 0.006, c = 1; EtOH.
11. Schröder, E. Justus Liebigs Ann. Chem. 1963, 670, 127.