Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells

FEBS Letters

Volumn 585, Issue 20, 2011, Pages 3328-3336

  Farina, Antonietta R ^a   Cappabianca, Lucia ^a   Desantis, Giuseppina ^a   Ianni, Natalia Di ^a   Ruggeri, Pierdomenico ^a   Ragone, Marzia ^a   Merolle, Stefania ^a   Tonissen, Kathryn F ^b   Gulino, Alberto ^c,d   MacKay, Andrew R ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b GRIFFITH UNIVERSITY   (Australia)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

Breast cancer; Invasion; Matrix metalloproteinase 9; MMP 9 TIMP 1 equilibrium; NF B; Thioredoxin

Indexed keywords

GELATINASE B; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN P50; SYNAPTOTAGMIN I; THIOREDOXIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL STRAIN MDA MB 231; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME REGULATION; EQUILIBRIUM CONSTANT; GENE OVEREXPRESSION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NF-KAPPA B P50 SUBUNIT; RESPONSE ELEMENTS; THIOREDOXINS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EID: 80054074183     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.09.023     Document Type: Article

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