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Volumn 45, Issue 47, 2006, Pages 8028-8032

Asymmetric total syntheses of ecteinascidin 597 and ecteinascidin 583

Author keywords

Alkaloids; Antitumor agents; Asymmetric synthesis; Marine natural products; Pictet Spengler reaction

Indexed keywords

PROBLEM SOLVING; SYNTHESIS (CHEMICAL);

EID: 33845476049     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200603179     Document Type: Article
Times cited : (44)

References (58)
  • 14
    • 33746299718 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2006, 45, 1754-1759;
    • (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 1754-1759
  • 16
    • 33746314816 scopus 로고    scopus 로고
    • Angew. Chem. Int. Ed. 2006, 45, 1749-1754;
    • (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 1749-1754
  • 46
    • 33845486048 scopus 로고    scopus 로고
    • note
    • 2, 80%. Compound 16 has a high tendency to undergo trimerization and should be used immediately after preparation.
  • 51
    • 33845500904 scopus 로고    scopus 로고
    • note
    • One of the referees proposed that we isolate the orthoquinone methide intermediate by using N-protected starting materials to probe the reaction sequence. We are investigating in detail the mechanism of this reaction.
  • 57
    • 0032568384 scopus 로고    scopus 로고
    • see
    • c) for a review, see: F. Guibé, Tetrahedron 1998, 54, 2967-3042.
    • (1998) Tetrahedron , vol.54 , pp. 2967-3042
    • Guibé, F.1
  • 58
    • 0033616691 scopus 로고    scopus 로고
    • see
    • Owing to the restricted availability of this family of natural products, there are very few reports in the literature that deal with SARs of these compounds, despite their medical importance; see: E. J. Martinez, T. Owa, S. L. Schreiber, E. J. Corey, Proc. Natl. Acad. Sci. USA 1999, 96, 3496-3501.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3496-3501
    • Martinez, E.J.1    Owa, T.2    Schreiber, S.L.3    Corey, E.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.