A win-win solution in oral delivery of lipophilic drugs: Supersaturation via amorphous solid dispersions increases apparent solubility without sacrifice of intestinal membrane permeability

Molecular Pharmaceutics

Volumn 9, Issue 7, 2012, Pages 2009-2016

  Miller, Jonathan M ^a   Beig, Avital ^b   Carr, Robert A ^a   Spence, Julie K ^a   Dahan, Arik ^b  

^a ABBOTT LABORATORIES   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

amorphous solid dispersions; drug transport analysis; intestinal permeability; low solubility drugs; oral drug absorption; solubility permeability interplay

Indexed keywords

CYCLODEXTRIN; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; PROGESTERONE; SURFACTANT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; CELL MEMBRANE PERMEABILITY; CHEMISTRY, PHARMACEUTICAL; CYCLODEXTRINS; EXCIPIENTS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; INTESTINES; MALE; METHYLCELLULOSE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 84863301279     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300104s     Document Type: Article

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