Apoptosis and cancer drug targeting

Journal of Clinical Investigation

Volumn 104, Issue 12, 1999, Pages 1655-1661

  Sellers, William R ^a,b   Fisher, David E ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53;

APOPTOSIS; CANCER; CELL KILLING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TARGET CELL; TUMOR CELL; TUMOR SUPPRESSOR GENE;

EID: 0033400809     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9053     Document Type: Review

References (21)

1. Evan, G.I., et al. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 69:119-128.
2. Pan, G., et al. 1997. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 277:815-818.
3. Holinger, E.P., Chittenden, T., and Lutz, R.J. 1999. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J. Biol. Chem. 274:13298-13304.
4. Baeuerle, P.A., and Baltimore, D. 1996. NF-kappa B: ten years after. Cell. 87:13-20.
5. Beg, A.A., and Baltimore, D. 1996. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science. 274:782-784.
6. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.-F., and Verma, I.M. 1999. Severe liver degeneration in mice lacking the IKappaB kinase 2. Science. 284:321-325.
7. Wang, C.Y., Mayo, M.W., Korneluk, R.G., Goeddel, D.V., and Baldwin, A.S., Jr. 1998. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation. Science. 281:1680-1683.
8. Zong, W.X., Edelstein, L.C., Chen, C., Bash, J., and Gelinas, C. 1999. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 13:382-387.
9. Gilmore, T.D., Koedood, M., Piffat, K.A., and White, D.W. 1996. Rel/NF-kappaB/IkappaB proteins and cancer. Oncogene. 13:1367-1378.
10. Cantley, L.C., and Neel, B.G. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the PI3K/AKT pathway. Proc. Natl. Acad. Sci. USA. 96:4240-4245.
11. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H., and Downward, J. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
12. Whitman, M., Kaplan, D.R., Schaffhausen, B., Cantley, L., and Roberts, T.M. 1985. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature. 315:239-242.
13. Skorski, T., et al. 1997. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI3K/Akr-dependent pathway. EMBO J. 16:6151-6161.
14. Lowe, S.W., Ruley, H.E., Jacks, T., and Housman, D.E. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957-967.
15. Lowe, S.W., et al. 1994. p53 status and the efficacy of cancer therapy in vivo. Science. 266:807-810.
16. Schmaltz, C., Hardenbergh, P.H., Wells, A., and Fisher, D.E. 1998. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18:2845-2854.
17. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:847-849.
18. Xu, C., Meikrantz, W., Schlegel, R., and Sager, R. 1995. The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage, Proc. Natl. Acad. Sci. USA. 92:7829-7833.
19. Bischoff, J.R., et al. 1996. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 274:373-376.
20. Attardi, L.D., Lowe, S.W., Brugarolas, J., and Jacks, T. 1996. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J. 15:3693-3701.
21. Ding, H.F., and Fisher, D.E. 1998. Mechanisms of p53-mediated apoptosis. Crit. Rev. Oncog. 9:83-98.