The solubility-permeability interplay: Mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1848-1856

  Miller, Jonathan M ^a   Beig, Avital ^b   Krieg, Brian J ^c   Carr, Robert A ^a   Borchardt, Thomas B ^a   Amidon, Gregory E ^c   Amidon, Gordon L ^c   Dahan, Arik ^b  

^a ABBOTT LABORATORIES   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

drug solubility; drug transport analysis; intestinal membrane permeability; intestinal permeation; low solubility drugs; oral drug absorption; progesterone; sodium lauryl sulfate; sodiumtaurocholate; solubility permeability trade off; surface active agents; surfactants

Indexed keywords

DODECYL SULFATE SODIUM; PROGESTERONE; SURFACTANT; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); DRUG DIFFUSION; DRUG SOLUBILITY; DRUG TRANSPORT; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; MATHEMATICAL MODEL; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MICELLE; NONHUMAN; PRIORITY JOURNAL; QUASI EQUILIBRIUM TRANSPORT MODEL; RAT; SOLUBILIZATION;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG COMPOUNDING; INTESTINAL ABSORPTION; JEJUNUM; MALE; MICELLES; MODELS, BIOLOGICAL; PERFUSION; PERMEABILITY; PHARMACEUTIC AIDS; PROGESTERONE; PROGESTINS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SODIUM DODECYL SULFATE; SOLUBILITY; SURFACE-ACTIVE AGENTS; TAUROCHOLIC ACID;

EID: 80053535563     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200181v     Document Type: Article

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