Phyllanthus suppresses prostate cancer cell, PC-3, proliferation and induces apoptosis through multiple signalling pathways (MAPKs, PI3K/Akt, NF B, and Hypoxia)

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Tang, Yin Quan ^a   Jaganath, Indubala ^b   Manikam, Rishya ^c   Sekaran, Shamala Devi ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b MALAYSIAN AGRICULTURAL RESEARCH AND DEVELOPMENT INSTITUTE MARDI   (Malaysia)

^c UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHYLLANTHUS NIRURI EXTRACT; PHYLLANTHUS URINARIA EXTRACT; PHYLLANTHUS WATSONII EXTRACT; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P52; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER THERAPY; CARCINOGENESIS; CELL ADHESION; CELL PROLIFERATION; ENERGY METABOLISM; GEL ELECTROPHORESIS; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; MALE; MASS SPECTROMETRY; METASTASIS; NONHUMAN; ONCOGENE RAS; PHYLLANTHUS; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEOMICS; WESTERN BLOTTING;

EID: 84877312967     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/609581     Document Type: Article

References (53)

1. Jemal A., Bray F., Center M. M., Ferlay J., Ward E., Forman D., Global cancer statistics. CA: Cancer Journal for Clinicians 2011 61 2 69 90 2-s2.0-79952232216 10.3322/caac.20107
2. Seo Y., Franc B. L., Hawkins R. A., Wong K. H., Hasegawa B. H., Progress in SPECT/CT imaging of prostate cancer. Technology in Cancer Research and Treatment 2006 5 4 329 336 2-s2.0-33748036069 (Pubitemid 44300248)
3. Coleman R. E., Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treatment Reviews 2001 27 3 165 176 2-s2.0-0035010803 10.1053/ctrv.2000.0210 (Pubitemid 32452017)
4. Garnero P., Buchs N., Zekri J., Rizzoli R., Coleman R. E., Delmas P. D., Markers of bone turnover for the management of patients with bone metastases from prostate cancer. The British Journal of Cancer 2000 82 4 858 864 2-s2.0-0033962103 (Pubitemid 30085239)
5. Hanahan D., Weinberg R. A., Hallmarks of cancer: the next generation. Cell 2011 144 5 646 674 2-s2.0-79952284127 10.1016/j.cell.2011.02.013
6. Anagnostopoulos K., Tentes I., Kortsaris A. H., Cell signaling in cancer. Journal of Balkan Union of Oncology 2008 13 1 17 22 2-s2.0-41549149118 (Pubitemid 351460871)
7. Dhillon A. S., Hagan S., Rath O., Kolch W., MAP kinase signalling pathways in cancer. Oncogene 2007 26 22 3279 3290 2-s2.0-34248583886 10.1038/sj.onc.1210421 (Pubitemid 46763021)
8. Tang Y. Q., Jaganath I. B., Sekaran S. D., Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PloS ONE 2010 5 9 e12644 2-s2.0-79952278556
9. Oh A. S., Lorant L. A., Holloway J. N., Miller D. L., Kern F. G., El-Ashry D., Hyperactivation of MAPK induces loss of ER α expression in breast cancer cells. Molecular Endocrinology 2001 15 8 1344 1359 2-s2.0-0034899503 10.1210/me.15.8.1344 (Pubitemid 32703482)
10. Barault L., Veyrie N., Jooste V., Lecorre D., Chapusot C., Ferraz J. M., Lièvre A., Cortet M., Bouvier A. M., Rat P., Roignot P., Faivre J., Laurent-Puig P., Piard F., Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. International Journal of Cancer 2008 122 10 2255 2259 2-s2.0-42149083899 10.1002/ijc.23388 (Pubitemid 351542328)
11. Fecher L. A., Amaravadi R. K., Flaherty K. T., The MAPK pathway in melanoma. Current Opinion in Oncology 2008 20 2 183 189 2-s2.0-39849108181 10.1097/CCO.0b013e3282f5271c (Pubitemid 351317406)
12. Chen K. H., Weng M. S., Lin J. K., Tangeretin suppresses IL-1 β -induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochemical Pharmacology 2007 73 2 215 227 2-s2.0-33845225077 10.1016/j.bcp.2006.09.018 (Pubitemid 44855721)
13. Polakis P., The many ways of Wnt in cancer. Current Opinion in Genetics and Development 2007 17 1 45 51 2-s2.0-33846193290 10.1016/j.gde.2006.12.007 (Pubitemid 46109296)
14. Ahn K. S., Sethi G., Aggarwal B. B., Nuclear factor- B: from clone to clinic. Current Molecular Medicine 2007 7 7 619 637 2-s2.0-36749091741 10.2174/156652407782564363 (Pubitemid 350201663)
15. Majumder P. K., Sellers W. R., Akt-regulated pathways in prostate cancer. Oncogene 2005 24 50 7465 7474 2-s2.0-27844506524 10.1038/sj.onc.1209096 (Pubitemid 41637986)
16. Ziello J. E., Jovin I. S., Huang Y., Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale Journal of Biology and Medicine 2007 80 2 51 60 2-s2.0-38449121857
17. Lam W. Y., Leung K. T., Law P. T. W., Lee S. M. Y., Chan H. L. Y., Fung K. P., Ooi V. E. C., Waye M. M. Y., Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis. Journal of Cellular Biochemistry 2006 97 4 795 812 2-s2.0-33644994326 10.1002/jcb.20611
18. Del Barrio G., Parra F., Evaluation of the antiviral activity of an aqueous extract from Phyllanthus orbicularis. Journal of Ethnopharmacology 2000 72 1-2 317 322 2-s2.0-0034285010 10.1016/S0378-8741(00)00228-2
19. Doughari J. H., Sunday D., Antibacterial activity of Phyllanthus muellerianus. Pharmaceutical Biology 2008 46 6 400 405 2-s2.0-45849129483 10.1080/13880200802055842 (Pubitemid 351882314)
20. Ahmed B., Al-Howiriny T. A., Mathew R., Antihepatotoxic activity of Phyllanthus fraternus. Pharmazie 2002 57 12 855 856 2-s2.0-0036917765 (Pubitemid 36014623)
21. Huang S. T., Pang J. H. S., Yang R. C., Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms. Chang Gung Medical Journal 2010 33 5 477 487 2-s2.0-78249282258
22. Shoeb M., Anticancer agents from medicinal plants. Bangladesh Journal of Pharmacology 2006 1 2 35 41
23. Ho H. H., Chang C. S., Ho W. C., Liao S. Y., Wu C. H., Wang C. J., Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF- B activity and downregulation of PI3K/AKT/small GTPase signals. Food and Chemical Toxicology 2010 48 8-9 2508 2516 2-s2.0-77955056022 10.1016/j.fct.2010.06.024
24. Huang S. T., Yang R. C., Pang J. H. S., Aqueous extract of Phyllanthus urinaria induces apoptosis in human cancer cells. The American Journal of Chinese Medicine 2004 32 2 175 183 2-s2.0-3543001129 10.1142/S0192415X04001849 (Pubitemid 39011012)
25. Sun J., Liu R. H., Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells. Cancer letters 2006 241 1 124 134 2-s2.0-33845973448 10.1016/j.canlet.2005.10.027
26. Reed J. C., Dysregulation of apoptosis in cancer. Journal of Clinical Oncology 1999 17 9 2941 2953 2-s2.0-0032877668 (Pubitemid 29415256)
27. Roberts P. J., Der C. J., Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007 26 22 3291 3310 2-s2.0-34248591612 10.1038/sj.onc.1210422 (Pubitemid 46763022)
28. Hennessy B. T., Smith D. L., Ram P. T., Lu Y., Mills G. B., Exploiting the PI3K/AKT pathway for cancer drug discovery. Nature Reviews Drug Discovery 2005 4 12 988 1004 2-s2.0-32044466838 10.1038/nrd1902
29. Crowell J. A., Steele V. E., Fay J. R., Targeting the AKT protein kinase for cancer chemoprevention. Molecular Cancer Therapeutics 2007 6 8 2139 2148 2-s2.0-34548079500 10.1158/1535-7163.MCT-07-0120 (Pubitemid 47294742)
30. Vara J. Á. F., Casado E., de Castro J., Cejas P., Belda-Iniesta C., González-Barón M., P13K/Akt signalling pathway and cancer. Cancer Treatment Reviews 2004 30 2 193 204 2-s2.0-1642617693 10.1016/j.ctrv.2003.07.007 (Pubitemid 38418057)
31. Kane L. P., Shapiro V. S., Stokoe D., Weiss A., Induction of NF- B by the Akt/PKB kinase. Current Biology 1999 9 11 601 604 2-s2.0-0033519453 10.1016/S0960-9822(99)80265-6 (Pubitemid 29273109)
32. Polakis P., Wnt signaling and cancer. Genes and Development 2000 14 15 1837 1851 2-s2.0-0033895709 (Pubitemid 30639518)
33. Asada M., Yamada T., Ichijo H., Delia D., Miyazono K., Fukumuro K., Mizutani S., Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO Journal 1999 18 5 1223 1234 2-s2.0-0033104495 (Pubitemid 29110307)
34. Farina A. R., Cappabianca L., DeSantis G., Di Ianni N., Ruggeri P., Ragone M., Merolle S., Tonissen K. F., Gulino A., Mackay A. R., Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells. FEBS Letters 2011 585 20 3328 3336 10.1016/j.febslet.2011.09.023
35. Levine L., Lucci J. A., Pazdrak B., Cheng J. Z., Guo Y. S., Townsend C. M., Hellmich M. R., Bombesin stimulates nuclear factor B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Research 2003 63 13 3495 3502 2-s2.0-0038079838 (Pubitemid 36793027)
36. Aggarwal B. B., Nuclear factor- B: the enemy within. Cancer Cell 2004 6 3 203 208 2-s2.0-4544342570 10.1016/j.ccr.2004.09.003 (Pubitemid 39222032)
37. Heiden M. G. V., Cantley L. C., Thompson C. B., Understanding the warburg effect: the metabolic requirements of cell proliferation. Science 2009 324 5930 1029 1033 2-s2.0-66249108601 10.1126/science.1160809
38. Lu H., Forbes R. A., Verma A., Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. The Journal of Biological Chemistry 2002 277 26 23111 23115 2-s2.0-0037189542 10.1074/jbc.M202487200 (Pubitemid 34952134)
39. Poon E., Harris A. L., Ashcroft M., Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Reviews in Molecular Medicine 2009 11 1, article e26 2-s2.0-70350452792 10.1017/S1462399409001173
40. Kar G., Gursoy A., Keskin O., Human cancer protein-protein interaction network: a structural perspective. PLoS Computational Biology 2009 5 12 2-s2.0-74549134502 10.1371/journal.pcbi.1000601 e1000601
41. Paccione R. J., Miyazaki H., Patel V., Waseem A., Gutkind J. S., Zehner Z. E., Yeudall W. A., Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Molecular Cancer Therapeutics 2008 7 9 2894 2903 2-s2.0-54049148253 10.1158/1535-7163.MCT-08-0450
42. Satelli A., Li S., Vimentin in cancer and its potential as a molecular target for cancer therapy. Cellular and Molecular Life Sciences 2011 68 18 3033 3046 10.1007/s00018-011-0735-1
43. Tew K. D., Glutathione-associated enzymes in anticancer drug resistance. Cancer Research 1994 54 16 4313 4320 2-s2.0-0028106016 (Pubitemid 24273141)
44. Hayes J. D., Flanagan J. U., Jowsey I. R., Glutathione transferases. Annual Review of Pharmacology and Toxicology 2005 45 51 88 2-s2.0-12844268268 10.1146/annurev.pharmtox.45.120403.095857 (Pubitemid 40261798)
45. Michael M., Doherty M. M., Tumoral drug metabolism: overview and its implications for cancer therapy. Journal of Clinical Oncology 2005 23 1 205 229 2-s2.0-16644379769 10.1200/JCO.2005.02.120 (Pubitemid 41702640)
46. Wallace D. C., Mitochondrial diseases in man and mouse. Science 1999 283 5407 1482 1488 2-s2.0-0033525773 10.1126/science.283.5407.1482 (Pubitemid 29133350)
47. Hiller S., Garces R. G., Malia T. J., Orekhov V. Y., Colombini M., Wagner G., Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 2008 321 5893 1206 1210 2-s2.0-50649121583 10.1126/science.1161302
48. Yamagata H., Shimizu S., Nishida Y., Watanabe Y., Craigen W. J., Tsujimoto Y., Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax. Oncogene 2009 28 40 3563 3572 2-s2.0-70349973323 10.1038/onc.2009.213
49. Chacko A. D., Liberante F., Paul I., Longley D. B., Fennell D. A., Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8. BMC Cancer 2010 10 1, article 380 2-s2.0-77954682904 10.1186/1471-2407-10-380
50. 2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. The Journal of Biological Chemistry 1997 272 29 18232 18239 2-s2.0-0030610583 10.1074/jbc.272.29.18232 (Pubitemid 27306411)
51. Arnaudeau S., Frieden M., Nakamura K., Castelbou C., Michalak M., Demaurex N., Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. The Journal of Biological Chemistry 2002 277 48 46696 46705 2-s2.0-0037195869 10.1074/jbc.M202395200 (Pubitemid 35417671)
52. Sreedhar A. S., Csermely P., Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy-a comprehensive review. Pharmacology and Therapeutics 2004 101 3 227 257 2-s2.0-1542718628 10.1016/j.pharmthera.2003. 11.004 (Pubitemid 38340861)
53. Zhou H., Zhang Y., Fu Y., Chan L., Lee A. S., Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). The Journal of Biological Chemistry 2011 286 29 25687 25696 2-s2.0-79960400840 10.1074/jbc.M110.212944