Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 7, 2013, Pages 1468-1478

  Dai, Qinsheng ^a   Yin, Yuehan ^a   Liu, Wei ^b   Wei, Libin ^a   Zhou, Yuxin ^a   Li, Zhiyu ^a   You, Qidong ^a   Lu, Na ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Aerobic glycolysis; Glucose metabolism; p53; SCO2; TIGAR

Indexed keywords

DOXORUBICIN; OROXYLIN A; OXIDOREDUCTASE; PHOSPHOGLYCERATE MUTASE; PROTEIN P53; SMALL INTERFERING RNA; 5,7-DIHYDROXY-6-METHOXY-2-PHENYLCHROMEN-4-ONE; APOPTOSIS REGULATORY PROTEIN; C12ORF5 PROTEIN, HUMAN; CARRIER PROTEIN; FLAVONOID; GLUCOSE; LACTIC ACID; MDM2 PROTEIN, HUMAN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PROTEIN MDM2; SCO2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; ENZYME SYNTHESIS; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; OXYGEN CONSUMPTION; PROTEIN EXPRESSION; APOPTOSIS; BIOSYNTHESIS; CELL PROLIFERATION; ENERGY METABOLISM; GENETICS; HEPG2 CELL LINE; LIVER TUMOR; METABOLISM; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION; PHYSIOLOGY; RNA INTERFERENCE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; ENERGY METABOLISM; FLAVONOIDS; GLUCOSE; GLYCOLYSIS; HEP G2 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LACTIC ACID; LIVER NEOPLASMS; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHOSPHOGLYCERATE MUTASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MDM2; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877676176     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.04.015     Document Type: Article

References (45)

1. K. Bensaad, A. Tsuruta, M.A. Selak, M.N. Vidal, K. Nakano, and R. Bartrons TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120 (Pubitemid 44040989)
2. Y. Chen, N. Lu, Y. Ling, Y. Gao, L. Wang, and Y. Sun Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction Toxicology 259 2009 10 17
3. Y. Chen, L. Yang, and T.J. Lee Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation Biochemical Pharmacology 59 2000 1445 1457 (Pubitemid 30177363)
4. C.V. Dang, and G.L. Semenza Oncogenic alterations of metabolism Trends in Biochemical Sciences 24 1999 68 72 (Pubitemid 29346576)
5. N.C. Denko Hypoxia, HIF1 and glucose metabolism in the solid tumour Nature reviews 8 2008 705 713
6. V.R. Fantin, J. St-Pierre, and P. Leder Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Cancer cell 9 2006 425 434 (Pubitemid 43832190)
7. Y. Gao, N. Lu, Y. Ling, Y. Chen, L. Wang, and Q. Zhao Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation Journal of Cancer Research and Clinical Oncology 136 2010 667 675
8. D.R. Green, and J.E. Chipuk p53 and metabolism: inside the TIGAR Cell 126 2006 30 32
9. R.D. Guarino, L.E. Dike, T.A. Haq, J.A. Rowley, J.B. Pitner, and M.R. Timmins Method for determining oxygen consumption rates of static cultures from microplate measurements of pericellular dissolved oxygen concentration Biotechnology and Bioengineering 86 2004 775 787 (Pubitemid 38745695)
10. G.Y. Gwak, J.H. Yoon, K.M. Kim, H.S. Lee, J.W. Chung, and G.J. Gores Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression Journal of Hepatology 42 2005 358 364 (Pubitemid 40254250)
11. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
12. P.P. Hsu, and D.M. Sabatini Cancer cell metabolism: Warburg and beyond Cell 134 2008 703 707
13. Y. Hu, Y. Yang, Q.D. You, W. Liu, H.Y. Gu, and L. Zhao Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity Biochemical and Biophysical Research Communications 351 2006 521 527 (Pubitemid 44666718)
14. N.P. Jones, and A. Schulze Targeting cancer metabolism - aiming at a tumour's sweet-spot Drug Discovery Today 17 2012 232 241
15. P.G. Komarov, E.A. Komarova, R.V. Kondratov, K. Christov-Tselkov, J.S. Coon, and M.V. Chernov A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy Science (New York, NY) 285 1999 1733 1737 (Pubitemid 29428873)
16. H. Kondoh Cellular life span and the Warburg effect Experimental Cell Research 314 2008 1923 1928
17. H. Kondoh, M.E. Lleonart, J. Gil, J. Wang, P. Degan, and G. Peters Glycolytic enzymes can modulate cellular life span Cancer Research 65 2005 177 185 (Pubitemid 40070808)
18. H.B. Li, and F. Chen Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography Journal of Chromatography 1074 2005 107 110 (Pubitemid 40615049)
19. H.N. Li, F.F. Nie, W. Liu, Q.S. Dai, N. Lu, and Q. Qi Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo Toxicology 257 2009 80 85
20. W. Liu, R. Mu, F.F. Nie, Y. Yang, J. Wang, and Q.S. Dai MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells Cancer Letters 284 2009 198 207
21. M. Lopez-Lazaro The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anti-Cancer Agents in Medicinal Chemistry 8 2008 305 312 (Pubitemid 351761435)
22. Z. Lu, N. Lu, C. Li, F. Li, K. Zhao, and B. Lin Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway Toxicology Letters 209 2012 211 220
23. W. Ma, H.J. Sung, J.Y. Park, S. Matoba, and P.M. Hwang A pivotal role for p53: balancing aerobic respiration and glycolysis Journal of Bioenergetics and Biomembranes 39 2007 243 246 (Pubitemid 47619376)
24. O.D. Maddocks, and K.H. Vousden Metabolic regulation by p53 Journal of Molecular Medicine (Berlin, Germany) 89 2011 237 245
25. S. Matoba, J.G. Kang, W.D. Patino, A. Wragg, M. Boehm, and O. Gavrilova p53 regulates mitochondrial respiration Science (New York, NY) 312 2006 1650 1653 (Pubitemid 43902663)
26. R. Moreno-Sanchez, S. Rodriguez-Enriquez, E. Saavedra, A. Marin-Hernandez, and J.C. Gallardo-Perez The bioenergetics of cancer: is glycolysis the main ATP supplier in all tumor cells Biofactors 35 2009 209 225
27. R. Mu, Q. Qi, H. Gu, J. Wang, Y. Yang, and J. Rong Involvement of p53 in oroxylin A-induced apoptosis in cancer cells Molecular Carcinogenesis 48 2009 1159 1169
28. A.D. Ortega, M. Sanchez-Arago, D. Giner-Sanchez, L. Sanchez-Cenizo, I. Willers, and J.M. Cuezva Glucose avidity of carcinomas Cancer Letters 276 2009 125 135
29. H. Pelicano, D.S. Martin, R.H. Xu, and P. Huang Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646 (Pubitemid 44187614)
30. T. Pfeiffer, S. Schuster, and S. Bonhoeffer Cooperation and competition in the evolution of ATP-producing pathways Science (New York, NY) 292 2001 504 507 (Pubitemid 32335953)
31. A. Salminen, and K. Kaarniranta Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process Journal of Cellular Physiology 224 2010 1 6
32. D.H. Schamhart, K.W. van de Poll, and R. van Wijk Comparative studies of glucose metabolism in HTC, RLC, MH1C1, and Reuber H35 rat hepatoma cells Cancer Research 39 1979 1051 1055 (Pubitemid 9135133)
33. K. Smolkova, L. Plecita-Hlavata, N. Bellance, G. Benard, R. Rossignol, and P. Jezek Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells The international Journal of Biochemistry & Cell Biology 43 2010 950 968
34. M. Stubbs, and J.R. Griffiths The altered metabolism of tumors: HIF-1 and its role in the Warburg effect Advances in Enzyme Regulation 50 2010 44 55
35. W.R. Taylor, and G.R. Stark Regulation of the G2/M transition by p53 Oncogene 20 2001 1803 1815 (Pubitemid 32458690)
36. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science (New York, NY) 324 2009 1029 1033
37. A. Vazquez, E.E. Bond, A.J. Levine, and G.L. Bond The genetics of the p53 pathway, apoptosis and cancer therapy Nature Reviews. Drug Discovery 7 2008 979 987
38. B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nature Medicine 10 2004 789 799 (Pubitemid 39070849)
39. K.H. Vousden, and K.M. Ryan p53 and metabolism Nature Reviews 9 2009 691 700
40. Z. Wang, N. Wang, J. Chen, and J. Shen Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy Evidence Based Complementary and Alternative Medicine 2012 2012 873175
41. O. Warburg On the origin of cancer cells Science (New York, NY) 123 1956 309 314
42. H.Y. Yang, L. Zhao, Z. Yang, Q. Zhao, L. Qiang, and J. Ha Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-kappaB signaling pathway Molecular Carcinogenesis 51 2012 185 195
43. Y. Yang, Y. Hu, H.Y. Gu, N. Lu, W. Liu, and Q. Qi Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells The Journal of Pharmacy and Pharmacology 60 2008 1459 1463
44. S.J. Yeung, J. Pan, and M.H. Lee Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer Cellular and Molecular Life Sciences 65 2008 3981 3999
45. M. Zou, N. Lu, C. Hu, W. Liu, Y. Sun, and X. Wang Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling Cell Signalling 24 2012 1722 1732