Inhibitors of chymase as mast cell-stabilizing agents: Contribution of chymase in the activation of human mast cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 2, 1999, Pages 517-523

  He, Shaoheng ^a   Gaça, Marianna D A ^a   Mceuen, Alan R ^a   Walls, Andrew F ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; CHYMASE; ISOLEUCYLGLUTAMYLPROLYLPHENYLALANYLMETHIONINAMIDE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ARTICLE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAST CELL; MAST CELL DEGRANULATION; PRIORITY JOURNAL;

CATHEPSINS; CHYMASES; HISTAMINE; HUMANS; IMMUNOGLOBULIN E; LUNG; MAST CELLS; OLIGOPEPTIDES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SKIN; SOYBEANS; TIME FACTORS; TONSIL;

EID: 0344172844     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Austen KF and Brocklehurst WE (1960) Inhibition of the anaphylactic release of histamine from chopped guinea pig lung by chymotrypsin substrates and inhibitors. Nature (Lond) 186:866-868.
2. Bastos M, Maeji NJ and Abeles RH (1995) Inhibitors of human heart chymase based on a peptide library. Proc Natl Acad Sci USA 92:6738-6742.
3. Beil WJ, Schulz M, McEuen AR, Buckley MG and Walls AF (1997) Number, fixation properties, dye-binding and protease expression of duodenal mast cells: Comparisons between healthy subjects and patients with gastritis or Crohn's disease. Histochem J 29:759-773.
4. Buckley MG, McEuen AR and Walls AF (1999) The detection of mast cell subpopulations in formalin-fixed human tissues using a new monoclonal antibody specific for chymase. J Pathol, in press.
5. Butterfield JH, Weiler D, Peterson EA, Gleich GJ and Leiferman KM (1990) Sequestration of eosinophil major basic protein in human mast cells. Lab Invest 62:77-86.
6. Caulfield JP, El-Lati S, Thomas G and Church MK (1990) Dissociated human foreskin mast cells degranulate in response to anti-IgE and substance P. Lab Invest 63:502-510.
7. Church MK, Bradding P, Walls AF and Okayama Y (1997) Human mast cells and basophils, in Allergy and Allergic Diseases (Kay AB ed) pp 149-170, Blackwell, Oxford.
8. Cochrane DE, Carraway RE, Feldberg RS, Boucher W and Gelfand JM (1993) Stimulated rat mast cells generate histamine-releasing peptide from albumin. Peptides 14:117-123.
9. Dietze SC, Sommerhoff CP and Fritz H (1990) Inhibition of histamine release from human mast cells ex vivo by natural and synthetic chymase inhibitors. Biol Chem Hoppe-Seyler 371:75-79.
10. Dvorak AM, Klebanoff SJ, Henderson WR, Monahan RA, Pyne K and Galli SJ (1985) Vesicular uptake of eosinophil peroxidase by guinea pig basophils and by cloned mouse mast cells and granule-containing lymphoid cells. Am J Pathol 118:425-438.
11. Emadi-Khiav B and Pearce FL (1998) Role of serine esterases in mast cell activation. Br J Pharmacol 123:1267-1273.
12. Harvima IT, Naukkarinen A, Paukkonen K, Harvima RJ, Aalto ML, Schwartz LB and Horsmanheimo M (1993) Mast cell tryptase and chymase in developing and mature psoriatic lesions. Arch Dermatol Res 285:184-192.
13. He S, Gaça MDA and Walls AF (1998) A role for tryptase in the activation of human mast cells: Modulation of histamine release by tryptase and inhibitors of tryptase. J Pharmacol Exp Ther 286:289-297.
14. He S and Walls AF (1997) Human mast cell tryptase: A stimulus of microvascular leakage and mast cell activation. Eur J Pharmacol 328:89-97.
15. He S and Walls AF (1998) The induction of a prolonged increase in microvascular permeability by human mast cell chymase. Eur J Pharmacol 352:91-98.
16. Hultsch T, Ennis M and Heidtmann HH (1988) The role of chymase in ionophore-induced histamine release from human pulmonary mast cells. Adv Exp Med Biol 240:133-136.
17. Huntley GF, Newlands GFJ, Gibson S, Ferguson A and Miller HRP (1985) Histochemical demonstration of chymotrypsin-like serine esterases in mucosal mast cells in four species including man. J Clin Pathol 38:375-384.
18. TC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem 37:1509-1515
19. TC cells. J Immunol 147: 247-253.
20. Irani AA, Schechter NM, Craig SS, De Blois G and Schwartz LB (1986) Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci USA 83:4464-4468.
21. Ishizaka T and Ishizaka K (1984) Activation of mast cells for mediator release through IgE receptor. Prog Allergy 34:188-235.
22. Ishizaka T, Sterk AR, Daeron M, Becker EL and Ishizaka K (1985) Biochemical analysis of desensitisation of mouse mast cells. J Immunol 135:492-501.
23. Kido H, Fukusen N and Katunuma N (1988) Antibodies and inhibitor of chymase are incorporated into mast cell granules and inhibit histamine release. Biol Chem Hoppe-Seyler 369 (Suppl):95-100.
24. McEuen AR, Ashworth DM and Walls AF (1998a) The conversion of recombinant human mast cell prochymase to enzymatically active chymase by dipeptidyl peptidase 1 is inhibited by heparin and histamine. Eur J Biochem 253:300-308.
25. McEuen AR, Gaça MDA, Buckley MG, He S, Gore MG and Walls AF (1998b) Two distinct forms of human mast cell chymase: Differences in affinity for heparin and in distribution in skin, heart, and other tissues. Eur J Biochem 256:461-470.
26. McEuen AR, Sharma B and Walls AF (1995) Regulation of the activity of human chymase during storage and release from mast cells: The contributions of inorganic cations, pH, heparin and histamine. Biochim Biophys Acta 1267:115-121.
27. Molinari JF, Moore WR, Clark J, Tanaka R, Butterfield JH and Abraham WM (1995) Role of tryptase in immediate cutaneous responses in allergic sheep. J Appl Physiol 79:1966-1970.
28. Molinari JF, Scuri M, Moore WR, Clark J, Tanaka R and Abraham WM (1996) Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am J Respir Crit Care Med 154:649-653.
29. Nakajima K, Powers JC, Ashe BM and Zimmerman M (1979) Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. J Biol Chem 254:4027-4034.
30. Nolte H, Schiotz PO and Skov PS (1987) A new glass fibre based histamine analysis for allergy testing in children: Results compared with conventional leukocyte histamine release assay, skin prick test, bronchial provocation test, and RAST. Allergy 42:366-377.
31. Okayama Y and Church MK (1992) Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. Int Arch Allergy Appl Immunol 97:216-222.
32. TC type of human mast cell. J Immunol 145:2652-2661.
33. Schechter NM, Slavin D, Fetter RD, Lazarus GS and Fräki JE (1988) Purification and identification of two serine class proteinases from dog mast cells biochemically and immunologically similar to human proteinases tryptase and chymase. Arch Biochem Biophys 262:232-243.
34. Schick B (1990) Cleavage of a rat serosal mast cell membrane component during degranulation mediated by chymase, a secretory granule protease. Immunology 69:423-428.
35. Schick B, Austen KF and Schwartz LB (1984) Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. J Immunol 132:2571-2577.
36. Smith TJ, Hougland MW and Johnson DA (1984) Human lung tryptase: Purification and characterization. J Biol Chem 259:11046-11051.
37. Walls AF (1995) The roles of neutral proteases in asthma and rhinitis, in Asthma and Rhinitis (Busse WW and Holgate ST eds) pp 801-824, Blackwell, Oxford.
38. Walls AF (1998) Mast cell proteases in asthma, in Inflammatory Mechanisms in Asthma (Holgate ST and Busse WW eds) pp 119-131, Marcel Dekker, New York.
39. Yanagida M, Fukamachi H, Takei M, Uzumaki H, Tokiwa T, Saite H, Iikura Y and Nakahata T (1997) Effect of a chymotrypsin-like inhibitor, TPCK, on histamine release from cultured human mast cells. J Pharm Pharmacol 49:537-541.