Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature

Angiogenesis

Volumn 12, Issue 2, 2009, Pages 159-164

  Ahn, G One ^a   Brown, J Martin ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Bone marrow derived cells; Endothelial progenitor cells; Lymphocytes; Macrophages; Monocytes; Myeloid cells; SDF 1; Vasculogenesis; VEGF

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ERYTHROPOIETIN; GAMMA INTERFERON; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 1; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL; BONE MARROW; BONE MARROW CELL; CARCINOGENESIS; CELL FUNCTION; CELL HETEROGENEITY; CELL MIGRATION; CELL PROLIFERATION; CELL TYPE; ENDOTHELIUM CELL; GROWTH REGULATION; HUMAN; LYMPHOCYTE CULTURE; MESENCHYME CELL; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL; TUMOR CLASSIFICATION; TUMOR VASCULARIZATION;

ANIMALS; BONE MARROW CELLS; ENDOTHELIAL CELLS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; STEM CELLS;

EID: 67650742630     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-009-9135-7     Document Type: Article

References (75)

1. S Rafii D Lyden 2003 Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration Nat Med 9 702 712 10.1038/nm0603-702
2. T Asahara 1997 Isolation of putative progenitor endothelial cells for angiogenesis Science 275 964 967 10.1126/science.275.5302.964
3. TM Schlaeger Y Qin Y Fujiwara J Magram TN Sato 1995 Vascular endothelial cell lineage-specific promoter in transgenic mice Development 121 1089 1098
4. T Motoike 2000 Universal GFP reporter for the study of vascular development Genesis 28 75 81 10.1002/1526-968X(200010)28:2<75::AID- GENE50>3.0.CO;2-S
5. DJ Nolan 2007 Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization Genes Dev 21 1546 1558 10.1101/gad.436307
6. D Lyden 2001 Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nat Med 7 1194 1201 10.1038/nm1101-1194
7. T Asahara 1999 Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization Circ Res 85 221 228 (Pubitemid 29377293)
8. T Takahashi 1999 Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization Nat Med 5 434 438 10.1038/8462
9. G Qin 2006 Functional disruption of a4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization J Exp Med 203 153 163 10.1084/jem.20050459
10. DJ Ceradini 2004 Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 Nat Med 10 858 864 10.1038/nm1075
11. M Garcia-Barros 2003 Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 300 1155 1159 10.1126/science.1082504
12. M De Palma MA Venneri C Roca L Naldini 2003 Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells Nat Med 9 789 795 10.1038/nm871
13. JR Gothert 2004 Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium Blood 104 1769 1777 10.1182/blood-2003-11-3952
14. S Purhonen 2008 Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Proc Natl Acad Sci USA 105 6620 6625 10.1073/pnas.0710516105
15. VR Shinde Patil 2005 Bone marrow-derived lin(-)c-kit(+)Sca-1+ stem cells do not contribute to vasculogenesis in Lewis lung carcinoma Neoplasia 7 234 240 10.1593/neo.04523
16. MR Machein S Renninger E de Lima-Hahn KH Plate 2003 Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas Brain Pathol 13 582 597 (Pubitemid 37420701)
17. GO Ahn JM Brown 2008 Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells Cancer Cell 13 193 205 10.1016/j.ccr.2007.11.032
18. RS Kerbel 2008 Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas Proc Natl Acad Sci USA 105 E54 10.1073/pnas. 0804876105
19. P Salven 2008 EPCs are again claimed to be essential in yet other models despite the irreproducibility of the original experiments introducing them Proc Natl Acad Sci USA 105 E55 10.1073/pnas.0805971105
20. BA Peters 2005 Contribution of bone marrow-derived endothelial cells to human tumor vasculature Nat Med 11 261 262 10.1038/nm1200
21. RP Naik 2008 Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer Breast Cancer Res Treat 107 133 138 10.1007/s10549-007-9519-6
22. C Igreja 2007 Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients Haematologica 92 469 477 10.3324/haematol.10723
23. D Gao 2008 Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis Science 319 195 198 10.1126/science.1150224
24. Y Shaked 2008 Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents Cancer Cell 14 263 273 10.1016/j.ccr.2008.08.001
25. Y Shaked 2006 Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors Science 313 1785 1787 10.1126/science.1127592
26. kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow Proc Natl Acad Sci USA 102 6890 6895 10.1073/pnas.0405823102
27. M Yamazaki 2008 Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells Cancer Sci 99 1131 1138 10.1111/j.1349-7006.2008.00795.x
28. G Furstenberger 2006 Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary beast cancer Br J Cancer 94 524 531 10.1038/sj.bjc.6602952
29. B Li 2006 VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization FASEB J 20 1495 1497 10.1096/fj.05-5137fje
30. L Yang 2004 Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis Cancer Cell 6 409 421 10.1016/j.ccr.2004.08.031
31. L Yang 2008 Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis Cancer Cell 13 23 35 10.1016/j.ccr.2007.12.004
32. EA Lin 2006 Macrophages regulate the angiogenic switch in a mouse model of breast cancer Cancer Res 66 11238 11246 10.1158/0008-5472.CAN-06-1278
33. E Rohde 2006 Blood monocytes mimic endothelial progenitor cells Stem Cells 24 357 367 10.1634/stemcells.2005-0072
34. SP Dineen 2008 Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice Cancer Res 68 4340 4346 10.1158/0008-5472.CAN-07-6705
35. S Rafii D Lyden R Benezra K Hattori B Heissig 2002 Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer 2 826 835 10.1038/nrc925
36. S Fujiyama 2003 Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1-dependent manner and accelerate reendothelialization as endothelial progenitor cells Circ Res 93 980 989 10.1161/01.RES.0000099245.08637.CE
37. A Luttun 2002 Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis, and atherosclerosis by anti-Flt1 Nat Med 8 831 840 (Pubitemid 34887247)
38. AS Bailey 2006 Myeloid lineage progenitors give rise to vascular endothelium Proc Natl Acad Sci USA 103 13156 13161 10.1073/pnas.0604203103
39. B Li 2009 Low levels of tumor necrosis factor a increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site Cancer Res 69 338 348 10.1158/0008-5472.CAN-08-1565
40. G Bergers 2000 Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nat Cell Biol 2 737 744 10.1038/35036374
41. R Du 2008 HIF1a induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion Cancer Cell 13 206 220 10.1016/j.ccr.2008.01.034
42. LM Coussens CL Tinkle D Hanahan Z Werb 2000 MMP-9 supplied by bone marrow-derived cells contribute to skin carcinogenesis Cell 103 481 490 10.1016/S0092-8674(00)00139-2
43. E Giraudo M Inoue D Hanahan 2004 An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis J Clin Invest 114 623 633 (Pubitemid 39578752)
44. H Nozawa C Chiu D Hanahan 2006 Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis Proc Natl Acad Sci USA 105 12493 12498 10.1073/pnas.0601807103
45. JA Joyce 2004 Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis Cancer Cell 5 443 453 10.1016/S1535-6108(04)00111-4
46. F Shojaei 2007 Bv8 regulates myeloid-cell-dependent tumour angiogenesis Nature 450 825 831 10.1038/nature06348
47. M Kujawski 2008 Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice J Clin Invest 118 3367 3377 10.1172/JCI35213
48. JR Sierra 2008 Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages J Exp Med 205 1673 1685 10.1084/jem.20072602
49. M Grunewald 2006 VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells Cell 124 175 189 10.1016/j.cell.2005.10. 036
50. M Aghi KS Cohen RJ Klein DT Scadden EA Chiocca 2006 Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes Cancer Res 66 9054 9064 10.1158/0008-5472.CAN-05-3759
51. LM Coussens 1999 Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis Genes Dev 13 1382 1397 10.1101/gad.13.11.1382 (Pubitemid 29270244)
52. B Heissig 2005 Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9 mediated progenitor cell mobilization J Exp Med 202 739 750 10.1084/jem.20050959
53. L Soucek 2007 Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors Nat Med 13 1211 1218 10.1038/nm1649
54. R Salgado 2001 Platelets and vascular endothelial growth factor (VEGF): a morphological and functional study Angiogenesis 4 37 43 10.1023/A:1016611230747
55. U Wartiovaara 1998 Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation Thromb Haemost 80 171 175 (Pubitemid 28353517)
56. S Rafii B Psaila J Butler DK Jin D Lyden 2008 Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells Arterioscler Thromb Vasc Biol 28 217 222 10.1161/ATVBAHA.107.151159
57. A Janowska-Wieczorek 2005 Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer Int J Cancer 113 752 760 10.1002/ijc.20657
58. + myeloid cells Nat Biotechnol 25 911 920 10.1038/nbt1323
59. S Hiratsuka A Watanabe H Aburatani Y Maru 2006 Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis Nat Cell Biol 8 1369 1375 10.1038/ncb1507
60. RN Kaplan 2005 VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche Nature 438 820 827 10.1038/nature04186
61. JW Pollard 2004 Tumour-educated macrophages promote tumour progression and metastasis Nat Rev Cancer 4 71 78 10.1038/nrc1256 (Pubitemid 38082155)
62. CM Koebel 2007 Adaptive immunity maintains occult cancer in an equilibrium state Nature 450 903 908 10.1038/nature06309
63. D Daniel 2003 Immune enhancement of skin carcinogenesis by CD4+ T cells J Exp Med 197 1017 1028 10.1084/jem.20021047
64. N Muller-Hermelink 2008 TNFR1 signaling and IFN-g signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis Cancer Cell 13 507 518 10.1016/j.ccr.2008.04.001
65. EA Manning 2007 A vascular endothelial growth factor receptor-2 inhibitor enhances antitumor immunity through an immune-based mechanism Clin Cancer Res 13 3951 3959 10.1158/1078-0432.CCR-07-0374
66. R Ganss D Hanahan 1998 Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes Cancer Res 58 4673 4681 (Pubitemid 28480634)
67. MA Haniffa MP Collin CD Buckley F Dazzi 2009 Mesenchymal stem cells: the fibroblasts' new clothes? Haematologica 94 2 258 263
68. PJ Mishira 2008 Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells Cancer Res 68 4331 4339 10.1158/0008-5472.CAN-08- 0943
69. P Au J Tam D Fukumura RK Jain 2008 Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature Blood 111 4551 4558 10.1182/blood-2007-10-118273
70. M de Palma 2005 Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors Cancer Cell 8 211 226 10.1016/j.ccr.2005.08.002
71. D Bexell 2009 Bone marrow multipotent mesenchymal stromal cells act as pericyte-like migratory vesicles in experimental gliomas Mol Ther 17 183 190 10.1038/mt.2008.229
72. BM Beckermann 2008 VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma Br J Cancer 99 622 631 10.1038/sj.bjc.6604508
73. M Studeny 2004 Mesenchymal stem cells: potential precursors for tumor stromal and targeted-delivery vehicles for anticancer agents J Natl Cancer Inst 96 1593 1603 (Pubitemid 39534883)
74. M Capillo 2003 Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors Clin Cancer Res 9 377 382 (Pubitemid 36109755)
75. R Suriano 2008 17Beta-estradiol mobilizes bone marrow-derived endothelial progenitor cells to tumors Cancer Res 68 6038 6042 10.1158/0008-5472.CAN-08- 1009