Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract

Advanced Drug Delivery Reviews

Volumn 25, Issue 1, 1997, Pages 3-14

  Horter D ^a   Dressman, J B ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Complexation; Dissolution; GI physiology; pK(a); Polymorphism; Solubilization; Wetting diffusivity

Indexed keywords

ABSORPTION; CHEMICAL REACTIONS; DISSOLUTION; DRUG DOSAGE; DRUG PRODUCTS; PH EFFECTS; PHYSIOLOGY; SOLUBILITY; SOLUTIONS; WETTING;

DRUG LIPOPHILICITY; GASTROINTESTINAL PHYSIOLOGY; NOYES WHITNEY DISSOLUTION MODEL; PHYSICOCHEMICAL PROPERTIES;

PHARMACOKINETICS;

BENZOIC ACID DERIVATIVE; BILE ACID; CHLORAMPHENICOL; CYCLODEXTRIN; DEXAMETHASONE; DIGOXIN; DIPYRIDAMOLE; FLUCONAZOLE; FUROSEMIDE; GEMFIBROZIL; GLUTETHIMIDE; GLYCEROL OLEATE; GRISEOFULVIN; HYDROCHLOROTHIAZIDE; INDOMETACIN; ITRACONAZOLE; KETOCONAZOLE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LONG CHAIN FATTY ACID; PARACETAMOL; PHOSPHATIDYLCHOLINE; STEROID; SURFACTANT; TAUROCHOLIC ACID; TRIACYLGLYCEROL; UNINDEXED DRUG;

COMPLEX FORMATION; DIFFUSION; DISSOCIATION CONSTANT; DISSOLUTION; DRUG ABSORPTION; DRUG DOSAGE FORM; DRUG SOLUBILITY; FOOD; GASTROINTESTINAL TRACT; HUMAN; HYDRODYNAMICS; LIPOPHILICITY; LIQUID; MODEL; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SOLID; VISCOSITY;

EID: 0038768850     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00487-5     Document Type: Review

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