메뉴 건너뛰기




Volumn 5, Issue 4, 2009, Pages 421-432

Current status of cediranib: The rapid development of a novel anti-angiogenic therapy

Author keywords

Angiogenesis; AZD2171; Cancer; Cediranib; Recentin

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTHRACYCLINE; BEVACIZUMAB; CALCIUM CHANNEL BLOCKING AGENT; CARBOPLATIN; CEDIRANIB; CISPLATIN; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DOCETAXEL; DOXORUBICIN; FIBROBLAST GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; FULVESTRANT; GEFITINIB; GEMCITABINE; IMATINIB; OXALIPLATIN; PACLITAXEL; PLACEBO; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SORAFENIB; SUNITINIB; TAMOXIFEN; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; 4 ((4 FLUORO 2 METHYL 1H INDOL 5 YL)OXY) 6 METHOXY 7 (3 (PYRROLIDIN 1 YL)PROPOXY)QUINAZOLINE; 4-((4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY)-6-METHOXY-7-(3-(PYRROLIDIN-1-YL)PROPOXY)QUINAZOLINE; QUINAZOLINE DERIVATIVE; VASCULOTROPIN A;

EID: 67651242368     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.09.18     Document Type: Article
Times cited : (41)

References (69)
  • 1
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF et al.: AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65(10), 4389-4400 (2005).
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 3
    • 0033556287 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
    • Meyer M, Clauss M, Lepple-Wienhues A et al.: A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 18(2), 363-374 (1999).
    • (1999) EMBO J , vol.18 , Issue.2 , pp. 363-374
    • Meyer, M.1    Clauss, M.2    Lepple-Wienhues, A.3
  • 4
    • 0035793623 scopus 로고    scopus 로고
    • Analysis of biological effects and signalling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
    • Gille H, Kowalski J, Li B et al. Analysis of biological effects and signalling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J. Biol. Chem. 276, 3222-3230 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 3222-3230
    • Gille, H.1    Kowalski, J.2    Li, B.3
  • 6
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285(21), 1182-1186 (1971).
    • (1971) N. Engl. J. Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 49649083397 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
    • Heckman CA, Holopainen T, Wirzenius M et al.: The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. Cancer Res. 68(12), 4754-4762 (2008).
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4754-4762
    • Heckman, C.A.1    Holopainen, T.2    Wirzenius, M.3
  • 8
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N: Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9(Suppl. 1), 2-10 (2004).
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 9
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N et al.: VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl Acad. Sci. USA 99(17), 11393-11398 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 10
    • 0036718947 scopus 로고    scopus 로고
    • Small molecule inhibitors of KDR (VEGFR-2) kinase: An overview of structure activity relationships
    • Boyer SJ: Small molecule inhibitors of KDR (VEGFR-2) kinase: an overview of structure activity relationships. Curr. Top Med. Chem. 2(9), 973-1000 (2002).
    • (2002) Curr. Top Med. Chem , vol.2 , Issue.9 , pp. 973-1000
    • Boyer, S.J.1
  • 11
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W et al.: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 23, 2335-2342 (2004).
    • (2004) N. Engl. J. Med , vol.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 12
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ et al.: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 25(12), 1539-1544 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 13
    • 77249164947 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC et al.: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 356(3), 318 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.3 , pp. 318
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 14
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized Phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E et al.: Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized Phase III study. J. Clin. Oncol. 26(12), 2013-2019 (2008).
    • (2008) J. Clin. Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 15
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111, 1287-1295 (2003).
    • (2003) J. Clin. Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 16
    • 34548101663 scopus 로고    scopus 로고
    • Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts
    • Smith NR, James NH, Oakley I et al.: Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts. Mol. Cancer Ther. 6(8), 2198-2208 (2007).
    • (2007) Mol. Cancer Ther , vol.6 , Issue.8 , pp. 2198-2208
    • Smith, N.R.1    James, N.H.2    Oakley, I.3
  • 17
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program
    • Maris JM, Courtright J, Houghton PJ et al.: Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. Pediatr. Blood Cancer 50(3), 581-587 (2008).
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.3 , pp. 581-587
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 18
    • 18144413583 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling in tumorigenesis
    • Grose R, Dickson C: Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev. 16(2), 179-186 (2005)
    • (2005) Cytokine Growth Factor Rev , vol.16 , Issue.2 , pp. 179-186
    • Grose, R.1    Dickson, C.2
  • 19
    • 9544251380 scopus 로고    scopus 로고
    • Immunohistochemical detection of K-sam protein in stomach cancer
    • Hattori Y, Itoh H, Uchino S et al.: Immunohistochemical detection of K-sam protein in stomach cancer. Clin. Cancer Res. 2(8), 1373-1381 (1996).
    • (1996) Clin. Cancer Res , vol.2 , Issue.8 , pp. 1373-1381
    • Hattori, Y.1    Itoh, H.2    Uchino, S.3
  • 20
    • 9344222224 scopus 로고    scopus 로고
    • Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells
    • Moffa AB, Tannheimer SL ethier SP: Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells. Mol. Cancer Res. 2(11), 643-652 (2004).
    • (2004) Mol. Cancer Res , vol.2 , Issue.11 , pp. 643-652
    • Moffa, A.B.1    Tannheimer2    SL ethier, S.P.3
  • 21
    • 14844307601 scopus 로고    scopus 로고
    • Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer
    • Gowardhan B, Douglas DA, Mathers ME et al.: Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer. Br. J. Cancer 92(2), 320-327 (2005).
    • (2005) Br. J. Cancer , vol.92 , Issue.2 , pp. 320-327
    • Gowardhan, B.1    Douglas, D.A.2    Mathers, M.E.3
  • 22
    • 14244249958 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors as molecular targets in thyroid carcinoma
    • St Bernard R, Zheng L, Liu W et al.: Fibroblast growth factor receptors as molecular targets in thyroid carcinoma. Endocrinology 146(3), 1145-1153 (2005).
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1145-1153
    • St Bernard, R.1    Zheng, L.2    Liu, W.3
  • 23
    • 34249783442 scopus 로고    scopus 로고
    • AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
    • Takeda M, Arao T, Yokote H et al.: AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin. Cancer Res. 13(10), 3051-3057 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.10 , pp. 3051-3057
    • Takeda, M.1    Arao, T.2    Yokote, H.3
  • 25
    • 33745743631 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: Perspectives for medical, surgical and radiation oncology
    • Verhoef C, de Wilt JH, Verheul HM: Angiogenesis inhibitors: perspectives for medical, surgical and radiation oncology. Curr. Pharm. Des. 12(21), 2623-2630 (2006).
    • (2006) Curr. Pharm. Des , vol.12 , Issue.21 , pp. 2623-2630
    • Verhoef, C.1    de Wilt, J.H.2    Verheul, H.M.3
  • 26
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
    • (2008) N. Engl. J. Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 27
    • 33846181370 scopus 로고    scopus 로고
    • sunitinib versus interferon a in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al. sunitinib versus interferon a in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 28
    • 0026486664 scopus 로고
    • Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease
    • Teicher BA, Sotomayor EA, Huang ZD: Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease. Cancer Res. 52(23), 6702-6704 (1992).
    • (1992) Cancer Res , vol.52 , Issue.23 , pp. 6702-6704
    • Teicher, B.A.1    Sotomayor, E.A.2    Huang, Z.D.3
  • 29
    • 41149138113 scopus 로고    scopus 로고
    • Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
    • Jain R: Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer. Nat. Rev. Cancer 8, 309-316 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 309-316
    • Jain, R.1
  • 30
    • 34547666982 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor, AZD2171, inhibits vascular endothelial growth factor receptor signaling and growth of anaplastic thyroid cancer in an orthotopic nude mouse model
    • Gomez-Rivera F, Santillan-Gomez AA, Younes MN et al.: The tyrosine kinase inhibitor, AZD2171, inhibits vascular endothelial growth factor receptor signaling and growth of anaplastic thyroid cancer in an orthotopic nude mouse model. Clin. Cancer Res. 13(15 Pt 1), 4519-4527 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.15 PART 1 , pp. 4519-4527
    • Gomez-Rivera, F.1    Santillan-Gomez, A.A.2    Younes, M.N.3
  • 31
    • 34548331823 scopus 로고    scopus 로고
    • Targeted therapy in rectal cancer
    • Willett CG, Duda DG, Czito BG et al.: Targeted therapy in rectal cancer. Oncology 21(9), 1055-1065 (2007).
    • (2007) Oncology , vol.21 , Issue.9 , pp. 1055-1065
    • Willett, C.G.1    Duda, D.G.2    Czito, B.G.3
  • 32
    • 49549123352 scopus 로고    scopus 로고
    • Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition
    • Bozec A, Gros FX, Penault-Llorca F et al.: Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition. Eur. J. Cancer 44(13), 1922-1930 (2008).
    • (2008) Eur. J. Cancer , vol.44 , Issue.13 , pp. 1922-1930
    • Bozec, A.1    Gros, F.X.2    Penault-Llorca, F.3
  • 33
    • 41749109989 scopus 로고    scopus 로고
    • Challenges in combinational oncology studies
    • MacPherson IR, Cassidy J: Challenges in combinational oncology studies. Pharm. Med. 22, 85-97 (2008).
    • (2008) Pharm. Med , vol.22 , pp. 85-97
    • MacPherson, I.R.1    Cassidy, J.2
  • 34
    • 33847344281 scopus 로고    scopus 로고
    • Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: Pathophysiologic effects and therapeutic benefit
    • Williams KJ, Telfer BA, Shannon AM et al.: Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit. Mol. Cancer Ther. 6(2), 599-606 (2007).
    • (2007) Mol. Cancer Ther , vol.6 , Issue.2 , pp. 599-606
    • Williams, K.J.1    Telfer, B.A.2    Shannon, A.M.3
  • 35
    • 0035866771 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
    • Geng L, Donnelly E, McMahon G et al.: Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res. 61(6), 2413-2419 (2001).
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2413-2419
    • Geng, L.1    Donnelly, E.2    McMahon, G.3
  • 36
    • 0034214159 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer
    • Koukourakis MI, Giatromanolaki A, Thorpe PE et al.: Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer. Cancer Res. 60(11), 3088-3095 (2000).
    • (2000) Cancer Res , vol.60 , Issue.11 , pp. 3088-3095
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Thorpe, P.E.3
  • 37
    • 33845780061 scopus 로고    scopus 로고
    • Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer
    • Cao C, Albert JM, Geng L et al.: Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer. Cancer Res. 66(23), 11409-11415 (2006).
    • (2006) Cancer Res , vol.66 , Issue.23 , pp. 11409-11415
    • Cao, C.1    Albert, J.M.2    Geng, L.3
  • 38
    • 34347333556 scopus 로고    scopus 로고
    • Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: Antitumour supra-additive effects on human head and neck cancer xenografts
    • Bozec A, Formento P, Lassalle S, Lippens C, Hofman P, Milano G: Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts. Br. J. Cancer 97(1), 65-72 (2007).
    • (2007) Br. J. Cancer , vol.97 , Issue.1 , pp. 65-72
    • Bozec, A.1    Formento, P.2    Lassalle, S.3    Lippens, C.4    Hofman, P.5    Milano, G.6
  • 39
    • 34547681379 scopus 로고    scopus 로고
    • Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors
    • Drevs J, Siegert P, Medinger M et al.: Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 25(21), 2993-2995 (2007).
    • (2007) J. Clin. Oncol , vol.25 , Issue.21 , pp. 2993-2995
    • Drevs, J.1    Siegert, P.2    Medinger, M.3
  • 40
    • 69849098527 scopus 로고    scopus 로고
    • Manegold C, von Pawel J, Zatloukal P et al.: Randomised, double-blind multicentre Phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J. Clin. Oncol. (Meeting Abstracts). 25(Suppl. 18) (2007).
    • Manegold C, von Pawel J, Zatloukal P et al.: Randomised, double-blind multicentre Phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J. Clin. Oncol. (Meeting Abstracts). 25(Suppl. 18) (2007).
  • 41
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A et al.: Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J. Clin. Oncol. 26(11), 1871-1878 (2008).
    • (2008) J. Clin. Oncol , vol.26 , Issue.11 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 42
    • 69849093189 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group
    • Goss G, Shepherd FA, Laurie S et al.: A Phase I and pharmacokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group. Eur. J. Cancer 25, 7649 (2008).
    • (2008) Eur. J. Cancer , vol.25 , pp. 7649
    • Goss, G.1    Shepherd, F.A.2    Laurie, S.3
  • 43
    • 69849090930 scopus 로고    scopus 로고
    • National Cancer Institute of Canada Clinical Trials Group Study Br.24, A randomized placebo controlled Phase II trial of Cediranib (Ced) plus carboplatin¶clitaxel (C_P) in advanced non-small cell lung cancer of any histology: Further analyses
    • S
    • Laurie SA, Arnold A, Shepherd FA et al.: National Cancer Institute of Canada Clinical Trials Group Study Br.24, A randomized placebo controlled Phase II trial of Cediranib (Ced) plus carboplatin¶clitaxel (C_P) in advanced non-small cell lung cancer of any histology: further analyses. J. Thoracic Oncology 3(11), S304 (2008).
    • (2008) J. Thoracic Oncology , vol.3 , Issue.11 , pp. 304
    • Laurie, S.A.1    Arnold, A.2    Shepherd, F.A.3
  • 44
    • 69849098312 scopus 로고    scopus 로고
    • Laurie SA, Arnold A, Shepherd FA et al.: Randomised double-blind Phase II trial of carboplatin + paclitaxel (C+P) with either daily oral cediranib, an inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, or placebo, in advanced non-small cell lung cancer (NSCLC): A study of the National Cancer Institute of Canada Clinical Trials Group. Ann. Oncol. 19 (Suppl. 8), viii90 (2008).
    • Laurie SA, Arnold A, Shepherd FA et al.: Randomised double-blind Phase II trial of carboplatin + paclitaxel (C+P) with either daily oral cediranib, an inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases, or placebo, in advanced non-small cell lung cancer (NSCLC): A study of the National Cancer Institute of Canada Clinical Trials Group. Ann. Oncol. 19 (Suppl. 8), viii90 (2008).
  • 45
    • 2942657615 scopus 로고    scopus 로고
    • Randomized Phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF et al.: Randomized Phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 22(11), 2184-2191 (2004).
    • (2004) J. Clin. Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 46
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J et al.: Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357(26), 2666-2676 (2007).
    • (2007) N. Engl. J. Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 47
    • 31544436073 scopus 로고    scopus 로고
    • A physiologic imaging pilot study of breast cancer treated with AZD2171
    • Miller KD, Miller M, Mehrotra S et al.: A physiologic imaging pilot study of breast cancer treated with AZD2171. Clin. Cancer Res. 12(1), 281-288 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.1 , pp. 281-288
    • Miller, K.D.1    Miller, M.2    Mehrotra, S.3
  • 48
    • 69849100297 scopus 로고    scopus 로고
    • AZD2171 for refractory breast cancer: A Phase 2 trial
    • S
    • Mayer EL, Hamel S, Savoie J et al.: AZD2171 for refractory breast cancer: a Phase 2 trial. Breast Cancer Res. 106(Suppl. 1), S274 (2007).
    • (2007) Breast Cancer Res , vol.106 , Issue.SUPPL. 1 , pp. 274
    • Mayer, E.L.1    Hamel, S.2    Savoie, J.3
  • 49
    • 30544434725 scopus 로고    scopus 로고
    • A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer
    • Denduluri N, Tan AR, Walshe J et al.: A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer. Clin. Breast Cancer 6(5), 460-463 (2005).
    • (2005) Clin. Breast Cancer , vol.6 , Issue.5 , pp. 460-463
    • Denduluri, N.1    Tan, A.R.2    Walshe, J.3
  • 50
    • 69849106968 scopus 로고    scopus 로고
    • Denduluri N, Berman AW, Vatas U et al.: Cardiotoxicity after doxorubicin and AZD2171, an oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, in patients (pts) with breast cancer. J. Clin. Oncol. (Meeting Abstracts). 25(Suppl. 18), 554 (2007).
    • Denduluri N, Berman AW, Vatas U et al.: Cardiotoxicity after doxorubicin and AZD2171, an oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor, in patients (pts) with breast cancer. J. Clin. Oncol. (Meeting Abstracts). 25(Suppl. 18), 554 (2007).
  • 51
    • 23044463773 scopus 로고    scopus 로고
    • Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer
    • Ryden L, Jirstrom K, Bendahl PO et al.: Tumor-specific expression of vascular endothelial growth factor receptor 2 but not vascular endothelial growth factor or human epidermal growth factor receptor 2 is associated with impaired response to adjuvant tamoxifen in premenopausal breast cancer. J. Clin. Oncol. 23(21), 4695-4704 (2005).
    • (2005) J. Clin. Oncol , vol.23 , Issue.21 , pp. 4695-4704
    • Ryden, L.1    Jirstrom, K.2    Bendahl, P.O.3
  • 52
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC et al.: Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am. J. Pathol. 151(6), 1523-1530 (1997).
    • (1997) Am. J. Pathol , vol.151 , Issue.6 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 53
    • 1842543455 scopus 로고    scopus 로고
    • HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF)
    • S
    • Epstein M, Ayala RE, Tchekmedyian N et al.: HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF). Breast Cancer Res. Treat 76(Suppl. 1), S143 (2002).
    • (2002) Breast Cancer Res. Treat , vol.76 , Issue.SUPPL. 1 , pp. 143
    • Epstein, M.1    Ayala, R.E.2    Tchekmedyian, N.3
  • 54
    • 34547654541 scopus 로고    scopus 로고
    • Phase I dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC)
    • Ryan CJ, Stadler WM, Roth B et al.: Phase I dose escalation and pharmacokinetic study of AZD2171, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinase, in patients with hormone refractory prostate cancer (HRPC). Invest. New Drugs 25(5), 445-451 (2007).
    • (2007) Invest. New Drugs , vol.25 , Issue.5 , pp. 445-451
    • Ryan, C.J.1    Stadler, W.M.2    Roth, B.3
  • 55
    • 0027717345 scopus 로고
    • Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma
    • Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143(2), 401-409 (1993).
    • (1993) Am. J. Pathol , vol.143 , Issue.2 , pp. 401-409
    • Weidner, N.1    Carroll, P.R.2    Flax, J.3    Blumenfeld, W.4    Folkman, J.5
  • 56
    • 0035866781 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: A cancer and leukemia group B study
    • Bok RA, Halabi S, Fei DT et al.: Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. Cancer Res. 61(6), 2533-2536 (2001).
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2533-2536
    • Bok, R.A.1    Halabi, S.2    Fei, D.T.3
  • 57
    • 69849107708 scopus 로고    scopus 로고
    • Karakunnel JJ, Gulley JL, Arlen PM et al.: Phase II trial of cediranib (AZD2171) in docetaxel-resistant, castrate-resistant prostate cancer (CRPC). J. Clin. Oncol. 26, ASCO annual meeting proceedings (2008) (Abstract 5136).
    • Karakunnel JJ, Gulley JL, Arlen PM et al.: Phase II trial of cediranib (AZD2171) in docetaxel-resistant, castrate-resistant prostate cancer (CRPC). J. Clin. Oncol. 26, ASCO annual meeting proceedings (2008) (Abstract 5136).
  • 58
    • 69849112897 scopus 로고    scopus 로고
    • Sridhar SS, Mackenzie MJ, Hotte SJ et al.: Activity of cediranib (AZD2171) in patients with previously untreated metastatic renal cell cancer (RCC). A Phase II trial of the PMH Consortium. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 5047).
    • Sridhar SS, Mackenzie MJ, Hotte SJ et al.: Activity of cediranib (AZD2171) in patients with previously untreated metastatic renal cell cancer (RCC). A Phase II trial of the PMH Consortium. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 5047).
  • 59
    • 69849092686 scopus 로고    scopus 로고
    • Cunningham D, Wong RP, D'haens G et al.: A Phase II, double-blind, randomized multicenter study of cediranib with FOLFOX versus bevacizumab with FOLFOX in patients with previously treated metastatic colorectal cancer (mCRC): Final PFS results. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 4028).
    • Cunningham D, Wong RP, D'haens G et al.: A Phase II, double-blind, randomized multicenter study of cediranib with FOLFOX versus bevacizumab with FOLFOX in patients with previously treated metastatic colorectal cancer (mCRC): Final PFS results. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 4028).
  • 60
    • 58149257819 scopus 로고    scopus 로고
    • Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer. ASCO annual meeting proceedings
    • 26 2008
    • Matulonis UA, Berlin ST, Krasner CN et al.: Cediranib (AZD2171) is an active agent in recurrent epithelial ovarian cancer. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008)
    • J. Clin. Oncol
    • Matulonis, U.A.1    Berlin, S.T.2    Krasner, C.N.3
  • 61
    • 69849095775 scopus 로고    scopus 로고
    • Hirte HW, Vidal L, Fleming GF et al.: A Phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 5521).
    • Hirte HW, Vidal L, Fleming GF et al.: A Phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 5521).
  • 62
    • 33845970553 scopus 로고    scopus 로고
    • Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers
    • Hormigo A, Gutin PH, Rafii S: Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers. Cancer Cell 11(1), 6-8 (2007).
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 6-8
    • Hormigo, A.1    Gutin, P.H.2    Rafii, S.3
  • 63
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11(1), 83-95 (2007).
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 65
    • 69849085447 scopus 로고    scopus 로고
    • Shields AF, Heath E, DeLuca P et al.: AZD2171 in combination with various anticancer regimens: Follow-up results of a Phase I multi-cohort study. ASCO annual meeting proceedings. J. Clin. Oncol. 25 (2007) (Abstract 3544).
    • Shields AF, Heath E, DeLuca P et al.: AZD2171 in combination with various anticancer regimens: Follow-up results of a Phase I multi-cohort study. ASCO annual meeting proceedings. J. Clin. Oncol. 25 (2007) (Abstract 3544).
  • 66
    • 38949156179 scopus 로고    scopus 로고
    • Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: An investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol)
    • Bradley DP, Tessier JL, Checkley D et al.: Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: an investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol). NMR Biomed. 21(1), 42-52 (2008).
    • (2008) NMR Biomed , vol.21 , Issue.1 , pp. 42-52
    • Bradley, D.P.1    Tessier, J.L.2    Checkley, D.3
  • 67
    • 0030022917 scopus 로고    scopus 로고
    • Effects of vascular endothelial growth factor on hemodynamics and cardiac performance
    • Yang R, Thomas GR, Bunting S et al.: Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J. Cardiovasc. Pharmacol. 27(6), 838-844 (1996).
    • (1996) J. Cardiovasc. Pharmacol , vol.27 , Issue.6 , pp. 838-844
    • Yang, R.1    Thomas, G.R.2    Bunting, S.3
  • 68
    • 49649091098 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-a signaling induces hypertension: Examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy
    • Curwen JO, Musgrove HL, Kendrew J et al.: Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy. Clin. Cancer Res. 14(10), 3124-3131 (2008).
    • (2008) Clin. Cancer Res , vol.14 , Issue.10 , pp. 3124-3131
    • Curwen, J.O.1    Musgrove, H.L.2    Kendrew, J.3
  • 69
    • 69849104641 scopus 로고    scopus 로고
    • Langenberg M, van Herpen CM, De Bono JS et al.: Optimal management of emergent hypertension during treatment with a VEGF signaling inhibitor: A randomized Phase II study of cediranib. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 3555).
    • Langenberg M, van Herpen CM, De Bono JS et al.: Optimal management of emergent hypertension during treatment with a VEGF signaling inhibitor: A randomized Phase II study of cediranib. ASCO annual meeting proceedings. J. Clin. Oncol. 26 (2008) (Abstract 3555).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.