The solubility-permeability interplay when using cosolvents for solubilization: Revising the way we use solubility-enabling formulations

Molecular Pharmaceutics

Volumn 9, Issue 3, 2012, Pages 581-590

  Miller, Jonathan M ^a   Beig, Avital ^b   Carr, Robert A ^a   Webster, Gregory K ^a   Dahan, Arik ^b  

^a ABBOTT LABORATORIES   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

drug transport analysis; intestinal permeation; low solubility drugs; oral drug absorption; solubility permeability trade off

Indexed keywords

CYCLODEXTRIN; MACROGOL 400; PROGESTERONE; PROPYLENE GLYCOL; SOLVENT; SURFACTANT;

ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TRANSPORT; INTESTINE MUCOSA PERMEABILITY; MALE; MEMBRANE PERMEABILITY; MICELLIZATION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILIZATION; THERMODYNAMICS;

ANIMALS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; INTESTINAL ABSORPTION; MALE; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; PROGESTERONE; RATS; RATS, WISTAR; SOLUBILITY; SOLVENTS; VISCOSITY;

EID: 84863229573     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200460u     Document Type: Article

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