Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

Molecular Pharmaceutics

Volumn 10, Issue 5, 2013, Pages 1874-1889

  Yeap, Yan Yan ^a   Trevaskis, Natalie L ^a   Quach, Tim ^a   Tso, Patrick ^b   Charman, William N ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

absorption; bile; cinnarizine; food effect; lipid based formulation; membrane permeability; micelles; poorly water soluble drug; supersaturation

Indexed keywords

CINNARIZINE; LIPID EMULSION; AZETIDINE DERIVATIVE; COLLOID; EZETIMIBE; LIPID; MICELLE; MONENSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; COLLOID; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DILUTION; DRUG ABSORPTION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG UPTAKE; GASTROINTESTINAL TRACT; LIPOPHILICITY; MALE; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILIZATION; THERMODYNAMICS; ADMINISTRATION AND DOSAGE; ANIMAL; BILE; BIOAVAILABILITY; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; MICELLE; ORAL DRUG ADMINISTRATION; PERMEABILITY; PHYSIOLOGY; SECRETION (PROCESS); SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; AZETIDINES; BILE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CINNARIZINE; COLLOIDS; EZETIMIBE; INTESTINAL ABSORPTION; LIPIDS; MALE; MICELLES; MODELS, BIOLOGICAL; MONENSIN; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; THERMODYNAMICS;

EID: 84877302171     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3006566     Document Type: Article

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