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Volumn 139, Issue 3, 2013, Pages 193-205

Never in neutral: A systems biology and evolutionary perspective on how aneuploidy contributes to human diseases

Author keywords

Aneuploidy; Cancer; Evolution; Fungi; Infectious diseases; Parasites; Phenotypic variation

Indexed keywords

PROTEOME; TRANSCRIPTOME;

EID: 84877585952     PISSN: 14248581     EISSN: 1424859X     Source Type: Journal    
DOI: 10.1159/000348303     Document Type: Review
Times cited : (10)

References (99)
  • 1
    • 70350017855 scopus 로고    scopus 로고
    • Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants
    • Arbour M, Epp E, Hogues H, Sellam A, Lacroix C, et al: Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants. FEMS Yeast Res 9: 1070-1077 (2009).
    • (2009) FEMS Yeast Res , vol.9 , pp. 1070-1077
    • Arbour, M.1    Epp, E.2    Hogues, H.3    Sellam, A.4    Lacroix, C.5
  • 3
    • 67649506317 scopus 로고    scopus 로고
    • Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCTR1
    • Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, et al: Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCTR1. Nature 459: 1126-1130 (2009).
    • (2009) Nature , vol.459 , pp. 1126-1130
    • Baek, K.H.1    Zaslavsky, A.2    Lynch, R.C.3    Britt, C.4    Okada, Y.5
  • 4
    • 58149334818 scopus 로고    scopus 로고
    • Genome stability is ensured by temporal control of kinetochore- microtubule dynamics
    • Bakhoum SF, Thompson SL, Manning AL, Compton DA: Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol 11: 27-35 (2009).
    • (2009) Nat Cell Biol , vol.11 , pp. 27-35
    • Bakhoum, S.F.1    Thompson, S.L.2    Manning, A.L.3    Compton, D.A.4
  • 6
    • 37549030093 scopus 로고    scopus 로고
    • Adaptation from standing genetic variation
    • Barrett RD, Schluter D: Adaptation from standing genetic variation. Trends Ecol Evol 23: 38-44 (2008).
    • (2008) Trends Ecol Evol , vol.23 , pp. 38-44
    • Barrett, R.D.1    Schluter, D.2
  • 8
    • 0030297089 scopus 로고    scopus 로고
    • The indigenous gastrointestinal microflora
    • DOI 10.1016/0966-842X(96)10057-3, PII S0966842X96100573
    • Berg RD: The indigenous gastrointestinal microflora. Trends Microbiol 4: 430-435 (1996). (Pubitemid 26373240)
    • (1996) Trends in Microbiology , vol.4 , Issue.11 , pp. 430-435
    • Berg, R.D.1
  • 9
    • 17144405643 scopus 로고    scopus 로고
    • Mitotic kinesins: Prospects for antimitotic drug discovery
    • DOI 10.2174/1568026053507697
    • Bergnes G, Brejc K, Belmont L: Mitotic kinesins: Prospects for antimitotic drug discovery. Curr Top Med Chem 5: 127-145 (2005). (Pubitemid 40514510)
    • (2005) Current Topics in Medicinal Chemistry , vol.5 , Issue.2 , pp. 127-145
    • Bergnes, G.1    Brejc, K.2    Belmont, L.3
  • 10
    • 43549110556 scopus 로고    scopus 로고
    • Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells
    • DOI 10.1111/j.1349-7006.2008.00815.x
    • Cao Y, Bryan TM, Reddel RR: Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci 99: 1092-1099 (2008). (Pubitemid 351676619)
    • (2008) Cancer Science , vol.99 , Issue.6 , pp. 1092-1099
    • Cao, Y.1    Bryan, T.M.2    Reddel, R.R.3
  • 12
    • 27744520116 scopus 로고    scopus 로고
    • Kinetochore structure and function
    • DOI 10.1016/j.tcb.2005.09.010, PII S0962892405002345
    • Chan GK, Liu ST, Yen TJ: Kinetochore structure and function. Trends Cell Biol 15: 589-598 (2005). (Pubitemid 41619423)
    • (2005) Trends in Cell Biology , vol.15 , Issue.11 , pp. 589-598
    • Chan, G.K.1    Liu, S.-T.2    Yen, T.J.3
  • 13
    • 84862777815 scopus 로고    scopus 로고
    • Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
    • Chen G, Bradford WD, Seidel CW, Li R: Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature 482: 246-250 (2012).
    • (2012) Nature , vol.482 , pp. 246-250
    • Chen, G.1    Bradford, W.D.2    Seidel, C.W.3    Li, R.4
  • 14
    • 77956536244 scopus 로고    scopus 로고
    • Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes
    • Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA: Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Curr Biol 20: 1522-1528 (2010).
    • (2010) Curr Biol , vol.20 , pp. 1522-1528
    • Chiang, T.1    Duncan, F.E.2    Schindler, K.3    Schultz, R.M.4    Lampson, M.A.5
  • 15
    • 0032700919 scopus 로고    scopus 로고
    • Differences in malsegregation rates obtained by scoring anatelophases or binucleate cells
    • Cimini D, Tanzarella C, Degrassi F: Differences in malsegregation rates obtained by scoring anatelophases or binucleate cells. Mutagenesis 14: 563-568 (1999).
    • (1999) Mutagenesis , vol.14 , pp. 563-568
    • Cimini, D.1    Tanzarella, C.2    Degrassi, F.3
  • 16
  • 17
    • 0029997093 scopus 로고    scopus 로고
    • Association between nondisjunction and maternal age in meiosis-II human oocytes
    • Dailey T, Dale B, Cohen J, Munne S: Association between nondisjunction and maternal age in meiosis-II human oocytes. Am J Hum Genet 59: 176-184 (1996). (Pubitemid 26189744)
    • (1996) American Journal of Human Genetics , vol.59 , Issue.1 , pp. 176-184
    • Dailey, T.1    Dale, B.2    Cohen, J.3    Munne, S.4
  • 18
    • 77953679536 scopus 로고    scopus 로고
    • A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes
    • De Cegli R, Romito A, Iacobacci S, Mao L, Lauria M, et al: A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes. Genome Biol 11:R64 (2010).
    • (2010) Genome Biol , vol.11
    • De Cegli, R.1    Romito, A.2    Iacobacci, S.3    Mao, L.4    Lauria, M.5
  • 19
    • 78650219403 scopus 로고    scopus 로고
    • Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome
    • De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, et al: Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome. Oncogene 29: 6102-6114 (2010).
    • (2010) Oncogene , vol.29 , pp. 6102-6114
    • De Vita, S.1    Canzonetta, C.2    Mulligan, C.3    Delom, F.4    Groet, J.5
  • 20
    • 55949096605 scopus 로고    scopus 로고
    • Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
    • Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R: Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci USA 105: 16719-16724 (2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16719-16724
    • Diaz-Rodriguez, E.1    Sotillo, R.2    Schvartzman, J.M.3    Benezra, R.4
  • 21
    • 67651036860 scopus 로고    scopus 로고
    • Aneuploidy: From a physiological mechanism of variance to Down syndrome
    • Dierssen M, Herault Y, Estivill X: Aneuploidy: From a physiological mechanism of variance to Down syndrome. Physiol Rev 89: 887-920 (2009).
    • (2009) Physiol Rev , vol.89 , pp. 887-920
    • Dierssen, M.1    Herault, Y.2    Estivill, X.3
  • 25
    • 0035949485 scopus 로고    scopus 로고
    • Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy
    • DOI 10.1073/pnas.201398998
    • Duesberg P, Stindl R, Hehlmann R: Origin of multidrug resistance in cells with and without multidrug resistance genes: Chromosome reassortments catalyzed by aneuploidy. Proc Natl Acad Sci USA 98: 11283-11288 (2001). (Pubitemid 32928720)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.20 , pp. 11283-11288
    • Duesberg, P.1    Stindl, R.2    Hehlmann, R.3
  • 27
    • 34447546660 scopus 로고    scopus 로고
    • The distribution of fitness effects of new mutations
    • DOI 10.1038/nrg2146, PII NRG2146
    • Eyre-Walker A, Keightley PD: The distribution of fitness effects of new mutations. Nat Rev Genet 8: 610-618 (2007). (Pubitemid 47077280)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.8 , pp. 610-618
    • Eyre-Walker, A.1    Keightley, P.D.2
  • 28
    • 80052563657 scopus 로고    scopus 로고
    • Stress alters rates and types of loss of heterozygosity in Candida albicans
    • 2011
    • Forche A, Abbey D, Pisithkul T, Weinzierl MA, Ringstrom T, et al: Stress alters rates and types of loss of heterozygosity in Candida albicans . MBio 2011;2:e00129-11 (2011).
    • (2011) MBio , vol.2
    • Forche, A.1    Abbey, D.2    Pisithkul, T.3    Weinzierl, M.A.4    Ringstrom, T.5
  • 29
  • 30
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D: A mechanism linking extra centrosomes to chromosomal instability. Nature 460: 278-282 (2009).
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 31
    • 63149148209 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition
    • Ganmore I, Smooha G, Izraeli S: Constitutional aneuploidy and cancer predisposition. Hum Mol Genet 18:R84-R93 (2009).
    • (2009) Hum Mol Genet , vol.18
    • Ganmore, I.1    Smooha, G.2    Izraeli, S.3
  • 33
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon DJ, Resio B, Pellman D: Causes and consequences of aneuploidy in cancer. Nat Rev Genet 13: 189-203 (2012).
    • (2012) Nat Rev Genet , vol.13 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 34
    • 58149166731 scopus 로고    scopus 로고
    • The repertoire and dynamics of evolutionary adaptations to controlled nutrientlimited environments in yeast
    • Gresham D, Desai MM, Tucker CM, Jenq HT, Pai DA, et al: The repertoire and dynamics of evolutionary adaptations to controlled nutrientlimited environments in yeast. PLoS Genet 4:e1000303 (2008).
    • (2008) PLoS Genet , vol.4
    • Gresham, D.1    Desai, M.M.2    Tucker, C.M.3    Jenq, H.T.4    Pai, D.A.5
  • 36
    • 0342905433 scopus 로고    scopus 로고
    • Risks of leukaemia and solid tumours in individuals with Down's syndrome
    • Hasle H, Clemmensen IH, Mikkelsen M: Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 355: 165-169 (2000). (Pubitemid 30068214)
    • (2000) Lancet , vol.355 , Issue.9199 , pp. 165-169
    • Hasle, H.1    Clemmensen, I.H.2    Mikkelsen, M.3
  • 37
    • 0035319804 scopus 로고    scopus 로고
    • To err (meiotically) is human: The genesis of human aneuploidy
    • DOI 10.1038/35066065
    • Hassold T, Hunt P: To err (meiotically) is human: The genesis of human aneuploidy. Nat Rev Genet 2: 280-291 (2001). (Pubitemid 33674776)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.4 , pp. 280-291
    • Hassold, T.1    Hunt, P.2
  • 38
    • 38449087657 scopus 로고    scopus 로고
    • The origin of human aneuploidy: Where we have been, where we are going
    • Spec No. 2
    • Hassold T, Hall H, Hunt P: The origin of human aneuploidy: Where we have been, where we are going. Hum Mol Genet 16; Spec No. 2:R203-R208 (2007).
    • (2007) Hum Mol Genet , vol.16
    • Hassold, T.1    Hall, H.2    Hunt, P.3
  • 39
    • 16844381577 scopus 로고    scopus 로고
    • A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities
    • DOI 10.1158/0008-5472.CAN-05-0002
    • Hida K, Klagsbrun M: A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities. Cancer Res 65: 2507-2510 (2005). (Pubitemid 40490041)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2507-2510
    • Hida, K.1    Klagsbrun, M.2
  • 40
    • 80054915824 scopus 로고    scopus 로고
    • Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from aids patients
    • Hu G, Wang J, Choi J, Jung WH, Liu I, et al: Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from aids patients. BMC Genomics 12: 526 (2011).
    • (2011) BMC Genomics , vol.12 , pp. 526
    • Hu, G.1    Wang, J.2    Choi, J.3    Jung, W.H.4    Liu, I.5
  • 42
    • 26444449908 scopus 로고    scopus 로고
    • Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy
    • Ikui AE, Yang CP, Matsumoto T, Horwitz SB: Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle 4: 1385-1388 (2005). (Pubitemid 41437128)
    • (2005) Cell Cycle , vol.4 , Issue.10 , pp. 1385-1388
    • Ikui, A.E.1    Chia-Ping, H.Y.2    Matsumoto, T.3    Horwitz, S.B.4
  • 43
    • 80053364894 scopus 로고    scopus 로고
    • Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    • Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH: Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 333: 1895-1898 (2011).
    • (2011) Science , vol.333 , pp. 1895-1898
    • Janssen, A.1    Van Der Burg, M.2    Szuhai, K.3    Kops, G.J.4    Medema, R.H.5
  • 45
    • 40049093400 scopus 로고    scopus 로고
    • Meiosis in oocytes: Predisposition to aneuploidy and its increased incidence with age
    • DOI 10.1093/humupd/dmm043
    • Jones KT: Meiosis in oocytes: Predisposition to aneuploidy and its increased incidence with age. Hum Reprod Update 14: 143-158 (2008). (Pubitemid 351321109)
    • (2008) Human Reproduction Update , vol.14 , Issue.2 , pp. 143-158
    • Jones, K.T.1
  • 48
    • 63249133197 scopus 로고    scopus 로고
    • Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum
    • Leprohon P, Legare D, Raymond F, Madore E, Hardiman G, et al: Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum . Nucleic Acids Res 37: 1387-1399 (2009).
    • (2009) Nucleic Acids Res , vol.37 , pp. 1387-1399
    • Leprohon, P.1    Legare, D.2    Raymond, F.3    Madore, E.4    Hardiman, G.5
  • 50
    • 84865172945 scopus 로고    scopus 로고
    • Adaptive mechanisms in pathogens: Universal aneuploidy in Leishmania
    • Mannaert A, Downing T, Imamura H, Dujardin J-C: Adaptive mechanisms in pathogens: Universal aneuploidy in Leishmania . Trends Parasitol 8: 370-376 (2012).
    • (2012) Trends Parasitol , vol.8 , pp. 370-376
    • Mannaert, A.1    Downing, T.2    Imamura, H.3    Dujardin, J.-C.4
  • 51
    • 0037403505 scopus 로고    scopus 로고
    • Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain
    • DOI 10.1016/S0888-7543(03)00035-1
    • Mao R, Zielke CL, Zielke HR, Pevsner J: Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain. Genomics 81: 457-467 (2003). (Pubitemid 36437522)
    • (2003) Genomics , vol.81 , Issue.5 , pp. 457-467
    • Mao, R.1    Zielke, C.L.2    Zielke, H.R.3    Pevsner, J.4
  • 53
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ: Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286: 971-974 (1999).
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1    Kapoor, T.M.2    Haggarty, S.J.3    King, R.W.4    Schreiber, S.L.5    Mitchison, T.J.6
  • 55
    • 34247333444 scopus 로고    scopus 로고
    • The spindle-assembly checkpoint in space and time
    • DOI 10.1038/nrm2163, PII NRM2163
    • Musacchio A, Salmon ED: The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8: 379-393 (2007). (Pubitemid 46643240)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 379-393
    • Musacchio, A.1    Salmon, E.D.2
  • 56
    • 77952978963 scopus 로고    scopus 로고
    • Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    • Ng AP, Hyland CD, Metcalf D, Carmichael CL, Loughran SJ, et al: Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 115: 3966-3969 (2010).
    • (2010) Blood , vol.115 , pp. 3966-3969
    • Ng, A.P.1    Hyland, C.D.2    Metcalf, D.3    Carmichael, C.L.4    Loughran, S.J.5
  • 57
    • 80053011752 scopus 로고    scopus 로고
    • How mitotic errors contribute to karyotypic diversity in cancer
    • Nicholson JM, Cimini D: How mitotic errors contribute to karyotypic diversity in cancer. Adv Cancer Res 112: 43-75 (2011).
    • (2011) Adv Cancer Res , vol.112 , pp. 43-75
    • Nicholson, J.M.1    Cimini, D.2
  • 58
    • 35548954250 scopus 로고    scopus 로고
    • The evolutionary consequences of polyploidy
    • DOI 10.1016/j.cell.2007.10.022, PII S0092867407013402
    • Otto SP: The evolutionary consequences of polyploidy. Cell 131: 452-462 (2007). (Pubitemid 350007701)
    • (2007) Cell , vol.131 , Issue.3 , pp. 452-462
    • Otto, S.P.1
  • 59
    • 0034500239 scopus 로고    scopus 로고
    • Polyploid incidence and evolution
    • DOI 10.1146/annurev.genet.34.1.401
    • Otto SP, Whitton J: Polyploid incidence and evolution. Annu Rev Genet 34: 401-437 (2000). (Pubitemid 32065927)
    • (2000) Annual Review of Genetics , vol.34 , pp. 401-437
    • Otto, S.P.1    Whitton, J.2
  • 60
    • 0035140231 scopus 로고    scopus 로고
    • Detection of trisomy 8 in Philadelphia chromosome-positive CML patients using conventional cytogenetic and interphase fluorescence in situ hybridization techniques and its relation to c-myc involvement
    • Oudat R, Khan Z, Glassman AB: Detection of trisomy 8 in Philadelphia chromosome-positive CML patients using conventional cytogenetic and interphase fluorescence in situ hybridization techniques and its relation to c-myc involvement. Ann Clin Lab Sci 31: 68-74 (2001). (Pubitemid 32097213)
    • (2001) Annals of Clinical and Laboratory Science , vol.31 , Issue.1 , pp. 68-74
    • Oudat, R.1    Khan, Z.2    Glassman, A.B.3
  • 62
    • 78649636162 scopus 로고    scopus 로고
    • Dr Jekyll and Mr Hyde: Role of aneuploidy in cellular adaptation and cancer
    • Pavelka N, Rancati G, Li R: Dr Jekyll and Mr Hyde: Role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol 22: 809-815 (2010a).
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 809-815
    • Pavelka, N.1    Rancati, G.2    Li, R.3
  • 63
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • Pavelka N, Rancati G, Zhu J, Bradford WD, Saraf A, et al: Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature 468: 321-325 (2010b).
    • (2010) Nature , vol.468 , pp. 321-325
    • Pavelka, N.1    Rancati, G.2    Zhu, J.3    Bradford, W.D.4    Saraf, A.5
  • 64
    • 84861880210 scopus 로고    scopus 로고
    • Chromosomal instability and aneuploidy in cancer: From yeast to man
    • Pfau SJ, Amon A: Chromosomal instability and aneuploidy in cancer: From yeast to man. EMBO Rep 13: 515-527 (2012).
    • (2012) EMBO Rep , vol.13 , pp. 515-527
    • Pfau, S.J.1    Amon, A.2
  • 66
    • 56349088536 scopus 로고    scopus 로고
    • Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor
    • Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, et al: Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell 135: 879-893 (2008).
    • (2008) Cell , vol.135 , pp. 879-893
    • Rancati, G.1    Pavelka, N.2    Fleharty, B.3    Noll, A.4    Trimble, R.5
  • 68
    • 83055181962 scopus 로고    scopus 로고
    • Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania
    • Rogers MB, Hilley JD, Dickens NJ, Wilkes J, Bates PA, et al: Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania . Genome Res 21: 2129-2142 (2011).
    • (2011) Genome Res , vol.21 , pp. 2129-2142
    • Rogers, M.B.1    Hilley, J.D.2    Dickens, N.J.3    Wilkes, J.4    Bates, P.A.5
  • 69
    • 33746506280 scopus 로고    scopus 로고
    • Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    • DOI 10.1126/science.1128242
    • Selmecki A, Forche A, Berman J: Aneuploidy and isochromosome formation in drug-resistant Candida albicans . Science 313: 367-370 (2006). (Pubitemid 44480964)
    • (2006) Science , vol.313 , Issue.5785 , pp. 367-370
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 70
    • 41749113291 scopus 로고    scopus 로고
    • An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    • DOI 10.1111/j.1365-2958.2008.06176.x
    • Selmecki A, Gerami-Nejad M, Paulson C, Forche A, Berman J: An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1 . Mol Microbiol 68: 624-641 (2008). (Pubitemid 351490182)
    • (2008) Molecular Microbiology , vol.68 , Issue.3 , pp. 624-641
    • Selmecki, A.1    Gerami-Nejad, M.2    Paulson, C.3    Forche, A.4    Berman, J.5
  • 71
    • 73449107205 scopus 로고    scopus 로고
    • Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
    • Selmecki AM, Dulmage K, Cowen LE, Anderson JB, Berman J: Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLoS Genet 5:e1000705 (2009).
    • (2009) PLoS Genet , vol.5
    • Selmecki, A.M.1    Dulmage, K.2    Cowen, L.E.3    Anderson, J.B.4    Berman, J.5
  • 72
    • 80054054260 scopus 로고    scopus 로고
    • The aneuploidy paradox: Costs and benefits of an incorrect karyotype
    • Sheltzer JM, Amon A: The aneuploidy paradox: Costs and benefits of an incorrect karyotype. Trends Genet 27: 446-453 (2011).
    • (2011) Trends Genet , vol.27 , pp. 446-453
    • Sheltzer, J.M.1    Amon, A.2
  • 75
    • 27144518175 scopus 로고    scopus 로고
    • Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
    • DOI 10.1038/nature03958, PII N03958
    • Shi Q, King RW: Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437: 1038-1042 (2005). (Pubitemid 41486986)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1038-1042
    • Shi, Q.1    King, R.W.2
  • 76
    • 68749084849 scopus 로고    scopus 로고
    • Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
    • Silkworth WT, Nardi IK, Scholl LM, Cimini D: Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS ONE 4:e6564 (2009).
    • (2009) PLoS ONE , vol.4
    • Silkworth, W.T.1    Nardi, I.K.2    Scholl, L.M.3    Cimini, D.4
  • 77
    • 77954047286 scopus 로고    scopus 로고
    • Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes
    • Sionov E, Lee H, Chang YC, Kwon-Chung KJ: Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog 6:e1000848 (2010).
    • (2010) PLoS Pathog , vol.6
    • Sionov, E.1    Lee, H.2    Chang, Y.C.3    Kwon-Chung, K.J.4
  • 78
    • 79957612407 scopus 로고    scopus 로고
    • Mutations in CEP57 cause mosaic variegated aneuploidy syndrome
    • Snape K, Hanks S, Ruark E, Barros-Nunez P, Elliott A, et al: Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. Nat Genet 43: 527-529 (2011).
    • (2011) Nat Genet , vol.43 , pp. 527-529
    • Snape, K.1    Hanks, S.2    Ruark, E.3    Barros-Nunez, P.4    Elliott, A.5
  • 79
    • 80051874823 scopus 로고    scopus 로고
    • Mutational inactivation of STAG2 causes aneuploidy in human cancer
    • Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, et al: Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 333: 1039-1043 (2011).
    • (2011) Science , vol.333 , pp. 1039-1043
    • Solomon, D.A.1    Kim, T.2    Diaz-Martinez, L.A.3    Fair, J.4    Elkahloun, A.G.5
  • 80
    • 77952254077 scopus 로고    scopus 로고
    • A general lack of compensation for gene dosage in yeast
    • Springer M, Weissman JS, Kirschner MW: A general lack of compensation for gene dosage in yeast. Mol Syst Biol 6: 368 (2010).
    • (2010) Mol Syst Biol , vol.6 , pp. 368
    • Springer, M.1    Weissman, J.S.2    Kirschner, M.W.3
  • 81
    • 78149464968 scopus 로고    scopus 로고
    • Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae
    • St Charles J, Hamilton ML, Petes TD: Meiotic chromosome segregation in triploid strains of Saccharomyces cerevisiae . Genetics 186: 537-550 (2010).
    • (2010) Genetics , vol.186 , pp. 537-550
    • St Charles, J.1    Hamilton, M.L.2    Petes, T.D.3
  • 82
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, et al: Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144: 27-40 (2011).
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1    Greenman, C.D.2    Fu, B.3    Yang, F.4    Bignell, G.R.5
  • 83
    • 84868290476 scopus 로고    scopus 로고
    • Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
    • Stingele S, Stoehr G, Peplowska K, Cox J, Mann M, Storchova Z: Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. Mol Syst Biol 8: 608 (2012).
    • (2012) Mol Syst Biol , vol.8 , pp. 608
    • Stingele, S.1    Stoehr, G.2    Peplowska, K.3    Cox, J.4    Mann, M.5    Storchova, Z.6
  • 84
    • 59349098193 scopus 로고    scopus 로고
    • The consequences of tetraploidy and aneuploidy
    • Storchova Z, Kuffer C: The consequences of tetraploidy and aneuploidy. J Cell Sci 121: 3859-3866 (2008).
    • (2008) J Cell Sci , vol.121 , pp. 3859-3866
    • Storchova, Z.1    Kuffer, C.2
  • 85
    • 0347762556 scopus 로고    scopus 로고
    • From polyploidy to aneuploidy, genome instability and cancer
    • DOI 10.1038/nrm1276
    • Storchova Z, Pellman D: From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 5: 45-54 (2004). (Pubitemid 38089840)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.1 , pp. 45-54
    • Storchova, Z.1    Pellman, D.2
  • 87
    • 38049069895 scopus 로고    scopus 로고
    • Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome
    • Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH: Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451: 73-75 (2008).
    • (2008) Nature , vol.451 , pp. 73-75
    • Sussan, T.E.1    Yang, A.2    Li, F.3    Ostrowski, M.C.4    Reeves, R.H.5
  • 88
    • 81055141515 scopus 로고    scopus 로고
    • Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors
    • Thompson SL, Compton DA: Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors. Proc Natl Acad Sci USA 108: 17974-17978 (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17974-17978
    • Thompson, S.L.1    Compton, D.A.2
  • 90
    • 34548131710 scopus 로고    scopus 로고
    • Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    • DOI 10.1126/science.1142210
    • Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, et al: Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317: 916-924 (2007). (Pubitemid 47301313)
    • (2007) Science , vol.317 , Issue.5840 , pp. 916-924
    • Torres, E.M.1    Sokolsky, T.2    Tucker, C.M.3    Chan, L.Y.4    Boselli, M.5    Dunham, M.J.6    Amon, A.7
  • 91
    • 49849103726 scopus 로고    scopus 로고
    • Aneuploidy: Cells losing their balance
    • Torres EM, Williams BR, Amon A: Aneuploidy: Cells losing their balance. Genetics 179: 737-746 (2008).
    • (2008) Genetics , vol.179 , pp. 737-746
    • Torres, E.M.1    Williams, B.R.2    Amon, A.3
  • 93
    • 49049118494 scopus 로고    scopus 로고
    • Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy
    • Ubeda JM, Legare D, Raymond F, Ouameur AA, Boisvert S, et al: Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy. Genome Biol 9:R115 (2008).
    • (2008) Genome Biol , vol.9
    • Ubeda, J.M.1    Legare, D.2    Raymond, F.3    Ouameur, A.A.4    Boisvert, S.5
  • 94
    • 4944234694 scopus 로고    scopus 로고
    • Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells
    • DOI 10.1158/0008-5472.CAN-04-0474
    • Upender MB, Habermann JK, McShane LM, Korn EL, Barrett JC, et al: Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res 64: 6941-6949 (2004). (Pubitemid 39331003)
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 6941-6949
    • Upender, M.B.1    Habermann, J.K.2    McShane, L.M.3    Korn, E.L.4    Barrett, J.C.5    Difilippantonio, M.J.6    Ried, T.7
  • 96
    • 0035900915 scopus 로고    scopus 로고
    • When theories collide: Experts develop different models for carcinogenesis
    • Webb T: When theories collide: Experts develop different models for carcinogenesis. J Natl Cancer Inst 93: 92-94 (2001). (Pubitemid 32111985)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.2 , pp. 92-94
    • Webb, T.1
  • 97
    • 55349112533 scopus 로고    scopus 로고
    • Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
    • Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, et al: Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322: 703-709 (2008).
    • (2008) Science , vol.322 , pp. 703-709
    • Williams, B.R.1    Prabhu, V.R.2    Hunter, K.E.3    Glazier, C.M.4    Whittaker, C.A.5
  • 98
    • 0035146128 scopus 로고    scopus 로고
    • The spindle: A dynamic assembly of microtubules and motors
    • DOI 10.1038/35050669
    • Wittmann T, Hyman A, Desai A: The spindle: A dynamic assembly of microtubules and motors. Nat Cell Biol 3:E28-E34 (2001). (Pubitemid 32114823)
    • (2001) Nature Cell Biology , vol.3 , Issue.1
    • Wittmann, T.1    Hyman, A.2    Desai, A.3
  • 99
    • 84863691442 scopus 로고    scopus 로고
    • Karyotypic determinants of chromosome instability in aneuploid budding yeast
    • Zhu J, Pavelka N, Bradford WD, Rancati G, Li R: Karyotypic determinants of chromosome instability in aneuploid budding yeast. PLoS Genet 8:e1002719 (2012).
    • (2012) PLoS Genet , vol.8
    • Zhu, J.1    Pavelka, N.2    Bradford, W.D.3    Rancati, G.4    Li, R.5


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