The possible potential therapeutic targets for drug induced gingival overgrowth

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Subramani, Tamilselvan ^a   Rathnavelu, Vidhya ^b   Alitheen, Noorjahan Banu ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b SRI RAMACHANDRA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN LINKED KINASE 5 INHIBITOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIFIBROTIC AGENT; CHYMASE INHIBITOR; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR; MACITENTAN; N (1 HYDROXY 2 NAPHTHOYL)ARGINYLPROLINAMIDE; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEIN KINASE INHIBITOR; PROTEINASE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 5; TRANSFORMING GROWTH FACTOR BETA; TRYPTASE INHIBITOR; UNCLASSIFIED DRUG; PLATELET DERIVED GROWTH FACTOR;

ANTIFIBROTIC ACTIVITY; CARDIOVASCULAR DISEASE; CELL ADHESION; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG TARGETING; ENZYME INHIBITION; FIBROBLAST; FIBROSIS; GINGIVA OVERGROWTH; HEART MUSCLE FIBROSIS; HUMAN; LUNG FIBROSIS; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REVIEW; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; METABOLISM; PATHOLOGY; CHEMICALLY INDUCED;

ANIMALS; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN-1; FIBROBLASTS; GINGIVAL OVERGROWTH; HUMANS; MODELS, BIOLOGICAL; PLATELET-DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84877289949     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/639468     Document Type: Review

References (103)

1. Seymour R. A., Calcium channel blockers and gingival overgrowth. British Dental Journal 1991 170 10 376 379 2-s2.0-0026431457
2. Miller C. S., Damm D. D., Incidence of verapamil-induced gingival hyperplasia in a dental population. Journal of Periodontology 1992 63 5 453 456 2-s2.0-0026659585
3. Nishikawa S., Nagata T., Morisaki I., Oka T., Ishida H., Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model. Journal of Periodontology 1996 67 5 463 471 2-s2.0-0030139665 (Pubitemid 126449799)
4. Ellis J. S., Seymour R. A., Steele J. G., Robertson P., Butler T. J., Thomason J. M., Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. Journal of Periodontology 1999 70 3 63 67 2-s2.0-0032983056 10.1902/jop.1999.70.1.63 (Pubitemid 29076012)
5. Perlik F., Kolinova M., Zvarova J., Patzelova V., Phenytoin as a risk factor in gingival hyperplasia. Therapeutic Drug Monitoring 1995 17 5 445 448 2-s2.0-0029119786
6. McGaw T., Lam S., Coates J., Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surgery Oral Medicine and Oral Pathology 1987 64 3 293 297 2-s2.0-0023281214 (Pubitemid 17148018)
7. Hassell T. M., Hefti A. F., Drug-induced gingival overgrowth: old problem, new problem. Critical Reviews in Oral Biology and Medicine 1991 2 1 103 137 2-s2.0-0025829628
8. Lucas R. M., Howell L. P., Wall B. A., Nifedipine-induced gingival hyperplasia. A histochemical and ultrastructural study. Journal of Periodontology 1985 56 4 211 215 2-s2.0-0021992722 (Pubitemid 15110273)
9. Barclay S., Thomason J. M., Idle J. R., Seymour R. A., The incidence and severity of nifedipine-induced gingival overgrowth. Journal of Clinical Periodontology 1992 19 5 311 314 2-s2.0-0026588561
10. Thomason J. M., Determinants of gingival overgrowth severity in organ transplant patients. An examination of the rôle of HLA phenotype. Journal of Clinical Periodontology 1996 23 7 628 634 2-s2.0-0030185707
11. Hassell T. M., Page R. C., Narayanan A. S., Cooper C. G., Diphenylhydantoin (dilantin) gingival hyperplasia: drug induced abnormality of connective tissue. Proceedings of the National Academy of Sciences of the United States of America 1976 73 8 2909 2912 2-s2.0-0042383278
12. Modéer T., Andurén I., Bengtsson A., Andersson G., Interleukin-1 beta and phenytoin reduce alpha 1 procollagen mRNA expression in human gingival fibroblasts. Journal of Periodontal Research 1996 31 8 563 569 (Pubitemid 126463418)
13. Spolidorio L. C., Gonzaga H. F. G., Spolidorio D. M. P., Quantitative analysis of gingival tissues of rats treated with phenytoin and cyclosporine. Pesquisa Odontológica Brasileira 2000 14 327 333 (Pubitemid 33312327)
14. Kane C. J. M., Hebda P. A., Mansbridge J. N., Hanawalt P. C., Direct evidence for spatial and temporal regulation of transforming growth factor β 1 expression during cutaneous wound healing. Journal of Cellular Physiology 1991 148 1 157 173 2-s2.0-0025830392 (Pubitemid 21910138)
15. Massague J., TGF-beta signal transduction. Annual Review of Biochemistry 1998 67 753 791
16. Leask A., Abraham D. J., TGF-beta signaling and the fibrotic response. The FASEB Journal 2004 18 7 816 827
17. Roberts A. B., TGF-beta signaling from receptors to the nucleus. Microbes and Infection 1999 1 15 1265 1273
18. Branton M. H., Kopp J. B., TGF-beta and fibrosis. Microbes and Infection 1999 1 15 1349 1365
19. Eickelberg O., Endless healing: TGF- β SMADs, and fibrosis. FEBS Letters 2001 506 1 11 14 2-s2.0-0035964939 10.1016/S0014-5793(01)02875-7 (Pubitemid 32925223)
20. Sime P. J., O'Reilly K. M. A., Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clinical Immunology 2001 99 3 308 319 2-s2.0-0035020567 10.1006/clim.2001.5008 (Pubitemid 32493696)
21. Li B., Sehajpal P. K., Khanna A., Vlassara H., Cerami A., Stenzel K. H., Suthanthiran M., Differential regulation of transforming growth factor β and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. Journal of Experimental Medicine 1991 174 5 1259 1262 2-s2.0-0026009177
22. Khanna A., Li B., Stenzel K. H., Suthanthiran M., Regulation of new DNA synthesis in mammalian cells by cyclosporine: demonstration of a transforming growth factor β -dependent mechanism of inhibition of cell growth. Transplantation 1994 57 4 577 582 2-s2.0-0028207526 (Pubitemid 24075806)
23. Shehata M., Cope G. H., Johnson T. S., Raftery A. T., El Nahas A. M., Cyclosporine enhances the expression of TGF- β in the juxtaglomerular cells of the rat kidney. Kidney International 1995 48 5 1487 1496 2-s2.0-0028858376
24. Wolf G., Thaiss F., Stahl R. A. K., Cyclosporine stimulates expression of transforming growth factor- β in renal cells: possible mechanism of cyclosporines antiproliferative effects. Transplantation 1995 60 3 237 241 2-s2.0-0029145672
25. Khanna A. K., Cairns V. R., Becker C. G., Hosenpud J. D., TGF- β: a link between immunosuppression, nephrotoxicity, and CsA. Transplantation Proceedings 1998 30 4 944 645 2-s2.0-0031859820 10.1016/S0041-1345(98)00102-X (Pubitemid 28309432)
26. Khanna A., Cairns V., Hosenpud J. D., Tacrolimus induces increased expression of transforming growth factor- β 1 in mammalian lymphoid as well as nonlymphoid cells. Transplantation 1999 67 4 614 619 2-s2.0-0033608385 (Pubitemid 29114227)
27. Dennison D. K., Vallone D. R., Pinero G. J., Rittman B., Caffesse R. G., Differential effect of TGF- β 1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts. Journal of Periodontology 1994 65 7 641 648 2-s2.0-0028060015 (Pubitemid 24236699)
28. Anderson T. J., Lapp C. A., Billman M. A., Schuster G. S., Effects of transforming growth factor- β and platelet-derived growth factor on human gingival fibroblasts grown in serum-containing and serum-free medium. Journal of Clinical Periodontology 1998 25 1 48 55 2-s2.0-0031606348 (Pubitemid 128705996)
29. James J. A., Irwin C. R., Linden G. J., Gingival fibroblast response to cyclosporin A and transforming growth factor β 1. Journal of Periodontal Research 1998 33 1 40 48 2-s2.0-0031608194 (Pubitemid 128529550)
30. Tipton D. A., Dabbous M. K., Autocrine transforming growth factor β stimulation of extracellular matrix production by fibroblasts from fibrotic human gingiva. Journal of Periodontology 1998 69 6 609 619 2-s2.0-0032088397 (Pubitemid 128518847)
31. Coletta R. D., Almeida O. P., Reynolds M. A., Sauk J. J., Alteration in expression of MMP-1 and MMP-2 but not TIMP-1 and TIMP-2 in hereditary gingival fibromatosis is mediated by TGF- β 1 autocrine stimulation. Journal of Periodontal Research 1999 34 8 457 463 2-s2.0-0033219402
32. de Andrade C. R., Cotrin P., Graner E., Almeida O. P., Sauk J. J., Coletta R. D., Transforming growth factor- β 1 autocrine stimulation regulates fibroblast proliferation in hereditary gingival fibromatosis. Journal of Periodontology 2001 72 12 1726 1733 2-s2.0-0035696739 10.1902/jop.2001.72.12. 1726 (Pubitemid 34092739)
33. Kisseleva T., Brenner D. A., Mechanisms of fibrogenesis. Experimental Biology and Medicine 2008 233 2 109 122 2-s2.0-38949128021 10.3181/0707-MR-190 (Pubitemid 351231543)
34. Thompson K., Hamilton D. W., Leask A., ALK5 inhibition blocks TGF β -induced CCN2 expression in gingival fibroblasts. Journal of Dental Research 2010 89 12 1450 1454 2-s2.0-78650115940 10.1177/0022034510379020
35. Stewart C. E. H., Rotwein P., Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiological Reviews 1996 76 4 1005 1026 2-s2.0-0029973924 (Pubitemid 26346814)
36. Jones J. I., Clemmons D. R., Insulin-like growth factors and their binding proteins: biological actions. Endocrine Reviews 1995 16 1 3 34 2-s2.0-0028958031
37. Xin X., Hou Y. T., Li L., Schmiedlin-Ren P., Christman G. M., Cheng H. L., Bitar K. N., Zimmermann E. M., IGF-I increases IGFBP-5 and collagen α 1(I) mRNAs by the MAPK pathway in rat intestinal smooth muscle cells. American Journal of Physiology 2004 286 5 G777 G783 2-s2.0-1942423681 10.1152/ajpgi.00293.2003 (Pubitemid 38506809)
38. Han X., Amar S., IGF-1 signaling enhances cell survival in periodontal ligament fibroblasts vs. gingival fibroblasts. Journal of Dental Research 2003 82 6 454 459 2-s2.0-0037831205 (Pubitemid 41766011)
39. Subramani T., Sakkarai A., Senthilkumar K., Periasamy S., Abraham G., Rao S., Expression of insulin like growth factor binding protein-5 in drug induced human gingival overgrowth. Indian Journal of Medical Research 2007 125 1 43 48 2-s2.0-33947129759 (Pubitemid 46403678)
40. Yoshida T., Nagata J., Yamane A., Growth factors and proliferation of cultured rat gingival cells in response to cyclosporin A. Journal of Periodontal Research 2005 40 1 11 19 2-s2.0-13244292406 10.1111/j.1600-0765.2004.00762.x (Pubitemid 40186621)
41. Choi J. E., Lee S. S., Sunde D. A., Huizar I., Haugk K. L., Thannickal V. J., Vittal R., Plymate S. R., Schnapp L. M., Insulin-Like growth factor-i receptor blockade improves outcome in mouse model of lung injury. American Journal of Respiratory and Critical Care Medicine 2009 179 3 212 219 2-s2.0-61449109155 10.1164/rccm.200802-228OC
42. Bonner J. C., Regulation of PDGF and its receptors in fibrotic diseases. Cytokine and Growth Factor Reviews 2004 15 4 255 273 2-s2.0-2942682928 10.1016/j.cytogfr.2004.03.006 (Pubitemid 38781050)
43. Heldin C. H., Westermark B., Mechanism of action and in vivo role of platelet-derived growth factor. Physiological Reviews 1999 79 4 1283 1316 2-s2.0-0032875460 (Pubitemid 29473317)
44. Uutela M., Wirzenius M., Paavonen K., Rajantie I., He Y., Karpanen T., Lohela M., Wiig H., Salven P., Pajusola K., Eriksson U., Alitalo K., PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood 2004 104 10 3198 3204 2-s2.0-8644226222 10.1182/blood-2004-04-1485 (Pubitemid 39507135)
45. Green R. J., Usui M. L., Hart C. E., Ammons W. F., Narayanan A. S., Immunolocalization of platelet-derived growth factor A and B chains and PDGF- α and β receptors in human gingival wounds. Journal of Periodontal Research 1997 32 2 209 214 2-s2.0-0031063654 (Pubitemid 127520067)
46. Shehata M., El Nahas A. M., Barkworth E., Cope G. H., Raftery A. T., Increased platelet-derived growth factor in the kidneys of cyclosporin-treated rats. Kidney International 1994 46 3 726 732 2-s2.0-0027930239 (Pubitemid 24272030)
47. Mailhot J. M., Schuster G. S., Garnick J. J., Hanes P. J., Lapp C. A., Lewis J. B., Human periodontal ligament and gingival fibroblast response to TGF-beta 1 stimulation. Journal of Clinical Periodontology 1995 22 9 679 685 2-s2.0-0029377212
48. Dill R. E., Miller E. K., Weil T., Lesley S., Farmer G. R., Iacopino A. M., Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes. Journal of Periodontology 1993 64 3 169 173 2-s2.0-0027315720 (Pubitemid 23125783)
49. Plemons J. M., Dill R. E., Rees T. D., Dyer B. J., Ng M. C., Iacopino A. M., PDGF-B producing cells and PDGF-B gene expression in normal gingiva and cyclosporine A-induced gingival overgrowth. Journal of Periodontology 1996 67 3 264 270 2-s2.0-0029870512 (Pubitemid 26117730)
50. Iacopino A. M., Doxey D., Cutler C. W., Nares S., Stoever K., Fojt J., Gonzales A., Dill R. E., Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia. Journal of Periodontology 1997 68 1 73 83 2-s2.0-0030614422
51. Nares S., Ng M. C., Dill R. E., Park B., Cutler C. W., Iacopino A. M., Cyclosporine A upregulates platelet-derived growth factor B chain in hyperplastic human gingiva. Journal of Periodontology 1996 67 3 271 278 2-s2.0-0029964002 (Pubitemid 26117731)
52. Ogawa S., Ochi T., Shimada H., Inagaki K., Fujita I., Nii A., Moffat M. A., Katragadda M., Violand B. N., Arch R. H., Masferrer J. L., Anti-PDGF-B monoclonal antibody reduces liver fibrosis development. Hepatology Research 2010 40 11 1128 1141 2-s2.0-77958607056 10.1111/j.1872-034X.2010.00718.x
53. Martin I. V., Borkham-Kamphorst E., Zok S., Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis. The American Journal of Pathology 2013 182 1 107 117
54. Liao C. H., Akazawa H., Tamagawa M., Ito K., Yasuda N., Kudo Y., Yamamoto R., Ozasa Y., Fujimoto M., Wang P., Nakauchi H., Nakaya H., Komuro I., Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts. Journal of Clinical Investigation 2010 120 1 242 253 2-s2.0-74949085470 10.1172/JCI39942
55. Oemar B. S., Luscher T. F., Connective tissue growth factor. Friend or foe? Arterioscler Thrombosis Vascular Biology 1997 17 8 1483 1489 (Pubitemid 27387766)
56. Brigstock D. R., The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocrine Reviews 1999 20 2 189 206 2-s2.0-0032787927 10.1210/er.20.2.189 (Pubitemid 29339590)
57. Ghosh A. K., Factors involved in the regulation of type I collagen gene expression: implication in fibrosis. Experimental Biology and Medicine 2002 227 5 301 314 2-s2.0-0036586090
58. Uzel M. I., Kantarci A., Hong H. H., Uygur C., Sheff M. C., Firatli E., Trackman P. C., Connective tissue growth factor in drug-induced gingival overgrowth. Journal of Periodontology 2001 72 7 921 931 2-s2.0-0035406280 10.1902/jop.2001.72.7.921 (Pubitemid 33665220)
59. Kantarci A., Black S. A., Xydas C. E., Murawel P., Uchida Y., Yucekal-Tuncer B., Atilla G., Emingil G., Uzel M. I., Lee A., Firatli E., Sheff M., Hasturk H., Van Dyke T. E., Trackman P. C., Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. Journal of Pathology 2006 210 1 59 66 2-s2.0-33747879489 10.1002/path.2000 (Pubitemid 44288181)
60. Blom I. E., Goldschmeding R., Leask A., Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biology 2002 21 6 473 482 2-s2.0-0036775477 10.1016/S0945-053X(02)00055-0 (Pubitemid 35248272)
61. Kennedy L., Liu S., Shi-Wen X., CCN2 is essential for fibroblast function. Experimental Cell Research 2007 313 5 952 964
62. Hayata N., Fujio Y., Yamamoto Y., Iwakura T., Obana M., Takai M., Mohri T., Nonen S., Maeda M., Azuma J., Connective tissue growth factor induces cardiac hypertrophy through Akt signaling. Biochemical and Biophysical Research Communications 2008 370 2 274 278 2-s2.0-42249092488 10.1016/j.bbrc.2008.03.100
63. Brigstock D. R., Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): from pharmacological inhibition in vitro to targeted siRNA therapy in vivo. Journal of Cell Communication and Signaling 2009 3 1 5 18 2-s2.0-67349196521 10.1007/s12079-009-0043-9
64. Ponticos M., Holmes A. M., Shi-wen X., Leoni P., Khan K., Rajkumar V. S., Hoyles R. K., Bou-Gharios G., Black C. M., Denton C. P., Abraham D. J., Leask A., Lindahl G. E., Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis and Rheumatism 2009 60 7 2142 2155 2-s2.0-67650069660 10.1002/art.24620
65. Takeda Y., Phagocytosis of mast cell granules by fibroblasts of the human gingiva. Virchows Archiv 1985 406 2 197 201 2-s2.0-0021798635 (Pubitemid 15072670)
66. Nurmenniemi P. K., Pernu H. E., Knuuttila M. L. E., Mast cell subpopulations in gingival overgrowth induced by immunosuppressive and nifedipine medication. Journal of Periodontology 2004 75 7 933 938 2-s2.0-4444238272 10.1902/jop.2004.75.7.933 (Pubitemid 39162101)
67. Ruoss S. J., Hartmann T., Caughey G. H., Mast cell tryptase is a mitogen for cultured fibroblasts. Journal of Clinical Investigation 1991 88 2 493 499 2-s2.0-0025864033
68. Cairns J. A., Walls A. F., Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. Journal of Clinical Investigation 1997 99 6 1313 1321 2-s2.0-0030952324 (Pubitemid 27142769)
69. Artuc M., Muscha Steckelings U., Henz B. M., Mast cell-fibroblast interactions: human mast cells as source and inducers of fibroblast and epithelial growth factors. Journal of Investigative Dermatology 2002 118 3 391 395 2-s2.0-0036118793 10.1046/j.0022-202x.2001.01705.x (Pubitemid 34227153)
70. Craig S. S., Schwartz L. B., Tryptase and chymase, markers of distinct types of human mast cells. Immunologic Research 1989 8 2 130 148 2-s2.0-0024319486 (Pubitemid 19135916)
71. Lindstedt K. A., Wang Y., Shiota N., Saarinen J., Hyytiäinen M., Kokkonen J. O., Keski-Oja J., Kovanen P. T., Activation of paracrine TGF- β 1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. The Journal of the Federation of American Societies for Experimental Biology 2001 15 8 1377 1388 2-s2.0-0034995590 10.1096/fj.00-0273com (Pubitemid 32531815)
72. Ohuchi N., Koike K., Sano M., Kusama T., Kizawa Y., Hayashi K., Taniguchi Y., Ohsawa M., Iwamoto K., Murakami H., Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture. Comparative Biochemistry and Physiology C 2002 132 4 451 460 2-s2.0-18644381315 10.1016/S1532-0456(02)00098-4 (Pubitemid 35239984)
73. Tamilselvan S., Raju S. N., Loganathan D., Kamatchiammal S., Abraham G., Suresh R., Endothelin-1 and its receptors ET(A) and ET(B) in drug-induced gingival overgrowth. Journal of Periodontology 2007 78 2 290 295
74. He S., Gaça M. D. A., Mceuen A. R., Walls A. F., Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells. Journal of Pharmacology and Experimental Therapeutics 1999 291 2 517 523 2-s2.0-0344172844 (Pubitemid 29503519)
75. Matsumoto T., Wada A., Tsutamoto T., Ohnishi M., Isono T., Kinoshita M., Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation 2003 107 20 2555 2558 2-s2.0-0037512313 10.1161/01.CIR.0000074041.81728.79 (Pubitemid 36628935)
76. Takai S., Jin D., Muramatsu M., Okamoto Y., Miyazaki M., Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis. European Journal of Pharmacology 2004 501 1-3 1 8 2-s2.0-4644289087 10.1016/j.ejphar.2004.08.040 (Pubitemid 39298930)
77. He S., Gaça M. D. A., Walls A. F., A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. The Journal of Pharmacology and Experimental Therapeutics 1998 286 1 289 297 2-s2.0-0031849608 (Pubitemid 28318002)
78. Subramani T., Senthilkumar K., Periasamy S., Rao S., Expression of angiotensin II and its receptors in cyclosporine-induced gingival overgrowth. Journal of Periodontal Research 2012 10.1111/jre.12020
79. Campbell S. E., Katwa L. C., Angiotensin II stimulated expression of transforming growth factor- β 1 in cardiac fibroblasts and myofibroblasts. Journal of Molecular and Cellular Cardiology 1997 29 7 1947 1958 2-s2.0-0031194295 10.1006/jmcc.1997.0435 (Pubitemid 27303099)
80. Schultz J. E. J., Witt S. A., Glascock B. J., Nieman M. L., Reiser P. J., Nix S. L., Kimballand T. R., Doetschman T., TGF- β 1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. Journal of Clinical Investigation 2002 109 6 787 796 2-s2.0-0036009157 10.1172/JCI200214190 (Pubitemid 34263155)
81. Yang F., Chung A. C. K., Ru Huang X., Lan H. Y., Angiotensin II induces connective tissue growth factor and collagen i expression via transforming growth factor- β -dependent and -independent Smad pathways: the role of Smad3. Hypertension 2009 54 4 877 884 2-s2.0-70349659185 10.1161/ HYPERTENSIONAHA.109.136531
82. Gao X., He X., Luo B., Peng L., Lin J., Zuo Z., Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts. European Journal of Pharmacology 2009 606 1-3 115 120 2-s2.0-60949097622 10.1016/j.ejphar.2008.12.049
83. Martin M. M., Buckenberger J. A., Jiang J., Malana G. E., Knoell D. L., Feldman D. S., Elton T. S., TGF- β 1 stimulates human at1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways. American Journal of Physiology 2007 293 3 L790 L799 2-s2.0-34548424486 10.1152/ajplung.00099.2007 (Pubitemid 47358842)
84. Hilgers K. F., Mann J. F. E., ACE inhibitors versus AT1 receptor antagonists in patients with chronic renal disease. Journal of the American Society of Nephrology 2002 13 4 1100 1108 2-s2.0-0036209899 (Pubitemid 34274109)
85. Schmidt A., Gruber U., Böhmig G., Köller E., Mayer G., The effect of ACE inhibitor and angiotensin II receptor antagonist therapy on serum uric acid levels and potassium homeostasis in hypertensive renal transplant recipients treated with CsA. Nephrology Dialysis Transplantation 2001 16 5 1034 1037 2-s2.0-0035022460 (Pubitemid 32440378)
86. Calò L. A., Davis P. A., Giacon B., Pagnin E., Sartori M., Riegler P., Antonello A., Huber W., Semplicini A., Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. Journal of Cardiovascular Pharmacology 2002 40 4 625 631 2-s2.0-0036784866 10.1097/00005344-200210000-00017
87. Clozel M., Salloukh H., Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Annals of Medicine 2005 37 1 2 12 2-s2.0-14844292619 10.1080/07853890410018925 (Pubitemid 40347290)
88. Teder P., Noble P. W., A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. American Journal of Respiratory Cell and Molecular Biology 2000 23 1 7 10 2-s2.0-0033876716 (Pubitemid 30597089)
89. Ishihata A., Katano Y., Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system. Annals of the New York Academy of Sciences 2006 1067 1 173 181 2-s2.0-33744488795 10.1196/annals.1354.021 (Pubitemid 43806322)
90. Neuhofer W., Pittrow D., Role of endothelin and endothelin receptor antagonists in renal disease. European Journal of Clinical Investigation 2006 36 3 78 88 2-s2.0-33746803789 10.1111/j.1365-2362.2006.01689.x (Pubitemid 44179788)
91. Ahmadi-Simab K., Hellmich B., Gross W. L., Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease. European Journal of Clinical Investigation 2006 36 3 44 48 2-s2.0-33746419967 10.1111/j.1365-2362.2006.01695.x (Pubitemid 44179781)
92. Subramani T., Dhanaraj L., Senthilkumar K., Periasamy S., Abraham G., Rao S., Expression of TNF- α and RANTES in drug-induced human gingival overgrowth. Indian Journal of Pharmacology 2010 42 3 174 177 2-s2.0-77955457072 10.4103/0253-7613.66842
93. Masaki T., Miwa S., Sawamura T., Ninomiya H., Okamoto Y., Subcellular mechanisms of endothelin action in vascular system. European Journal of Pharmacology 1999 375 1-3 133 138 2-s2.0-0032980752 10.1016/S0014-2999(99)00252- 6 (Pubitemid 29317599)
94. Ergul A., Jupin D., Johnson M. H., Prisant L. M., Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients. Journal of Clinical Hypertension 2006 8 8 549 554 2-s2.0-33750934751 10.1111/j.1524-6175.2006.05514.x
95. Horstmeyer A., Licht C., Scherr G., Eckes B., Krieg T., Signalling and regulation of collagen I synthesis by ET-1 and TGF- β 1. FEBS Journal 2005 272 24 6297 6309 2-s2.0-29144492719 10.1111/j.1742-4658.2005.05016.x (Pubitemid 41815618)
96. Khan Z. A., Farhangkhoee H., Mahon J. L., Bere L., Gonder J. R., Chan B. M., Uniyal S., Chakrabarti S., Endothelins: regulators of extracellular matrix protein production in diabetes. Experimental Biology and Medicine 2006 231 6 1022 1029 2-s2.0-33744941829 (Pubitemid 43845571)
97. Shi-wen X., Kennedy L., Renzoni E. A., Bou-Gharios G., Du Bois R. M., Black C. M., Denton C. P., Abraham D. J., Leask A., Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts. Arthritis and Rheumatism 2007 56 12 4189 4194 2-s2.0-37149016368 10.1002/art.23134 (Pubitemid 350262347)
98. Shephard P., Hinz B., Smola-Hess S., Meister J. J., Krieg T., Smola H., Dissecting the roles of endothelin, TGF- β and GM-CSF on myofibroblast differentiation by keratinocytes. Thrombosis and Haemostasis 2004 92 2 262 274 2-s2.0-4444236084 (Pubitemid 39172306)
99. Cheng T. H., Cheng P. Y., Shih N. L., Chen I. B., Wang D. L., Chen J. J., Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts. Journal of the American College of Cardiology 2003 42 10 1845 1854 2-s2.0-0242721091 10.1016/j.jacc.2003.06.010 (Pubitemid 37433668)
100. Mucke H. A. M., Pulmonary arterial hypertension: on the way to a manageable disease. Current Opinion in Investigational Drugs 2008 9 9 957 962 2-s2.0-50249097607
101. Raja S. G., Macitentan, a tissue-targeting endothelin receptor antagonist for the potential oral treatment of pulmonary arterial hypertension and idiopathic pulmonary fibrosis. Current Opinion in Investigational Drugs 2010 11 9 1066 1073 2-s2.0-77956242973
102. Kowala M. C., Murugesan N., Tellew J., Carlson K., Monshizadegan H., Ryan C., Gu Z., Kane B., Fadnis L., Baska R. A., Beyer S., Arthur S., Dickinson K., Zhang D., Perrone M., Ferrer P., Giancarli M., Baumann J., Bird E., Panchal B., Yang Y., Trippodo N., Barrish J., Macor J. E., Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension. Journal of Pharmacology and Experimental Therapeutics 2004 309 1 275 284 2-s2.0-12144288600 10.1124/jpet.103.055855 (Pubitemid 38393140)
103. Palaniswamy C., Selvaraj D. R., Palaniappan D., Dual angiotensin II and endothelin receptor antagonists. American Journal of Therapeutics 2011 18 3 e67 e70 2-s2.0-79958059032 10.1097/MJT.0b013e3181cb4031