A kinetic evaluation of the absorption, efflux, and metabolism of verapamil in the autoperfused rat jejunum

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 1, 2003, Pages 151-158

  Johnson, Brendan M ^a   Chen, Weiqing ^b,c   Borchardt, Ronald T ^b   Charman, William N ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF KANSAS   (United States)

^c PHARMACOPEIA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; GLYCOPROTEIN P; KETOCONAZOLE; MIDAZOLAM; VALSPODAR; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BINDING SITE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENZYME REGULATION; ENZYME SUBSTRATE; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE PERFUSION; JEJUNUM; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; VENOUS BLOOD;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM CHANNEL BLOCKERS; INTESTINAL ABSORPTION; JEJUNUM; KINETICS; MALE; MODELS, BIOLOGICAL; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

EID: 0037382055     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.045328     Document Type: Article

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