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Volumn 14, Issue 23, 2008, Pages 7878-7883

A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; BEVACIZUMAB; BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; GEFITINIB; LOPERAMIDE; PACLITAXEL; TAXANE DERIVATIVE; TETRACYCLINE; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; QUINAZOLINE DERIVATIVE;

EID: 59449097074     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-0141     Document Type: Article
Times cited : (111)

References (49)
  • 1
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3:391 -400.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 2
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L,Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 3
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 4
    • 0042343801 scopus 로고    scopus 로고
    • Arandomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC,Haworth L, Sherry RM,et al. Arandomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-34.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 5
    • 23844485828 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): A Gynecologic Oncology Group (GOG) study
    • 457s
    • Burger RA SM, Monk BJ, Greer B, Sorosky J. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): A Gynecologic Oncology Group (GOG) study. J Clin Oncol 2005;23:457s.
    • (2005) J Clin Oncol , vol.23
    • Burger, R.S.1    Monk, B.J.2    Greer, B.3    Sorosky, J.4
  • 6
    • 0242468884 scopus 로고    scopus 로고
    • A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
    • Cobleigh MA, Langmuir VK, Sledge GW, et al. A phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin Oncol 2003;30:117-24.
    • (2003) Semin Oncol , vol.30 , pp. 117-124
    • Cobleigh, M.A.1    Langmuir, V.K.2    Sledge, G.W.3
  • 7
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plusbevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plusbevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357:2666-76.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 9
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plusadjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plusadjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673-84.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 10
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plusa monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plusa monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 11
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21:2787-99.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 12
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, RodriguesPereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    RodriguesPereira, J.2    Ciuleanu, T.3
  • 13
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutationsin the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutationsin the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 14
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutationsare common in lung cancers from never smokers and areassociated with sensitivity of tumors to gefitinib and erlotinib
    • PaoW, MillerV, Zakowski M,et al. EGF receptor gene mutationsare common in lung cancers from never smokers and areassociated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 15
    • 12444299509 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemistry (EGFR IHC): Assay selection and application to breast cancers
    • Eberhard DA, Huntzicker E, Anderson S. Epidermal growth factor receptor immunohistochemistry (EGFR IHC): assay selection and application to breast cancers. Proc Am Soc Clin Oncol 2002;21:448a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Eberhard, D.A.1    Huntzicker, E.2    Anderson, S.3
  • 16
    • 0036164390 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
    • Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer ResTreat 2002;71:67-75.
    • (2002) Breast Cancer ResTreat , vol.71 , pp. 67-75
    • Tsutsui, S.1    Ohno, S.2    Murakami, S.3    Hachitanda, Y.4    Oda, S.5
  • 17
    • 0042675500 scopus 로고    scopus 로고
    • Open-label phase II, multicenter trial of ZD1839 (Iressa) in patients with advanced breast cancer
    • Albain K, Elledge R, GradisharW, et al. Open-label phase II, multicenter trial of ZD1839 (Iressa) in patients with advanced breast cancer. Breast Cancer ResTreat 2002;76.
    • (2002) Breast Cancer ResTreat , pp. 76
    • Albain, K.1    Elledge, R.2    GradisharW3
  • 19
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase in hibitor leads to apoptosis of endothelial cells an dtherapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano CC, Harbison MT, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase in hibitor leads to apoptosis of endothelial cells an dtherapy of human pancreatic carcinoma. Cancer Res2000;60:2926-35.
    • Cancer Res2000;60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 20
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancercellsbyZD1839 (Iressa),a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, et al. Inhibition of growth factor production and angiogenesis in human cancercellsbyZD1839 (Iressa),a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res2001;7:1459-65.
    • Clin Cancer Res2001;7 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 21
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Ire-ssa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A, Ogawa S, Kometani T, et al. ZD1839 (Ire-ssa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res2002;62:2554-60.
    • Cancer Res2002;62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 22
    • 0036848820 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice
    • KedarD,BakerCH,KillionJJ,DinneyCP,Fidler IJ. Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 2002;8:3592-600.
    • (2002) Clin Cancer Res , vol.8 , pp. 3592-3600
    • Kedar, D.1    Baker, C.H.2    Killion, J.J.3    Dinney, C.P.4    Fidler, I.J.5
  • 23
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, MatsumotoT, Inoue K, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999;5:257-65.
    • (1999) Clin Cancer Res , vol.5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 24
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapieson the growth of gastric cancer in a nude mouse model
    • Jung YD, Mansfield PF, Akagi M, et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapieson the growth of gastric cancer in a nude mouse model. Eur J Cancer 2002;38:1133-40.
    • (2002) Eur J Cancer , vol.38 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3
  • 25
    • 0036847719 scopus 로고    scopus 로고
    • Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy
    • Li M, Ye C, Feng C, et al. Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy. Clin Cancer Res 2002;8:3570-8.
    • (2002) Clin Cancer Res , vol.8 , pp. 3570-3578
    • Li, M.1    Ye, C.2    Feng, C.3
  • 26
    • 30944452354 scopus 로고    scopus 로고
    • Hainsworth JD, Sosman JA, Spigel DR, Edwards DL, Baughman C, Greco A. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib.J Clin Oncol2005;23:7889-96.
    • Hainsworth JD, Sosman JA, Spigel DR, Edwards DL, Baughman C, Greco A. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib.J Clin Oncol2005;23:7889-96.
  • 27
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/ II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combinaion with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E, et al. Phase I/ II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combinaion with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:2544-55.
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 28
    • 34248995210 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and erlotinib in carcinomasof unknown primary site: The Minnie Pearl Cancer Research Network
    • Hainsworth JD, Spigel DR, Farley C,Thompson DS, Shipley DL, Greco FA. Phase II trial of bevacizumab and erlotinib in carcinomasof unknown primary site: The Minnie Pearl Cancer Research Network. J Clin Oncol 2007;25:1747-52.
    • (2007) J Clin Oncol , vol.25 , pp. 1747-1752
    • Hainsworth, J.D.1    Spigel, D.R.2    Farley, C.3    Thompson, D.S.4    Shipley, D.L.5    Greco, F.A.6
  • 29
    • 0034594628 scopus 로고    scopus 로고
    • New guidelinesto evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelinesto evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 30
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • Simon R. Optimal two-stage designs for phase II clinical trials. Control ClinTrials 1989;10:1 -10.
    • (1989) Control ClinTrials , vol.10 , pp. 1-10
    • Simon, R.1
  • 31
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • Baselga J, Albanell J, Ruiz A, et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J Clin Oncol 2005;23: 5323-33.
    • (2005) J Clin Oncol , vol.23 , pp. 5323-5333
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 32
    • 33749011681 scopus 로고    scopus 로고
    • A phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer
    • Modi S. A phase I study of cetuximab/paclitaxel in patients with advanced-stage breast cancer. Clin Breast Cancer 2006;7:270-7.
    • (2006) Clin Breast Cancer , vol.7 , pp. 270-277
    • Modi, S.1
  • 33
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer. N Engl J Med 2005; 353:1659-72.
    • (2005) N Engl J Med , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 34
    • 46449113024 scopus 로고    scopus 로고
    • Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
    • Gomez HL, Doval DC, Chavez MA, et al. Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 2008;26:2999-3005.
    • (2008) J Clin Oncol , vol.26 , pp. 2999-3005
    • Gomez, H.L.1    Doval, D.C.2    Chavez, M.A.3
  • 35
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-43.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 36
    • 18444362087 scopus 로고    scopus 로고
    • ECOG1100: A phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib ('Ire- ssa') in patients (pts) with HER2-overexpressing metastatic breast cancer (met br ca)
    • Arteaga CL, O'Neil A, Moulder SL, et al. ECOG1100: a phase I-II study of combined blockade of the erbB receptor network with trastuzmab and gefitinib ('Ire- ssa') in patients (pts) with HER2-overexpressing metastatic breast cancer (met br ca). Breast Cancer Res Treat 2004;88:S15-6.
    • (2004) Breast Cancer Res Treat , vol.88
    • Arteaga, C.L.1    O'Neil, A.2    Moulder, S.L.3
  • 37
    • 61349122221 scopus 로고    scopus 로고
    • neoadjuvant anastrozole alone or with gefitinib in early breast cancer: A phase II placebo-controlled trial (study 223) with biological and clinical outcomes
    • Smith IE, Walsh G, Skene A, et al. neoadjuvant anastrozole alone or with gefitinib in early breast cancer: a phase II placebo-controlled trial (study 223) with biological and clinical outcomes. J Clin Oncol 2007; 6578:2006-9.
    • (2007) J Clin Oncol , vol.6578 , pp. 2006-2009
    • Smith, I.E.1    Walsh, G.2    Skene, A.3
  • 38
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • SorlieT, Perou CM,Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 39
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004;10:5367-74.
    • (2004) Clin Cancer Res , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 40
    • 35248889408 scopus 로고    scopus 로고
    • EGFR associated expression profiles vary with breast tumor subtype
    • Hoadley KWV, Fan C, Sawyer L, et al. EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics2007;8:258.
    • BMC Genomics2007;8 , vol.258
    • Hoadley, K.W.V.1    Fan, C.2    Sawyer, L.3
  • 41
    • 61349152550 scopus 로고    scopus 로고
    • TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer
    • Carey L, Rugo H, Marcom P, et al. TBCRC 001: EGFR inhibition with cetuximab added to carboplatin in metastatic triple-negative (basal-like) breast cancer. J Clin Oncol 2008;26.
    • (2008) J Clin Oncol , pp. 26
    • Carey, L.1    Rugo, H.2    Marcom, P.3
  • 42
    • 35648938219 scopus 로고    scopus 로고
    • Randomized phase II Study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
    • Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II Study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007;25: 4536-41.
    • (2007) J Clin Oncol , vol.25 , pp. 4536-4541
    • Bukowski, R.M.1    Kabbinavar, F.F.2    Figlin, R.A.3
  • 43
    • 18244387980 scopus 로고    scopus 로고
    • A multicenter phaseII trial of ZD6474,avascular endothelial growth factor receptor-2 and epidermal growth factor recep- tor tyrosine kinase inhibitor,inpatients with previously treated metastatic breast cancer
    • Miller KD,Trigo JM, Wheeler C, et al. A multicenter phaseII trial of ZD6474,avascular endothelial growth factor receptor-2 and epidermal growth factor recep- tor tyrosine kinase inhibitor,inpatients with previously treated metastatic breast cancer. Clin Cancer Res 2005;11:3369-76.
    • (2005) Clin Cancer Res , vol.11 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3
  • 44
    • 2542539956 scopus 로고    scopus 로고
    • Rationale for biomarkers and surrogate end points in mechanismdriven oncology drug development
    • Park JW,KerbelRS, Kelloff GJ, et al.Rationale for biomarkers and surrogate end points in mechanismdriven oncology drug development. Clin Cancer Res 2004;10:3885-96.
    • (2004) Clin Cancer Res , vol.10 , pp. 3885-3896
    • Park, J.W.1    Kerbel, R.S.2    Kelloff, G.J.3
  • 45
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in meta- static breast cancer
    • CristofanilliM,Budd GT, Ellis MJ,et al. Circulating tumor cells, disease progression, and survival in meta- static breast cancer. N Engl J Med 2004;351:781-91.
    • (2004) N Engl J Med , vol.351 , pp. 781-791
    • CristofanilliM1    Budd, G.T.2    Ellis, M.J.3
  • 46
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that theVEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, BoucherY, di Tomaso E, et al. Direct evidence that theVEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004;10:145-7.
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    BoucherY2    di Tomaso, E.3
  • 47
    • 33144461478 scopus 로고    scopus 로고
    • Change in circulating endothelial cells(CEC) and tumor cells (CTC) in patients receiving bevacizumab and erloti- nib for metastatic breast cancer predicts stable disease at first evaluation
    • Rugo H, Dickler M, Scott J, et al. Change in circulating endothelial cells(CEC) and tumor cells (CTC) in patients receiving bevacizumab and erloti- nib for metastatic breast cancer predicts stable disease at first evaluation. Proc Am Soc Clin Oncol 2005;23.
    • (2005) Proc Am Soc Clin Oncol , pp. 23
    • Rugo, H.1    Dickler, M.2    Scott, J.3
  • 48
    • 12144291334 scopus 로고    scopus 로고
    • Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
    • Konecny GE, MengYG, Untch M, et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004;10: 1706-16.
    • (2004) Clin Cancer Res , vol.10 , pp. 1706-1716
    • Konecny, G.E.1    Meng, Y.G.2    Untch, M.3
  • 49
    • 21044443432 scopus 로고    scopus 로고
    • Phase I combined biological therapy of breast cancer using two humanized monoclonal antibioties directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF)
    • Pegram MD,Yeon C, Ku NC, GaudreaultJ, Slamon DJ. Phase I combined biological therapy of breast cancer using two humanized monoclonal antibioties directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2004;88:S124.
    • (2004) Breast Cancer Res Treat , vol.88
    • Pegram, M.D.1    Yeon, C.2    Ku, N.C.3    Gaudreault, J.4    Slamon, D.J.5


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